CN1114893A - "Yuanshen" pill-medicine for treatment of encephalatrophy - Google Patents
"Yuanshen" pill-medicine for treatment of encephalatrophy Download PDFInfo
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- CN1114893A CN1114893A CN94110366A CN94110366A CN1114893A CN 1114893 A CN1114893 A CN 1114893A CN 94110366 A CN94110366 A CN 94110366A CN 94110366 A CN94110366 A CN 94110366A CN 1114893 A CN1114893 A CN 1114893A
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Abstract
The Chinese patent medicine "Yuanshen Dan" for curing encephalatrophy with 94.2% total effective rate and 24.2% cure rate is prepared with 14 Chinese-medicinal components such as tortoise plastron or its gelatin, antler glue, fleece flower root, dodder seed, cordyceps, etc. and features high and quick curative effect and no toxic by-effect.
Description
The present invention relates to use a kind of medicine for the treatment of encephalatrophy of motherland's traditional Chinese medical science theory of medicine preparation, this medicine claims Yuanshen pill again, belongs to multiple pure Chinese medicine mix preparation.
Encephalatrophy is the universally recognized a kind of difficult pertinacious disease of world wide medical circle, belongs to the cancer that is not Cancerous disease.The etiology and pathogenesis that present people produce brain atrophy still is among the further research, clinical common brain atrophy can be divided into three major types: a class is the vascular brain atrophy, for long-term cerebral ischemia and repeatedly apoplexy cause that another kind of is simple property brain atrophy, for agnogenic degeneration causes; Also having a class is the Secondary cases brain atrophy, is by due to the various brain diseases.Judge that brain atrophy mainly scans according to patient's head CT or nuclear magnetic resonance check is made a definite diagnosis.Suffering from its cerebral tissue situation of encephalatrophy generally shows as: 1. the ventricles of the brain enlarge; 2. broadening is deepened in brain ditch, brain pond; 3. gyrus flattens; 4. the brain side is split intensification broadening.Brain atrophy patient generally shows as:
1. intelligence changes: show as memory and obviously descend, forgetful, there is obstacle in the understanding aspect, bradykinesia.
2. mind changes: apathetic expression or depression, mind is dull or dull-witted, dizziness, headache, irritability, insomnia.
3. language performance: dysphonia or can speech.
4. motor function: the starting difficulty, be slow in action, the shakiness of standing, walk, haltingly, and hemianesthesia or paralysis, brothers' Chinese holly contraction is trembled, facial hemiparalysis sialorrhea, dysphagia, frequent micturition, perhaps gatism.
Before the present invention finishes, do not have a kind of medicine can be used in both at home and abroad and specially control encephalatrophy, there is not other therapies can treat brain atrophy yet.Can only adopt conventional medicine at present for encephalatrophy, treat as medicines such as cerebrolysin, Ahylysantinfarctase, Energy mixture, MAILUONING ZHUSHEYE, citicoline, Wei Naolu, low molecular dextran, piracetam, nimodipine.Above-mentioned various medicine is used for the treatment of brain atrophy and does not obviously belong to and suiting the remedy to the case, and also just can't effect a radical cure brain atrophy.
Because be subjected to the constraint of traditional medicine idea, this is written into the final conclusion of document history " brain cell death can not be regenerated ", has hindered people's thinking to a great extent, has influenced the research and development of people to encephalatrophy and medicine thereof.This also is not treat brain atrophy special-purpose medicaments key point in the present world wide.
The present invention has broken the confinement and the constraint of " brain cell death can not be regenerated " this medical tradition idea, and combination and application traditional Chinese medical science medicine scientific principle opinion, and the treatment brain atrophy medicine that provides a kind of regeneration to brain cell death that facilitation is arranged is provided its purpose.
Tcm theory thinks that human brain is all neuropsychic commander and dominant forces of whole body.Put down in writing according to " interior warp ": " kidney governing bones is given birth on the marrow and is led in brain ", " kidney master water, be subjected to the essence of five ZANG-organs and six FU-organs and hide it ", " all marrow persons all belong to brain ", the visible traditional Chinese medical science thinks that kidney, bone, marrow, brain are one.Li Shizhen (1518-1593 A.D.) is then pointed out in Compendium of Material Medica: " the brain being the house of mentality ".According to motherland's traditional medicine above-mentioned theory, explore to produce the etiology and pathogenesis of encephalatrophy, mainly be because the human body deficiency of kidney-essence, deficiency of marrow-reservoir, brains disappear to contract and cause; Secondly, the turbid and blood stasis of expectorant is the pathological product of encephalopathy, is again another factor that causes encephalopathy; Three, during the human body caused by liver and kidney deficiency, expectorant is turbid, blood stasis is tied mutually and is condensed in the brain network, and the brain key all can make brain god not normal, and its cause and effect conversion also can cause the generation of brain atrophy or the deterioration that aggravates one's illness.
