CN111492246A - 用于预测对napi2b靶向疗法的响应的组合物和方法 - Google Patents

用于预测对napi2b靶向疗法的响应的组合物和方法 Download PDF

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Publication number
CN111492246A
CN111492246A CN201880074734.0A CN201880074734A CN111492246A CN 111492246 A CN111492246 A CN 111492246A CN 201880074734 A CN201880074734 A CN 201880074734A CN 111492246 A CN111492246 A CN 111492246A
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napi2b
antibody
cancer
amino acid
seq
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CN201880074734.0A
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Chinese (zh)
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R.莫舍尔
L.L.波林
D.A.贝里斯特隆
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Mersana Therapeutics Inc
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Mersana Therapeutics Inc
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    • A—HUMAN NECESSITIES
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
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    • A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/0004—Screening or testing of compounds for diagnosis of disorders, assessment of conditions, e.g. renal clearance, gastric emptying, testing for diabetes, allergy, rheuma, pancreas functions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C—CHEMISTRY; METALLURGY
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    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • G01N33/57492—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites involving compounds localized on the membrane of tumor or cancer cells
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CN201880074734.0A 2017-09-20 2018-09-20 用于预测对napi2b靶向疗法的响应的组合物和方法 Pending CN111492246A (zh)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201762561107P 2017-09-20 2017-09-20
US62/561107 2017-09-20
US201762571397P 2017-10-12 2017-10-12
US62/571397 2017-10-12
US201862718692P 2018-08-14 2018-08-14
US62/718692 2018-08-14
PCT/US2018/051951 WO2019060542A2 (en) 2017-09-20 2018-09-20 COMPOSITIONS AND METHODS FOR PREDICTING RESPONSE TO NAPI2B TARGETING THERAPY

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US (2) US11596694B2 (cg-RX-API-DMAC7.html)
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KR (1) KR20200055770A (cg-RX-API-DMAC7.html)
CN (1) CN111492246A (cg-RX-API-DMAC7.html)
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BR (1) BR112020005390A2 (cg-RX-API-DMAC7.html)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116830204A (zh) * 2021-02-08 2023-09-29 株式会社岛津制作所 估计装置、学习装置、优化装置、估计方法、学习方法以及优化方法

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3836972A1 (en) 2018-08-17 2021-06-23 Mersana Therapeutics, Inc. Napi2b-targeted polymer antibody-drug conjugates and methods of use thereof
CN114585623A (zh) 2019-08-02 2022-06-03 梅尔莎纳医疗公司 双[N-((5-氨基甲酰基)-1H-苯并[d]咪唑-2-基)吡唑-5-甲酰胺]衍生物和相关化合物作为STING（干扰素基因刺激物）激动剂用于治疗癌症
EP4087614A1 (en) 2020-01-09 2022-11-16 Mersana Therapeutics, Inc. Site specific antibody-drug conjugates with peptide-containing linkers
WO2021202984A1 (en) 2020-04-02 2021-10-07 Mersana Therapeutics, Inc. Antibody drug conjugates comprising sting agonists
CN116194138A (zh) 2020-08-07 2023-05-30 博德研究所 治疗性靶向癌症中经由xpr1:kidins220蛋白质复合物的磷酸盐调节异常
WO2024082056A1 (en) * 2022-10-19 2024-04-25 Zymeworks Bc Inc. Anti-napi2b antibodies and methods of use
KR20250089499A (ko) * 2022-10-19 2025-06-18 자임워크스 비씨 인코포레이티드 Napi2b를 표적화하는 항체-약물 접합체 및 사용 방법
TW202530268A (zh) * 2023-10-19 2025-08-01 加拿大商酵活英屬哥倫比亞有限公司 抗ｎａｐｉ２ｂ抗體－藥物結合物及使用方法

