CN111426622B - Blood detection device for medical examination - Google Patents

Blood detection device for medical examination Download PDF

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Publication number
CN111426622B
CN111426622B CN202010374992.XA CN202010374992A CN111426622B CN 111426622 B CN111426622 B CN 111426622B CN 202010374992 A CN202010374992 A CN 202010374992A CN 111426622 B CN111426622 B CN 111426622B
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blood sample
detection
sampling needle
blood
sample
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CN111426622A (en
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张军
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First Affiliated Hospital of Bengbu Medical College
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First Affiliated Hospital of Bengbu Medical College
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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/02Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/023Cleaning the external surface
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/02Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027Cleaning the internal surfaces; Removal of blockages
    • B08B9/032Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B08CLEANING
    • B08BCLEANING IN GENERAL; PREVENTION OF FOULING IN GENERAL
    • B08B9/00Cleaning hollow articles by methods or apparatus specially adapted thereto 
    • B08B9/02Cleaning pipes or tubes or systems of pipes or tubes
    • B08B9/027Cleaning the internal surfaces; Removal of blockages
    • B08B9/032Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing
    • B08B9/035Cleaning the internal surfaces; Removal of blockages by the mechanical action of a moving fluid, e.g. by flushing by suction
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N1/00Sampling; Preparing specimens for investigation
    • G01N1/28Preparing specimens for investigation including physical details of (bio-)chemical methods covered elsewhere, e.g. G01N33/50, C12Q
    • G01N1/38Diluting, dispersing or mixing samples
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/01Arrangements or apparatus for facilitating the optical investigation
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N2015/1006Investigating individual particles for cytology
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10Investigating individual particles
    • G01N15/14Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1486Counting the particles

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  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Mechanical Engineering (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Dispersion Chemistry (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The invention provides a blood detection device for medical examination, which belongs to the technical field of blood detection equipment and comprises a sampling needle, a cleaning mechanism, a quantitative dilution mechanism and a detection mechanism, wherein the sampling needle is used for sucking and distributing a blood sample to the detection mechanism; the cleaning mechanism is arranged on one side of the sampling needle and is used for cleaning the outer wall and the inner wall of the sampling needle and drying the sampling needle; the quantitative dilution mechanism is arranged on the other side of the sampling needle and is used for quantitatively diluting the blood sample to be detected; the detection mechanism is arranged below the quantitative dilution mechanism and is used for detecting the diluted blood sample and counting the detection result; one side of the detection mechanism is provided with a blood sample detection cup, and one side of the blood sample detection cup is provided with an oscillation mechanism for oscillating and mixing the diluted blood sample. The device dilutes, detects blood sample according to different dilution multiples in proper order through diluting the mechanism, improves and detects the precision, washs the inner wall and the outer wall of sampling needle through wiper mechanism, improves the accuracy of testing result.

Description

Blood detection device for medical examination
Technical Field
The invention belongs to the technical field of blood detection equipment, and particularly relates to a blood detection device for medical examination.
Background
Medical tests generally involve various tests such as immunology, etc., on materials taken from human bodies, and are used for diagnosing and preventing human diseases. In medical tests, blood is the most widely used material, and general blood routine tests, hemolytic tests, cytological tests, blood type tests, and the like can be performed on blood.
In general, a blood sample is detected by a laser light scattering method, and the number of cells in the blood and other data information of the blood sample are detected by transmitting a laser light through the blood sample.
However, the inner wall and the outer wall of the sampling needle cannot be effectively cleaned by the existing detection device, so that the sampling needle has a small amount of residual sample for the last time in the process of repeated sampling for multiple times, which not only can influence the accuracy of a detection result, but also can influence the service life of the sampling needle.
In addition, because the sample can dilute the sample after advancing the kind to cell quantity in the reduction unit volume helps the data information in the laser dispersion method detection blood sample, but, current detection device can't carry out the ration to the sample and dilutes, and the route that detects is longer, can change the concentration of sample at continuous transfer in-process, influences the accurate measurement of final blood sample, wastes time and energy, and detection efficiency is lower.
Disclosure of Invention
In order to solve the above problems, an object of the present invention is to provide a blood testing device for medical examination, which effectively cleans the inner wall and the outer wall of a sampling needle by a cleaning mechanism, thereby improving the accuracy of sample testing; through concentrating blood sample testing sample in blood sample testing cup, need not to carry out other shifts and can realize the accurate measurement and the detection to blood sample, improve detection efficiency.