Explore the brain atrophy pathogeny, though its sick position from the differentiation of disease according to pathological changes of the viscera and their, is positioned at kidney at brain.The deficiency of marrow-reservoir of suffering from a deficiency of the kidney is a deficiency in origin, and blood stasis turbid phlegm blocking the clear orifices criminal brain network resembles for mark.So the treatment cerebral atrophy should be a principle with kidney tonifying, essence replenishing, accent venting QI-blood blood stasis dispelling clearing away phlegm.According to mentioned above principle, in conjunction with Chinese medicine medicinal properties such as Carapax et Plastrum Testudinis or Colla Plastri Testudinis, Radix Polygoni Multiflori, Cordycepss, the present invention studies for a long period of time to apolegamy, each herbal medicine weight in prescription of medicine, according to traditional Chinese medical science medicine scientific principle opinion, adopt monarch, minister, help, make the different pharmaceutical cooperation to form treatment brain atrophy medicine of the present invention.Each single medicinal material weight is respectively in the prescription of the present invention:
Monarch drug: Carapax et Plastrum Testudinis or Colla Plastri Testudinis 10-20g, Colla cornus cervi 10-20g, Cordyceps 30-50g, Radix Polygoni Multiflori 50-60g;
Ministerial drug: Radix Rehmanniae Preparata 60-80g, Fructus Corni 20-30g, Fructus Lycii or Fructus Mori 20-30g, Semen Cuscutae 60-80g, Herba Epimedii 20-30g, Fructus Alpiniae Oxyphyllae 20-30g;
Adjuvant drug: Radix Ginseng 15-25g, the Radix Astragali 80-100g, Radix Salviae Miltiorrhizae 80-100g, Hirudo 60-70g, Radix Notoginseng 50-70 g, 100-150 of Scolopendras;
Messenger drug: Rhizoma Acori Graminei 15-25g, Radix Polygalae 16-25g.
It is monarch drug that the present invention adopts Carapax et Plastrum Testudinis or Colla Plastri Testudinis, Colla cornus cervi, Cordyceps, Radix Polygoni Multiflori, mainly is to play the kidney tonifying, essence replenishing effect.Because brain atrophy patient pathogenic factor and state of an illness situation have certain difference, in order to reach the purpose of mediator's yin-yang, bring into play the therapeutic effect of above-mentioned monarch drug better, add Radix Rehmanniae Preparata, Fructus Corni, Fructus Lycii, Semen Cuscutae, Herba Epimedii, Fructus Alpiniae Oxyphyllae as ministerial drug with nourishing kidney-yin, with invigorating kidney-YANG.Add Radix Ginseng, Radix Salviae Miltiorrhizae, the Radix Astragali, Hirudo, Radix Notoginseng, each single medicinal material of Scolopendra as adjuvant drug, help the human body QI invigorating and blood producing, tonify Qi of the kidney, disperse blood stasis and dredge collateral, promoting tissue regeneration by removing blood stasis, desirable more to treating all kinds of brain atrophy effects.Eliminate phlegm for resuscitation for medicine of the present invention is had, the effect of Fructus Alpiniae Oxyphyllae refreshment can be harmonious above-mentioned each herbal medicine, coordinates all kinds of component performances of medicine, and the present invention selects Rhizoma Acori Graminei and Radix Polygalae two flavor Chinese medicines as messenger drug.
