CN111449995B - Water-in-oil type whitening skin care emulsion and preparation method thereof - Google Patents

Abstract

The invention discloses a water-in-oil type whitening and skin-protecting emulsion which comprises the following components in parts by weight: 26-29 parts of camellia oil, 18-23 parts of grape seed oil, 22-25 parts of squalane, 2-3 parts of an antioxidant whitening agent, 4-6 parts of emulsifying wax, 8-16 parts of distilled water, 11-14 parts of a humectant and 1-2 parts of a surfactant. The antioxidant whitening agent prepared by the invention contains sulfadiazine, has certain antibacterial and bacteriostatic properties, can effectively realize the sterilization and anti-inflammation effects of skin care products, can effectively inhibit the breeding of bacteria, realizes the antiseptic effect, further reduces the addition of antiseptic in the emulsion, effectively reduces the burden of skin, and further effectively solves the problem that the skin care emulsion prepared by a plurality of people cannot tolerate the existing skin care products because the antiseptic is usually directly added into the skin care products in the preparation process of the skin care products, the antibacterial effect is realized through the antiseptic, but the burden of skin is easily increased due to the addition of the antiseptic, and the antiseptic has certain irritation.

Description

Water-in-oil type whitening skin care emulsion and preparation method thereof

Technical Field

The invention belongs to the field of preparation of skin care emulsion, and relates to water-in-oil type whitening skin care emulsion and a preparation method thereof.

Background

The skin of human body is affected by ultraviolet radiation and air pollutants, which can cause excessive free radicals and active oxygen to be generated in the body, and the generation of free radicals and active oxygen is also accompanied in the self-aging process of the body. Meanwhile, the content of antioxidant substances such as SOD of a human body is relatively reduced, so that a series of problems such as metabolic balance disorder, cell activity reduction and the like are caused, and finally, the characteristics such as dark skin color, skin aging and the like are presented.

The existing skin-whitening skin-care product is usually prepared by directly adding a whitening agent to achieve the skin-whitening effect, the whitening agent achieves the skin-whitening effect by inhibiting the activity of the neuraminidase, but for people who work outdoors for a long time, the skin-whitening skin-care product is often subjected to ultraviolet irradiation, the skin-whitening effect is poor by independently inhibiting the neuraminidase, meanwhile, due to the fact that the skin-whitening skin-care product contains rich nutrition positions, bacteria are easy to breed, the quality guarantee period is shortened, and skin allergy can be caused by breeding of the bacteria, so that the preservative is usually directly added into the skin-care product in the existing skin-care product preparation process, the antibacterial effect is achieved through the preservative, the burden of the skin is easily increased due to the addition of the preservative, and the preservative has certain irritation, so that many people cannot tolerate the prepared skin-care emulsion.

Disclosure of Invention

The invention aims to provide a water-in-oil type whitening and skin-care emulsion and a preparation method thereof²⁺The anti-oxidation whitening agent contains isoflavone groups, the isoflavone groups have strong absorption in the range of 245-270nm in an ultraviolet region, and have certain absorption in the range of 300-400nm, the strength of ultraviolet rays directly acting on human skin is reduced by absorbing the ultraviolet rays through the isoflavone groups, the activity inhibition of tyrosinase is realized through the action of sulfadiazine, the whitening effect is realized, the whitening effect can be effectively realized through the synergistic effect of the two, and further the problem that the whitening agent is usually directly added for realizing the whitening effect in the preparation process of the existing whitening skin care product is effectively solved, the whitening effect is usually realized through inhibiting the activity of the neuraminidase, but people who work outdoors for a long time often experience ultraviolet irradiation, the whitening effect is poor by independently inhibiting the neuraminidase.

