CN111419733A - Ceramide polypeptide compound Anmyo honey - Google Patents
Ceramide polypeptide compound Anmyo honey Download PDFInfo
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- CN111419733A CN111419733A CN202010456709.8A CN202010456709A CN111419733A CN 111419733 A CN111419733 A CN 111419733A CN 202010456709 A CN202010456709 A CN 202010456709A CN 111419733 A CN111419733 A CN 111419733A
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- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/68—Sphingolipids, e.g. ceramides, cerebrosides, gangliosides
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
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Abstract
The invention discloses a ceramide polypeptide compound Anmyo honey; aiming at providing an Anmyo honey which can promote the cell to be new and old and increase the value, enhance the activity of epidermal cells, improve the skin microcirculation, deeply moisturize water, relieve inflammation and repair skin barriers, and the technical proposal comprises the following steps: 13-5% of ceramide, 31-2% of ceramide, 0.01-0.01% of tripeptide 10.005, 0.01-40.002-0.01% of palmitoyl pentapeptide, 0.5-0.8% of sodium hyaluronate, 0.3-1.2% of hydrogenated lecithin, 0.1-0.5% of allantoin, 0.2-0.6% of tocopherol acetate, 0.01-0.05% of crocus sativus flower extract, 0.02-0.06% of rosemary leaf extract, 0.01-0.03% of coix seed extract, 0.05-0.1% of seaweed extract, 0.01-0.06% of rice bran oil, 0.05-0.1% of tea seed oil and the like; belongs to the field of cosmetics.
Description
Technical Field
The invention relates to skin care honey, in particular to ceramide polypeptide compound Anmyo honey, and belongs to the technical field of cosmetics.
Background
The physical barrier of skin is composed of sebum membrane, horny layer keratin, lipid, sandwich structure, brick wall structure, mucopolysaccharide, etc., and has effects in resisting external harmful substances, irritants, and ultraviolet, keeping moisture, regulating inflammation, and resisting aging.
However, due to the increasing serious environmental pollution, ultraviolet irradiation, closed air-conditioning environment, poor living habits, especially poor skin care habits, such as skin barrier damage caused by long-term use of cosmetics containing hormones, lead and mercury and a large amount of essence and preservatives, dry skin, dull skin, rough skin with large pores, accelerated skin aging, thinned cuticle, red and dull skin, atopic dermatitis, eczema, psoriasis, ichthyosis, solar dermatitis and other skin sensitivity, irritant dermatitis, hormone-dependent dermatitis and other skin greasiness, seborrheic diseases such as acne, rosacea and seborrheic dermatitis, and accelerated skin aging problems.
In addition, as the aging of the skin progresses, the decline of APSC multipotential cells in vivo is caused, dead skin adheres to the skin surface without falling off, and the skin aging is accelerated. In addition, excessive exposure of the skin to sunlight results in excessive oxidation of the skin, leading to skin aging.
Peptides are bioactive substances that are involved in various cellular functions in the body and participate in regulating various complex physiological processes in the human body. The molecular peptide has good conditioning effect on human bodies, can effectively activate the activity of cells, inhibit cell degeneration, effectively remove free radicals harmful to the human bodies, balance the immunity of the organisms and maintain the normal metabolism of the cells. Besides, the peptide can also repair damaged cells to have physiological activities such as cardiovascular function improvement, aging resistance and the like, which provides a theoretical basis for developing peptide cosmetics. However, the price of peptides is relatively expensive, which in turn imposes limitations and obstacles to the wide-scale, high-volume use of peptides in skin care products.
Moreover, the skin care products on the market at present have single effect, cannot promote the cell regeneration, promote the proliferation of epithelial cells and fibroblasts, enhance the activity of epidermal cells, improve skin microcirculation, deeply moisturize water, relieve inflammation, repair skin barriers and other multiple effects. Or are very expensive and do not benefit the general population.
