CN111493944A - Freely-connected plugging device with 3D printing forming framework structure and forming method - Google Patents

Freely-connected plugging device with 3D printing forming framework structure and forming method Download PDF

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Publication number
CN111493944A
CN111493944A CN201910778857.9A CN201910778857A CN111493944A CN 111493944 A CN111493944 A CN 111493944A CN 201910778857 A CN201910778857 A CN 201910778857A CN 111493944 A CN111493944 A CN 111493944A
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occluder
freely
printing
framework structure
forming
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张瑾
张健
马彩霞
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Shanghai Jinkui Medical Devices Co ltd
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Shanghai Jinkui Medical Devices Co ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B22F10/20—Direct sintering or melting
    • B22F10/22—Direct deposition of molten metal
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B22—CASTING; POWDER METALLURGY
    • B22F—WORKING METALLIC POWDER; MANUFACTURE OF ARTICLES FROM METALLIC POWDER; MAKING METALLIC POWDER; APPARATUS OR DEVICES SPECIALLY ADAPTED FOR METALLIC POWDER
    • B22F10/00—Additive manufacturing of workpieces or articles from metallic powder
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B29—WORKING OF PLASTICS; WORKING OF SUBSTANCES IN A PLASTIC STATE IN GENERAL
    • B29C—SHAPING OR JOINING OF PLASTICS; SHAPING OF MATERIAL IN A PLASTIC STATE, NOT OTHERWISE PROVIDED FOR; AFTER-TREATMENT OF THE SHAPED PRODUCTS, e.g. REPAIRING
    • B29C64/00—Additive manufacturing, i.e. manufacturing of three-dimensional [3D] objects by additive deposition, additive agglomeration or additive layering, e.g. by 3D printing, stereolithography or selective laser sintering
    • B29C64/10—Processes of additive manufacturing
    • B29C64/106—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material
    • B29C64/118—Processes of additive manufacturing using only liquids or viscous materials, e.g. depositing a continuous bead of viscous material using filamentary material being melted, e.g. fused deposition modelling [FDM]
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y10/00—Processes of additive manufacturing
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B33—ADDITIVE MANUFACTURING TECHNOLOGY
    • B33Y—ADDITIVE MANUFACTURING, i.e. MANUFACTURING OF THREE-DIMENSIONAL [3-D] OBJECTS BY ADDITIVE DEPOSITION, ADDITIVE AGGLOMERATION OR ADDITIVE LAYERING, e.g. BY 3-D PRINTING, STEREOLITHOGRAPHY OR SELECTIVE LASER SINTERING
    • B33Y80/00—Products made by additive manufacturing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/0057—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect
    • A61B2017/00575—Implements for plugging an opening in the wall of a hollow or tubular organ, e.g. for sealing a vessel puncture or closing a cardiac septal defect for closure at remote site, e.g. closing atrial septum defects
    • A61B2017/00628—T-shaped occluders
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P10/00—Technologies related to metal processing
    • Y02P10/25—Process efficiency

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Abstract

The invention discloses a freely-connected plugging device with a 3D printing forming framework structure and a forming method. This freely connect plugging device includes: the framework structure is integrally formed by 3D printing and comprises a net-shaped body, the net-shaped body is provided with a near end and a far end which are oppositely arranged, the far end is provided with a flat and smooth surface, the near end is provided with a connecting piece or a flat and smooth surface, the connecting piece comprises an operation area and is of any structure capable of 3D printing, and the operation area is used for being connected with a conveyor for conveying the freely-connected plugging device; and the flow blocking interlayer is positioned inside the reticular body and used for blocking the blood flow. The molding method comprises the following steps: adopting 3D printing to integrally form a framework structure; the choke interlayer is placed inside the mesh body. The framework structure adopts 3D printing integrated into one piece, the forming mode is simpler, connecting devices are not required to be arranged between the structural components of the framework structure, the overall occupied space of the framework structure is less, the forming efficiency is higher, and the manufacturing cost is favorably reduced.

Description

Freely-connected plugging device with 3D printing forming framework structure and forming method
Technical Field
The invention relates to the field of medical instruments, in particular to a free connection occluder with a 3D printing forming skeleton structure and a forming method thereof, which are used for treating diseases requiring occlusion treatment, such as atrial septal defect, patent ductus arteriosus, ventricular septal defect, patent foramen ovale, left atrial appendage, or blood vessel, other tissue cavities and the like.
