CN111465427B - 用于刺激皮肤再生的设备 - Google Patents
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Abstract
描述了一种用于刺激皮肤再生的设备和方法,其允许利用表面血管系统(通过真空作用给出)和细胞再生(通过电容系统生成的电磁场给出)与所施加的皮肤电刺激相结合的共同作用,在这种情况下来增强电磁场的生物效应。
Description
技术领域
本发明涉及用于刺激皮肤修复和再生的设备和方法的领域。
现有技术
皮肤老化是时间老化(chronoaging)现象、或时间流逝、和光老化的总和,或是暴露于环境、且因此暴露于紫外线、烟雾等的后果。
这些现象导致了众所周知的、用一个极其简单的概念来概括的后果:我们的皮肤不再能够繁殖所有因为细胞凋亡和由于错误生活方式而衰变的细胞和分子。
随之而来的是再生不足,皮肤日复一日明显且显著地老化,导致皮肤越来越排空(emptied)、弹性越来越小、以及水分越来越少。这种再生不足本身也可以表现为创伤和损伤(擦伤、术后疤痕、痤疮、烧伤)或美学病理(如蜂窝织炎和妊娠纹)的结果。
在过去的20年里,美容医学提出了不同的方法来减缓皮肤老化现象,或者增加再生现象。
许多方法明确基于损伤原理,另外一些方法基于局部化妆品的使用,还另外一些方法基于或多或少的深度剥脱(deep peels),再另外一些方法基于用于递送活性成分的系统,其他一些方法基于注射疗法(填充剂和再生剂(revitalizer))。
所有提出的方法都提供了暂时的改善,但要理解的是,它们是基于一种永久性损伤,该永久性损伤从由针刺引起的简单纤维化一直到现有胶原蛋白的变性,实际上在中期造成了进一步的皮肤老化。
因此,对于能够减弱时间老化和光老化现象、以及创伤和损伤或美学病理的后果而不产生进一步损伤但又直接进行皮肤再生的关注是很明显的。
在运动医学和康复治疗领域,利用电容性射频生成的电磁场促进肌纤维再生的能力受到重视。
还众所周知的是,肌纤维比皮肤血管化程度高得多,流经其中的血液含氧量更高,并且富含电解质,因为电解质代表了肌动蛋白纤维与肌球蛋白纤维相互渗透的要素,其是实现肌肉收缩的基本要素,所以已经在肌肉中以很高的百分比存在。
正是因为这个原因,肌肉在其正常状态下是一种比皮肤更好的电导体且因此也是一种比皮肤更好的电磁导体。
由此可见,相对于肌纤维获得的再生目前无法在相同程度下对皮肤组织复制,因为较低的电导率成比例地减弱了由朝向被处理组织的电磁场引起的振荡运动。
本发明的目的是提高皮肤组织的电导率和电磁传导率,从而可以实现与表征经电磁场处理的肌纤维的再生相适应的再生。
美国文档01/0112520和WO03/079916描述了一种在真空和射频的共同作用下处理皮肤的装置,没有提到电刺激。此外,上述文档中描述的装置仅提供电阻耦合射频或电阻射频,如所示的,在所引用文档中描述的RF电极的表面上完全没有屏蔽,并且在这些文档中完全没有提到电容射频或电容耦合或一般的电容效应。没有提到电刺激。
文档WO2007/096009(代表同一申请人)类似地描述了一种用于通过对皮肤同时施加按摩和增温作用来处理皮肤纹的设备,在该情况中也没有提到电刺激。
发明概述
描述了一种用于刺激皮肤再生的设备,该设备允许利用表面血管系统(例如通过可能施加真空和/或通过对待处理部位的皮肤刺激而给出)、细胞再生(例如通过利用电容系统生成的电磁场的施加而给出)和皮肤电刺激的共同作用。皮肤电刺激的使用,连同电容耦合射频的施加,也使得电容耦合射频生成的电磁场的有效性明显增强。事实上,这种电刺激传送被处理的生物组织上的额外电子量,穿过患者的皮肤并降低其电阻。由于给予的电磁场的有效剂量与患者皮肤的电阻成反比,所以降低被处理的生物组织的电阻会增强电磁场的有效性。