Disclosure of Invention
Aiming at the problems, the invention aims to provide an Anmyo honey for promoting cell regeneration, promoting the proliferation of epithelial cells and fibroblasts, enhancing the activity of epidermal cells, improving skin microcirculation, deeply replenishing water, relieving inflammation and repairing skin barriers.
In order to solve the technical problems, the technical scheme provided by the invention is as follows:
a ceramide polypeptide compound Anmyo honey comprises the following components in percentage by mass: 13-5% of ceramide, 31-2% of ceramide, 0.01-0.01% of tripeptide-10.005, 0.5-0.01% of palmitoyl pentapeptide-40.002, 0.5-0.8% of sodium hyaluronate, 0.3-1.2% of hydrogenated lecithin, 0.1-0.5% of allantoin, 0.2-0.6% of tocopherol acetate, 0.01-0.05% of crocus sativus flower extract, 0.02-0.06% of rosemary leaf extract, 0.01-0.03% of coix seed extract, 0.05-0.1% of seaweed extract, 0.01-0.06% of rice bran oil, 0.05-0.1% of tea seed oil, 0.5-0.8% of dipotassium glycyrrhizinate, 0.5-1% of styrene/acrylic acid (ester) copolymer, 1-2% of lauroyl sarcosine isopropyl ester, 0.2-1% of dimethiconol, 0.1-1% of cyclotetrasiloxane, and polysorbate-3 801%, 0.1-0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5-2% of plant preservative, a proper amount of pH regulator and a proper amount of deionized water.
Further, the ceramide polypeptide compound Anmyo honey also comprises 0.1-0.5% of a peony root extract.
Further, the ceramide polypeptide compound Anmyo honey also comprises 0.05-0.2% of yeast/rice fermentation product filtrate.
Further, the ceramide polypeptide compound Anmyo honey also comprises 0.5-2% of vegetable compound oil.
Further, the ceramide polypeptide compound anmei comprises the following components in percentage by mass: comprises the following components in percentage by mass: 13-5% of ceramide, 31-2% of ceramide, 0.01-0.01% of tripeptide-10.005, 0.5-0.01% of palmitoyl pentapeptide-40.002, 0.5-0.8% of sodium hyaluronate, 0.3-1.2% of hydrogenated lecithin, 0.1-0.5% of allantoin, 0.2-0.6% of tocopherol acetate, 0.01-0.05% of crocus sativus flower extract, 0.02-0.06% of rosemary leaf extract, 0.01-0.03% of coix seed extract, 0.05-0.1% of seaweed extract, 0.01-0.06% of rice bran oil, 0.05-0.1% of tea seed oil, 0.5-0.8% of dipotassium glycyrrhizinate, 0.5-1% of styrene/acrylic acid (ester) copolymer, 1-2% of lauroyl sarcosine isopropyl ester, 0.2-1% of dimethiconol, 0.1-1% of cyclotetrasiloxane, and polysorbate-3 801%, 0.1-0.5% of medicinal root extract, 0.05-0.2% of yeast/rice fermentation product filtrate, 0.5-2% of plant compound oil, 0.1-0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5-2% of plant preservative, a proper amount of peony pH regulator and a proper amount of deionized water.
Further, the plant preservative of the ceramide polypeptide compound Anmyo honey is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 2-5:2-5:1-3:1-2
Furthermore, the ceramide polypeptide compound Anmyo honey is prepared by the following steps of:
1) cleaning and drying the tea seeds, the raspberry seeds and the grape seeds according to a mass ratio of 2-3: 1-2, uniformly mixing, and crushing to obtain mixed powder;
2) adding alkaline protease, pectinase, xylanase and deionized water into the mixed powder, mixing, adjusting to alkalinity, placing in an ultrasonic instrument, and performing enzymolysis at 35-42 deg.C for 15-40min to obtain extract;
3) inactivating enzymes in the leaching liquor obtained in the step 2), performing centrifugal separation at a high speed, and collecting upper-layer liquid;
4) adding an extracting agent into the collected upper layer liquid for extraction for 2-3 times, pumping out the collected oil phase layer, and removing the extracting agent to obtain the final product.