The above-mentioned Chinese medicine of respectively distinguishing the flavor of of the present invention with reference to " national Chinese medicine processing standard ", both can have been produced Chinese patent medicine---the Yuanshen pill of treatment brain atrophy.At first, with Carapax et Plastrum Testudinis or Colla Plastri Testudinis with the stir-baking with sand quench in vinegar it; Colla cornus cervi places pot interior slow fire to fry with Talcum and does; Radix Polygoni Multiflori boils it with decoction of black soybean; Cordyceps is mixed thoroughly with saline and is soaked it, fries to yellowish-brown with slow fire.Secondly with Radix Rehmanniae Preparata, Fructus Corni, Fructus Lycii, Semen Cuscutae, Herba Epimedii, Fructus Alpiniae Oxyphyllae, the Radix Astragali, Radix Salviae Miltiorrhizae etc., together with Scolopendra together decocting in water be concentrated into thick paste, drying, being mixed with the above-mentioned medicine of respectively distinguishing the flavor of is crushed to 120 order fine powders.Other a few flavor Chinese medicines can be concocted according to " national Chinese medicine processing standard ", get final product among allocating the above-mentioned medicine of respectively distinguishing the flavor of into.
Said medicine can be made into different dosage forms such as powder, tablet, pill, and pill conventional medicine dose is generally 3.5g.In the time of need making pill, refining can be mixed into by medicine and Mel ratio to 180 ℃ Mel at 1: 0.8 and cuts or polish jade with an emery wheel pelleting and make.
The present invention is a pure Chinese medicinal preparation, belongs to treatment brain atrophy initiative medicine.The present invention is through clinical trial, treat example surplus the brain atrophy patient 400 altogether, wherein observe statistics according to clinical 120 routine patient treatments, prove this Drug therapy brain atrophy total effective rate 94.2%, wherein clinical cure rate is 24.7%, obvious effective rate is 37.5%, and improvement rate is 32.5%, and inefficiency only is 5.8%.Clinical practice and toxicity trial prove that this medicine is little to pair effect of human body poison.Treatment interrelated data to 120 routine brain atrophy patients is provided below.
One, physical data:
This is organized in 120 examples, wherein outpatient service 69 examples.51 examples of being in hospital; Male's 98 examples (81.7%), women's 22 examples (18.3%); Cadre's 81 examples (67.5%), workman's 29 examples (24.2%), peasant's 10 examples (8.3%); Through CT scan 96 examples, 24 examples are checked in magnetic resonance (MR1).The course of disease the shortest half a year, the longest 8 years; Minimum 6 years old of age, maximum 83 years old.Effective time is the shortest 2 days after the medication, elder 2 months.
Age course of disease comparison sheet
Two, Therapeutic Method 1. consumptions and usage: (1) day clothes secondary, early, respectively obey a ball, warm water delivery service after the supper.(2) day clothes are once obeyed 2 balls, warm water delivery service before sleeping evening.(3) follow the doctor's advice in case of necessity.2. points for attention: (1) rheumatic heart disease, anemia of pregnant woman, shaking palsy, spastic disease forbidding.(2) atrial fibrillation, the careful usefulness of gastric and duodenal ulcers.(3) take medicine and avoid eating anything raw or cold in back 2 hours.3. specification: every ball weighs 3.5 grams.Moistureproof, put cool place, dry place.
| Project | Age | The course of disease | ||||||||||
| Below 40 years old | 41 ?| ?50 | ?51 ?| ?60 | ?61 ?| ?70 | ?71 ?| ?80 | More than 30 years old | Half a year | 1 year | 2 years | 3 years | 4 years | More than 5 years | |
| The example number | 11 | ?15 | ?31 | ?42 | ?19 | ?2 | ?9 | ?16 | ?27 | ?25 | 20 | 23 |
| ??％ | 9.1 | ?12.5 | ?25.8 | ?35.2 | ?15.8 | ?1.6 | ?7.5 | ?13.3 | ?22.5 | ?20.8 | 16.6 | 19.3 |
Three, curative effect determinate standard
1. clinical cure: cardinal symptom disappears, sanity, and memory is obviously recovered, and it is correct to answer a question, and is quick on the draw, and life is taken care of oneself fully, can normally participate in social activity.
2. produce effects: cardinal symptom takes a turn for the better, and partial symptoms disappears, and it is correct to answer a question, and life is taken care of oneself substantially.
3. take a turn for the better: partial symptoms alleviates, and intelligence and personality still have partial impairment, and life needs the people to look after.
Four, therapeutic outcome
Primary disease 120 examples, clinical cure 29 examples, produce effects 45 examples, 39 examples that take a turn for the better, invalid 7 examples, total effective rate 92.4%.