附图简述
本发明的其他特征和优点将从以下通过非限制性示例给出并在附图中示出的详细描述中变得更加明显,其中:
图1示意性展示了根据本发明的设备的优选实施例;
图2示意性展示了凹面手持件(concave-surface handpiece)的头部(即,与皮肤接触的末端部);以及
图3示意性展示了另一种平面手持件(flat-surface handpiece)的头部(即,与皮肤接触的末端部)。
图4示意性展示了根据本发明的设备的另一优选实施例。
根据本说明书的装置的组成部分在附图中适当地用常规符号表示,仅示出了与理解本发明的实施例相关的那些具体细节,以便不突出对本领域技术人员来说参考本文给出的描述将是很明显的细节。
发明的详细描述
本发明允许利用一种设备来克服上述问题,该设备允许利用表面血管化(例如通过真空作用给出)和细胞再生(通过利用电容系统生成的电磁场给出)与皮肤电刺激相结合的共同作用。
如图1所示,根据本发明的设备10的优选实施例包括:
-逻辑单元11;
-真空生成系统12;
-电容系统13;
-电刺激系统14;
-手持件A;
-由患者握持的参考手持件27。
参考附图4,根据本发明的设备10的另一优选实施例包括:
-逻辑单元11,
-电容系统13;
-电刺激系统14;
-手持件A;
-由患者握持的参考手持件27。
逻辑单元11是指配备有微处理器的印刷电路,微处理器能够管理所有电源部件、确定它们的强度、频率、性质和定时,逻辑单元11通常配备有键盘15和显示器16,以便操作者进行必要的干预。
逻辑单元11管理和调节可能的真空生成、电容系统和电刺激。
真空生成系统12指的是真空泵或其他能够产生真空的设备,其然后优选地通过电磁阀的电池或适合于改变其负压的其他方法来提供真空,优选地连接到用于读取产生的实际真空的系统。
电容系统13包括电子电路,其包括AC电源,该AC电源通过屏蔽电缆24连接到一个或更多个屏蔽电极19,并通过单极电缆26连接到参考手持件27;系统生成频率范围从0.3到10兆赫(MHz)且优选地从0.3到1.5兆赫的信号。
电刺激系统14包括电子电路,其包括电刺激生成器,所述电刺激生成器产生直流电和各种类型的具有确定极性的方波和半波,通过屏蔽多极电缆25连接到布置在手持件的头部上的成对的电极21。
手持件A包括:
-握持部28;
-头部T;
-用于为电容系统供电的一个或更多个屏蔽电极19,该一个或更多个屏蔽电极19被布置在头部T的内表面和/或边缘上,但是被电介质20涂覆;
-用于递送电刺激的一对或更多对电极21,该一对或更多对电极21被布置在头部T的内表面和/或边缘上,使得每对电极中的两个电极彼此径向相对;
-可能的用于真空施加的空腔22。
屏蔽电极19包括两个不同的部分:包括优良的电导体(通常为金属)的电极本身和旨在用于与患者皮肤接触的电介质涂层20。
头部T可以是凹面(如图2所示的17)或平面(见图3的18),并且:
-通过屏蔽同轴电缆24(例如RG58 MIL型)连接到电容生成器13;
-(通过屏蔽多极电缆25)连接到电刺激生成器14;
-(通过气动电缆23)连接到真空生成器12。
凹面手持件17具有例如由于内弯(introflected)部分而允许良好真空密闭性的形状,内弯部分可以具有各种形状和尺寸,以便例如产生能够确保良好真空密封的空腔22。
相反,平面手持件18用于在有真空的作用或没有真空的作用下,用于电容生成器13和电刺激生成器的递送。
由患者握持的参考手持件27包括金属体或另一种非常好的电导体,并通过单极电缆26连接到电容生成器13。
电缆23、24、25和26可以彼此机械连接或者保持分离。
因此,设备10能够(同时或分离地)生成真空效应、电容信号和电刺激。
如果优选的话,设备10可以配备有定时器,该定时器允许在特定时间之后自动停用。