Furthermore, the ceramide polypeptide compound Anmyo honey is prepared by adding 0.5-1.5% of alkaline protease, 0.2-0.5% of pectinase and 0.3-0.5% of xylanase.
Furthermore, the ceramide polypeptide compound Anmyo honey is prepared by using diethyl ether as an extracting agent.
Furthermore, the ceramide polypeptide compound Anmyo honey has a solid-to-liquid ratio of 1g to 4-6m L.
Compared with the prior art, the technical scheme provided by the invention has the following beneficial effects:
1. the composition has the advantages of scientific formula, synergistic effect, effective activation of cell activity, inhibition of cell degeneration, effective elimination of free radicals harmful to human body, penetration into epidermis layer of skin, promotion of skin nutrition supply and waste excretion, promotion of proliferation and differentiation of epidermis cells, balance of immunity of skin organism, maintenance of normal metabolism of cells, adhesion of keratinocyte nerves, combination with water in stratum corneum to form a net structure, and water locking.
2. The technical scheme provided by the invention has good smoothness, can form a layer of film on the surface of the skin, enables the skin to generate good smoothness and moisture, plays a role in protecting the skin, and forms an external isolation barrier to repair the internal skin barrier.
3. The technical scheme provided by the invention can quickly supplement the influencing components required by the skin, such as alginic acid, crude protein, various vitamins, biological enzymes, fatty acids, lipids, saccharides, sterols, alkaloid triterpenes, trace elements, volatile oil, fatty oil, flavone, alkaloid, baicalin and baicalein, lactone and flavone, carotenoid in the extract of scutellaria baicalensis, protein, vitamin, glycolic acid and the like, so that the effects of improving the blood circulation of the skin, promoting the metabolism of the skin, preventing the water loss of the skin, deeply supplementing water and moisturizing, deeply nourishing the skin are achieved, the damage repair of skin cells can be effectively promoted, the skin barrier can be repaired, the aging can be resisted, and the skin darkness can be improved.
4. According to the technical scheme provided by the invention, the Chinese herbaceous peony root extract, the yeast/rice fermentation product filtrate, the vegetable compound oil and the like are compounded, so that the damaged skin can be calmed, the inflammation and oxidation resistance are effectively realized, the skin quality is conditioned, the skin regeneration is promoted, the free radicals are eliminated, the melanin deposition is inhibited, the deep water replenishing is realized, the cell activity is recovered, and the skin aging is delayed.
5. According to the technical scheme provided by the invention, the plant essential oil is extracted by enzyme-assisted ultrasonic waves, the extraction efficiency is high, effective nutrient components can be retained to the greatest extent, the release of sensitization factors is inhibited, lipid peroxidation caused by free radicals is inhibited, the elasticity of capillary vessels of the skin is enhanced, the regeneration of skin cells is promoted, and the plant essential oil has the effects of antibiosis, anti-inflammation, anti-allergy, anti-aging and antioxidation.
6. The technical scheme provided by the invention adopts the plant preservative to inhibit gram-negative bacteria such as enterobacteria and the like, and gram-positive bacteria and fungi such as staphylococcus aureus, escherichia coli, pseudomonas aeruginosa, candida albicans, bacillus subtilis, streptococcus and the like, so that the damage to skin cells of a human body is minimized, no stimulation or anaphylactic reaction exists, and the plant preservative has biodegradability.
Detailed Description
The technical solution of the present invention is further described in detail with reference to the following embodiments, but the present invention is not limited thereto, and any limited number of modifications made by anyone within the scope of the present invention are still within the scope of the present invention.
It should be noted that the raw materials used in the technical scheme provided by the present invention, except for the specific description, are prepared by conventional means or purchased through commercial channels.