The purpose of the invention can be realized by the following technical scheme:

the water-in-oil type whitening and skin-protecting emulsion comprises the following components in parts by weight:

26-29 parts of camellia oil, 18-23 parts of grape seed oil, 22-25 parts of squalane, 2-3 parts of an antioxidant whitening agent, 4-6 parts of emulsifying wax, 8-16 parts of distilled water, 11-14 parts of a humectant and 1-2 parts of a surfactant;

the preparation process of the antioxidant whitening agent is as follows:

step 1: weighing a certain amount of resorcinol, adding the resorcinol into an ethanol solution, stirring and dissolving, adjusting the pH value of a reaction solution to 1 with hydrochloric acid, then adding polyformaldehyde into a reaction container, stirring and dissolving, heating to 70-80 ℃, then adding sulfadiazine into the reaction container, stirring and dissolving, reacting at constant temperature for 4-5 hours, then cooling to room temperature, dropwise adding a sodium hydroxide solution with the mass concentration of 1% into a product until precipitation is separated out, stopping dropwise adding, and then filtering, washing and drying to obtain a product A, wherein the reaction structural formula is as follows, wherein the ratio of the resorcinol to the sulfadiazine is 1: 1, and simultaneously adding 23-26g of polyformaldehyde into each mol of resorcinol; because the hydrogen on the ortho-position and the para-position of phenolic hydroxyl in resorcinol has higher activity, the resorcinol can generate a Mannich reaction with paraformaldehyde and sulfadiazine under an acidic condition, and the resorcinol contains two phenolic hydroxyl ortho-position groups, the sulfadiazine and the resorcinol are prepared by controlling the addition amount of the sulfadiazine according to the material amount of 1: 1, only one action site is introduced with sulfadiazine, and the other action site still has higher activity and no reaction;

step 2: adding the product A prepared in the step 1 into a reaction container, adding p-hydroxyphenylacetic acid, aluminum chloride and ethyl acetate into the reaction container, heating to 70-75 ℃, stirring until the solid is dissolved, reacting at a constant temperature for 2-2.5h, then carrying out reduced pressure distillation to recover the solvent, adding a certain amount of hydrochloric acid solution with the mass concentration of 8% into the reaction container, stirring for reaction for 30-40min, filtering, washing and drying to obtain a product B, wherein the reaction structural formula is shown as follows, 0.43-0.45g of p-hydroxyphenylacetic acid is added into each gram of the product A, and 2.16-2.17g of aluminum chloride is added; the p-hydroxyphenylacetic acid generates acyl positive ions with acylation capacity under the action of aluminum chloride, and the o-para position of the o-hydroxyl of the resorcinol has an active wave action site, so that the acyl positive ions can attack the action site and are grafted on the o-para position of the resorcinol;

and step 3: adding the product B prepared in the step 2 and N, N-dimethylformamide into a reaction vessel at the same time, then adding piperidine into the reaction vessel, dropwise adding phosphorus trichloride into the reaction vessel after stirring and dissolving, heating to 55-60 ℃ after stirring and reacting for 40-50min, reacting at constant temperature for 3-4h, then cooling to room temperature, pouring the product into water, filtering, washing and drying to obtain the antioxidant whitening agent, wherein the reaction structural formula is shown as follows, 4.2-4.4g of piperidine is added into the product B per gram, 9-10mL of N, N-dimethylformamide is added, and 2.1-2.2g of phosphorus trichloride is added; n, N-dimethylformamide and phosphorus trichloride are complexed to form a complex, a product B loses a alpha hydrogen under the catalytic action of piperidine to generate a carbanion, and meanwhile piperidine and a phenolic hydroxyl group are complexed to passivate a benzene ring, so that formaldehyde in the complex formed by complexing N, N-dimethylformamide and phosphorus trichloride selectively sublimates methylene, and then an antioxidant whitening agent is obtained through cyclization and hydrolysis reaction²⁺The antioxidant whitening agent contains isoflavone groups, the isoflavone groups have strong absorption in the ultraviolet region of 245-270nm and have certain absorption in the range of 300-400nm, the strength of ultraviolet rays directly acting on human skin is reduced by absorbing the ultraviolet rays through the isoflavone groups, the tyrosinase activity inhibition is realized through the sulfadiazine effect, the whitening effect is realized, the whitening effect can be effectively realized through the synergistic effect of the two, and the whitening effect is simultaneously preparedThe antioxidant whitening agent contains a large amount of phenolic hydroxyl groups, and the phenolic hydroxyl groups can capture free radicals, so that the generation of the free radicals is effectively reduced, and the antioxidant aging effect is further realized;