In order to achieve the above object, the technical solution of the present invention is as follows.
A blood detection device for medical examination, which comprises a sampling needle, a cleaning mechanism, a quantitative dilution mechanism and a detection mechanism,
a sampling needle for aspirating and dispensing a blood sample to the detection mechanism;
the cleaning mechanism is arranged on one side of the sampling needle and is used for cleaning the outer wall and the inner wall of the sampling needle and drying the sampling needle;
the quantitative dilution mechanism is arranged on the other side of the sampling needle and is used for quantitatively diluting the blood sample to be detected;
the detection mechanism is arranged below the quantitative dilution mechanism and is used for detecting the diluted blood sample and counting the detection result;
one side of the detection mechanism is provided with a blood sample detection cup, and one side of the blood sample detection cup is provided with an oscillation mechanism for oscillating and mixing the diluted blood sample.
Further, the cleaning mechanism includes:
a cleaning pool configured on one side of the sampling needle;
a waste liquid collecting unit disposed at a lower side of the washing tank; and
the pipeline is used for connecting the cleaning pool and the waste liquid collecting unit;
a liquid outlet is formed in the bottom of the cleaning pool, and an electromagnetic valve is arranged on the liquid outlet;
a plurality of spray headers are uniformly arranged on the side wall of the top of the cleaning pool, and a compressed gas spray head is arranged on one side of each spray header; a plurality of gas guide vanes are arranged on the side wall of the bottom of the cleaning pool; each gas guide vane is arranged at one side opposite to the corresponding compressed gas nozzle.
Further, the quantitative dilution mechanism includes:
a diluent unit for storing a diluent; and
a first syringe, the end of which is provided with a first one-way valve for quantitatively transferring the diluent in the diluent unit to the blood sample;
the first injector is respectively connected with the diluent unit and the blood sample detection cup through the first one-way valve.
Furthermore, a guide pipe is arranged on the upper side of the blood sample detection cup, one end of the guide pipe extends to one side of the diluent unit, and the first injector is respectively connected with the diluent unit and the guide pipe through a first one-way valve.
Further, it is characterized in that a rotation guard is provided at the bottom of the blood sample measuring cup, and the blood sample measuring cup is mounted in the rotation guard and is rotatably connected with the rotation guard.
Furthermore, the device also comprises a detection table,
a sample tray is arranged on the detection table, and a plurality of blood sample tubes are uniformly arranged on the sample tray; the sample tray is rotatably connected with the detection platform;
an automatic sample injector is arranged on one side of the sample plate and used for controlling a sampling needle to absorb and distribute a blood sample; one end of the sampling needle is installed on the automatic sampler and is movably connected with the automatic sampler.
Furthermore, be provided with laser sensor on the lateral wall that autosampler is close to the sample dish for the response blood sample pipe that awaits measuring is rotatory to the downside of sampling needle, all is provided with the label that is used for laser sensor discernment on the lateral wall of every blood sample pipe that awaits measuring.
Further, the oscillating mechanism comprises a mounting frame, and a rotating disc and a cam which are positioned in the mounting frame, wherein the rotating disc is coaxially connected with the cam; a power mechanism for driving the turntable to rotate in a reciprocating manner is arranged on the lower side of the turntable;
two ends of the top of the cam are provided with 2 rocker arms in parallel, and each rocker arm is rotatably connected with the cam; two ends of each rocker arm penetrate through the mounting frame and are in sliding connection with the mounting frame;
the blood sample detection cup is arranged between the 2 rocker arms and is in tooth-shaped meshed connection with the 2 rocker arms.
Here, be provided with 2 bar holes on the cam, equal rotatable the installing of every bar downthehole axis of rotation, every axis of rotation all can dismantle rather than the rocking arm that corresponds and be connected.
Furthermore, every the rocking arm passes the tip of installation frame all is provided with the rack, be provided with the ring gear on the lateral wall of blood sample detection cup, 2 the rack set up respectively in the relative both sides of ring gear, and with ring gear tooth form meshing.
Further, the detection mechanism comprises a detector;
the detector is provided with a second syringe, and the end part of the second syringe is provided with a second one-way valve for sucking the diluted blood sample into the detector.
