CN111494519A

CN111494519A - A topical Chinese medicinal composition for treating vitiligo, and its preparation method

Info

Publication number: CN111494519A
Application number: CN202010535130.0A
Authority: CN
Inventors: 张奇虎; 张亚强
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-06-12
Filing date: 2020-06-12
Publication date: 2020-08-07

Abstract

The invention provides an external traditional Chinese medicine composition for treating leucoderma, which comprises the following raw materials in parts by weight: 40-60 parts of sophora flavescens powder, 20-40 parts of stellera chamaejasme, 20-30 parts of cocklebur fruit, 30-60 parts of rhizoma typhonii, 20-40 parts of realgar, 10-60 parts of angelica dahurica, 30-60 parts of dried alum, 20-60 parts of fructus cnidii, 20-30 parts of plum slice, 15-50 parts of calomel and 50-200 parts of lithargite; the preparation method comprises the following steps: (1) pulverizing radix Euphorbiae Fischerianae, fructus Xanthii, rhizoma Typhonii, radix Angelicae Dahuricae, dried Alumen, fructus Cnidii, Borneolum Syntheticum and Lithargyrum into fine powder; (2) weighing the raw materials, grinding into fine powder, radix sophorae flavescentis powder, realgar and calomel; (3) putting the weighed raw materials into a traditional Chinese medicine grinder together for grinding for 5-10 min, and uniformly mixing; the invention has the beneficial effect of good treatment effect and is suitable for the field of external medicaments for treating leucoderma.

Description

A topical Chinese medicinal composition for treating vitiligo, and its preparation method

Technical Field

The invention relates to the technical field of external medicaments for treating leucoderma, in particular to an external Chinese medicinal composition for treating leucoderma and a preparation method thereof.

Background

Vitiligo is a relatively common acquired pigmentary dermatosis and is characterized by complete loss of pigment of local or generalized skin mucous membrane, which is caused by the disappearance of melanocyte function of skin. All parts of the body can occur, usually in the skin folds of the back, wrist, forearm, face and neck of the finger. The common symptoms are that the skin damage part is milky white or light pink, the surface is smooth and has no rash, the white spot boundary is clear, the pigment at the edge is increased compared with the normal skin, and the hair in the white spot is normal or whitened. Under the condition of no treatment, white spots can spread to a plurality of parts of patients with leucoderma, and the disease condition of most patients can be aggravated under the conditions of insolation, fatigue and mental stress, thereby causing serious adverse effects on the psychology of the patients. At present, a plurality of leucoderma treatment methods are available, but the preparation method is complex, most of the leucoderma treatment methods only have the function of relieving leucoderma, the leucoderma cannot be completely cured, and the relapse phenomenon often occurs.

In order to solve the problems, a preparation method of a liniment special for vitiligo is proposed, although the liniment has a certain relieving effect on the treatment of vitiligo, the preparation method is complex, the traditional Chinese medicine needs to be decocted twice by adding water, filtered, stood, taken supernatant, concentrated, added with ethanol for concentration, added with water for even stirring, subpackaged and the like, ethanol and water are used as solvents, the skin is stimulated by using excessive ethanol, the treatment is not facilitated, and the drug effect is weakened by adding water.

Disclosure of Invention

Aiming at the defects in the related technology, the technical problem to be solved by the invention is as follows: provides an externally applied traditional Chinese medicine composition with good treatment effect for treating leucoderma and a preparation method thereof.

In order to solve the technical problems, the technical scheme adopted by the invention is as follows: an external traditional Chinese medicine composition for treating leucoderma comprises the following raw materials in parts by weight: 40-60 parts of sophora flavescens powder, 20-40 parts of stellera chamaejasme, 20-30 parts of cocklebur fruit, 30-60 parts of rhizoma typhonii, 20-40 parts of realgar, 10-60 parts of angelica dahurica, 30-60 parts of dried alum, 20-60 parts of fructus cnidii, 20-30 parts of plum slice, 15-50 parts of calomel and 50-200 parts of lithargite.

Preferably, the feed comprises the following raw materials in parts by weight: 50 parts of sophora flavescens powder, 20 parts of stellera chamaejasme, 25 parts of cocklebur fruit, 35 parts of rhizoma typhonii, 20 parts of realgar, 40 parts of angelica dahurica, 50 parts of dried alum, 30 parts of fructus cnidii, 20 parts of plum slice, 25 parts of calomel and 100 parts of lithargite.