Example 1
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 13% of ceramide, 31% of ceramide, 10.01% of tripeptide, 0. 40.002% of palmitoyl pentapeptide, 0.6% of sodium hyaluronate, 1.2% of hydrogenated lecithin, 0.1% of allantoin, 0.6% of tocopherol acetate, 0.05% of crocus sativus flower extract, 0.02% of rosemary leaf extract, 0.03% of coix seed extract, 0.05% of seaweed extract, 0.06% of rice bran oil, 0.05% of tea seed oil, 0.5% of dipotassium glycyrrhizinate, 1% of styrene/acrylic acid (ester) copolymer, 1% of lauroyl sarcosine isopropyl ester, 1% of dimethiconol, 0.1% of cyclotetrasiloxane, polysorbate-803, 0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1% of plant preservative, 0.03% of citric acid and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 2:2:3: 2.
Example 2
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 15% of ceramide, 31% of ceramide, 10.005% of tripeptide, 40.008% of palmitoyl pentapeptide, 0.8% of sodium hyaluronate, 0.3% of hydrogenated lecithin, 0.5% of allantoin, 0.2% of tocopherol acetate, 0.02% of crocus sativus flower extract, 0.06% of rosemary leaf extract, 0.01% of coix seed extract, 0.1% of seaweed extract, 0.01% of rice bran oil, 0.1% of tea seed oil, 0.8% of dipotassium glycyrrhizinate, 0.5% of styrene/acrylic acid (ester) copolymer, 2% of lauroyl sarcosine isopropyl ester, 0.2% of dimethiconol, 1% of cyclotetrasiloxane, 801% of polysorbate-801, 0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2% of plant preservative, 0.01% of citric acid and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 5:5:1: 1.
Example 3
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 13% of ceramide, 31.6% of ceramide, 10.006% of tripeptide, 40.004% of palmitoyl pentapeptide, 0.7% of sodium hyaluronate, 0.7% of hydrogenated lecithin, 0.2% of allantoin, 0.4% of tocopherol acetate, 0.05% of crocus sativus flower extract, 0.02% of rosemary leaf extract, 0.02% of coix seed extract, 0.07% of seaweed extract, 0.07% of rice bran oil, 0.07% of tea seed oil, 0.7% of dipotassium glycyrrhizinate, 0.8% of styrene/acrylic acid (ester) copolymer, 1.3% of isopropyl lauroyl sarcosinate, 0.7% of dimethiconol, 0.3% of cyclotetrasiloxane, polysorbate-801.7%, 0.2% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1.2% of plant preservative, 0.02% of citric acid, and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 3:3:2: 2.
Example 4
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 14% of ceramide, 31% of ceramide, 10.008% of tripeptide, 40.004% of palmitoyl pentapeptide, 0.6% of sodium hyaluronate, 0.8% of hydrogenated lecithin, 00.4% of allantoin, 0.3% of tocopherol acetate, 0.04% of crocus sativus flower extract, 0.05% of rosemary leaf extract, 0.02% of coix seed extract, 0.08% of seaweed extract, 0.05% of rice bran oil, 0.08% of tea seed oil, 0.7% of dipotassium glycyrrhizinate, 0.8% of styrene/acrylic acid (ester) copolymer, 1.5% of lauroyl sarcosine isopropyl ester, 0.8% of dimethiconol, 0.6% of cyclotetrasiloxane, 801.5% of polysorbate-801.5%, 0.1-0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1.0% of plant preservative, 0.01% of citric acid and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 3:3:2: 1.
Example 5
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 14% of ceramide, 31.2% of ceramide, 10.008% of tripeptide, 40.007% of palmitoyl pentapeptide, 0.6% of sodium hyaluronate, 1.0% of hydrogenated lecithin, 0.3% of allantoin, 0.3% of tocopherol acetate, 0.03% of crocus sativus flower extract, 0.03% of rosemary leaf extract, 0.4% of peony root extract, 0.02% of coix seed extract, 0.07% of seaweed extract, 0.05% of rice bran oil, 0.08% of tea seed oil, 0.6% of dipotassium glycyrrhizinate, 0.8% of styrene/acrylic acid (ester) copolymer, 1.2% of isopropyl lauroyl sarcosinate, 0.5% of dimethiconol, 0.7% of cyclotetrasiloxane, 802% of polysorbate-802%, 0.2% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1.2% of plant preservative, 0.02% of citric acid, and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 2:5:3: 2.
