CN111420013A - A Chinese medicinal composition for treating cholecystitis, cholangitis and cholelithiasis - Google Patents

A Chinese medicinal composition for treating cholecystitis, cholangitis and cholelithiasis Download PDF

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CN111420013A
CN111420013A CN202010416546.0A CN202010416546A CN111420013A CN 111420013 A CN111420013 A CN 111420013A CN 202010416546 A CN202010416546 A CN 202010416546A CN 111420013 A CN111420013 A CN 111420013A
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cholangitis
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cholecystitis
treating cholecystitis
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仲崇允
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • A61K36/718Coptis (goldthread)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/282Artemisia, e.g. wormwood or sagebrush
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/288Taraxacum (dandelion)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/39Convolvulaceae (Morning-glory family), e.g. bindweed
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/66Papaveraceae (Poppy family), e.g. bloodroot
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/73Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736Prunus, e.g. plum, cherry, peach, apricot or almond
    • AHUMAN NECESSITIES
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    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/906Zingiberaceae (Ginger family)
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    • AHUMAN NECESSITIES
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    • A61K9/0056Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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Abstract

The invention discloses a traditional Chinese medicine for treating cholecystitis, cholangitis and biliary calculus, which is prepared from the following raw material medicines in parts by weight: 2-4 parts of goldthread root; 4-8 parts of turmeric; 6-12 parts by weight of silybum marianum, fennel, dark plum and oriental wormwood; 9-18 parts of artemisia stelleriana; 15-30 parts of creeping dichondra, dandelion, linearstripe rabdosia herb and uncinata spikemoss herb. It is contraindicated for patients with yang deficiency, external cold, and spleen and stomach deficiency.