Further, the detector comprises a detection chamber, a detection channel, a laser and a photodetector;
the second syringe is respectively connected with the blood sample detection cup and the detection chamber through a second one-way valve;
the detection channel set up in the middle part of detection room, the both sides of detection channel are provided with sheath liquid passageway respectively, laser instrument and photoelectric detector set up respectively in the relative both sides of detection room along blood sample flow direction for detect the cell number in the blood sample.
The invention provides a blood detection device for medical examination, which has the following beneficial effects:
1. according to the device, the cleaning mechanism is arranged on one side of the sampling needle, so that the inner wall and the outer wall of the sampling needle are effectively cleaned through the cleaning mechanism, and the influence on the accuracy of a detection result caused by attaching a batch of detection samples on the inner wall and the outer wall of the sampling needle is avoided. Through adopting the mode that sprays and wash and the mode that pumps repeatedly to combine together, make the inner wall and the outer wall homoenergetic of sampling needle obtain abundant washing, improve the accuracy of sample testing result.
2. The device also concentrates the blood sample and the diluent in the blood sample detection cup, mixes the blood sample detection cup by the oscillation mechanism, and directly detects by the detection mechanism, thereby shortening the detection steps and improving the detection efficiency; moreover, the detection sample does not need to be transferred for multiple times, and only needs to be quantitatively and accurately diluted by the quantitative dilution mechanism for detection, so that the accurate measurement of the blood sample and the accuracy of the detection result are improved.
Drawings
Fig. 1 is a schematic structural diagram of a blood testing apparatus according to an embodiment.
Fig. 2 is a schematic structural view of a portion a in fig. 1.
FIG. 3 is a schematic view showing the structure of the cleaning tank of FIG. 1.
Fig. 4 is a schematic structural view of a portion B in fig. 1.
Fig. 5 is a schematic view of the mounting frame and the swing arm of fig. 4.
Fig. 6 is a schematic structural view of the rotary disk and the cam in fig. 4.
Fig. 7 is a schematic diagram of the operation of the detector of fig. 1.
In the figure: 100. a detection table; 110. a sample tray; 111. a blood sample tube; 120. a flow guide pipe;
200. an autosampler; 210. a sampling needle; 220. a laser sensor;
300. a cleaning mechanism; 310. a cleaning tank; 311. a liquid discharge port; 312. a shower head; 313. a compressed gas showerhead; 314. a gas guide vane; 320. a waste liquid collection unit; 330. a pipeline;
400. a quantitative dilution mechanism; 410. a diluent unit; 420. a first syringe;
500. a detection mechanism; 510. a blood sample detection cup; 511. a gear ring; 512. a turning guard; 520. an oscillating mechanism; 521. mounting the frame; 522. a turntable; 523. a cam; 524. a rocker arm; 525. a rack; 530. a detector; 531. a detection chamber; 532. a detection channel; 533. a laser; 534. a photodetector; 535. a sheath fluid channel; 540. a second syringe.
Detailed Description
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to the accompanying drawings and embodiments. It should be understood that the specific embodiments described herein are merely illustrative of the invention and do not limit the invention.
All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Fig. 1 is a schematic structural diagram of a blood testing device for medical examination according to an embodiment. In the present embodiment, the blood test apparatus includes a test table 100, an automatic sampler 200, a washing mechanism 300, a quantitative dilution mechanism 400, and a test mechanism 500.
Wherein, the test table 100 is provided with a sample tray 110 for placing a blood sample to be tested. A plurality of blood sample tubes 111 are uniformly arranged on the sample tray 110, are distributed on the periphery of the sample tray and are encircled to form a ring shape; the sample tray 110 is rotatably coupled to the test station 100. The sample disc can be rotated to rotate the corresponding sample to be detected to the lower side of the sampling needle, so that sample introduction is facilitated. For example, the bottom of the sample is provided with a first motor for controlling the rotation of the sample, the first motor is arranged in the top surface of the detection platform, and the output shaft of the first motor is connected with the sample plate.
The auto-sampler 200 is located at one side of the sample tray 110, and controls the sampling needle 200 to aspirate and dispense a blood sample; one end of the sampling needle 210 is mounted to the autosampler 200 and is removably connected to the autosampler 200 for aspirating and dispensing a blood sample to the detection mechanism 500. A horizontal sliding groove is formed in one side wall of the automatic sample injector, and one end of the sampling needle is installed in the horizontal sliding groove and can move along the horizontal sliding groove.