Example 6
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 13.5% of ceramide, 31.3% of ceramide, 10.009% of tripeptide, 40.008% of palmitoyl pentapeptide, 0.5% of sodium hyaluronate, 0.8% of hydrogenated lecithin, 0.2% of allantoin, 0.4% of tocopherol acetate, 0.05% of crocus sativus flower extract, 0.06% of rosemary leaf extract, 0.1% of yeast/rice fermentation product filtrate, 0.025% of coix seed extract, 0.09% of seaweed extract, 0.01% of rice bran oil, 0.05% of tea seed oil, 0.8% of dipotassium glycyrrhizinate, 0.6% of styrene/acrylic acid (ester) copolymer, 1.4% of isopropyl lauroyl sarcosinate, 0.6% of dimethiconol, 0.5% of cyclotetrasilyl, 802% of polysorbate-802%, 0.1% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 2.0.0% of plant preservative, 0.02% of citric acid, and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 4:4:1: 1.
Example 7
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 14% of ceramide, 34% of ceramide, 10.01% of tripeptide, 40.009% of palmitoyl pentapeptide, 0.6% of sodium hyaluronate, 1.0% of hydrogenated lecithin, 0.3% of allantoin, 0.2% of tocopherol acetate, 0.025% of crocus sativus flower extract, 0.036% of rosemary leaf extract, 1.3% of vegetable compound oil, 0.02% of coix seed extract, 0.05% of seaweed extract, 0.05% of rice bran oil, 0.05% of tea seed oil, 0.6% of dipotassium glycyrrhizinate, 0.6% of styrene/acrylic acid (ester) copolymer, 1.4% of isopropyl lauroyl sarcosinate, 0.8% of dimethiconol, 0.6% of cyclotetrasiloxane, 801.4% of polysorbate-801, 0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1.2% of plant preservative, 0.02% of citric acid, and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 5:5:3: 2.
Example 8
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 13-5% of ceramide, 31-2% of ceramide, 10.007% of tripeptide, 0.01-40.002% of palmitoyl pentapeptide, 0.5-0.8% of sodium hyaluronate, 0.3-1.2% of hydrogenated lecithin, 0.3% of allantoin, 0.3% of tocopherol acetate, 0.03% of saffron extract, 0.03% of rosemary leaf extract, 0.03% of coix seed extract, 0.07% of seaweed extract, 0.03% of rice bran oil, 0.08% of tea seed oil, 0.7% of dipotassium glycyrrhizinate, 0.8% of styrene/acrylic acid (ester) copolymer, 1.6% of lauroyl sarcosine isopropyl ester, 0.7% of dimethiconol, 0.7% of cyclotetrasilyl, 802.2% of polysorbate-802.2% of radix paeoniae extract, 0.15% of yeast/rice fermentation product filtrate, 1.5% of vegetable compound oil, 0.15% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1.5% of plant preservative, 0.03% of citric acid and the balance of deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 4:3:3: 2.
Example 9
The invention discloses ceramide polypeptide compound Anmyo honey which comprises the following components in percentage by mass: 13.5% of ceramide, 31.2% of ceramide, 10.009% of tripeptide, 40.008% of palmitoyl pentapeptide, 0.6% of sodium hyaluronate, 1.0% of hydrogenated lecithin, 0.4% of allantoin, 0.3% of tocopherol acetate, 0.04% of crocus sativus flower extract, 0.04% of rosemary leaf extract, 0.02% of coix seed extract, 0.07% of seaweed extract, 0.04% of rice bran oil, 0.05% of tea seed oil, 0.6% of dipotassium glycyrrhizinate, 0.7% of styrene/acrylic acid (ester) copolymer, 1.2% of isopropyl lauroyl sarcosinate, 0.6% of dimethiconol, 0.4% of cyclotetrasilyl chloride, 0.3% of polysorbate-801, 0.25% of peony root extract, 0.2% of yeast/rice fermentation product filtrate, 1.5% of vegetable complex oil, 0.25% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 1.5% of plant preservative, 0.05% of citric acid, the balance being deionized water.