a preparation method of a water-in-oil type whitening and skin-care emulsion comprises the following specific preparation processes:

firstly, adding camellia oil, grape seed oil, squalane, antioxidant whitening and emulsifying wax into a reaction kettle according to a certain proportion, heating to 80-90 ℃, stirring and mixing for 3-4min, then adding a surfactant into the mixture, keeping the temperature unchanged, stirring and mixing for 8-10min to obtain a composite oil phase;

step two, adding the humectant into distilled water, uniformly stirring, and then uniformly mixing the mixture and the composite oil phase prepared in the step one at the temperature of 80-90 ℃;

and step three, cooling to 45-50 ℃, stirring and mixing for 30-40min, and cooling to room temperature to obtain the water-in-oil type whitening skin-care emulsion.

The invention has the beneficial effects that:

1. the antioxidant whitening agent is directly added into the emulsion, the antioxidant whitening agent contains sulfadiazine, a large amount of amino contained in the sulfadiazine can react with binuclear Cu of a tyrosinase activity center²⁺The antioxidant whitening agent contains isoflavone groups, the isoflavone groups have strong absorption in the ultraviolet region of 245-270nm and have certain absorption in the range of 300-400nm, the strength of ultraviolet rays directly acting on human skin is reduced by absorbing the ultraviolet rays through the isoflavone groups, the tyrosinase activity inhibition is realized through the sulfadiazine effect, the whitening effect is realized, the whitening effect can be effectively realized through the synergistic effect of the isoflavone groups and the sulfadiazine, and the problem that the whitening agent is usually directly added to realize the whitening effect in the preparation process of the existing whitening skin care product is effectively solved, and the whitening agent is usually used for inhibiting the activity of the neuraminidaseThe whitening effect is realized, but for people who work outdoors for a long time, the whitening effect is poor due to the fact that the whitening effect is achieved by independently inhibiting the neuraminidase under the condition of often suffering from ultraviolet irradiation.

2. The antioxidant whitening agent prepared by the invention contains sulfadiazine, has certain antibacterial and bacteriostatic properties, can effectively realize the sterilization and anti-inflammation effects of skin care products, can effectively inhibit the breeding of bacteria, realizes the antiseptic effect, further reduces the addition of antiseptic in the emulsion, effectively reduces the burden of skin, and further effectively solves the problem that the skin care emulsion prepared by a plurality of people cannot tolerate the existing skin care products because the antiseptic is usually directly added into the skin care products in the preparation process of the skin care products, the antibacterial effect is realized through the antiseptic, but the burden of skin is easily increased due to the addition of the antiseptic, and the antiseptic has certain irritation.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1:

the preparation process of the antioxidant whitening agent comprises the following steps:

step 1: weighing 11g of resorcinol, adding the resorcinol into 200mL of ethanol solution, stirring and dissolving, adjusting the pH value of the reaction solution to 1 with hydrochloric acid, then adding 2.3g of paraformaldehyde into a reaction container, stirring and dissolving, heating to 70-80 ℃, then adding 25g of sulfadiazine into the reaction container, stirring and dissolving, reacting at a constant temperature for 4-5 hours, then cooling to room temperature, dropwise adding a sodium hydroxide solution with the mass concentration of 1% into the product until precipitation is separated out, stopping dropwise adding, and then filtering, washing and drying to obtain a product A, wherein the reaction structural formula is shown as follows;

step 2: adding 10g of the product A prepared in the step 1 into a reaction container, adding 4.3g of p-hydroxyphenylacetic acid, 21.6g of aluminum chloride and 150mL of ethyl acetate, heating to 70-75 ℃, stirring until the solid is dissolved, reacting at constant temperature for 2-2.5h, then carrying out reduced pressure distillation to recover the solvent, adding a certain amount of hydrochloric acid solution with the mass concentration of 8% into the reaction container, stirring for reacting for 30-40min, and then filtering, washing and drying to obtain a product B, wherein the reaction structural formula is shown as follows;