Background
In the prior art, the stopper is generally provided with a connecting member at one end thereof, and the connecting member is internally threaded to be connected with a conveyor to realize the conveying of the stopper. Because the internal thread processing degree of difficulty is higher, can produce higher defective percentage in the production process moreover, cause the waste of raw and other materials and invalid improvement of cost of labor like this. When treating tumor and vascular diseases, the plugging device can also be implanted into the supply vessel of the diseased organ to block the supply vessel and interrupt the blood supply, so as to achieve the purposes of controlling bleeding, treating tumor and vascular diseases and eliminating the functions of the diseased organ. The occluding device may also be placed in some tissue cavities to close the tissue cavity and cut off the delivery of internal material.
The skeleton structure of the occluder in the prior art adopts a method of heat setting after weaving, and has complex process and long time consumption. If the framework structure of the plugging device can be formed by adopting a 3D printing method, the conventional processing shaping process can be omitted, the process is simplified, the production efficiency is improved, and the cost is reduced.
In summary, the prior art has difficulty in manufacturing and increased manufacturing cost due to the complicated and time-consuming process of manufacturing the stopper.
Disclosure of Invention
The invention aims to overcome the defects that the forming method of the occluder in the prior art is complex in process and long in time consumption, and provides a freely-connected occluder with a 3D printing forming framework structure and a forming method thereof.
The invention solves the technical problems through the following technical scheme:
the utility model provides a shutoff ware is connected freely with 3D prints shaping skeleton texture which characterized in that, the shutoff ware is connected including freely: the framework structure is integrally formed by 3D printing and comprises a net-shaped body, the net-shaped body is provided with a near end and a far end which are oppositely arranged, the far end is provided with a flat and smooth surface, and the near end is provided with a connecting piece or a flat and smooth surface; wherein the connecting piece comprises an operating area and is any structure capable of being printed in a 3D mode, and the operating area is used for being connected with a conveyor for conveying the freely-connected plugging device; and the flow blocking interlayer is positioned inside the reticular body and used for blocking the blood flow.
In this scheme, the integrated into one piece is printed by 3D to the skeleton texture, need not to set up special connecting device between each structure of skeleton texture is constituteed, and the whole space that occupies of skeleton texture is less, and the process is comparatively simple in the forming process, and the shaping is efficient. In addition, the connecting piece of the freely-connected plugging device can realize the connection of the conveyor without threads, is easy to manufacture and is beneficial to reducing the cost.
Preferably, the link is shaped to fit into a catch formation of the conveyor, wherein the catch formation is adapted to catch the link;
preferably, the connecting piece is of a cylindrical structure, a spherical structure or an ellipsoidal structure.
In the scheme, the shape of the connecting piece can be adaptively set according to the shape of the catching structure, and the application range is wide.
In the scheme, the connecting pieces in various shapes have smooth and mellow structures, so that the connecting pieces can be safely implanted into a human body without damaging heart tissues around defects.
Preferably, the mesh body is a mesh structure with double disc surfaces.
Preferably, the meshes of the mesh body are designed according to the simulation of an actual woven product;
preferably, the shape of the mesh body comprises a parallelogram, a rhombus, a parallelogram-like shape, a rhombus-like shape, or a combination of at least two of the above figures.
In the scheme, the meshes of the reticular body have certain constraint performance, so that the product keeps a certain shape and has larger movement space, and the product is easy to deform. When a product is conveyed, the product can be stretched into a small-diameter cross section and passed through a conveying sheath, and can be restored to the original shape after reaching the defect site. The actual woven product refers to a shape corresponding to a product processed by adopting a weaving forming mode.
Preferably, the choke partition is perpendicular to the central axis of the mesh body, and the choke partition is made of non-woven fabric, thin film or fabric.
Preferably, the material of the skeleton structure is metal, metal alloy, or polymer material.
Preferably, the freely-connected occluder is an atrial septal defect occluder, an arterial duct patent occluder, an ventricular septal defect occluder, a patent foramen ovale occluder, a left atrial appendage occluder, a vascular plug or an occluder for parts needing to be repaired, occluded and blocked in a human body structure.
The invention also provides a forming method of the freely-connected plugging device with the 3D printing forming framework structure, which is characterized by comprising the following steps of:
when the proximal end has a connector, the molding method comprises the steps of:
s1, integrally forming the framework structure by adopting 3D printing, wherein the framework structure comprises the mesh body and the connecting piece;
s2, placing the anti-flow interlayer inside the net-shaped body;
when the proximal end is a flat and smooth surface, the molding method comprises the following steps:
s1', integrally forming the framework structure by adopting 3D printing;
s2', placing the anti-flow interlayer inside the reticular body.
