CN111407710A - Water-free hand sanitizer and preparation method thereof - Google Patents
Water-free hand sanitizer and preparation method thereof Download PDFInfo
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- CN111407710A CN111407710A CN202010292561.9A CN202010292561A CN111407710A CN 111407710 A CN111407710 A CN 111407710A CN 202010292561 A CN202010292561 A CN 202010292561A CN 111407710 A CN111407710 A CN 111407710A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9794—Liliopsida [monocotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
- A61Q17/005—Antimicrobial preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/10—Washing or bathing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/82—Preparation or application process involves sonication or ultrasonication
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Abstract
The invention provides an anhydrous hand sanitizer and a preparation method thereof, wherein the hand sanitizer is prepared from the following components in percentage by mass: 30 to 60 percent of extracting solution, 0.1 to 2 percent of graphene, 0.5 to 2 percent of glycerol and the balance of water; the extractive solution contains Bulbus Allii extract, and also contains one or two of semen Maydis extract and semen glycines extract; the weight ratio of the garlic extract in the extract is 50%, and the balance is corn extract and/or soybean extract. According to the invention, the graphene is added to the extract of daily food, and the effects of the graphene and the extract of daily food are combined, so that the antibacterial effect is good, the antibacterial effect can be effectively enhanced, and the antibacterial agent has natural moisturizing and moistening effects, an effect of accelerating wound healing and an effect of repairing micro-wounds on the skin surface.
Description
Technical Field
The invention relates to an anhydrous hand sanitizer, and belongs to the technical field of biochemical engineering.
Background
The traditional solid toilet soap is easy to be contaminated by bacteria and dirt on hands in the using process and becomes a secondary pollution source. The hand sanitizer is convenient to take and clean, and gradually becomes a substitute of perfumed soap, so that the hand sanitizer is popular with people. However, according to the report of the website of the American 'network doctor', the hand sanitizer is not as comprehensive in function as people imagine, has a poor disinfection effect on certain germs, and can ensure that the hands are washed more and more dry.
Hand sanitizer is usually composed of water, alcohol, perfume and glycerin, wherein alcohol is the main disinfecting ingredient. The society of infectious diseases, news, speaker, allen glatt, states: "alcohol-based hand cleaners are ineffective in certain situations. For example, the hand sanitizer cannot resist clostridium and is far less effective than soap. The united states centers for disease control and prevention have investigated 91 panelists and found that people who prefer to use hand sanitizers are 6 times as likely to be infected with the disease as people who use toilet soaps. In addition, alcohol accelerates the loss of water from the skin, causing it to become dry and taut. In addition, some hand sanitizer contains the effective sterilization component which is not alcohol, such as benzalkonium chloride, and replaces alcohol for sterilization, but the effective sterilization component is limited in the amount of the hand sanitizer, and the concentration of the effective sterilization component is not higher than 0.1%. Because high concentration benzalkonium chloride is harmful to human body, it has some irritation and corrosion to skin and mucous membrane.
The common hand sanitizer in the market needs to be used with the help of water, but many occasions use water inconveniently and are difficult to wash hands, so the problem of the awkwardness can be well solved by the hand sanitizer without washing, the hand sanitizer only needs to be lightly smeared on the hands and is applied to the hands to be naturally volatilized, the requirement of hand disinfection can be met, and the hand sanitizer is particularly suitable for hand disinfection in occasions with water shortage or inconvenient water use, such as office work, subway taking, outdoor travel and the like.
The no-clean hand sanitizer is used as a novel hand sanitizer, has the effect of cleaning hands without a water source, is not limited by the water source, and is extremely convenient to use. However, most of the existing no-clean hand sanitizers have certain defects, and most of the existing no-clean hand sanitizers use common alcohol, and the alcohol smell is heavy. Because the no-wash hand sanitizer contains a large amount of alcohol, the skin of both hands is easy to be dried and chapped after use, and the skin feeling is poor; some of the no-clean hand sanitizer has a chemical component as a sterilization part, has large irritation to the hand skin, and can cause side effect reactions such as skin irritation, allergy and the like.