and step 3: adding 10g of the product B prepared in the step 2 and 95ml of N, N-dimethylformamide into a reaction container at the same time, then adding 42g of piperidine into the reaction container, dropwise adding 21g of phosphorus trichloride into the reaction container after stirring and dissolving, stirring and reacting for 40-50min, then heating to 55-60 ℃, reacting for 3-4h at constant temperature, then cooling to room temperature, then pouring the product into water, filtering, washing and drying to obtain the antioxidant whitening agent, wherein the reaction structural formula is shown as follows;

example 2:

the preparation process of the antioxidant whitening agent comprises the following steps: weighing 11g of resorcinol, adding the resorcinol into 200mL of ethanol solution, stirring and dissolving, adjusting the pH value of the reaction solution to 1 with hydrochloric acid, then adding 4.5g of paraformaldehyde into a reaction container, stirring and dissolving, heating to 70-80 ℃, then adding 55g of sulfadiazine into the reaction container, stirring and dissolving, reacting at a constant temperature for 4-5 hours, then cooling to room temperature, dropwise adding a sodium hydroxide solution with the mass concentration of 1% into the product until precipitation is separated out, stopping dropwise adding, and then filtering, washing and drying to obtain a product A, namely the antioxidant whitening agent, wherein the reaction structural formula is shown as follows;

example 3:

the preparation process of the antioxidant whitening agent comprises the following steps:

step 1: adding 10g of resorcinol into a reaction vessel, adding 8.6g of p-hydroxyphenylacetic acid, 41.6g of aluminum chloride and 250mL of ethyl acetate, heating to 70-75 ℃, stirring until the solid is dissolved, reacting at constant temperature for 2-2.5h, then recovering the solvent by reduced pressure distillation, adding a certain amount of hydrochloric acid solution with the mass concentration of 8% into the reaction vessel, stirring for reacting for 30-40min, and filtering, washing and drying to obtain a product A, wherein the reaction structural formula is shown as follows;

step 2: adding 10g of the product A prepared in the step 1 and 95ml of N, N-dimethylformamide into a reaction container at the same time, then adding 42g of piperidine into the reaction container, dropwise adding 21g of phosphorus trichloride into the reaction container after stirring and dissolving, stirring and reacting for 40-50min, then heating to 55-60 ℃, reacting for 3-4h at constant temperature, then cooling to room temperature, then pouring the product into water, filtering, washing and drying to obtain the antioxidant whitening agent, wherein the reaction structural formula is shown as follows;

example 4:

the preparation process of the antioxidant whitening agent comprises the following steps:

step 1: adding 11g of resorcinol into a reaction vessel, adding 15.2g of p-hydroxyphenylacetic acid, 23.6g of aluminum chloride and 150mL of ethyl acetate, heating to 70-75 ℃, stirring until the solid is dissolved, reacting at constant temperature for 2-2.5h, then recovering the solvent by reduced pressure distillation, adding a certain amount of hydrochloric acid solution with the mass concentration of 8% into the reaction vessel, stirring for reacting for 30-40min, and filtering, washing and drying to obtain a product A, wherein the reaction structural formula is shown as follows;

step 2: adding 10g of the product A prepared in the step 1 and 95ml of N, N-dimethylformamide into a reaction container at the same time, then adding 21g of piperidine into the reaction container, dropwise adding 13g of phosphorus trichloride into the reaction container after stirring and dissolving, stirring and reacting for 40-50min, heating to 55-60 ℃, reacting for 3-4h at a constant temperature, then cooling to room temperature, pouring the product into water, filtering, washing and drying to obtain the antioxidant whitening agent, wherein the reaction structural formula is shown as follows;

example 5:

the preparation process of the antioxidant whitening agent comprises the following steps: weighing 11g of resorcinol, adding the resorcinol into 200mL of ethanol solution, stirring and dissolving, adjusting the pH value of the reaction solution to 1 with hydrochloric acid, then adding 2.3g of paraformaldehyde into a reaction container, stirring and dissolving, heating to 70-80 ℃, then adding 25g of sulfadiazine into the reaction container, stirring and dissolving, reacting at a constant temperature for 4-5 hours, then cooling to room temperature, dropwise adding a sodium hydroxide solution with the mass concentration of 1% into the product until precipitation is separated out, stopping dropwise adding, and then filtering, washing and drying to obtain a product A, namely the antioxidant whitening agent, wherein the reaction structural formula is shown as follows;