In this scheme, skeleton texture adopts 3D to print integrated into one piece, and the shaping mode is comparatively simple, and process time is shorter relatively, need not to set up special connecting device between each structure of skeleton texture is constituteed, and the whole space that occupies of skeleton texture is less, and shaping efficiency is higher, is favorable to reducing the cost of manufacture.
Preferably, step S1 includes the following steps:
s11, making a model file of the skeleton structure;
s12, importing the model file of the skeleton structure into a corresponding 3D printer;
s13, sending the materials for manufacturing the framework structure to a printing material port of a corresponding 3D printer.
S14, melting and extruding the material by the 3D printer;
and S15, cooling the extruded material on a printing table, and stacking the extruded material layer by layer to complete the molding of the skeleton structure.
Preferably, in step S13, the material is in the form of powder, fiber or gel. When the framework is made of metal or metal alloy, the materials can be powder; when the material of the skeleton is a polymer material, these materials may be in a fibrous or gel form.
On the basis of the common knowledge in the field, the above preferred conditions can be combined randomly to obtain the preferred embodiments of the invention.
The positive progress effects of the invention are as follows:
the freely-connected occluder framework structure disclosed by the invention is integrally formed by 3D printing, the forming mode is simpler, a special connecting device is not required to be arranged among all the structural components of the framework structure, the overall occupied space of the framework structure is less, the forming efficiency is higher, and the manufacturing cost is favorably reduced. The forming method of the freely-connected plugging device is simple, the forming process of conventional processing can be omitted, and the forming process is simple. The freely-connected occluder can also be used as a medical appliance for occluding blood vessels, is implanted into a supply vessel of a diseased organ to occlude the vessel and interrupt blood supply so as to achieve the purposes of controlling bleeding, treating tumors and vascular diseases and eliminating the functions of the diseased organ, and can also be placed in certain tissue cavities to close the tissue cavities and cut off the delivery of internal substances.
Drawings
Fig. 1 is a schematic structural diagram of a free connection occluder with a 3D printing molded skeleton structure according to embodiment 1 of the present invention.
Fig. 2 is a partial structural schematic view of the freely-connected occluder with a 3D-printed skeleton structure in embodiment 1 of the present invention, which shows the relative position relationship between the flow-resisting partition and the mesh body.
Fig. 3 is a schematic structural diagram of a free connection occluder having a 3D printing skeleton structure in embodiment 2 of the present invention.
Fig. 4 is another schematic structural diagram of the freely-connected occluder with a 3D-printed skeleton structure in embodiment 2 of the present invention.
Fig. 5 is a schematic structural diagram of a free connection occluder having a 3D printing skeleton structure in embodiment 3 of the present invention.
Fig. 6 is another schematic structural diagram of the freely-connected occluder with a 3D-printed skeleton structure in embodiment 3 of the present invention.
Fig. 7 is a schematic structural diagram of a free connection occluder having a 3D printing molded skeleton structure in embodiment 4 of the present invention.
Fig. 8 is a schematic structural diagram of a free connection occluder having a 3D printing molded skeleton structure in embodiment 5 of the present invention.
Fig. 9 is a flowchart of a method for forming a free-connection occluder having a 3D-printed molded skeleton structure in embodiment 6 of the present invention.
Fig. 10 is a sub-flowchart of step S1 of the method for forming a free-attachment occluder having a 3D-printed molded skeleton structure in embodiment 6 of the present invention.
Description of reference numerals:
10: net-shaped body
101: distal end
102: proximal end
30: connecting piece
40: choked flow interlayer
Detailed Description
The present invention will be more clearly and completely described in the following description of preferred embodiments, taken in conjunction with the accompanying drawings.
Example 1
The embodiment discloses a free connection occluder with a 3D printing and molding framework structure, which is an patent ductus arteriosus occluder. As will be appreciated with reference to fig. 1, the free-connect occluder comprises a skeletal structure and a flow-blocking barrier. The framework structure is integrally formed by 3D printing, and comprises a net-shaped body 10, wherein the net-shaped body 10 is provided with a near end 102 and a far end 101 which are oppositely arranged, the far end 101 is provided with a flat and smooth surface, and the near end 102 is provided with a connecting piece 30 or a flat and smooth surface; wherein the connecting member 30 comprises an operative area for connection with a conveyor for conveying the freely attachable occluder, and is of any 3D printable construction. The barrier layer is located inside the mesh body 10 to block the flow of blood.