120 routine bacterium atrophy treatment statistics
| Project | Clinical cure | Produce effects | Take a turn for the better | Invalid |
| The example number | ????29 | ????45 | ????39 | ????7 |
| ????％ | ????24.2 | ????37.5 | ????32.5 | ????5.8 |
Common sympton relatively before and after the 120 routine brain atrophy treatments
| Symptom | Forgetful | Dizzy | Dull | Drowsiness | Insomnia | Irritable | Hypomnesis | The computing power obstacle | Dyskinesia | Reaction should be pure late | Be slow in action | The forced smile of crying by force | Incontinence of urination and defecation | Language is puckery | Choke and cough stream Ting | |
| Treatment precedent number | 43 | 32 | 40 | ?37 | 24 | 16 | 77 | 66 | 68 | 76 | 71 | 21 | 65 | 75 | 49 | |
| The routine number in treatment back | Alleviate | 13 | 10 | 15 | ?5 | 8 | 13 | 23 | 24 | 35 | 22 | 41 | 7 | 18 | 33 | 24 |
| Disappear | 30 | 22 | 25 | ?32 | 16 | 33 | 54 | 42 | 33 | 54 | 30 | 14 | 47 | 42 | 25 | |
Introduce two kinds of specific embodiments below in conjunction with said medicine component of the present invention.
Embodiment one: select Carapax et Plastrum Testudinis 15g for use, and Colla cornus cervi 15g, Cordyceps 50g, Radix Polygoni Multiflori 50g is as monarch drug.Be equipped with Radix Rehmanniae Preparata 60g, Fructus Corni 25g, Semen Cuscutae 70g, Herba Epimedii 25g, Fructus Alpiniae Oxyphyllae 25g is as ministerial drug.Adjuvant drug is selected Radix Ginseng 20g for use, Radix Astragali 90g, Radix Salviae Miltiorrhizae 90g, Hirudo 60g, Radix Notoginseng 60g, 110 of Scolopendras.Rhizoma Acori Graminei 20g, Radix Polygalae 20g be as messenger drug, above-mentioned monarch, minister, help, make medicine according to the rules concocting method be processed into Chinese herbal pill.
Embodiment two: each component and content are respectively in the present embodiment: Colla Plastri Testudinis 10g, Colla cornus cervi 20g, Cordyceps 40g, Radix Polygoni Multiflori 60g, Radix Rehmanniae Preparata 70g, Fructus Corni 20g, Fructus Mori 30g, Semen Cuscutae 70g, Herba Epimedii 25g, Fructus Alpiniae Oxyphyllae 30g, Radix Ginseng 15g, Radix Astragali 80g, Radix Salviae Miltiorrhizae 100g, Hirudo 50g, Radix Notoginseng 70g, 150 of Scolopendras, Rhizoma Acori Graminei 15g, Radix Polygalae 25g.
The present invention is according to " the brain being the house of mentality " theory of Chinese medical science, so this medicine is named as Yuanshen pill.This medicine is also quite effective for the treatment vascular dementia.
Claims (3)
1. treat brain atrophy medicine-Yuanshen pill for one kind, each single medicinal material weight is in its component:
Monarch drug: Carapax et Plastrum Testudinis or Colla Plastri Testudinis 10-20g, Colla cornus cervi 10-20g, Cordyceps 30-50g, Radix Polygoni Multiflori 50-60g;
Ministerial drug: Radix Rehmanniae Preparata 60-80g, Fructus Corni 20-30g, Fructus Lycii or Fructus Mori 20-30g, Semen Cuscutae 60-80g, Herba Epimedii 20-30, Fructus Alpiniae Oxyphyllae 20-30g;
Adjuvant drug: 100-150 of Radix Ginseng 15-25g, the Radix Astragali 80-100g, Radix Salviae Miltiorrhizae 80-100g, Hirudo 50-70g, Radix Notoginseng 50-70g, Scolopendras;
Messenger drug: Rhizoma Acori Graminei 15-25g, Radix Polygalae 15-25g.
2. treatment brain atrophy medicine according to claim 1 is characterized in that the component weight of the said medicine of respectively distinguishing the flavor of is: Carapax et Plastrum Testudinis 15g, Colla cornus cervi 15g, Cordyceps 50g, Radix Polygoni Multiflori 50g, Radix Rehmanniae Preparata 60g, Fructus Corni 25g, Fructus Lycii 20g, Semen Cuscutae 70g, Herba Epimedii 25g, Fructus Alpiniae Oxyphyllae 25g, Radix Ginseng 20g, Radix Astragali 90g, Radix Salviae Miltiorrhizae 90g, Hirudo 60g, Radix Notoginseng 60g, 110 of Scolopendras, Rhizoma Acori Graminei 20g, Radix Polygalae 20g.