example 6:

a preparation method of a water-in-oil type whitening and skin-care emulsion comprises the following specific preparation processes:

firstly, adding 26g of camellia oil, 18g of grape seed oil, 22g of squalane and 2g of the antioxidant whitening agent prepared in the embodiment 1 and 4g of emulsifying wax into a reaction kettle, heating to 80-90 ℃, stirring and mixing for 3-4min, then adding 1gOP-10 nonionic surfactant into the mixture, keeping the temperature constant, stirring and mixing for 8-10min to obtain a composite oil phase;

step two, adding 11g of sorbitol into 9g of distilled water, uniformly stirring, and then uniformly mixing the mixture and the composite oil phase prepared in the step one at the temperature of 80-90 ℃;

and step three, cooling to 45-50 ℃, stirring and mixing for 30-40min, and cooling to room temperature to obtain the water-in-oil type whitening skin-care emulsion.

Example 7:

a preparation method of a water-in-oil type whitening and skin-care emulsion comprises the following specific preparation processes:

firstly, adding 26g of camellia oil, 18g of grape seed oil, 22g of squalane and 2g of the antioxidant whitening agent prepared in the embodiment 2 and 4g of emulsifying wax into a reaction kettle, heating to 80-90 ℃, stirring and mixing for 3-4min, then adding 1gOP-10 nonionic surfactant into the mixture, keeping the temperature constant, stirring and mixing for 8-10min to obtain a composite oil phase;

step two, adding 11g of sorbitol into 9g of distilled water, uniformly stirring, and then uniformly mixing the mixture and the composite oil phase prepared in the step one at the temperature of 80-90 ℃;

and step three, cooling to 45-50 ℃, stirring and mixing for 30-40min, and cooling to room temperature to obtain the water-in-oil type whitening skin-care emulsion.

Example 8:

a preparation method of a water-in-oil type whitening and skin-care emulsion comprises the following specific preparation processes:

firstly, adding 26g of camellia oil, 18g of grape seed oil, 22g of squalane and 2g of the antioxidant whitening agent prepared in the embodiment 3 and 4g of emulsifying wax into a reaction kettle, heating to 80-90 ℃, stirring and mixing for 3-4min, then adding 1gOP-10 nonionic surfactant into the mixture, keeping the temperature constant, stirring and mixing for 8-10min to obtain a composite oil phase;

step two, adding 11g of sorbitol into 9g of distilled water, uniformly stirring, and then uniformly mixing the mixture and the composite oil phase prepared in the step one at the temperature of 80-90 ℃;

and step three, cooling to 45-50 ℃, stirring and mixing for 30-40min, and cooling to room temperature to obtain the water-in-oil type whitening skin-care emulsion.

Example 9:

a preparation method of a water-in-oil type whitening and skin-care emulsion comprises the following specific preparation processes:

firstly, adding 26g of camellia oil, 18g of grape seed oil, 22g of squalane and 2g of the antioxidant whitening agent prepared in the embodiment 4 and 4g of emulsifying wax into a reaction kettle, heating to 80-90 ℃, stirring and mixing for 3-4min, then adding 1gOP-10 nonionic surfactant into the mixture, keeping the temperature constant, stirring and mixing for 8-10min to obtain a composite oil phase;

step two, adding 11g of sorbitol into 9g of distilled water, uniformly stirring, and then uniformly mixing the mixture and the composite oil phase prepared in the step one at the temperature of 80-90 ℃;

and step three, cooling to 45-50 ℃, stirring and mixing for 30-40min, and cooling to room temperature to obtain the water-in-oil type whitening skin-care emulsion.