Referring to fig. 1 to 2, a laser sensor 220 is disposed on a side wall of the autosampler 200 close to the sample tray for sensing that the blood sample tube 111 to be tested rotates to a lower side of the sampling needle 210, and a label for identification by the laser sensor 220 is disposed on a side wall of each blood sample tube to be tested. Each label corresponds to a blood sample tube to be detected, and during operation, the first motor is started to drive the sample disc 110 to rotate, so that the blood sample tube to be detected is controlled to rotate towards one side of the sampling needle in sequence.
Referring to fig. 1 and 3, the cleaning mechanism 300 is disposed at one side of the sampling needle 210, and is used for cleaning the outer wall and the inner wall of the sampling needle 210 and drying the sampling needle. Because a small amount of blood samples are attached to the inner wall and the outer wall of the needle head of the sampling needle after sampling, if the sampling needle is not cleaned in time, the sampling needle can be blocked, bacterial pollution is generated on the inner wall and the outer wall of the sampling needle, and the accuracy of a sample to be injected later is influenced. Therefore, the sampling needle needs to be cleaned before and after sample introduction.
The cleaning mechanism 300 includes a cleaning tank 310, a waste liquid collecting unit 320, and a pipe 330.
The cleaning tank 310 is disposed at one side of the sampling needle 210; the sampling needle is located on one side of the sample disc, and the needle head of the sampling needle can be cleaned in time before and after sample introduction. The top of the cleaning pool 310 is provided with a cover plate, and the cover plate is provided with a jack for inserting a sampling needle. The apron can block to spray liquid blowout and wash the pond, guarantees to detect clean and tidy of platform.
The inner wall of the cleaning pool 310 is uniformly provided with a plurality of spray heads 312 for spraying and cleaning the outer wall of the sampling needle. One side of each spray header 312 is provided with a compressed gas spray head 313; the sampling needle is dried after being cleaned. A plurality of gas guide vanes 314 are arranged on the side wall of the bottom of the cleaning pool 310; each gas guide vane 314 is disposed at an opposite side of the compressed gas showerhead 313 corresponding thereto. The gas guide vanes are positioned on the side wall of the bottom of the cleaning pool, so that gas sprayed by the compressed gas nozzle forms spiral upward airflow in the cleaning pool, and the drying of the inner wall and the outer wall of the sampling needle is accelerated. A liquid outlet 311 is formed in the bottom of the cleaning pool 310, and an electromagnetic valve is arranged on the liquid outlet 311 and used for controlling the opening and closing of the liquid outlet;
the waste liquid collecting unit 320 is disposed at the lower side of the washing tank 310; for receiving cleaning waste liquid from the cleaning tank 310. Waste liquid collection unit 320's bottom one side is provided with the waste liquid export, is provided with control flap on the waste liquid export. A transparent observation window is arranged on one side of the top of the waste liquid collecting unit 320 for observing the liquid level in the waste liquid collecting unit 320. Here, the waste liquid collecting unit 320 is a waste liquid collecting tank.
A pipe 330 for connecting the washing tank 310 and the waste liquid collecting unit 320; the top end of the pipeline is connected with a liquid outlet 311 at the bottom of the cleaning pool 310, and the bottom end of the pipeline is connected with a top waste liquid inlet of the waste liquid collecting unit 320.
In the embodiment, the cleaning mechanism is arranged on one side of the sampling needle, the inner wall and the outer wall of the sampling needle are effectively cleaned through the cleaning mechanism, and the influence on the accuracy of a detection result caused by the fact that a batch of detection samples are attached to the inner wall and the outer wall of the sampling needle is avoided. Through adopting the mode that sprays and wash and the mode that pumps repeatedly to combine together, make the inner wall and the outer wall homoenergetic of sampling needle obtain abundant washing, improve the accuracy of sample testing result. For example, in operation, the sampling needle 210 is first moved to the upper side of the cleaning tank 310, inserted into the cleaning tank 310, the shower head is opened to fill 2/3 of the cleaning liquid into the cleaning tank, the sampling needle is inserted into the cleaning liquid, the sampling needle is repeatedly sucked and flushed, and the waste liquid is discharged; repeating the suction and flushing step for 2-3 times, and discharging waste liquid; the plurality of showerheads 312 are then activated for cleaning the outer wall of the sampling needle 210. And opening the liquid outlet 311 to discharge waste liquid, then opening the spray head to spray and wash the wall of the cleaning pool, and discharging the waste liquid. And finally, opening a compressed gas spray head 313 for performing spiral air flow drying on the inner wall and the outer wall of the sampling needle, performing vacuum suction drying on the inner wall of the sampling needle through an automatic sampler, and waiting for next sample injection after drying is finished.