Preferably, the external traditional Chinese medicine composition is external powder.

The invention also provides a preparation method of the external traditional Chinese medicine composition for treating leucoderma, which comprises the following steps: (1) pulverizing radix Euphorbiae Fischerianae, fructus Xanthii, rhizoma Typhonii, radix Angelicae Dahuricae, dried Alumen, fructus Cnidii, Borneolum Syntheticum and Lithargyrum into fine powder; (2) weighing the raw materials, grinding into fine powder, radix sophorae flavescentis powder, realgar and calomel; (3) putting the weighed raw materials into a traditional Chinese medicine grinder together for grinding for 5-10 min, and uniformly mixing.

Preferably, the fineness of the fine powder is 200 meshes.

The invention has the beneficial technical effects that:

1. the external traditional Chinese medicine composition prepared by taking the sophora flavescens powder, the euphorbia fischeriana, the cocklebur fruit, the giant typhonium rhizome, the realgar, the angelica dahurica, the dried alum, the common cnidium fruit, the plum slice, the calomel and the lithargite as raw materials has a good effect on treating the leucoderma.

The raw materials can play a good role in treating skin damage caused by leucoderma through reasonable compatibility, the effective rate reaches 98.9%, and the recurrence rate is low; can effectively control the continuous diffusion of the white spots, eliminate the white spots at the skin lesion part and restore the natural color of the skin at the skin lesion part, thereby improving the psychological state of patients.

2. The external traditional Chinese medicine composition prepared by the invention is external powder and has good effect on treating leucoderma.

3. By adopting the preparation method of the external traditional Chinese medicine composition provided by the invention, the prepared external traditional Chinese medicine composition has long storage time and has good effect on treating leucoderma; the method has the advantages that the steps are simple, the weighed raw materials are placed into the traditional Chinese medicine grinder together for grinding, all the raw materials can be fully mixed together, the skin damage part can be uniformly wiped when the method is used, and the effect is better.

4. The fineness of the fine powder is 200 meshes, and when the fineness of the fine powder is 200 meshes, the raw materials are mixed and used, so that the mixed medicinal value can be effectively exerted, and the curative effect on vitiligo is better.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments, and it is obvious that the described embodiments are some embodiments, but not all embodiments, of the present invention; all other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

The preparation method of the external traditional Chinese medicine composition for treating vitiligo in the first embodiment to the third embodiment comprises the following steps:

(1) pulverizing radix Euphorbiae Fischerianae, fructus Xanthii, rhizoma Typhonii, radix Angelicae Dahuricae, dried Alumen, fructus Cnidii, Borneolum Syntheticum and Lithargyrum into fine powder; the fineness of the fine powder is 200 meshes;

(2) weighing the raw materials, grinding into fine powder, radix sophorae flavescentis powder, realgar and calomel;

(3) putting the weighed raw materials into a traditional Chinese medicine grinder together for grinding for 5-10 min, and uniformly mixing.

By adopting the preparation method of the external traditional Chinese medicine composition provided by the invention, the prepared external traditional Chinese medicine composition has long storage time and has good effect on treating leucoderma; the method has the advantages that the steps are simple, the weighed raw materials are placed into the traditional Chinese medicine grinder together for grinding, all the raw materials can be fully mixed together, the skin damage part can be uniformly wiped when the method is used, and the effect is better.

The fineness of the fine powder is 200 meshes, and when the fineness of the fine powder is 200 meshes, the raw materials are mixed and used, so that the mixed medicinal value can be effectively exerted, and the curative effect on vitiligo is better.

Specifically, the weight parts of the raw materials correspond to the grams when the external traditional Chinese medicine composition is actually prepared.

Furthermore, 1 part of the traditional Chinese medicine composition for external use is prepared in the actual preparation according to the proportion of 1 g.

Weighing the following raw materials in proportion:

example one

50 parts of sophora flavescens powder, 20 parts of stellera chamaejasme, 25 parts of cocklebur fruit, 35 parts of rhizoma typhonii, 20 parts of realgar, 40 parts of angelica dahurica, 50 parts of dried alum, 30 parts of fructus cnidii, 20 parts of plum slice, 25 parts of calomel and 100 parts of lithargite.

