CN111419943A - Antiviral traditional Chinese medicine Qilanbao disease drink for livestock, preparation method and application - Google Patents

Antiviral traditional Chinese medicine Qilanbao disease drink for livestock, preparation method and application Download PDF

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CN111419943A
CN111419943A CN202010417017.2A CN202010417017A CN111419943A CN 111419943 A CN111419943 A CN 111419943A CN 202010417017 A CN202010417017 A CN 202010417017A CN 111419943 A CN111419943 A CN 111419943A
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traditional chinese
chinese medicine
drink
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汤法银
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Nanjing Dafang Bioengineering Co ltd
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Nanjing Dafang Bioengineering Co ltd
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    • A—HUMAN NECESSITIES
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    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K31/33—Heterocyclic compounds
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
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Abstract

The invention relates to a veterinary antiviral traditional Chinese medicine astragalus blue capsule disease drink, a preparation method and application thereof, and the veterinary antiviral traditional Chinese medicine astragalus blue capsule disease drink comprises the following steps: respectively crushing astragalus, isatis root, indigowoad leaf, rehmannia root and red paeony root, sieving by a 30-40-mesh sieve, mixing according to a certain proportion to obtain a mixture, soaking the mixture in water, keeping the mixture and the water at a mass ratio of 1:2-3, standing for 30min-1h at 60-70 ℃, and filtering to obtain a material I; putting the first material into a steam explosion tank, introducing steam until the pressure in the steam explosion tank is 2.5-2.7MPa, and performing steam explosion treatment for 2-5min to obtain a second material; boiling the second material in 10-12 times of water for 2 times, each time for 2-3h, mixing the two extractive solutions, filtering the extractive solution, concentrating, and sterilizing to obtain third material; and adding 0.5-1% of compound vitamin and 0.5-1% of mineral substance into the third material to obtain the veterinary antiviral traditional Chinese medicine Qilan capsule disease drink. The invention has better disease-resistant effect, and simultaneously supplements nutrition for beasts and improves immunity by adding vitamins and minerals.

