CN111479926A - 具有两个表达盒的猿猴腺病毒载体 - Google Patents

具有两个表达盒的猿猴腺病毒载体 Download PDF

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Publication number
CN111479926A
CN111479926A CN201880081337.6A CN201880081337A CN111479926A CN 111479926 A CN111479926 A CN 111479926A CN 201880081337 A CN201880081337 A CN 201880081337A CN 111479926 A CN111479926 A CN 111479926A
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vector
adenovirus vector
expression cassette
chad155
simian
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Chinese (zh)
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S.科罗卡
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GlaxoSmithKline Biologicals SA
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GlaxoSmithKline Biologicals SA
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CN201880081337.6A 2017-10-16 2018-10-16 具有两个表达盒的猿猴腺病毒载体 Pending CN111479926A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762572944P 2017-10-16 2017-10-16
US62/572944 2017-10-16
PCT/EP2018/078210 WO2019076880A1 (en) 2017-10-16 2018-10-16 SIMIENS ADENOVIRAL VECTORS COMPRISING TWO EXPRESSION CASSETTES

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CN111479926A true CN111479926A (zh) 2020-07-31

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US (2) US20200299651A1 (cg-RX-API-DMAC7.html)
EP (1) EP3697918B1 (cg-RX-API-DMAC7.html)
JP (1) JP2021500880A (cg-RX-API-DMAC7.html)
CN (1) CN111479926A (cg-RX-API-DMAC7.html)
AR (1) AR114989A1 (cg-RX-API-DMAC7.html)
BR (1) BR112020007413A2 (cg-RX-API-DMAC7.html)
CA (1) CA3084346A1 (cg-RX-API-DMAC7.html)
MX (1) MX2020003746A (cg-RX-API-DMAC7.html)
WO (1) WO2019076880A1 (cg-RX-API-DMAC7.html)

Families Citing this family (4)

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Publication number Priority date Publication date Assignee Title
JP7454645B2 (ja) 2019-07-16 2024-03-22 ギリアード サイエンシーズ, インコーポレイテッド Hivワクチン並びにその作製方法及び使用方法
IL315295A (en) 2019-09-30 2024-10-01 Gilead Sciences Inc Hbv vaccines and methods treating hbv
TW202144570A (zh) * 2020-01-28 2021-12-01 美商科達金尼克斯有限公司 去最佳化(DEOPTIMIZED)SARS-CoV-2及其方法及用途
CA3259040A1 (en) 2022-07-12 2024-01-18 Gilead Sciences, Inc. HIV Immunogenic Polypeptides and Vaccines and Their Uses

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040136963A1 (en) * 2001-06-22 2004-07-15 The Trustees Of The University Of Pennsylvania Simian adenovirus vectors and methods of use
CN1965086A (zh) * 2004-04-28 2007-05-16 宾夕法尼亚州立大学托管会 多价病毒载体和产生它的系统
WO2017017049A1 (en) * 2015-07-27 2017-02-02 Glaxosmithkline Biologicals S.A. Novel adenovirus

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008095027A2 (en) 2007-01-30 2008-08-07 Cedars-Sinai Medical Center Adenoviral vector comprising herpes simplex virus type 1 thymidine kinase and a transgene for increasing the expression of the transgene
EP2181121A4 (en) 2007-03-21 2012-07-11 Id Biomedical Corp Quebec CHIMÄRE ANTIGENE
CA2738654C (en) 2008-09-27 2019-02-26 Witricity Corporation Wireless energy transfer systems
EP3385387B1 (en) 2009-02-02 2021-08-25 GlaxoSmithKline Biologicals SA Simian adenovirus nucleic acid- and amino acid-sequences, vectors containing same, and uses thereof
WO2012021730A2 (en) * 2010-08-11 2012-02-16 Genvec, Inc. Respiratory syncytial virus (rsv) vaccine
WO2012089231A1 (en) 2010-12-30 2012-07-05 Okairòs Ag Paramyxovirus vaccines
CN103492574B (zh) 2011-02-22 2015-12-09 加州理工学院 使用腺相关病毒(aav)载体递送蛋白
EP2764011B1 (en) * 2011-10-05 2021-04-07 GenVec, Inc. Adenoviral vector-based respiratory syncytial virus (rsv) vaccine
MX384992B (es) * 2014-06-13 2025-03-14 Glaxosmithkline Biologicals Sa Combinaciones inmunógenas.
BE1024420B1 (fr) 2015-06-12 2018-02-19 Glaxosmithkline Biologicals Sa Polynucleotides et polypeptides d'adenovirus
BE1024774B1 (fr) 2016-09-29 2018-07-02 Glaxosmithkline Biologicals Sa Compositions et procedes de traitement

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20040136963A1 (en) * 2001-06-22 2004-07-15 The Trustees Of The University Of Pennsylvania Simian adenovirus vectors and methods of use
CN1965086A (zh) * 2004-04-28 2007-05-16 宾夕法尼亚州立大学托管会 多价病毒载体和产生它的系统
WO2017017049A1 (en) * 2015-07-27 2017-02-02 Glaxosmithkline Biologicals S.A. Novel adenovirus

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
D. L. LI等: "Modified recombinant adenoviruses increase porcine circovirus 2 capsid protein expression and induce enhanced immune responses in mice" *
JULIANA C. SMALL等: "Construction and Characterization of E1- and E3-Deleted Adenovirus Vectors Expressing Two Antigens from Two Separate Expression Cassettes" *

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JP2021500880A (ja) 2021-01-14
WO2019076880A1 (en) 2019-04-25
AR114989A1 (es) 2020-11-18
EP3697918A1 (en) 2020-08-26
MX2020003746A (es) 2020-11-06
US20240093161A1 (en) 2024-03-21
US12180512B2 (en) 2024-12-31
EP3697918B1 (en) 2025-11-26
US20200299651A1 (en) 2020-09-24
CA3084346A1 (en) 2019-04-25
BR112020007413A2 (pt) 2020-12-08

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Application publication date: 20200731