Citations (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050232929A1 (en) * 2004-04-07 2005-10-20 Genentech, Inc. Mass spectrometry of antibody conjugates
WO2009097128A1 (en) * 2008-01-29 2009-08-06 Ludwig Institute For Cancer Research Ltd. Membrane transporter napi2b (slc34a2) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy
WO2009099741A1 (en) * 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
US20100298404A1 (en) * 2006-01-20 2010-11-25 Cell Signaling Technology, Inc. Translocation and mutant ROS kinase in human non-small cell lung carcinoma
WO2012080822A2 (en) * 2010-12-14 2012-06-21 Recepta Biopharma S.A. Antitumor peptide derived from a complementarity determining region of a humanized monoclonal antibody to napi2b transporter
EP2507264A2 (en) * 2009-11-30 2012-10-10 F. Hoffmann-La Roche AG Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211 = seqid 2)
CN102973947A (zh) * 2004-06-01 2013-03-20 健泰科生物技术公司 抗体-药物偶联物和方法
CN103747804A (zh) * 2011-06-10 2014-04-23 梅尔莎纳医疗公司 蛋白质-聚合物-药物共轭物
US20150104407A1 (en) * 2013-10-11 2015-04-16 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
WO2017008169A1 (en) * 2015-07-15 2017-01-19 Zymeworks Inc. Drug-conjugated bi-specific antigen-binding constructs
CN106488768A (zh) * 2014-04-25 2017-03-08 埃克塞里艾克西斯公司 治疗肺腺癌的方法
WO2017068097A1 (en) * 2015-10-23 2017-04-27 Roche Diagnostics Gmbh Methods of identifying an individual as to be treated by chemotherapy based on marker molecules and related uses
CN107074962A (zh) * 2014-06-18 2017-08-18 梅尔莎纳医疗公司 针对her2表位的单克隆抗体及其使用方法
US20170266311A1 (en) * 2016-03-15 2017-09-21 Mersana Therapeutics, Inc. NaPi2b-targeted Antibody-Drug Conjugates and Methods of Use Thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE3900534A1 (de) * 1989-01-10 1990-07-12 Boehringer Mannheim Gmbh Diagnostischer nachweis unter verwendung von chimaeren antikoerpern
CH694588A5 (de) 1999-02-09 2005-04-15 Hoffmann La Roche Menschliche intestinale Npt2B.
CN1671416B (zh) 2001-07-12 2013-01-02 杰斐逊·富特 超人源化抗体
WO2003060086A2 (en) 2002-01-15 2003-07-24 Board Of Regents, The University Of Texas System Napi type iib polypeptides and methods for making and using same
KR101438983B1 (ko) 2003-11-06 2014-09-05 시애틀 지네틱스, 인크. 리간드에 접합될 수 있는 모노메틸발린 화합물
WO2008051980A2 (en) 2006-10-25 2008-05-02 Wisconsin Alumni Research Foundation Methods of reducing phosphate absorption
CN102159248B (zh) 2008-07-15 2013-09-11 健泰科生物技术公司 蒽环类衍生物缀合物、它们的制备方法以及它们作为抗肿瘤化合物的用途
JP5370826B2 (ja) * 2009-04-20 2013-12-18 株式会社パソロジー研究所 癌の組織型を判別するカクテル抗体、判別キット及び判別方法
WO2012006473A1 (en) 2010-07-07 2012-01-12 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
EP2590656B1 (en) 2010-07-07 2017-11-15 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
JP5827328B2 (ja) 2010-07-07 2015-12-02 アーデリクス，インコーポレーテッド リン酸輸送を阻害する化合物及び方法
EP2590965B1 (en) 2010-07-07 2016-04-20 Ardelyx, Inc. Compounds and methods for inhibiting phosphate transport
CN105813655B (zh) 2013-10-11 2022-03-15 阿萨纳生物科技有限责任公司 蛋白-聚合物-药物缀合物
ES2810856T3 (es) 2015-06-03 2021-03-09 Bristol Myers Squibb Co Anticuerpos ANTI-GITR para diagnóstico de cáncer
US20170261766A1 (en) 2016-03-14 2017-09-14 Vance M. Thompson Contact lens with flexible center and rigid periphery
US10287259B2 (en) 2016-03-14 2019-05-14 The Penn State Research Foundation Selenazolidine and thiazolidine compounds for treating cancer and other diseases
CN111315414A (zh) 2017-06-22 2020-06-19 梅尔莎纳医疗公司 产生载药聚合物支架和蛋白-聚合物-药物缀合物的方法