Referring to fig. 1 again, the quantitative dilution mechanism 400 is disposed at the other side of the sampling needle 210 and at one side of the auto-sampler 200 for quantitatively diluting the blood sample to be detected. The detecting mechanism 500 is disposed below the quantitative dilution mechanism 400 and on one side of the waste liquid collecting unit 320, and is used for detecting the diluted blood sample and counting the detection results.
The quantitative dilution mechanism 400 includes a diluent unit 410 and a first syringe 420.
Specifically, the diluent unit 410 is mainly used for storing diluent, for example, the diluent unit 410 is a diluent storage box, one side of the top of the diluent storage box is provided with a liquid inlet and a liquid level meter convenient for observing the liquid level, the prepared diluent is filled from the liquid inlet, the liquid level in the diluent storage box can be observed through the liquid level meter, overflow during adding is avoided, and the normal detection is prevented from being influenced by too little diluent in the storage box; the diluent is mainly used for diluting a blood sample to be detected, and is convenient to detect.
Specifically, the end of the first syringe 420 is provided with a first check valve for quantitatively transferring the diluent in the diluent unit 410 to the blood sample in the blood sample measuring cup 510. A blood sample detection cup 510 is arranged on one side of the detection mechanism 500, a guide tube 120 is arranged on the upper side of the blood sample detection cup 510, one end of the guide tube 120 extends to one side of the diluent unit 410, and the first syringe 420 is respectively connected with the diluent unit 410 and the guide tube 120 through a first one-way valve. The first one-way valve on the first syringe is connected with the flow guide pipe through the connecting pipe, namely, the first syringe is respectively connected with the diluent unit and the blood sample detection cup.
In this embodiment, the auto-sampler controls the sampling needle to transfer the blood sample to the flow guide tube, and the blood sample flows into the blood sample detection cup through the flow guide tube. Then, the first syringe 420 sucks diluent from the diluent unit 410 through the first one-way valve, the extracted diluent is injected into the guide pipe through the first one-way valve, the diluent flows into the blood sample detection cup from the upper end of the guide pipe, and the blood sample in the guide pipe is washed into the blood sample detection cup, so that the blood sample to be detected is prevented from being attached to the wall of the guide pipe, and the accuracy of a subsequent detection result is prevented from being influenced.
Referring to fig. 4 to 6, a rotary guard 512 is disposed at the bottom of the blood sample testing cup 510, and the blood sample testing cup 510 is mounted in the rotary guard 512 and is rotatably connected to the rotary guard 512. For example, the rotation protection member is a protection ring, the structure of the rotation protection member is a hollow ring, the inner diameter of the rotation protection member is slightly larger than the outer diameter of the blood sample detection cup, and the height of the rotation protection member is 1/4-1/2 of the height of the blood sample detection cup, so that the blood sample detection cup can stably rotate in the protection ring to uniformly mix the blood sample in the blood sample detection cup.
An oscillating mechanism 520 is arranged on one side of the blood sample detection cup 510 and is used for oscillating and mixing the diluted blood sample; the blood sample is mixed by reciprocating the blood sample detection cup for rotation.
Specifically, the oscillating mechanism 520 includes a mounting frame 521, and a rotating disc 522 and a cam 523 located in the mounting frame 521, the rotating disc 522 and the cam 523 being coaxially connected; a power mechanism for driving the turntable 522 to rotate back and forth is arranged on the lower side of the turntable 522; for example, power unit is the second motor, and the output shaft of second motor is connected with the carousel for drive carousel realization reciprocating rotation, because carousel and cam coaxial coupling, make the cam follow the rotation of carousel and reciprocal swing then.