The plant preservative is prepared from chamomile essential oil, a sage extract, a magnolia flower extract and a zanthoxylum fruit extract according to the mass ratio: 4:2:3: 1.
The vegetable complex oils described in examples 6 to 9 were prepared by sequentially performing the following steps:
1) cleaning and drying the tea seeds, the raspberry seeds and the grape seeds according to a mass ratio of 2-3: 1-2 (preferably 2:2: 1), uniformly mixing, and crushing to obtain mixed powder;
2) adding 0.5-1.5% (preferably 1%) alkaline protease (25000U/g), 0.2-0.5% (preferably 0.4%) pectase (15000U/g), 0.3-0.5% (preferably 4%) xylanase ((15000U/g) and deionized water (solid-to-liquid ratio controlled at 1g:5m L) into the mixed powder, mixing well, adjusting to alkalinity, placing in an ultrasonic instrument, and performing enzymolysis at 35-42 deg.C (preferably 40 deg.C) for 15-40min (preferably 30min) to obtain a leaching solution;
3) inactivating enzyme of the leaching liquor obtained in the step 2), performing centrifugal separation at a high speed (4000r/min), and collecting upper-layer liquid;
4) adding ether as extractant into the collected upper layer liquid, extracting for 2-3 times, extracting the collected oil phase layer, heating and evaporating to remove ether.
The ceramide polypeptide compound Anmyo honey prepared in the examples 1 to 9 is prepared according to the conventional process in the field; and evaluating the safety of the prepared ceramide polypeptide compound Anmyo honey.
(1) Microbiological test item experiments: according to the determination method and the specification of the total number of bacterial colonies, faecal coliform, staphylococcus aureus, pseudomonas aeruginosa, mould and saccharomycetes in the cosmetic hygiene specification, the ceramide polypeptide compound amycomycetes detection is all qualified.
(2) And (3) testing sanitary chemical inspection projects: according to the determination method and the specified indexes of total mercury, total arsenic and total lead in the cosmetic hygiene Specifications, the ceramide polypeptide compound anmei metal element provided by the invention is completely qualified.
(3) Skin irritation/corrosivity test: according to the skin irritation/corrosivity classification standard in the cosmetic hygiene standard, the ceramide polypeptide compound anmei provided by the invention has no irritation.
To better demonstrate the efficacy of the present invention, the efficacy experiments of the present application, as well as the efficacy experiments of the comparative examples, are given below:
comparative example 1
The other components were in the same amounts as in example 9, except that the same amount of seaweed extract was used in place of ceramide 1, ceramide 3, tripeptide-1, palmitoyl pentapeptide-4 in example 9.
Comparative example 2
The other components were in the same amounts as in example 9, except that the same amount of the extract of coix seed was used instead of the extract of seaweeds in example 9.
Comparative example 3
The other ingredients were the same as in example 9 except that phenoxyethanol/ethylhexylglycerin (0.4%) was used in place of the plant preservative in example 9 and the remainder was supplemented with deionized water.
Comparative example 4
The other components and the content are the same as those in the example 9, except that the plant composite oil is prepared by separately purchasing the catechu seed oil, the raspberry seed oil and the grape seed oil according to the mass ratio of 2:2: 1 and mixing.
Efficacy experiments section:
1. moisture retention test:
reference standard: refer to QB/T4256-.
The testing personnel: 48 healthy volunteers were selected, aged 30-40 years each.
And (3) testing conditions are as follows: the capacitance method skin moisture tester Corneometer CM825 is used for testing the temperature of 20-22 ℃ and the humidity of 40-60%.