Example 10:

a preparation method of a water-in-oil type whitening and skin-care emulsion comprises the following specific preparation processes:

firstly, adding 26g of camellia oil, 18g of grape seed oil, 22g of squalane and 2g of the antioxidant whitening agent prepared in the embodiment 5 and 4g of emulsifying wax into a reaction kettle, heating to 80-90 ℃, stirring and mixing for 3-4min, then adding 1gOP-10 nonionic surfactant into the mixture, keeping the temperature constant, stirring and mixing for 8-10min to obtain a composite oil phase;

step two, adding 11g of sorbitol into 9g of distilled water, uniformly stirring, and then uniformly mixing the mixture and the composite oil phase prepared in the step one at the temperature of 80-90 ℃;

and step three, cooling to 45-50 ℃, stirring and mixing for 30-40min, and cooling to room temperature to obtain the water-in-oil type whitening skin-care emulsion.

Example 11:

skin whitening was measured after 30 days, 60 days and 90 days using the water-in-oil type whitening skin care emulsion prepared in examples 6 to 10 for each group, by selecting 20 healthy women aged 20 to 40 years, having a skin gloss type of type II (according to Fitzpatrick-Pathak day-responsive skin typing), giving predominance to outdoor activities, having spots on the face due to sun exposure, age under working pressure, etc., and the results are shown in table 1:

TABLE 1 whitening of Water-in-oil whitening skin care emulsions prepared in examples 6-10

As can be seen from table 1, the whitening skin care lotion prepared in example 6 has a relatively high whitening effect, and the skin becomes white obviously after 90 days of use, and because the whitening antioxidant added to the whitening skin care lotion contains sulfadiazine, a large amount of amino groups contained in sulfadiazine can react with the binuclear Cu at the tyrosinase activity center²⁺The antioxidant whitening agent contains isoflavone groups, the isoflavone groups have strong absorption in the ultraviolet region of 245-270nm and have certain absorption in the range of 300-400nm, the strength of ultraviolet rays directly acting on human skin is reduced by absorbing the ultraviolet rays through the isoflavone groups, the tyrosinase activity inhibition is realized through the sulfadiazine effect, the whitening effect is realized, and the whitening effect can be effectively realized through the synergistic effect of the isoflavone groups and the sulfadiazine. The whitening antioxidants of example 7 and example 9 only contain sulfadiazine, wherein a large amount of amino groups contained in sulfadiazine can react with binuclear Cu in the active center of tyrosinase²⁺Performing complexation to inhibit the activity of tyrosinase and achieve whitening effect, but because of the strong ultraviolet intensity during long-term outdoor activities, the effect of whitening with high efficiency is difficult to achieve under the action of strong ultraviolet, whereas in example 6, the effect of whitening is achieved by absorbing ultraviolet rays and reducing the intensity of ultraviolet rays acting on skin, and then the effect of sulfadiazine is used to achieve the activity inhibition of tyrosinase and achieve the effect of whitening, and the antioxidant whitening agent used in example 8 and example 10 can achieve the effect of whitening with high efficiency, and simultaneouslyAlthough only the isoflavone group has a certain absorption effect on ultraviolet rays, the activity of the isoflavone group is low in inhibition effect on the activity of the tyrosinase present in the skin, and the whitening effect is reduced, so that the effective whitening effect can be achieved only by simultaneously achieving the absorption of ultraviolet rays and the inhibition of the tyrosinase activity.

Example 12:

weighing 100 g of each of the whitening and skin-care emulsions prepared in examples 6 to 10, sterilizing, adding a bacterial solution of mixed mold and escherichia coli, wherein the mold content of each gram of sample is 1X10⁶CFU/g; the content of Escherichia coli is 1 × 10⁵CFU/g; then, the sample is placed at 25 ℃, and is sampled and analyzed at 7, 15 and 30 days of inoculation, the content of the mold and the content of the escherichia coli in the sample are determined, and the specific determination results are shown in table 2:

TABLE 2 content of mold and E.coli in the sample after several days of cultivation (CFU/g)

As can be seen from table 2, the skin care emulsions prepared in examples 6, 7 and 10 have a certain antibacterial property, and the antioxidant whitening agent contains sulfadiazine, so that the skin care product has a certain antibacterial and bacteriostatic property, and can effectively achieve the bactericidal and anti-inflammatory effects of the skin care product, effectively inhibit bacterial growth, achieve the preservative effect, further reduce the addition of the preservative in the emulsion, and effectively reduce the burden on the skin, while the emulsions prepared in examples 8 and 9 only have a weak bactericidal effect due to phenolic hydroxyl groups, have a low bacteriostatic property, further shorten the shelf life of the emulsion, and need to additionally add the preservative, which easily increases the burden on the skin.