Two ends of the top of the cam 523 are provided with 2 rocker arms 524 in parallel, and each rocker arm 524 is rotatably connected with the cam 523; both ends of each rocker arm 524 penetrate through the mounting frame 521 and are connected with the mounting frame 521 in a sliding manner; for example, elongated through holes are formed in two ends of the cam, a support arm used for connecting a rocker arm corresponding to the through holes is arranged in each through hole, the lower end of each support arm is inserted into the through hole, a U-shaped clamping jaw is arranged at the upper end of each support arm, and the rocker arm is clamped in a U-shaped groove of the U-shaped clamping jaw and is detachably or fixedly connected with the U-shaped clamping jaw. Because the bottom size of U type jack catch is greater than the size of through-hole, and the size of support arm lower extreme then slightly is less than the size of through-hole for the support arm can move in rectangular shape through-hole, and rotate around this through-hole. In order to improve the installation stability of the support arm, a limit nut can be arranged on the lower end part of the support arm extending out of the through hole, so that the support arm is not easy to separate from the through hole and can move along the through hole. Thereby enabling the two rocker arms to oscillate reciprocally.
Here, both ends of each swing arm pass through both side walls of the mounting frame, so that each swing arm moves along the through holes on both side walls of the mounting frame. When the structure works, the cam rotates to drive the rocker arm to swing in a reciprocating mode, and the support arm moves in the through hole in the cam and rotates with the through hole, so that the rocker arm swings back and forth, and the mounting stability of the structure is improved.
The blood sample detection cup 510 is disposed between the 2 rocker arms 521, and is in toothed meshing connection with the 2 rocker arms 521. For example, be provided with 2 bar holes on the cam 523, the downthehole equal rotatable rotation axis of installing of every bar, every rotation axis all can dismantle rather than the rocking arm 524 that corresponds and be connected, and along with the rotation of cam, the rotation axis still can be followed the bar hole that corresponds and taken place to remove to make the rocking arm can be stable move on the installation frame. The end of each rocker arm 524 that passes through the mounting frame 521 is provided with a rack 525, the side wall of the blood sample detection cup 510 is provided with a gear ring 511, and 2 racks 525 are respectively arranged on two opposite sides of the gear ring 511 and are in toothed engagement with the gear ring 511. Because two racks all with gear ring tooth-like meshing, along with the swing back and forth of rocking arm, just can drive gear ring and take place to rotate, and then make blood sample detection cup take place to rotate, be convenient for carry out intensive mixing to the blood sample. For example, an elastic connecting piece, such as a spring or an elastic belt, may be further disposed on a side of the two rocker arms close to the mounting frame, and the two rocker arms are connected by the elastic connecting piece, so that the two rocker arms are both tensioned toward each other, and further, the two racks are tightly engaged with the gear ring, and are not easy to slide.
The device also concentrates the blood sample and the diluent in the blood sample detection cup, the blood sample detection cup is subjected to oscillation mixing through the oscillation mechanism, and then the detection mechanism directly detects the blood sample and the diluent, so that the detection steps are shortened, and the detection efficiency is improved; moreover, the detection sample does not need to be transferred for multiple times, and only needs to be quantitatively and accurately diluted by the quantitative dilution mechanism for detection, so that the accurate measurement of the blood sample and the accuracy of the detection result are improved.
Referring to fig. 1 and 7, the detecting mechanism 500 includes a detector 530; the detector 530 is provided with a second syringe 540, and the end of the second syringe 540 is provided with a second one-way valve for sucking the diluted blood sample into the detector 530. The second syringe 540 is connected to the blood sample detection cup 510 and the detection chamber 531 through the second one-way valve, and the detection chamber 531 is located in the detector 530. The second syringe is connected with the blood sample detection cup through the connecting pipe, the second syringe absorbs the blood sample from the blood sample detection cup through the second one-way valve, and the extracted blood sample is pumped into a detection chamber in the detector through the second one-way valve for blood sample detection.
In particular, detector 530 includes a detection chamber 531, a detection channel 532, a laser 533, and a photodetector 534.
The detection channel 532 is arranged in the middle of the detection chamber 531 and used for blood sample flow; sheath fluid channels 535 are respectively arranged at two sides of the detection channel 532 and are used for flowing sheath fluid; the laser 533 and the photodetector 534 are respectively disposed on two opposite sides of the detecting chamber 531 along the blood sample flowing direction, for detecting the number of cells in the blood sample. Here, sheath liquid flows in sheath fluid passage, and blood sample cell is a straight line when its effect is and passes through the detection channel, conveniently counts the cell that passes through laser instrument and photoelectric detector, guarantees correctly to count every cell, and the cell that can also avoid after the count simultaneously flows backward.