Test samples: the experimental group is the product provided by the comparison of examples 1, 5, 6 and 9 and the comparison of control group 1, 2, 3 and 4.
The test method comprises the following steps: each area is fixedly measured at three points according to a certain sequence, and an average value of the three points is obtained. Then, the ceramide polypeptide compound Anmyo honey is smeared on the tested part (according to (2.0 +/-0.1) mg/cm2For a single application), the moisture content of the skin at the test site was measured using a probe at initial 0h, 1h, 4h and 8h, and the average value of each group was calculated for the corresponding time point, and the results are shown in table 1.
TABLE 1
The skin moisture content increase rate calculation formula is as follows:
skin moisture content increase rate [ (% MMVt-MMV) ]0)/MMV0×100％
MMV0MMV on the skin before application
MMVtMMV of the skin t periods after application
The results are shown in Table 2.
TABLE 2
2. Skin elasticity test
Test samples: the experimental group is the product provided by the comparison of examples 1, 5, 6 and 9 and the comparison of control group 1, 2, 3 and 4.
The experimental method comprises the following steps: the testing personnel: 40 healthy volunteers aged 30-40 years were selected, and randomly grouped into 5 groups. The samples were applied twice daily in the morning and evening. During the experiment, the subject was not able to apply any other cosmetic product at the experimental site.
Skin elasticity test: the skin condition of week 0 and week 4 was measured using the skin elastometer MPA580, the test site was the cheekbone, the probe repeated 3 times in the same test area during the measurement, and the average was taken.
The skin elasticity increase rate W ═ NT-N0)/N0×100％
N0-skin elasticity test value before application.
NT-elasticity test value T period after application.
The test results are shown in table 3:
TABLE 3
3. DPPH free radical scavenging test experiment
0.2 mmol/L DPPH solution is prepared by 50% ethanol and stored away from light, 0.2mg/m L solution to be tested is prepared by 1, 5, 6, 9 and the product provided by the comparison group 1, 2, 3, 4, the absorbance A is measured at 517nm for 3 times, the average value is taken, and the experimental result is shown in Table 4.
In the formula: a. theiIs the absorbance of the reaction after addition of the test substance;
Ajthe absorbance of the test solution is the self absorbance of the test solution;
A0the blank value is the blank value without test solution.
TABLE 4
As is apparent from tables 1 to 4, the technical scheme provided by the invention can deeply penetrate into the bottom layer of the skin to replenish moisture, lock moisture, effectively remove free radicals, recover skin elasticity, promote the skin to recover a good barrier function, keep moisture for a long time, and carefully nourish the skin.
Human body trial
1. The test population: 100 people, age 30-40 years.
2. Test samples: by using the product provided in example 9, trial and civil investigation statistics are performed, and experience statistics on various senses such as moisture retention, soothing sense, repairing sense, irritation and the like are performed, wherein 98% of the results are satisfied with the moisture retention and the moisture retention, 96% of the results are satisfied with the soothing sense, 97% of the results are satisfied with the repairing sense, 100% of the results are satisfied with the overall evaluation of the product, and the testers are satisfied with the overall evaluation of the product.
Claims (10)
1. The ceramide polypeptide compound Anmyo honey is characterized by comprising the following components in percentage by mass: 13-5% of ceramide, 31-2% of ceramide, 0.01-0.01% of tripeptide-10.005, 0.5-0.01% of palmitoyl pentapeptide-40.002, 0.5-0.8% of sodium hyaluronate, 0.3-1.2% of hydrogenated lecithin, 0.1-0.5% of allantoin, 0.2-0.6% of tocopherol acetate, 0.01-0.05% of crocus sativus flower extract, 0.02-0.06% of rosemary leaf extract, 0.01-0.03% of coix seed extract, 0.05-0.1% of seaweed extract, 0.01-0.06% of rice bran oil, 0.05-0.1% of tea seed oil, 0.5-0.8% of dipotassium glycyrrhizinate, 0.5-1% of styrene/acrylic acid (ester) copolymer, 1-2% of lauroyl sarcosine isopropyl ester, 0.2-1% of dimethiconol, 0.1-1% of cyclotetrasiloxane, and polysorbate-3 801%, 0.1-0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5-2% of plant preservative, a proper amount of pH regulator and a proper amount of deionized water.