Patent Citations (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050232929A1 (en) * 2004-04-07 2005-10-20 Genentech, Inc. Mass spectrometry of antibody conjugates
CN102973947A (zh) * 2004-06-01 2013-03-20 健泰科生物技术公司 抗体-药物偶联物和方法
US20100298404A1 (en) * 2006-01-20 2010-11-25 Cell Signaling Technology, Inc. Translocation and mutant ROS kinase in human non-small cell lung carcinoma
US20140193417A1 (en) * 2008-01-29 2014-07-10 Ludwig Institute For Cancer Research Ltd. Membrane Transporter NaPi2b (SCL34A2) Epitope for Antibody Therapy, Antibodies Directed Thereto, and Target for Cancer Therapy
WO2009097128A1 (en) * 2008-01-29 2009-08-06 Ludwig Institute For Cancer Research Ltd. Membrane transporter napi2b (slc34a2) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy
US8603474B2 (en) * 2008-01-29 2013-12-10 Ludwig Institute For Cancer Research, Ltd. Membrane transporter NaPi2b (SCL34A1) epitope for antibody therapy, antibodies directed thereto, and target for cancer therapy
WO2009099741A1 (en) * 2008-02-01 2009-08-13 Genentech, Inc. Nemorubicin metabolite and analog reagents, antibody-drug conjugates and methods
EP2507264A2 (en) * 2009-11-30 2012-10-10 F. Hoffmann-La Roche AG Antibodies for treating and diagnosing tumors expressing slc34a2 (tat211 = seqid 2)
CN102741294A (zh) * 2009-11-30 2012-10-17 霍夫曼-拉罗奇有限公司 治疗和诊断表达slc34a2(tat211=seqid2)的肿瘤的抗体
WO2012080822A2 (en) * 2010-12-14 2012-06-21 Recepta Biopharma S.A. Antitumor peptide derived from a complementarity determining region of a humanized monoclonal antibody to napi2b transporter
CN103747804A (zh) * 2011-06-10 2014-04-23 梅尔莎纳医疗公司 蛋白质-聚合物-药物共轭物
US20150104407A1 (en) * 2013-10-11 2015-04-16 Mersana Therapeutics, Inc. Protein-polymer-drug conjugates
CN106488768A (zh) * 2014-04-25 2017-03-08 埃克塞里艾克西斯公司 治疗肺腺癌的方法
CN107074962A (zh) * 2014-06-18 2017-08-18 梅尔莎纳医疗公司 针对her2表位的单克隆抗体及其使用方法
WO2017008169A1 (en) * 2015-07-15 2017-01-19 Zymeworks Inc. Drug-conjugated bi-specific antigen-binding constructs
WO2017068097A1 (en) * 2015-10-23 2017-04-27 Roche Diagnostics Gmbh Methods of identifying an individual as to be treated by chemotherapy based on marker molecules and related uses
US20170266311A1 (en) * 2016-03-15 2017-09-21 Mersana Therapeutics, Inc. NaPi2b-targeted Antibody-Drug Conjugates and Methods of Use Thereof

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
BEATRICE W T YIN 等: "Monoclonal antibody MX35 detects the membrane transporter NaPi2b (SLC34A2) in human carcinomas", CANCER IMMUN, vol. 8 *
IBERE CAUDURO SOARES 等: "In Silico Analysis and Immunohistochemical Characterization of NaPi2b Protein Expression in Ovarian Carcinoma With Monoclonal Antibody Mx35", APPL IMMUNOHISTOCHEM MOL MORPHOL, vol. 20, no. 2, pages 170 *
KRISTINA LEVAN 等: "Immunohistochemical evaluation of epithelial ovarian carcinomas identifies three different expression patterns of the MX35 antigen, NaPi2b", BMC CANCER, vol. 17, no. 1 *
周;刘小宇;卢小玲;: "抗体偶联药物研究进展", 中国海洋药物, no. 05 *
郭楠楠;刘阳;张文;赵英男;: "非小细胞肺癌个体化分子靶向治疗研究进展", 北京医学, no. 03 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116830204A (zh) * 2021-02-08 2023-09-29 株式会社岛津制作所 估计装置、学习装置、优化装置、估计方法、学习方法以及优化方法

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