In this embodiment, sampling syringe needle one side is provided with belt cleaning device, and the waste liquid collecting box of belt cleaning device intercommunication bottom washs the syringe needle with the mode that sprays earlier, then adopts the mode of repeated suction many times to wash the cylinder inner wall, then flows into the waste liquid collecting box with the washing liquid along the pipeline in. The lower side of the spraying structure is provided with a valve for controlling the cleaning liquid to flow downwards. Lifting the sampling needle and drying by compressed air.
When the sample is fed, the sample disc 110 is rotated, the laser sensor 220 scans and senses the sample, and the outer wall of the blood sample tube 111 is provided with the scanning label, so that when the laser sensor senses the scanning label by the laser sensor 220, the sample disc 110 is stopped to be rotated, and the sampling needle 210 is controlled by the automatic sample feeder 200 to sample.
The sampling needle 210 sucks and dispenses a blood sample to the corresponding blood sample measuring cup 510, and quantitatively sucks the diluent from the diluent unit through the first syringe 420 and transfers the same into the corresponding blood sample measuring cup 510.
An oscillating mechanism 520 is provided on the lower side of the blood sample measuring cup 510 to mix the sample in the blood sample measuring cup 510 by oscillation. The oscillating mechanism 520 comprises a square mounting frame 521, a rotating disc 522 positioned in the frame and a cam 523 positioned on the rotating disc 522, wherein the cam 523 is symmetrically provided with strip-shaped holes, a rotating shaft is rotatably mounted in the holes, a rocker 524 is hinged above the rotating shaft, and the rocker 524 penetrates through two side walls of the mounting frame 521 and is slidably connected with the mounting frame 521.
The end of the rocker arm 524 penetrating through the mounting frame 521 is oppositely provided with a rack 525, the outer side wall of the blood sample detection cup 510 is provided with a gear ring 511, the gear ring 511 is meshed with the 2 teeth 525, and the blood sample detection cup 510 is driven to repeatedly rotate back and forth by the acting force of the 2 teeth 525 in the opposite direction, so that the oscillation and mixing of the detection sample are realized.
The diluted sample is drawn into the detector 530 through the second syringe 540. After the detection is completed, the device is cleaned, the previous sample is diluted continuously through the first injector 420, the detection steps are repeated, a second detection result is obtained, and a third detection result is obtained in sequence. The three dilution fold and test 530 include: the detection chamber 531, the detection channel 532, both sides of the detection channel 532 are provided with sheath fluid channels 535, both sides of the sheath fluid channels 535 are provided with a laser detector 533 and a photoelectric detector 534, respectively, thereby measuring the number of cells to be detected in the blood sample. The detected sample flows into the waste liquid collecting unit 320 through the pipe.
The present invention is not limited to the above preferred embodiments, and any modifications, equivalent substitutions and improvements made within the spirit and principle of the present invention should be included in the protection scope of the present invention.

Claims (9)

1. A blood detection device for medical examination is characterized by comprising a sampling needle (210), a cleaning mechanism (300), a quantitative dilution mechanism (400) and a detection mechanism (500),
a sampling needle (210) for aspirating and dispensing a blood sample to a testing mechanism (500);
the cleaning mechanism (300) is arranged on one side of the sampling needle (210) and is used for cleaning the outer wall and the inner wall of the sampling needle (210) and drying the sampling needle;
the quantitative dilution mechanism (400) is arranged on the other side of the sampling needle (210) and is used for quantitatively diluting the blood sample to be detected;
a detection mechanism (500) which is arranged below the quantitative dilution mechanism (400) and is used for detecting the diluted blood sample and counting the detection result;
a blood sample detection cup (510) is arranged on one side of the detection mechanism (500), and an oscillation mechanism (520) is arranged on one side of the blood sample detection cup (510) and is used for oscillating and mixing the diluted blood sample;
the washing mechanism (300) comprises:
a cleaning tank (310) disposed on one side of the sampling needle (210);
a waste liquid collection unit (320) disposed below the cleaning tank (310); and
a pipe (330) for connecting the washing tank (310) and the waste liquid collecting unit (320);
a liquid outlet (311) is formed in the bottom of the cleaning pool (310), and an electromagnetic valve is arranged on the liquid outlet (311);
a plurality of spray heads (312) are uniformly arranged on the side wall of the top of the cleaning pool (310), and a compressed gas spray head (313) is arranged on one side of each spray head (312); a plurality of gas guide vanes (314) are arranged on the side wall of the bottom of the cleaning pool (310); each gas guide vane (314) is arranged at one side opposite to the corresponding compressed gas spray head (313).