2. The ceramide polypeptide compound Anmyo honey as claimed in claim 1, further comprising radix Paeoniae extract 0.1-0.5%.
3. The ceramide polypeptide compound Anmyo honey as claimed in claim 1, further comprising 0.05-0.2% of yeast/rice fermentation product filtrate.
4. The ceramide polypeptide compound Anmyo honey as claimed in claim 1, further comprising 0.5-2% of vegetable compound oil.
5. The ceramide polypeptide compound Anmyo honey as claimed in claim 1, which is characterized by comprising the following components in percentage by mass: 13-5% of ceramide, 31-2% of ceramide, 0.01-0.01% of tripeptide-10.005, 0.5-0.01% of palmitoyl pentapeptide-40.002, 0.5-0.8% of sodium hyaluronate, 0.3-1.2% of hydrogenated lecithin, 0.1-0.5% of allantoin, 0.2-0.6% of tocopherol acetate, 0.01-0.05% of crocus sativus flower extract, 0.02-0.06% of rosemary leaf extract, 0.01-0.03% of coix seed extract, 0.05-0.1% of seaweed extract, 0.01-0.06% of rice bran oil, 0.05-0.1% of tea seed oil, 0.5-0.8% of dipotassium glycyrrhizinate, 0.5-1% of styrene/acrylic acid (ester) copolymer, 1-2% of lauroyl sarcosine isopropyl ester, 0.2-1% of dimethiconol, 0.1-1% of cyclotetrasiloxane, and polysorbate-3 801%, 0.1-0.5% of medicinal root extract, 0.05-0.2% of yeast/rice fermentation product filtrate, 0.5-2% of plant compound oil, 0.1-0.3% of hydroxyethyl acrylate/sodium acryloyldimethyl taurate copolymer, 0.5-2% of plant preservative, a proper amount of peony pH regulator and a proper amount of deionized water.
6. The ceramide polypeptide compound Anmyo-inositol honey as claimed in claim 1, wherein the plant preservative is prepared by mixing chamomile essential oil, sage extract, magnolia officinalis flower extract and zanthoxylum piperitum fruit extract according to the mass ratio of 2-5:2-5:1-3: 1-2.
7. The ceramide polypeptide compound Anmyo honey as claimed in claim 1, wherein the plant compound oil is prepared by the following steps in sequence:
1) cleaning and drying the tea seeds, the raspberry seeds and the grape seeds according to a mass ratio of 2-3: 1-2, uniformly mixing, and crushing to obtain mixed powder;
2) adding alkaline protease, pectinase, xylanase and deionized water into the mixed powder, mixing, adjusting to alkalinity, placing in an ultrasonic instrument, and performing enzymolysis at 35-42 deg.C for 15-40min to obtain extract;
3) inactivating enzymes in the leaching liquor obtained in the step 2), performing centrifugal separation at a high speed, and collecting upper-layer liquid;
4) adding an extracting agent into the collected upper layer liquid for extraction for 2-3 times, pumping out the collected oil phase layer, and removing the extracting agent to obtain the final product.
8. The ceramide polypeptide compound Anmyo honey as claimed in claim 7, wherein the addition amount of alkaline protease is 0.5-1.5%, the addition amount of pectinase is 0.2-0.5%, and the addition amount of xylanase is 0.3-0.5%.
9. The ceramide polypeptide compound Anmyo honey as claimed in claim 7, wherein the extractant is diethyl ether.
10. The ceramide polypeptide compound Anmyo honey as claimed in claim 7, wherein the solid-to-liquid ratio is 1g:4-6m L.
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