In this embodiment, the framework structure is printed integrated into one piece by 3D, need not to set up special connecting device between each structure of framework structure is constituteed, and the whole space that occupies of framework structure is less, and the shaping is efficient. In addition, the connecting piece 30 for freely connecting the plugging device can realize the connection of the conveyor without arranging threads, is easy to manufacture and is beneficial to reducing the cost.
Further, the shape of the link 30 is adapted to fit a catching structure of the conveyor for catching the link 30. The shape of the connecting piece 30 can be adaptively set according to the shape of the catching structure, and the application range is wide.
Further, as will be understood with reference to FIG. 1, the connecting member 30 is a cylindrical structure. It should be noted that, in other alternative embodiments, the connecting member 30 may be configured as a spherical or ellipsoidal structure according to actual needs. It should be noted that the length of the connecting member 30 in fig. 1 is merely illustrative, and the actual length of the connecting member 30 or the length of the connecting member 30 relative to the mesh body 10 may be set according to actual needs.
Still further, as will be appreciated with continued reference to FIG. 1, the mesh body 10 is a mesh structure having dual disk faces. The mesh of the mesh body 10 is designed according to the simulation of the actual woven product. The shape of the mesh body 10 is a combination of a parallelogram and a parallelogram-like shape.
In other alternative embodiments, the grid may be shaped to include other patterns such as parallelograms, rhombuses, parallelogram-like patterns, rhombuses, or combinations of at least two of the foregoing.
Further, in the present embodiment, the material of the skeleton structure is metal, such as stainless steel, titanium, etc. In other alternative embodiments, the material of the skeleton structure may also be a metal alloy material, or a polymer material. Wherein the metal alloy material comprises cobalt-based alloy, titanium alloy or nickel-titanium alloy shape memory material and the like. The polymer material can be degradable and absorbable biomedical polymer material, including polylactide, polyglycolide, polycaprolactone, polydioxanone, and copolymers or mixtures of these materials; or a biological inert medical polymer material, including nylon, polyester resin, polytetrafluoroethylene, ultra-high molecular weight polyethylene, high-density polyethylene, polymethyl methacrylate, polypropylene, polycarbonate, polyurethane, organic silicon or polyacrylonitrile, and copolymers or mixtures of the materials.
Further, as shown in fig. 2, the choke interlayer 40 is perpendicular to the central axis of the mesh body 10, and the material of the choke interlayer 40 is non-woven fabric, thin film or woven fabric.
Example 2
The freely-connected occluder with a 3D-printed skeleton structure disclosed in this embodiment is an atrial septal defect occluder, and as shown in fig. 3, the structure of the freely-connected occluder in this embodiment is substantially the same as that of the freely-connected occluder in embodiment 1. The difference is mainly as follows: the structure of the mesh body 10. The plugging device is mainly used for plugging atrial septal defect, the disc surface of the reticular body is double disc-shaped, and the diameter of the disc surface is larger, so that enough supporting force can be provided to firmly fix the plugging device at the atrial septal defect. The diameter of the waist part is slightly larger than that of the defect, thereby improving the plugging effect.
Similar to embodiment 1, the length of the connecting member 30 in fig. 3 is only illustrated, and the actual length of the connecting member 30 or the length of the connecting member 30 relative to the mesh body 10 may be set according to actual needs.
It should be noted that the coupling 30 may also be a cylindrical coupling as shown in fig. 4, which has no internal thread at the end intended for connection to the conveyor.
Example 3
The freely-connected occluder with a 3D-printed skeleton structure disclosed in this embodiment is a patent foramen ovale occluder, and as shown in fig. 5 and 6, the structure of the freely-connected occluder in this embodiment is substantially the same as that of the freely-connected occluder in embodiment 1. The difference is mainly as follows: the structure of the mesh body 10. The plugging device is mainly used for plugging patent foramen ovale, the reticular body of the plugging device is in an I shape and in a double disc shape, the diameter of the disc surface is large, so that enough supporting force can be provided to firmly fix the plugging device at the patent foramen ovale, and the larger disc surface of the plugging device can increase the plugging effect. The diameter of the waist part is smaller because the gap at the patent foramen ovale is generally smaller, and the smaller diameter of the waist part is beneficial to the placement of the occluder without damaging the surrounding tissues.