In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.

The preferred embodiments of the invention disclosed above are intended to be illustrative only. The preferred embodiments are not intended to be exhaustive or to limit the invention to the precise embodiments disclosed. Obviously, many modifications and variations are possible in light of the above teaching. The embodiments were chosen and described in order to best explain the principles of the invention and the practical application, to thereby enable others skilled in the art to best utilize the invention. The invention is limited only by the claims and their full scope and equivalents.

Claims (2)

1. The water-in-oil type whitening and skin-care emulsion is characterized by comprising the following components in parts by weight: 26-29 parts of camellia oil, 18-23 parts of grape seed oil, 22-25 parts of squalane, 2-3 parts of an antioxidant whitening agent, 4-6 parts of emulsifying wax, 8-16 parts of distilled water, 11-14 parts of a humectant and 1-2 parts of a surfactant;

the preparation process of the antioxidant whitening agent comprises the following steps:

step 1: weighing a certain amount of resorcinol, adding the resorcinol into an ethanol solution, stirring and dissolving, adjusting the pH value of a reaction solution to 1 with hydrochloric acid, then adding polyformaldehyde into a reaction container, stirring and dissolving, heating to 70-80 ℃, then adding sulfadiazine into the reaction container, stirring and dissolving, reacting at constant temperature for 4-5 hours, then cooling to room temperature, dropwise adding a sodium hydroxide solution with the mass concentration of 1% into a product until a precipitate is separated out, stopping dropwise adding, and then filtering, washing and drying to obtain a product A, wherein the reaction structural formula is shown as follows;

step 2: adding the product A prepared in the step 1 into a reaction vessel, adding p-hydroxyphenylacetic acid, aluminum chloride and ethyl acetate into the reaction vessel, heating to 70-75 ℃, stirring until the solid is dissolved, reacting at constant temperature for 2-2.5h, then carrying out reduced pressure distillation to recover the solvent, adding a certain amount of hydrochloric acid solution with the mass concentration of 8% into the reaction vessel, stirring for reacting for 30-40min, and then filtering, washing and drying to obtain a product B, wherein the reaction structural formula is shown as follows;

and step 3: adding the product B prepared in the step 2 and N, N-dimethylformamide into a reaction vessel at the same time, then adding piperidine into the reaction vessel, dropwise adding phosphorus trichloride into the reaction vessel after stirring and dissolving, heating to 55-60 ℃ after stirring and reacting for 40-50min, reacting at constant temperature for 3-4h, then cooling to room temperature, pouring the product into water, filtering, washing and drying to obtain the antioxidant whitening agent, wherein the reaction structural formula is shown as follows;

in the step 1, the ratio of resorcinol to sulfadiazine according to the amount of substances is 1: 1, and simultaneously adding 23-26g of polyformaldehyde into each mol of resorcinol;

in the step 2, 0.43-0.45g of p-hydroxyphenylacetic acid and 2.16-2.17g of aluminum chloride are added into each gram of the product A;

adding 4.2-4.4g of piperidine into each gram of product B, adding 9-10mL of N, N-dimethylformamide, and adding 2.1-2.2g of phosphorus trichloride.

2. A method for preparing the water-in-oil type whitening and skin-care emulsion according to claim 1, which is characterized by comprising the following steps:

firstly, adding camellia oil, grape seed oil, squalane, antioxidant whitening and emulsifying wax into a reaction kettle according to a certain proportion, heating to 80-90 ℃, stirring and mixing for 3-4min, then adding a surfactant into the mixture, keeping the temperature unchanged, stirring and mixing for 8-10min to obtain a composite oil phase;

step two, adding the humectant into distilled water, uniformly stirring, and then uniformly mixing the mixture and the composite oil phase prepared in the step one at the temperature of 80-90 ℃;

and step three, cooling to 45-50 ℃, stirring and mixing for 30-40min, and cooling to room temperature to obtain the water-in-oil type whitening skin-care emulsion.