Graphene (Graphene) is a polymer made of carbon atoms in sp2The hybrid tracks form a hexagonal honeycomb lattice two-dimensional carbon nanomaterial. Graphene is successfully separated from graphite by virtue of a micro-mechanical stripping method by physicists Andeli Gem and Constantine Novoschofu of Manchester university in England, and is a novel nano material (Lechangwei et al) which is the thinnest, the highest in strength and the strongest in electric and heat conduction performances and is discovered at present]The journal of chemistry, 2013,71(9): 1201-.]. The antibacterial performance of graphene was first confirmed in 2010 by Shanghai applied physics research institute of Chinese academy of sciences. Foreign experts disclose a mechanism for destroying bacterial cell membranes by graphene, and compared with traditional inorganic and organic antibacterial agents, the graphene has no cytotoxicity basically and is more suitable for being in direct contact with human skins. According to the research on the antibacterial mechanism of graphene by experts at home and abroad, two main modes are provided, one mode is that the structure of bacteria is damaged and the function of the bacteria is disordered by destroying the integrity of cell membranes; the other is to make the microorganism free radical metabolize by interacting with the microorganism and then entering the microorganismImbalance causes paper hyperoxidation damage to biological membranes and macromolecular substances, thereby achieving the bacteriostatic effect.
Disclosure of Invention
In order to overcome the defects in the prior art, the invention provides an anhydrous hand sanitizer which is prepared by combining effective components extracted from conventional foods and graphene. The invention also provides a method for preparing the hand sanitizer.
On one hand, the invention provides an anhydrous hand sanitizer which is prepared from the following components in percentage by mass: 30 to 60 percent of extracting solution, 0.1 to 2 percent of graphene, 0.5 to 2 percent of glycerol and the balance of water; the extractive solution contains Bulbus Allii extract, and also contains one or two of semen Maydis extract and semen glycines extract; the weight ratio of the garlic extract in the extract is 50 percent, and the balance is corn extract and/or soybean extract.
Preferably, the hand sanitizer is prepared from the following components in percentage by mass: 45 to 55 percent of extract, 0.5 to 1 percent of graphene, 0.5 to 1 percent of glycerol and the balance of water.
Preferably, the hand sanitizer is prepared from the following components in percentage by mass: 50% of extracting solution, 0.8% of graphene, 0.8% of glycerol and the balance of water.
Preferably, the extracting solution is a mixed solution of garlic extract, corn extract and soybean extract; the weight percentage of the garlic extract in the mixed solution is 50 percent, and the balance is corn extract and soybean extract.
Preferably, the graphene is graphene oxide.
Preferably, the hand sanitizer further comprises ethanol, and the mass percentage of the ethanol is 10-30%.
Preferably, the ethanol of the invention is 20% by mass.
Preferably, the hand sanitizer further comprises carbomer 940, wherein the weight percentage of the carbomer 940 is 10-20%.
Preferably, the weight percentage of the carbomer 940 is 16.8 percent.
In another aspect, the present invention also provides a method for preparing the hand sanitizer, the method comprising the steps of:
1) preparing an extracting solution: taking one or two of corn and soybean and garlic as raw materials, wherein the mass ratio of the garlic to the soybean and/or the corn is 1:1, washing and crushing the raw materials, mixing the raw materials with 95% ethanol according to the mass ratio of 1:1 at normal temperature, carrying out ultrasonic vibration leaching for 50-80 minutes for 2-3 times, filtering, and combining leaching solutions; distilling the leaching liquor, and collecting 80-85 ℃ fractions as extracting solution;
2) adding graphene into deionized water, stirring at high speed of 5000-10000 rpm at room temperature, and continuously stirring for 30-60 min to form uniform aqueous dispersion;
3) and mixing the water dispersion and the extracting solution, adjusting the pH to 5.5-6.5, adding glycerol, ethanol and carbomer 940, and stirring for 20-30 min at the homogenization speed of 1000-2000 rpm to obtain the hand sanitizer.