设备10显然包括一般的电的和气动的内部电路,以及与电源或电池电源的连接。
设备10既提供了真空生成器12、电容系统13和电刺激生成器14被容纳在单一结构中的可能性,又提供了生成器本身包括独立单元并且然后被连接在具有任何形状的单一手持件上或者通过不同手持件被同时递送到相同患者身上的可能性。
如果需要,根据本发明的设备可以配备有以下补充设备:
配备有能够进行有效剥脱的研磨表面的设备,其通过气动电缆23或不同的平行电缆连接到真空生成器12。
具有不同尺寸和形状的板(plate),其被设计为通过使用电阻器或红外热生成器或进行热/冷联合管理的珀尔帖单体(Peltier cells)或其他等效技术来递送热和冷。
具有不同尺寸和形状的手持件或板,其适于以连续或脉冲发射方式递送传统或聚焦的、不同频率和强度的超声波。
具有不同尺寸和形状的手持件或板,其适于通过LED和其他等效技术递送偏振光和非偏振光。
对根据本发明的设备的使用本身是清楚的。
在设置了处理所需的值并启动设备后,手持件A的头部直接在患者的皮肤表面之上传递。
当接受处理的患者握持被设计成闭合电磁电路并读取生物反馈的参考手持件27的时候,设备10生成高频交流电,高频交流电通过涂覆有电介质20的屏蔽电极19施加到皮肤上。
处理一直持续到被处理的皮肤与周围组织相比是稍微变红、变亮和变暖为止。
将要理解的是,屏蔽电极19和参考手持件27的作用类似于电容器的极板,其中电介质20和被处理的皮肤的角质层形成电容器电介质。当电流被供应时,在涂覆有电介质20的屏蔽电极19上建立电荷,电荷快速交替,从而在生物组织内产生电磁场,电磁场同样快速地改变方向并生成热量。被处理的组织部分被电介质(由去核细胞组成的角质层)同化,部分被电导体(真皮)同化。在电导体内部并通过电介质发生电磁场的作用。
一旦逻辑单元11确定了在电容生成器13和待处理的组织之间的最佳调谐,设备就开始通过成对的电极21递送电刺激。
由于这个位置,在电磁场的力线中涉及的皮肤组织也将受到电子迁移和随之发生的被处理的皮肤的双向离子流的影响,这将有助于提高组织的电导率,并因此成比例地提高电磁场的有效性。
刺激可以通过交替信号、通过连续极化信号或通过极性反转信号发生。
电刺激的功能很简单:允许电磁场通过电子流,这使得电荷在皮肤组织内有序移动。
所有这些都使生物组织内具有更大的离子迁移率,并且有利于减小电阻,即,增加了电导率和电磁传导率,因此电磁场以与组织的更好的传导率或其更低的电阻成比例的更大的速度移动。
电磁场的更好传播所带来的另一个效应是皮肤组织的快速过热,皮肤组织的温度稳定在39℃到40℃之间,也就是说,在最大再生潜能点,正如范特霍夫定律(Law of Van’tHoff)所记载的,其证明了在这个温度范围内,细胞繁殖率超过300%。
真空的协同作用旨在促进良好的血管体操运动(vascular gymnastics),且从而使更多的血液供应到皮肤中,并随之释放氧气和营养元素,温度稳定在39℃至40℃之间有利于这种协同作用,这降低了血液的粘度,并使泵送作用产生更好的效果。
所有这些导致了皮肤再生的增加,这与数十年的科学出版物所记载的利用电磁场处理的肌肉的再生能力非常相似。
使用由飞利浦集团旗下恩智浦(NXP)半导体公司开发的综合阅读平台(在该平台上开发了“生物反馈(Bio-feed-back)”应用程序),将专利WO2007/096009所涵盖的设备所生成的电磁波在被处理的皮肤组织上的滑动速度和用本申请设备获得的电磁波在被处理的皮肤组织上的滑动速度进行了比较。
对于WO2007/096009中描述的设备,发现的平均有效值在300和450mV之间。
通过将一对或更多对电极定位在手持件的边缘上,在相同的组织上同时施加如本发明所示的电刺激,发现平均有效值在700和800mV之间。