Similar to embodiment 1, the length of the connecting member 30 in fig. 5 is only illustrated, and the actual length of the connecting member 30 or the length of the connecting member 30 relative to the mesh body 10 may be set according to actual needs.
Example 4
The freely-connected occluder with a 3D-printed skeleton structure disclosed in this embodiment is a ventricular septal defect occluder, and as shown in fig. 7, the structure of the freely-connected occluder in this embodiment is substantially the same as that of the freely-connected occluder in embodiment 1. The difference is mainly as follows: the structure of the mesh body 10. The plugging device is mainly used for ventricular septal defect, the waist diameter of the reticular body is slightly larger than the defect, and the diameter of the disc surface is slightly larger than the waist, so that enough supporting force can be provided to firmly fix the plugging device at the ventricular septal defect, and the larger waist diameter can increase the plugging effect. A plurality of conducting key cables are arranged around the ventricular septal defect, and in order to prevent conduction block, the diameter of the disc surface of the occluder cannot be too large and is slightly larger than the diameter of the waist.
Similar to embodiment 1, the length of the connecting member 30 in fig. 7 is only illustrated, and the actual length of the connecting member 30 or the length of the connecting member 30 relative to the mesh body 10 may be set according to actual needs.
Example 5
The freely-connected occluder with a 3D-printed skeleton structure disclosed in this embodiment is a left atrial appendage occluder, and as shown in fig. 8, the structure of the freely-connected occluder in this embodiment is substantially the same as that of the freely-connected occluder in embodiment 1. The difference is mainly as follows: the structure of the mesh body 10. The plugging device is mainly used for the left auricle, the reticular body of the plugging device is similar to a hat, the disk surface with smaller diameter is beneficial to being placed at the left auricle, and the disk surface with larger diameter is placed at the entrance of the left auricle and completely covers the entrance, thereby completely plugging the left auricle. The structure has enough supporting force to be placed at the left auricle and is beneficial to completely blocking the left auricle.
Similar to embodiment 1, the length of the connecting member 30 in fig. 8 is only illustrated, and the actual length of the connecting member 30 or the length of the connecting member 30 relative to the mesh body 10 may be set according to actual needs.
Example 6
This example discloses a method of forming a free-attachment occluder as in any of examples 1-5, comprising the steps of:
step S1, adopting 3D printing to integrally form a skeleton structure, which comprises a reticular body and a connecting piece;
step S2, placing the choke interlayer inside the mesh body.
In this embodiment, the framework structure adopts 3D to print integrated into one piece, and the shaping mode is comparatively simple, need not to set up special connecting device between each structure of framework structure is constituteed, and the whole space that occupies of framework structure is less, and shaping efficiency is higher, is favorable to reducing the cost of manufacture.
It should be noted that, for the freely-connected occluder with the net-shaped body having a flat and smooth surface at the proximal end, the forming method comprises the following steps:
step S1', adopting 3D printing to integrally form a framework structure;
step S2', placing a choke barrier inside the mesh body.
Specifically, as understood with reference to fig. 10, in the present embodiment, step S1 includes the steps of:
s11, making a model file of the skeleton structure;
s12, importing the model file of the skeleton structure into a corresponding 3D printer;
s13, sending the material for manufacturing the framework structure to a printing material port of the corresponding 3D printer.
S14, melting and extruding the material by a 3D printer;
and S15, cooling the extruded material on a printing table, and stacking the extruded material layer by layer to complete the molding of the skeleton structure.
In step S13, the material for forming the skeleton structure is a powder, fiber, or gel material. Specifically, when the material of the skeleton is a metal or a metal alloy, the material may be in a powder form. When the material of the skeleton is a polymer material, these materials may be in a fibrous or gel form.
In describing the present invention, an embodiment may be provided with multiple figures, and reference numerals for like parts of the same embodiment are not necessarily shown in each figure; it will be appreciated by those skilled in the art that while one or more figures in an embodiment are described, they may be understood in conjunction with other figures in the embodiment; it will be understood by those skilled in the art that when no specific reference is made to which figure the text specifically corresponds, the text can be understood in conjunction with all of the figures in the embodiment.
In the description of the present invention, it is to be understood that the terms "upper", "lower", "front", "rear", "left", "right", "vertical", "horizontal", "top", "bottom", "inner", "outer", etc., indicate orientations or positional relationships based on those shown in the drawings, and are only for convenience of description and simplicity of description, but do not indicate or imply that the device or element being referred to must have a particular orientation, be constructed and operated in a particular orientation, and thus, are not to be construed as limiting the present invention.