Description

A Chinese medicinal composition for treating cholecystitis, cholangitis and cholelithiasis
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for treating cholecystitis, cholangitis and biliary calculus.
Background
Sudden obstruction or incarceration of the cystic duct of the gallbladder is a common cause of acute cholecystitis, which can also be caused by cystic duct torsion, stenosis, and obstruction of biliary ascariasis or biliary tumor. At present, no specific medicine for treating cholecystitis, cholangitis and biliary calculus exists. Western medicine adopts spasmolysis, analgesia and antibacterial therapy, and 50% of magnesium copaiate, dehydrocholic acid tablet or cholecystectomy is orally taken. Western medicines can only relieve the state of an illness, cannot radically cure the operation, and are high in cost and high in risk.
Disclosure of Invention
The invention aims to improve the defects of the prior art and provides the traditional Chinese medicine composition for treating cholecystitis, cholangitis and biliary calculi, which can effectively improve or even eliminate clinical symptoms of patients and has the characteristics of obvious treatment effect, short treatment period, no toxic or side effect and the like.
Cholecystitis belongs to the category of diseases such as shaoyang disease, gallbladder excess heat, gallbladder distention and hypochondriac pain. Ancient people thought that the gallbladder is attached to the liver, and the gallbladder is exterior-interior to the liver, and the liver-gallbladder is located in the hypochondrium, which is called Ling Shu-distending Lun: for gallbladder distention, hypochondriac pain and distension, bitter taste in mouth and frequent sighing. The expression "syndrome treatment tonifying" means: the liver is the most yin, prefers to be stripped and dislocated, the gallbladder is not cleared, and prefers to be developed and dislocated, so the pain is more serious when the liver is not depressed, the qi is not released, and the fire is not released, so the liver is not healed and the pain is cured. "this fully indicates that the onset of cholecystitis is caused by failure to reach the body. The gallbladder is rigid and straight, mainly breaks, emotional disorder, cold and warm discomfort, improper diet, greasy and fat food overeating, or insect accumulation and the like can cause qi and blood stagnation, diseases of the gallbladder can cause damp-heat fatigue and middle-jiao accumulation, the middle-jiao clearing and descending of the gallbladder are affected, stagnation of the gallbladder qi is obstructed and pain is caused, the bile reversely overflows the skin to become yellow, and the heat accumulation is not dispersed to form pus. When the secretion of liver and gallbladder and the movement function of gallbladder and sphincter are affected, the bile is retained and may be infected, and the metabolism function of bile is changed to form calculus. The pathological factors are damp-heat, qi stagnation, blood stasis and excessive toxicity. Therefore, it has the effects of clearing away heat and toxic materials, removing blood stasis, promoting circulation of qi, protecting liver, promoting function of gallbladder, and removing dampness and swelling. The organism of the human body is regulated on the whole, thereby achieving the purpose of thorough healing.
1. Based on the theory, the invention provides a traditional Chinese medicine for treating cholecystitis, cholangitis and biliary calculus, which is prepared from the following raw material medicines in parts by weight: 2-4 parts of goldthread root; 4-8 parts of turmeric; 6-12 parts by weight of silybum marianum, fennel, dark plum and oriental wormwood; 9-18 parts of artemisia stelleriana; 15-30 parts of creeping dichondra, dandelion, linearstripe rabdosia herb and uncinata spikemoss herb.
2. In a preferred embodiment, the traditional Chinese medicine composition for treating cholecystitis, cholangitis and biliary calculus comprises the following raw material medicines in parts by weight: 4 parts of goldthread root; 8 parts of turmeric; silybum marianum, fennel, dark plum fruit and oriental wormwood 12 parts by weight; 18 parts of artemisia stelleriana; 30 parts of creeping dichondra, dandelion, rabdosia lophanthide and uncinata spikemoss herb.
Wherein silybum marianum is bitter and cool. Clearing away heat and toxic material, protecting liver, promoting function of gallbladder, protecting brain, and resisting X-ray. Can be used for treating cholelithiasis; cholangitis. Has good curative effect on liver and gall diseases such as acute or chronic hepatitis, liver cirrhosis, fatty liver, metabolic poisoning liver injury, cholelithiasis, cholangitis, perihepatitis of the liver and the like.
Herba talinae: pungent and mild in flavor. Clear heat and promote diuresis, remove toxicity and relieve swelling. Can be used for treating hepatitis, cholecystitis, nephritis, edema, urinary system infection, urinary calculus, tonsillitis, and traumatic injury.
And (3) yellow lotus: bitter and cold. It enters heart, spleen, stomach, liver, gallbladder and large intestine meridians. Clear heat and dry dampness, purge fire and remove toxicity. Berberine contained in Coptidis rhizoma has bile benefiting effect, and can increase bile formation and dilute bile, and has good effect for patients with chronic cholecystitis by oral administration.
Dandelion: bitter, sweet and cold. It enters liver and stomach meridians. Clearing away heat and toxic material, dispersing swelling and dissipating stagnation, inducing diuresis and treating stranguria. Dandelion has the function of benefiting gallbladder, Dandelion liquid can contract gallbladder and relax sphincter Oddi, thus being beneficial to discharge bile into intestine and being clinically effective to chronic cholecystospasm and lithiasis.
Artemisia princeps Pampanini: pungent and warm. Dry dampness and kill parasites. Can be used for treating cholecystitis, ascaris, and enterobiasis.
Fragrant horns: is bitter in taste; pungent taste; and (6) cooling. Entering the lung; the large intestine; the liver meridian. Clearing away heat and toxic materials; relieving cough and pain. Can be used for treating hepatitis; cholecystitis, and the like.
Rabdosia lophanthide: is bitter in taste; is cold in nature. Liver diseases entering; a bladder; the large intestine channel. Clearing away heat and toxic materials; removing dampness and eliminating jaundice; dispel stasis and relieve swelling. Used for treating damp-heat jaundice; cholecystitis is known as cholecystitis.
B, emerald green grass: sweet, bland and cool. Clear heat and promote diuresis, stop bleeding, and relieve cough. It is indicated for cholecystitis.
Herba artemisiae scopariae: bitter, pungent and slightly cold. It is entered into spleen, stomach, liver and gallbladder meridians. Clear damp-heat and alleviate jaundice. Can be used for treating jaundice, oliguria, eczema, and pruritus; infectious icteric hepatitis. Herba Artemisiae Scopariae has obvious choleretic effect, and can increase bile secretion and discharge of solid, cholic acid and bilirubin in bile.
Turmeric: pungent, bitter and warm. It enters spleen and liver meridians. Break blood and move qi, dredge meridians to alleviate pain. The turmeric extract, curcumin, volatile oil, turmerone, shogaol, borneol, sesquiterpene alcohol and the like all have the beneficial effects of benefiting bile, increasing the generation and secretion of bile, recovering bile components to be normal and promoting gallbladder contraction, and the effect of curcumin is the strongest. Curcumin or its sodium salt has choleretic effect, and can reduce solid content to increase bile secretion, but in terms of total absolute value, bile salt, bilirubin, and cholesterol secretion increase, and fatty acid component remains constant. Can be used for treating cholelithiasis. The 50% decoction of Curcuma rhizome can promote appetite.
Dark plum: sour, astringent and neutral. It enters liver, spleen, lung and large intestine meridians. Astringe lung, astringe intestine, promote fluid production and relieve ascaris. Can be used for treating abdominal pain due to ascariasis, emesis, and ascariasis of biliary tract. The dark plum soup has the effects of promoting contraction and cholagogue of gallbladder, facilitating drainage of bile in biliary tract, reducing and preventing infection of biliary tract, and reducing biliary calculus formed by ascarid eggs left in biliary tract, so as to reduce occurrence of cholelithiasis, increase secretion of bile, and make bile tend to be acidic.
The Chinese medicine is prepared from traditional Chinese herbal medicines, and is a Chinese medicine for effectively treating cholecystitis, cholangitis and biliary calculus by orderly matching certain natural extracts with determined components and clear effects according to a plurality of principles of traditional Chinese medicine treatment based on syndrome differentiation and modern medicine.
The invention can be used throughout the whole treatment process of cholecystitis, cholangitis and biliary calculus, treats both symptoms and root causes, is not easy to relapse, is safe and reliable, has no obvious toxic or side effect, is convenient for patients to insist on taking for a long time, has no adverse reaction for the patients after taking the medicine for many years, and tracks the blood to check normally.
The traditional Chinese medicine composition has the advantages of easily available raw materials, simple process, low cost and high efficiency, and is beneficial to pharmaceutical enterprises for medicine production and quality control; the product has low price and is easy to be accepted by patients.
The traditional Chinese medicine composition has remarkable effect of treating cholecystitis, cholangitis and biliary calculus, and clinical experiment results show that the prescription is used for treatment, one dose of the traditional Chinese medicine composition is taken every day, 100 ml of water is decocted, the traditional Chinese medicine composition is divided into two parts, the medicine composition is taken one part in the morning and evening, one month is taken as a treatment course, generally one treatment course is effective, three treatment courses can be obviously improved, and the functions of six treatment courses are basically cured. The cure rate is 78 percent after 6 treatment courses, the significant efficiency is 88 percent, and the total effective rate is 100 percent.
The invention also provides an oral preparation prepared from the traditional Chinese medicine composition for treating cholecystitis, cholangitis and biliary calculus, wherein the oral preparation comprises oral liquid, tablets, capsules, pills and the like, preferably the dosage forms are tablets and capsules, and one dose is taken in the morning and at night.
The traditional Chinese medicine composition can be prepared into various dosage forms. For example, the decocted liquid medicine is sterilized and disinfected and then packaged to prepare oral liquid; or concentrating the decoction, oven drying, adding pharmaceutically acceptable adjuvants, and making into tablet, capsule, pill, etc.
The medically acceptable auxiliary materials comprise starch, dextrin, sodium carboxymethylcellulose, polyethylene glycol, calcium hydrophosphate, sodium alginate, potassium sorbate and the like.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the present invention in any way, and it will be apparent to those skilled in the art that the above description of the present invention can be applied to various modifications, equivalent variations or modifications without departing from the spirit and scope of the present invention.