因为电流速度与导体的电阻成反比,所以本发明实现了预定的结果,即皮肤组织的电阻的暂时大大降低,使其更接近肌纤维的规格。
因此,较低的电阻允许在相同的分配时间和递送强度下,由于具有更大的生物活性剂量,使得皮肤组织上的电磁场具有更大的功效。
电磁场的电压提高到700/800mV,导致对钠离子和钾离子的更大推动,这将导致更快地穿过细胞膜(众所周知,其“膜电位”介于50到70mV之间),并因此实现更大的皮肤再生,类似于数十年来表征电磁场对肌纤维的施加的最大再生潜能。
应当注意,该设备非常容易使用,并且逻辑单元通过根据对反馈信号的读取而自动改变其参数设置来进行干预,反馈信号允许评估在患者的皮肤组织上产生和施加的能量的实际有效性。
Claims (7)
1.一种用于刺激皮肤再生的设备,其允许同时在患者的皮肤上施加由射频RF电容系统(13)生成的电磁场和由皮肤电刺激系统(14)生成的皮肤电刺激,所述设备包括:
所述RF电容系统(13),其包括电子电路,所述电子电路包括能够生成频率从0.3兆赫到10兆赫变化的信号的交流电源,所述交流电源与由患者握持的参考手持件(27)相连,且与一个或更多个屏蔽电极(19)相连,所述一个或更多个屏蔽电极用于向所述患者的皮肤递送由所述RF电容系统生成的所述电磁场;
所述皮肤电刺激系统(14),其包括电子电路,所述电子电路包括电刺激生成器,所述电刺激生成器产生直流电和各种类型的具有确定极性的方波和半波,所述电刺激生成器与用于向所述患者的皮肤递送电刺激的一对或更多对电刺激电极(21)相连;
逻辑单元(11),其能够管理和调节所述RF电容系统(13)和所述皮肤电刺激系统(14);以及
手持件(A),包括:
握持部(28);
头部(T),其具有凹面或平面,旨在用于与所述患者的皮肤接触;
所述一个或更多个屏蔽电极(19),其与用于将由所述RF电容系统生成的所述电磁场递送给所述患者的皮肤的所述RF电容系统(13)相连,所述一个或更多个屏蔽电极被布置在所述头部(T)的内中央部分表面和/或所述表面的边缘上,且涂覆有旨在用于与所述患者的皮肤接触的电介质(20);以及
所述一对或更多对电刺激电极(21),其与用于向所述患者的皮肤递送电刺激的所述皮肤电刺激系统(14)相连,所述一对或更多对电刺激电极被布置成使得每对电极中的两个电极在旨在用于与所述患者的皮肤接触的所述头部的所述中央部分和/或所述表面的边缘上彼此径向相对;
其中,所述一个或更多个屏蔽电极(19)和所述一对或更多对电刺激电极(21)被配置成同时且分别向所述患者的皮肤施加由所述RF电容系统(13)生成的电磁场和由所述皮肤电刺激系统(14)生成的皮肤电刺激。
2.根据权利要求1所述的设备,还包括真空生成系统(12)。
3.根据权利要求2所述的设备,其中,所述逻辑单元(11)能够管理和调节所述真空生成系统(12)、所述RF电容系统(13)和所述皮肤电刺激系统(14)。
4.根据权利要求2或3所述的设备,其中,所述真空生成系统(12)是真空泵。
5.根据权利要求1-4中任一项所述的设备,其中,所述交流电源能够生成频率从0.3兆赫到1.5兆赫变化的信号。
6.根据权利要求1-5中任一项所述的设备,其中,所述手持件(A)包括:
-一个屏蔽电极(19),其被布置在所述头部(T)的内表面且被所述电介质(20)涂覆;
-用于提供电刺激的一对电刺激电极(21),其被布置在所述头部的边缘上;
-用于真空施加的空腔(22)。
7.根据权利要求2-6中任一项所述的设备,其中,所述手持件(A):
-通过屏蔽同轴电缆(24)连接到所述RF电容系统(13);
-通过屏蔽多极电缆(25)连接到所述皮肤电刺激系统(14);
-通过气动电缆(23)连接到真空生成系统(12)。
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