Description

Antiviral traditional Chinese medicine Qilanbao disease drink for livestock, preparation method and application
Technical Field
The invention relates to an antiviral traditional Chinese medicine astragalus blue capsule disease drink for livestock, a preparation method and application thereof.
Background
In the prior art, the preparation process of the astragalus-bluestone disease drink comprises the following steps: 300g of astragalus, 200g of isatis root, 200g of dyers woad leaf, 200g of rehmannia root and 100g of red paeony root, the five medicines are decocted with water twice, filtered, the filtrates are combined, concentrated to 1000ml, 0.4 percent of sodium benzoate is added, and the mixture is kept stand, filtered or centrifuged, filled and sterilized to obtain the traditional Chinese medicine. The functions are as follows: remove toxicity, cool blood, supplement qi and nourish yin. The main treatment is as follows: can be used for preventing and treating infectious bursal disease of chicken.
The method for extracting the active ingredients of the five traditional Chinese medicines by adding water and decocting cannot fully realize the cell wall breaking of the five traditional Chinese medicines, so that the dissolution of the active ingredients is limited. Moreover, when the astragalus blue cystic disease drink is taken by livestock, the stomach mouth of the livestock is worsened, the gastrointestinal function is nourished, and the balanced nutrition is influenced.
Disclosure of Invention
In order to overcome the defects, the invention provides the veterinary antiviral traditional Chinese medicine Qilanbao disease drink with better disease resistance, a preparation method and application thereof, and simultaneously, vitamins and minerals are added to supplement nutrition for the veterinary and improve immunity.
In order to solve the technical problems, the technical scheme adopted by the invention is as follows: a preparation method of a veterinary antiviral traditional Chinese medicine Qilanbao disease drink is characterized by comprising the following steps:
respectively crushing astragalus, isatis root, indigowoad leaf, rehmannia root and red paeony root, sieving by a 30-40-mesh sieve, mixing according to a certain proportion to obtain a mixture, soaking the mixture in water, keeping the mixture and the water at a mass ratio of 1:2-3, standing for 30min-1h at 60-70 ℃, and filtering to obtain a material I; putting the first material into a steam explosion tank, introducing steam until the pressure in the steam explosion tank is 2.5-2.7MPa, and performing steam explosion treatment for 2-5min to obtain a second material; boiling the second material in 10-12 times of water for 2 times (heating temperature is 100 ℃), each time for 2-3h, mixing the secondary extract, filtering the extract, concentrating, and sterilizing to obtain a third material;
and adding 0.5-1% of compound vitamin and 0.5-1% of mineral substance into the third material to obtain the veterinary antiviral traditional Chinese medicine Qilan capsule disease drink.
The steam explosion method is adopted to prepare the materials, so that the cells of the five traditional Chinese medicines can be fully damaged, and the effective components can be fully dissolved out. Mixing the mixture with water, standing at 60-70 deg.C for 30min-1h, and pretreating the Chinese medicinal materials before steam explosion to realize rehydration, and is helpful for destroying Chinese medicinal cells during steam explosion.
Vitamins and minerals are added to supplement nutrition for animals, improve immunity, and improve appetite of livestock and poultry, especially sick livestock and poultry.
Preferably, the mass ratio of the astragalus root, the isatis root, the dyers woad leaf, the rehmannia root and the red paeony root is (1-2): (1-2): (1-2): (1-2): (1-2). More preferably, the mass ratio of the astragalus to the radix isatidis to the folium isatidis to the rehmannia to the radix paeoniae rubra is 1:1:1: 1.
Specifically, radix astragali, radix isatidis, folium isatidis, rehmannia glutinosa and radix paeoniae rubra are respectively ground and sieved by a 30-40-mesh sieve, the mixture is mixed according to a certain proportion to obtain a mixture, the mixture is soaked in water, the mass ratio of the mixture to the water is 1:2, standing is carried out for 40min at 70 ℃, and filtering is carried out to obtain a material I.
Preferably, the first material is placed into a steam explosion tank, steam is introduced until the pressure in the steam explosion tank is 2.6MPa, and steam explosion treatment is carried out for 5min to obtain a second material.
And (3) boiling the second material in water with the mass of 12 times for 2 times, and each time for 2.5 hours, combining the secondary extracting solutions, and filtering, concentrating and sterilizing the extracting solutions to obtain a third material.
And adding 0.5 mass percent of compound vitamin and 0.5 mass percent of mineral substance into the material III to obtain the antiviral traditional Chinese medicine Qilanbao disease drink for livestock.
The composition of the compound vitamin is as follows: 0.5-1 part of vitamin B10.5-1 part of vitamin B20.5-1 part of vitamin B61-2 parts of vitamin C, wherein the parts are parts by weight.
The composite mineral comprises the following components: 10-15 parts of iron salt, 2-4 parts of zinc salt and 0.1-0.15 part of iodized salt, wherein the parts are parts by weight.
The invention also aims to provide the veterinary antiviral traditional Chinese medicine astragalus and bluebeard disease beverage prepared by the preparation method.
The invention also aims to provide the veterinary antiviral traditional Chinese medicine Qilan capsule disease drink or the application of the preparation method in preparing the anti-chicken infectious bursal disease medicine.
Compared with the prior art, the invention has the beneficial effects that: the steam explosion method is adopted to prepare the materials, so that the cells of the five traditional Chinese medicines can be fully damaged, and the effective components can be fully dissolved out. Mixing the mixture with water, standing at 60-70 deg.C for 30min-1h, and pretreating the Chinese medicinal materials before steam explosion to realize rehydration, and is helpful for destroying Chinese medicinal cells during steam explosion.
Vitamins and minerals are added to supplement nutrition for animals, improve immunity, and improve appetite of livestock and poultry, especially sick livestock and poultry.
Detailed Description