Claims (4)

1. The traditional Chinese medicine for treating cholecystitis, cholangitis and biliary calculus is characterized by comprising the following raw material medicines in parts by weight: 2-4 parts of goldthread root; 4-8 parts of turmeric; 6-12 parts by weight of silybum marianum, fennel, dark plum and oriental wormwood; 9-18 parts of artemisia stelleriana; 15-30 parts of creeping dichondra, dandelion, linearstripe rabdosia herb and uncinata spikemoss herb.
2. The traditional Chinese medicine for treating cholecystitis, cholangitis and biliary calculus according to claim 1, which is prepared from the following raw materials in parts by weight: 4 parts of goldthread root; 8 parts of turmeric; silybum marianum, fennel, dark plum fruit and oriental wormwood 12 parts by weight; 18 parts of artemisia stelleriana; 30 parts of creeping dichondra, dandelion, rabdosia lophanthide and uncinata spikemoss herb.
3. An oral preparation for treating cholecystitis, cholangitis and biliary calculus, which is prepared from the Chinese medicinal composition of any one of claims 1 or 2.
4. The oral preparation for treating cholecystitis, cholangitis and biliary calculus according to claim 3, which comprises oral liquid, tablets, capsules and pills, preferably oral liquid and tablets.
CN202010416546.0A 2020-05-18 2020-05-18 A Chinese medicinal composition for treating cholecystitis, cholangitis and cholelithiasis Pending CN111420013A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111714601A (en) * 2020-08-09 2020-09-29 仲崇允 A Chinese medicinal composition for treating fungal infection

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN111714601A (en) * 2020-08-09 2020-09-29 仲崇允 A Chinese medicinal composition for treating fungal infection

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Application publication date: 20200717