CN111491920B - 毒蕈碱性乙酰胆碱受体m4的拮抗剂 - Google Patents

毒蕈碱性乙酰胆碱受体m4的拮抗剂 Download PDF

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CN111491920B
CN111491920B CN201880081828.0A CN201880081828A CN111491920B CN 111491920 B CN111491920 B CN 111491920B CN 201880081828 A CN201880081828 A CN 201880081828A CN 111491920 B CN111491920 B CN 111491920B
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hexahydro
cyclopenta
pyridazin
pyrrol
amine
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CN111491920A (zh
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C.W.林斯利
P.J.孔
D.W.恩格尔斯
J.L.恩格尔斯
K.J.滕普尔
A.M.本德
L.A.贝克
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Vanderbilt University
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    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/501—Pyridazines; Hydrogenated pyridazines not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P25/16—Anti-Parkinson drugs
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    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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  • Hospice & Palliative Care (AREA)
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  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Indole Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN201880081828.0A 2017-10-20 2018-10-20 毒蕈碱性乙酰胆碱受体m4的拮抗剂 Active CN111491920B (zh)

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US201762574912P 2017-10-20 2017-10-20
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PCT/US2018/056803 WO2019079783A1 (en) 2017-10-20 2018-10-20 ANTAGONISTS OF THE MUSCARINIC RECEPTOR OF ACETYLCHOLINE M4

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KR (2) KR102776114B1 (OSRAM)
CN (2) CN118063442A (OSRAM)
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JP2023522959A (ja) * 2020-04-24 2023-06-01 ヴァンダービルト ユニヴァーシティ ムスカリンアセチルコリン受容体ｍ４のアンタゴニストとしての縮合置換ヒドロピロール
WO2022036177A1 (en) * 2020-08-13 2022-02-17 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
US20240010640A1 (en) * 2020-11-18 2024-01-11 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
CN116669737A (zh) * 2020-12-22 2023-08-29 范德堡大学 毒蕈碱型乙酰胆碱受体m4的拮抗剂
US20240109873A1 (en) * 2020-12-22 2024-04-04 Vanderbilt University Antagonists of the muscarinic acetylcholine receptor m4
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