The following describes embodiments of the present invention with reference to examples.
Example 1
Respectively crushing the astragalus, the isatis root, the indigowoad leaf, the rehmannia root and the red paeony root, sieving by a 30-40-mesh sieve, mixing according to the mass ratio of 1:1:1:1:1 to obtain a mixture, soaking the mixture in water, standing for 40min at the temperature of 70 ℃ according to the mass ratio of 1:2, and filtering to obtain a material I.
And putting the first material into a steam explosion tank, introducing steam until the pressure in the steam explosion tank is 2.6MPa, and performing steam explosion treatment for 5min to obtain a second material.
Boiling the second material in 12 times of water for 2 times (heating temperature is 100 ℃), each time for 2.5h, mixing the secondary extracting solutions, filtering the extracting solutions, concentrating to 30% (namely concentrating to 30% of the volume of the filtered extracting solution), and sterilizing to obtain a third material.
And adding 0.5 mass percent of compound vitamin and 0.5 mass percent of mineral substance into the material III to obtain the antiviral traditional Chinese medicine Qilanbao disease drink for livestock. The composition of the compound vitamin is as follows: 1 part of vitamin B11 part of vitamin B21 part of vitamin B6And 2 parts of vitamin C. The composite mineral comprises the following components: 15 parts of iron salt, 4 parts of zinc salt and 0.15 part of iodized salt.
Example 2
Respectively crushing the astragalus, the isatis root, the indigowoad leaf, the rehmannia root and the red paeony root, sieving by a 30-40-mesh sieve, mixing according to the mass ratio of 2:1:1:1:1 to obtain a mixture, soaking the mixture in water, standing for 40min at the temperature of 70 ℃ according to the mass ratio of 1:2, and filtering to obtain a material I.
And putting the first material into a steam explosion tank, introducing steam until the pressure in the steam explosion tank is 2.6MPa, and performing steam explosion treatment for 5min to obtain a second material.
Boiling the second material in 12 times of water for 2 times (heating temperature is 100 ℃), each time for 2.5h, mixing the secondary extracting solutions, filtering the extracting solutions, concentrating to 32% (namely concentrating to 32% of the volume of the filtered extracting solution), and sterilizing to obtain a third material.
And adding 0.5 mass percent of compound vitamin and 0.5 mass percent of mineral substance into the material III to obtain the antiviral traditional Chinese medicine Qilanbao disease drink for livestock. The composition of the compound vitamin is as follows: 1 part of vitamin B11 part of vitamin B21 part of vitamin B6And 2 parts of vitamin C. The composite mineral comprises the following components: 15 parts of iron salt, 4 parts of zinc salt and 0.15 part of iodized salt.
Example 3
Respectively crushing the astragalus, the isatis root, the indigowoad leaf, the rehmannia root and the red paeony root, sieving the crushed materials by a 30-40-mesh sieve, mixing the materials in a mass ratio of 1:1.5:1:1:1 to obtain a mixture, soaking the mixture in water, standing the mixture and the water for 40min at the temperature of 70 ℃, and filtering the mixture to obtain a first material.
And putting the first material into a steam explosion tank, introducing steam until the pressure in the steam explosion tank is 2.6MPa, and performing steam explosion treatment for 5min to obtain a second material.
Boiling the second material in 12 times of water for 2 times (heating temperature is 100 ℃), each time for 2.5h, mixing the secondary extracting solutions, filtering the extracting solutions, concentrating to 32% (namely concentrating to 32% of the volume of the filtered extracting solution), and sterilizing to obtain a third material.
And adding 0.5 mass percent of compound vitamin and 0.5 mass percent of mineral substance into the material III to obtain the antiviral traditional Chinese medicine Qilanbao disease drink for livestock. The composition of the compound vitamin is as follows: 1 part of vitamin B11 part of vitamin B21 part of vitamin B6And 2 parts of vitamin C. The composite mineral comprises the following components: 15 parts of iron salt, 4 parts of zinc salt and 0.15 part of iodized salt.
Comparative example
Respectively crushing the astragalus, the isatis root, the indigowoad leaf, the rehmannia root and the red paeony root, sieving the crushed materials by a 30-40-mesh sieve, mixing the materials in a mass ratio of 1:1:1:1:1 to obtain a mixture, boiling the mixture in water of which the mass is 12 times that of the mixture for 2 times (the heating temperature is 100 ℃) for 2.5 hours each time, combining secondary extracting solutions, filtering the extracting solutions, concentrating the extracting solutions to 30% (namely concentrating the extracting solutions to 30% of the volume of the filtered extracting solutions), and sterilizing to obtain a comparative product.
Application example
40 chickens with infectious bursal disease (the onset time is 2 days, the onset symptoms are similar, the chickens are the same age) were selected at the farm and divided into four groups of 10 chickens, including test group 1 to which the product of example 1 was applied, test group 2 to which the product of example 2 was applied, test group 3 to which the product of example 3 was applied, and a control group to which the comparative product of the comparative example was applied.
Each chicken was given 20m L of product per day and observed for 15 days during which the average time required for the chicken to exhibit significant improvement (significant improvement means that the chicken was mentally, normally fed, could move normally, feathered, and had no significant diarrhea) was observed and the mortality rate was observed, as shown in table 1.
TABLE 1 Observation of the difference in therapeutic effects between the test group and the control group
Figure BDA0002495368220000041
Therefore, the veterinary antiviral traditional Chinese medicine Qilanbao disease drink greatly shortens the average time required by the chickens to obviously improve, and obviously reduces the death rate of the sick chickens.
The foregoing illustrates and describes the principles, general features, and advantages of the present invention. It should be understood by those skilled in the art that the above embodiments do not limit the present invention in any way, and all technical solutions obtained by using equivalent alternatives or equivalent variations fall within the scope of the present invention.