3. treatment brain atrophy medicine according to claim 1 is characterized in that the said medicine component weight of respectively distinguishing the flavor of is Colla Plastri Testudinis 10g, Colla cornus cervi 20g, Cordyceps 40y, Radix Polygoni Multiflori 60g, Radix Rehmanniae Preparata 70g, Fructus Corni 20g, Fructus Mori 30g, Semen Cuscutae 70g, Herba Epimedii 25g, Fructus Alpiniae Oxyphyllae 30g, Radix Ginseng 15g, Radix Astragali 80g, Radix Salviae Miltiorrhizae 100g, Hirudo 50g, Radix Notoginseng 70g, 150 of Scolopendras, Rhizoma Acori Graminei 15g, Radix Polygalae 25g.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN94110366A CN1051462C (en) | 1993-10-14 | 1994-07-02 | "Yuanshen" pill-medicine for treatment of encephalatrophy |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 93118191 CN1101560A (en) | 1993-10-14 | 1993-10-14 | Medicine for curing encephalatrophy |
| CN93118191.7 | 1993-10-14 | ||
| CN94110366A CN1051462C (en) | 1993-10-14 | 1994-07-02 | "Yuanshen" pill-medicine for treatment of encephalatrophy |
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| Publication Number | Publication Date |
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| CN1114893A true CN1114893A (en) | 1996-01-17 |
| CN1051462C CN1051462C (en) | 2000-04-19 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN94110366A Expired - Fee Related CN1051462C (en) | 1993-10-14 | 1994-07-02 | "Yuanshen" pill-medicine for treatment of encephalatrophy |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810814A (en) * | 2010-04-28 | 2010-08-25 | 史建钢 | Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof |
| CN104587192A (en) * | 2015-02-06 | 2015-05-06 | 丁桂芹 | Traditional Chinese medicine preparation for treating brain atrophy and preparation method thereof |
| CN104984115A (en) * | 2015-06-30 | 2015-10-21 | 虞志秋 | Traditional Chinese medicine capsules for preventing and treating senile psychosis |
| CN104983960A (en) * | 2015-06-30 | 2015-10-21 | 虞志秋 | Traditional Chinese medicine decoction for preventing and treating senile psychosis |
| CN108096525A (en) * | 2017-12-28 | 2018-06-01 | 南宁多灵生物科技有限公司 | A kind of drug for treating encephalatrophy |
| CN112641903A (en) * | 2020-12-23 | 2021-04-13 | 马宇振 | Pharmaceutical composition for treating encephalatrophy and application thereof |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101953963B (en) * | 2009-07-16 | 2011-12-07 | 邹长青 | Traditional Chinese medicinal preparation for treating brain and renal function failure |
-
1994
- 1994-07-02 CN CN94110366A patent/CN1051462C/en not_active Expired - Fee Related
Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101810814A (en) * | 2010-04-28 | 2010-08-25 | 史建钢 | Medicament for curing cerebral palsy, hyperkinetic syndrome and dementia and preparation method thereof |
| CN104587192A (en) * | 2015-02-06 | 2015-05-06 | 丁桂芹 | Traditional Chinese medicine preparation for treating brain atrophy and preparation method thereof |
| CN104984115A (en) * | 2015-06-30 | 2015-10-21 | 虞志秋 | Traditional Chinese medicine capsules for preventing and treating senile psychosis |
| CN104983960A (en) * | 2015-06-30 | 2015-10-21 | 虞志秋 | Traditional Chinese medicine decoction for preventing and treating senile psychosis |
| CN108096525A (en) * | 2017-12-28 | 2018-06-01 | 南宁多灵生物科技有限公司 | A kind of drug for treating encephalatrophy |
| CN112641903A (en) * | 2020-12-23 | 2021-04-13 | 马宇振 | Pharmaceutical composition for treating encephalatrophy and application thereof |
| CN114377098A (en) * | 2020-12-23 | 2022-04-22 | 马宇振 | Pharmaceutical composition for treating encephalatrophy and application thereof |
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| Publication number | Publication date |
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| CN1051462C (en) | 2000-04-19 |
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