2. The blood test device for medical examination according to claim 1, wherein the quantitative dilution mechanism (400) comprises:
a diluent unit (410) for storing a diluent; and
a first syringe (420) provided at an end thereof with a first check valve for quantitatively transferring the diluent in the diluent unit (410) into the blood sample;
the first syringe (420) is respectively connected with the diluent unit (410) and the blood sample detection cup (510) through a first one-way valve.
3. The blood test device for medical examination according to claim 2, wherein a flow guide tube (120) is provided on an upper side of the blood sample test cup (510), one end of the flow guide tube (120) extends to one side of the diluent unit (410), and the first syringe (420) is connected to the diluent unit (410) and the flow guide tube (120) through first one-way valves, respectively.
4. The blood testing device for medical examination as claimed in claim 1 or 3, wherein a rotary guard (512) is provided at the bottom of said blood sample testing cup (510), said blood sample testing cup (510) is mounted in said rotary guard (512) and is rotatably connected with said rotary guard (512).
5. The blood test device for medical examination according to claim 1, further comprising a test stand (100),
a sample tray (110) is arranged on the detection table (100), and a plurality of blood sample tubes (111) are uniformly arranged on the sample tray (110); the sample plate (110) is rotatably connected with the detection platform (100);
an automatic sampler (200) is arranged on one side of the sample plate (110) and is used for controlling a sampling needle (210) to suck and distribute a blood sample; one end of the sampling needle (210) is mounted on the auto-sampler (200) and movably connected with the auto-sampler (200).
6. The blood test apparatus for medical examination according to claim 5, wherein the auto-sampler (200) is provided with a laser sensor (220) on a side wall thereof near the sample tray for sensing the rotation of the blood sample tube (111) to be tested to the lower side of the sampling needle (210), and a label for identification by the laser sensor (220) is provided on a side wall of each blood sample tube to be tested.
7. The blood test apparatus for medical examination according to claim 1, wherein the oscillation mechanism (520) comprises a mounting frame (521), and a turntable (522) and a cam (523) located in the mounting frame (521), the turntable (522) and the cam (523) being coaxially connected; a power mechanism for driving the rotary table (522) to rotate in a reciprocating manner is arranged on the lower side of the rotary table (522);
two ends of the top of the cam (523) are provided with 2 rocker arms (524) in parallel, and each rocker arm (524) is rotatably connected with the cam (523); both ends of each rocker arm (524) penetrate through the mounting frame (521) and are in sliding connection with the mounting frame (521);
the blood sample detection cup (510) is arranged between the 2 rocker arms (524), and is in tooth-shaped meshing connection with the 2 rocker arms (524).
8. The blood test device for medical examination as claimed in claim 7, wherein each of said rocker arms (524) is provided with a rack (525) at an end portion thereof passing through said mounting frame (521), a gear ring (511) is provided on a side wall of said blood sample test cup (510), and 2 of said racks (525) are respectively provided at opposite sides of said gear ring (511) and are in toothed engagement with said gear ring (511).
9. The blood test device for medical examination according to claim 1, wherein the detection mechanism (500) comprises a detector (530);
the detector (530) is provided with a second syringe (540), and the end part of the second syringe (540) is provided with a second one-way valve for sucking the diluted blood sample into the detector (530).
CN202010374992.XA 2020-04-28 2020-04-28 Blood detection device for medical examination Active CN111426622B (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3505906B2 (en) * 1996-04-04 2004-03-15 東ソー株式会社 Glycated hemoglobin analyzer
CN205067201U (en) * 2015-11-10 2016-03-02 单先芬 Automatic medical examination sample diluter
CN208636331U (en) * 2018-05-02 2019-03-22 深圳开立生物医疗科技股份有限公司 Sampling needle cleaning device

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
邱跃华 ; .血液分析仪全血与稀释模式测定值的比较.2007,(第11期),97-98. *

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