Claims (10)

1. A preparation method of a veterinary antiviral traditional Chinese medicine Qilanbao disease drink is characterized by comprising the following steps:
respectively crushing astragalus, isatis root, indigowoad leaf, rehmannia root and red paeony root, sieving by a 30-40-mesh sieve, mixing according to a certain proportion to obtain a mixture, soaking the mixture in water, keeping the mixture and the water at a mass ratio of 1:2-3, standing for 30min-1h at 60-70 ℃, and filtering to obtain a material I; putting the first material into a steam explosion tank, introducing steam until the pressure in the steam explosion tank is 2.5-2.7MPa, and performing steam explosion treatment for 2-5min to obtain a second material; boiling the second material in 10-12 times of water for 2 times, each time for 2-3h, mixing the two extractive solutions, filtering the extractive solution, concentrating, and sterilizing to obtain third material;
and adding 0.5-1% of compound vitamin and 0.5-1% of mineral substance into the third material to obtain the veterinary antiviral traditional Chinese medicine Qilan capsule disease drink.
2. The preparation method of the antiviral traditional Chinese medicine Qilanbao decoction for veterinary use according to claim 1, which is characterized in that the mass ratio of the astragalus root, the isatis root, the dyers woad leaf, the rehmannia root and the red paeony root is (1-2): (1-2): (1-2): (1-2): (1-2).
3. The preparation method of the antiviral traditional Chinese medicine Qilanbao drink for livestock according to claim 2, characterized in that the first material is obtained by respectively crushing radix astragali, radix isatidis, folium isatidis, rehmannia glutinosa and radix paeoniae rubra, sieving with a 30-40 mesh sieve, mixing in a certain proportion to obtain a mixture, soaking the mixture in water with the mass ratio of the mixture to the water being 1:2, standing at 70 ℃ for 40min, and filtering.
4. The preparation method of the antiviral traditional Chinese medicine Qilan capsule disease drink for veterinary use according to claim 3, wherein the first material is put into a steam explosion tank, steam is introduced until the pressure in the steam explosion tank is 2.6MPa, and steam explosion treatment is carried out for 5min to obtain a second material.
5. The preparation method of the antiviral traditional Chinese medicine Qilanbao drink for livestock according to claim 4, characterized in that the second material is boiled in water with the mass of 12 times for 2 times, each time for 2.5h, the secondary extracting solutions are combined, and the third material is obtained after the extracting solutions are filtered, concentrated and sterilized.
6. The preparation method of the antiviral traditional Chinese medicine Qilanchou drink for veterinary use according to claim 3, wherein the antiviral traditional Chinese medicine Qilanchou drink for veterinary use is obtained by adding 0.5 mass percent of compound vitamin and 0.5 mass percent of mineral into the material III.
7. The preparation method of the antiviral traditional Chinese medicine Qilanbao drink for livestock according to claim 1, characterized in that the composition of the compound vitamins is as follows: 0.5-1 part of vitamin B10.5-1 part of vitamin B20.5-1 part of vitamin B61-2 parts of vitamin C, wherein the parts are parts by weight.
8. The preparation method of the antiviral traditional Chinese medicine Qilanbao drink for veterinary use according to claim 1, wherein the compound mineral comprises the following components: 10-15 parts of iron salt, 2-4 parts of zinc salt and 0.1-0.15 part of iodized salt, wherein the parts are parts by weight.
9. The antiviral traditional Chinese medicine Qilanbao drink for livestock prepared by the method of any one of claims 1 to 8.
10. The veterinary antiviral traditional Chinese medicine Qilanbao drink of claim 9 or the preparation method of any one of claims 1 to 8, and the application of the veterinary antiviral traditional Chinese medicine Qilanbao drink or the preparation method of any one of claims 1 to 8 in preparing the anti-infectious bursal disease medicine.
CN202010417017.2A 2020-05-18 2020-05-18 Antiviral traditional Chinese medicine Qilanbao disease drink for livestock, preparation method and application Pending CN111419943A (en)

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Citations (3)

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CN101879243A (en) * 2009-05-05 2010-11-10 天津市圣世莱科技有限公司 Chinese medicinal composition for treating bursa of fabricius diseases of poultry and preparation method thereof
CN106421545A (en) * 2016-09-01 2017-02-22 山西农业大学 Poultry antiviral traditional Chinese veterinary medicine
CN107982305A (en) * 2016-10-27 2018-05-04 北京中科百瑞能工程技术有限责任公司 A kind of method of steam explosion assisted extraction astragaloside and astragalus polyose

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Publication number Priority date Publication date Assignee Title
CN101879243A (en) * 2009-05-05 2010-11-10 天津市圣世莱科技有限公司 Chinese medicinal composition for treating bursa of fabricius diseases of poultry and preparation method thereof
CN106421545A (en) * 2016-09-01 2017-02-22 山西农业大学 Poultry antiviral traditional Chinese veterinary medicine
CN107982305A (en) * 2016-10-27 2018-05-04 北京中科百瑞能工程技术有限责任公司 A kind of method of steam explosion assisted extraction astragaloside and astragalus polyose

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