Example two

40 parts of sophora flavescens powder, 40 parts of euphorbia fischeriana, 20 parts of cocklebur fruit, 30 parts of rhizoma typhonii, 25 parts of realgar, 10 parts of angelica dahurica, 30 parts of dried alum, 20 parts of fructus cnidii, 25 parts of plum slice, 15 parts of calomel and 50 parts of litharge.

EXAMPLE III

60 parts of sophora flavescens powder, 30 parts of euphorbia fischeriana, 30 parts of cocklebur fruit, 60 parts of rhizoma typhonii, 40 parts of realgar, 60 parts of angelica dahurica, 60 parts of dried alum, 60 parts of fructus cnidii, 30 parts of plum slice, 50 parts of calomel and 200 parts of litharge.

The external traditional Chinese medicine composition prepared by taking the sophora flavescens powder, the euphorbia fischeriana, the cocklebur fruit, the giant typhonium rhizome, the realgar, the angelica dahurica, the dried alum, the common cnidium fruit, the plum slice, the calomel and the lithargite as raw materials has a good effect on treating the leucoderma.

The external traditional Chinese medicine composition prepared by the invention is external powder and has good effect on treating leucoderma.

In order to show the treatment effect of the external traditional Chinese medicine composition for treating the leucoderma, 280 leucoderma patients using the external traditional Chinese medicine composition are subjected to medication and observation for 60 days.

1. The using method comprises the following steps: disinfecting the affected part with a disinfectant liquid, peeling with cucurbitaceae plants, dipping the external traditional Chinese medicine composition, and wiping the affected part for 10-20 min; administration: 1-2 times a day; a treatment course is 30 days. No dietetic restraint and normal diet.

The disinfectant liquid is iodophor.

The Cucurbitaceae plant is one of cucumber, pumpkin, towel gourd and watermelon.

The cucurbitaceae plant has little harm to human body, and avoids the problem that the traditional Chinese medicine is ineffective when dissolved by water.

It should be noted that: in daily life, a patient needs to pay attention to adjust the psychological state of the patient, keep a pleasant mood, reduce sunshine insolation, strengthen exercise and improve the immunity of the body.

2. The therapeutic effect judgment standard is as follows: refer to the relevant standard regulation of the clinical research guideline of new Chinese medicine.

And (3) curing: the discomfort symptoms such as skin lesion enlargement, leukoplakia edge pigment increase and the like disappear;

the effect is shown: the discomfort symptoms such as skin lesion part enlargement, white spot edge pigment increase and the like are obviously improved;

the method has the following advantages: the discomfort symptoms such as enlargement of skin lesion, white spot, increase of pigment at the edge of white spot and the like are relieved;

and (4) invalidation: the discomfort symptoms such as skin lesion enlargement, leukoplakia edge pigment increase, etc. are not improved.

3. The treatment effect is as follows:

165 male patients and 115 female patients of 280 psoriasis patients who use the ointment are 15-35 years old. After the ointment provided by the invention is used for 30 days, 130 cases are cured, 125 cases are obviously effective, 22 cases are effective, and 3 cases are ineffective, so that the effective rate reaches 98.9%; basically no recurrence. After most patients use the ointment for 10 days, uncomfortable symptoms such as skin lesion enlargement, leukoplakia edge pigment increase and the like are improved to different degrees, and the patients are basically cured after two treatment courses.

The therapeutic effects are further specified by exemplifying several typical cases.

Typical case one: lie in le, woman, 25 years old, shanxi jifen. Symptoms are: the patients with leucoderma are diagnosed in 3 years and 2013 years, and the skin lesion part is as follows: the treatment has a certain effect, but the treatment is repeated in 3 years, and the condition that the white spot region is diffused appears in 2016 to see a doctor everywhere, after the external traditional Chinese medicine composition provided by the embodiment of the invention is used for one treatment course, the skin damage part is not enlarged any more, the white spot position is obviously improved, the skin color at the lower jaw position is basically recovered, and the white spots at the affected parts of the arm and the neck are gradually weakened; after two courses of treatment, the skin color of the skin lesion part is recovered to be normal, and the treatment is not repeated until now.