While specific embodiments of the invention have been described above, it will be appreciated by those skilled in the art that this is by way of example only, and that the scope of the invention is defined by the appended claims. Various changes and modifications to these embodiments may be made by those skilled in the art without departing from the spirit and scope of the invention, and these changes and modifications are within the scope of the invention.

Claims (10)

1. The utility model provides a stopper is connected freely with 3D prints shaping skeletal structure which characterized in that, the stopper is connected including freely: the framework structure is integrally formed by 3D printing and comprises a net-shaped body, the net-shaped body is provided with a near end and a far end which are oppositely arranged, the far end is provided with a flat and smooth surface, and the near end is provided with a connecting piece or a flat and smooth surface; wherein the connecting piece comprises an operating area and is any structure capable of being printed in a 3D mode, and the operating area is used for being connected with a conveyor for conveying the freely-connected plugging device; and the flow blocking interlayer is positioned inside the reticular body and used for blocking the blood flow.
2. The free-connect occluder with 3D printed contoured skeleton structure of claim 1 wherein said connector is shaped to fit a catch structure of said conveyor for catching said connector;
preferably, the connecting piece is of a cylindrical structure, a spherical structure or an ellipsoidal structure.
3. The free-connect occluder with 3D printed molded skeletal structure of claim 1, wherein the mesh body is a mesh structure with double disk faces.
4. The freely-connected occluder with 3D-printed molded skeletal structure of claim 1 wherein the mesh of the mesh body is designed according to actual woven product simulation;
preferably, the shape of the mesh body comprises a parallelogram, a rhombus, a parallelogram-like shape, a rhombus-like shape, or a combination of at least two of the above figures.
5. The freely-connected occluder with 3D-printed skeletal structure in accordance with claim 1 wherein the flow-impeding barrier is perpendicular to the central axis of the mesh body and is made of non-woven fabric, film or fabric.
6. The freely attachable occluder with 3D printed molded framework in accordance with claim 1 wherein the framework is made of metal, metal alloy or polymer.
7. The freely attachable occluder with 3D printed molded skeleton structure of any one of claims 1 to 6 wherein said freely attachable occluder is an atrial septal defect occluder, patent ductus arteriosus occluder, ventricular septal defect occluder, patent foramen ovale occluder, left atrial appendage occluder, vascular plug or occluder for use in a body structure where occlusion, blockage is to be repaired.
8. A method of forming a free-connect occluder having a 3D printed molded skeletal structure in accordance with any one of claims 1 to 7, wherein:
when the proximal end has a connector, the molding method comprises the steps of:
s1, integrally forming the framework structure by adopting 3D printing, wherein the framework structure comprises the mesh body and the connecting piece;
s2, placing the anti-flow interlayer inside the net-shaped body;
when the proximal end is a flat and smooth surface, the molding method comprises the following steps:
s1', integrally forming the framework structure by adopting 3D printing;
s2', placing the anti-flow interlayer inside the reticular body.
9. The method of forming a free-attachment occluder having a 3D printed molded skeletal structure in accordance with claim 8, wherein step S1 comprises the steps of:
s11, making a model file of the skeleton structure;
s12, importing the model file of the skeleton structure into a corresponding 3D printer;
s13, sending the materials for manufacturing the framework structure to a printing material port of a corresponding 3D printer.
S14, melting and extruding the material by the 3D printer;
and S15, cooling the extruded material on a printing table, and stacking the extruded material layer by layer to complete the molding of the skeleton structure.
10. The method of claim 9, wherein in step S13, the material is in a form of powder, fiber, or gel.
CN201910778857.9A 2019-08-22 2019-08-22 Freely-connected plugging device with 3D printing forming framework structure and forming method Pending CN111493944A (en)

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CN105997158A (en) * 2016-05-06 2016-10-12 广州新诚生物科技有限公司 A heart defect occluder
CN106413590A (en) * 2014-08-14 2017-02-15 后续医疗股份有限公司 Filamentary devices for treatment of vascular defects
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CN109464168A (en) * 2018-12-17 2019-03-15 先健科技(深圳)有限公司 Plugging device
CN210931564U (en) * 2019-08-22 2020-07-07 上海锦葵医疗器械股份有限公司 Freely connect plugging device with 3D prints shaping skeleton texture

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102697528A (en) * 2012-06-01 2012-10-03 姬尚义 Closure device
CN106413590A (en) * 2014-08-14 2017-02-15 后续医疗股份有限公司 Filamentary devices for treatment of vascular defects
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