Typical case two: zhangiao, female, age 30, Shanxi Linfen. Symptoms are: a small amount of white spots are formed at the lower part of the lips and the forehead, after the external traditional Chinese medicine composition provided by the embodiment of the invention is used for one treatment course, the skin damage area does not have the diffusion phenomenon, the white spots at the lower part of the lips and the forehead gradually recover the natural color of the skin, and the white spot edges at the skin damage part can be seen only in a short distance; after a treatment course is continued, the skin lesion basically recovers the original color of the skin, and the treatment course is not repeated until now.

Typical case three: he, male, 18 years old, Shanxi Yuancheng. Symptoms are: the abdomen is affected with leukoplakia and slight pruritus, and after the externally-applied traditional Chinese medicine composition provided by the embodiment II of the invention is used for one treatment course, the symptom of pruritus is relieved; in the early stage of the second treatment course, the symptoms of pruritus disappear, but the treatment effect on the leukoplakia is not obvious; a large number of black spots appear at the white spots in the later period of the second treatment course; after a treatment course, the white spot symptom is basically cured, and the subsequent revisit is not repeated.

Typical case four: wangzhi, Man, age 33, Shanxi Yuncheng Cheng. Symptoms are: after the externally-applied traditional Chinese medicine composition provided by the third embodiment of the invention is used for a treatment course, the small-area white spots on the face are obviously improved, and the diffusion of the white spots on the face is effectively controlled; the edge of the white spot at the arm gradually recovers the natural color of the skin, and the boundary is unclear; after a treatment course is continuously used, the face and most of leukoplakia on the arms are cured, and all the leukoplakia on the arms are cured after 10 days of continuous consolidation, so far, the treatment course is not repeated.

In the description of the present invention, the terms "first" and "second" are used for descriptive purposes only and are not to be construed as indicating or implying relative importance or implying any number of technical features indicated. Thus, a feature defined as "first" or "second" may explicitly or implicitly include at least one such feature.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.

In the foregoing embodiments, the descriptions of the respective embodiments have respective emphasis, and for parts that are not described in detail in a certain embodiment, reference may be made to related descriptions of other embodiments.

It will be appreciated that the relevant features of the method, apparatus and system described above are referred to one another. In addition, "first", "second", and the like in the above embodiments are for distinguishing the embodiments, and do not represent merits of the embodiments.

It can be clearly understood by those skilled in the art that, for convenience and brevity of description, the specific working processes of the system and the module described above may refer to the corresponding processes in the foregoing method embodiments, and are not described herein again.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; while the invention has been described in detail and with reference to the foregoing embodiments, it will be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; and the modifications or the substitutions do not make the essence of the corresponding technical solutions depart from the scope of the technical solutions of the embodiments of the present invention.

Claims

1. An external traditional Chinese medicine composition for treating leucoderma is characterized in that: the feed comprises the following raw materials in parts by weight: 40-60 parts of sophora flavescens powder, 20-40 parts of stellera chamaejasme, 20-30 parts of cocklebur fruit, 30-60 parts of rhizoma typhonii, 20-40 parts of realgar, 10-60 parts of angelica dahurica, 30-60 parts of dried alum, 20-60 parts of fructus cnidii, 20-30 parts of plum slice, 15-50 parts of calomel and 50-200 parts of lithargite.

2. The topical Chinese medicinal composition for treating vitiligo according to claim 1, wherein: the feed comprises the following raw materials in parts by weight: 50 parts of sophora flavescens powder, 20 parts of stellera chamaejasme, 25 parts of cocklebur fruit, 35 parts of rhizoma typhonii, 20 parts of realgar, 40 parts of angelica dahurica, 50 parts of dried alum, 30 parts of fructus cnidii, 20 parts of plum slice, 25 parts of calomel and 100 parts of lithargite.

3. The topical Chinese medicinal composition for treating vitiligo according to claim 1, wherein: the external traditional Chinese medicine composition is external powder.

4. The method for preparing the externally-applied traditional Chinese medicine composition for treating leucoderma according to any one of claims 1 to 3, which is characterized by comprising the following steps: the method comprises the following steps:

(1) pulverizing radix Euphorbiae Fischerianae, fructus Xanthii, rhizoma Typhonii, radix Angelicae Dahuricae, dried Alumen, fructus Cnidii, Borneolum Syntheticum and Lithargyrum into fine powder;

5. The preparation method of the external traditional Chinese medicine composition for treating leucoderma according to claim 4, which is characterized by comprising the following steps: the fineness of the fine powder is 200 meshes.