Compared with the prior art, the water-free hand sanitizer provided by the invention has the following characteristics:
1) according to the invention, the graphene is added to the extract of daily food, and is a two-dimensional structure nano material with antibacterial property and good biocompatibility, and has antibacterial effect on various bacteria and fungi, so that the hand sanitizer has a long-acting antibacterial effect, basically has no cytotoxicity, and has the advantages of environmental friendliness. Meanwhile, the effective components (such as phytosterol, garlic oil and the like) in the garlic and soybean (and/or corn) extracts have high permeability to the skin, can keep the surface moisture of the skin, promote the metabolism of the skin, inhibit the skin inflammation, prevent sunburn erythema and skin aging, and have the effects of hair growth and hair nourishing; the extract also has broad-spectrum antibacterial effect, strong bacteriostatic ability, no toxicity, no side effect, no drug residue and no drug resistance. Therefore, the combination of the two has good synergistic effect, which not only can effectively enhance the degerming effect, but also has the natural moisturizing and moistening effects, the effect of accelerating wound healing and the effect of repairing micro-wounds on the skin surface.
2) The hand sanitizer disclosed by the invention is simple in preparation process, low in processing cost, easy to master, safe, environment-friendly and low in toxicity to human bodies, can effectively improve the processing and preparation working efficiency of the sterilizing sanitizer on one hand, improves the killing and inhibiting effects of the sterilizing sanitizer on the activities of bacteria, viruses and other microorganisms, has good universality and stability on the other hand, and can effectively meet the use requirements of different people.
3) The hand sanitizer disclosed by the invention does not contain toxic chemical components, does not contain alcohol or low-concentration alcohol (the low-concentration alcohol can further enhance the sterilization effect and the odor regulation effect), and therefore, has no safety risk, and does not cause skin dryness and dehydration.
Brief description of the drawings (none)
Detailed Description
The following detailed description of the preferred embodiments of the present invention is provided to enable those skilled in the art to more readily understand the advantages and features of the present invention, and to clearly and unequivocally define the scope of the present invention. The experimental procedures not described in detail in the examples are generally carried out according to the routine procedures in the art or according to the conditions recommended by the manufacturers. In the embodiment, the graphene is graphene oxide. The reagents and drugs mentioned in the examples are all common commercial products unless otherwise specified.
Embodiment 1 is an anhydrous hand sanitizer, which is prepared from the following components in percentage by mass: 30% of extraction liquid, 0.1% of graphene, 0.5% of glycerol and the balance of water; the extracting solution is a garlic extract and a corn extract, wherein the mass ratio of the garlic extract to the corn extract in the extract is 50%, and the balance is the corn extract.
Embodiment 2 discloses an anhydrous hand sanitizer, which is prepared from the following components in percentage by mass: 60% of extraction liquid, 2% of graphene, 2% of glycerol and the balance of water; the extracting solution is garlic extract and soybean extract, wherein the mass ratio of the garlic extract in the extract is 50%, and the balance is the soybean extract.
Embodiment 3 is an anhydrous hand sanitizer, which is prepared from the following components in percentage by mass: 45% of extraction liquid, 0.5% of graphene, 0.5% of glycerol and the balance of water; the extracting solution is a mixture of garlic extract, soybean extract and corn extract, wherein the mass ratio of the garlic extract in the extract is 50%, the balance of the soybean extract and the corn extract, and the mass ratio of the soybean extract to the corn extract is 40% to 60%.
Embodiment 4 discloses an anhydrous hand sanitizer, which is prepared from the following components in percentage by mass: 55% of extraction liquid, 1% of graphene, 1% of glycerol and the balance of water; the extracting solution is a mixture of garlic extract, soybean extract and corn extract, the mass ratio of the garlic extract in the extract is 50%, the balance of the soybean extract and the corn extract, and the mass ratio of the soybean extract to the corn extract is 50% to 50%.
Embodiment 5 discloses an anhydrous hand sanitizer, which is prepared from the following components in percentage by mass: 50% of extraction liquid, 0.8% of graphene, 0.8% of glycerol and the balance of water; the extracting solution is a mixture of garlic extract, soybean extract and corn extract, wherein the mass ratio of the garlic extract in the extract is 50%, and the balance of the soybean extract and the corn extract is 50% to 50%.
Embodiment 6 discloses an anhydrous hand sanitizer, which is prepared from the following components in percentage by mass: 50% of extraction liquid, 0.8% of graphene, 0.8% of glycerol, 10% of ethanol, 10% of carbomer 940 and the balance of water; the extracting solution is a mixture of garlic extract, soybean extract and corn extract, wherein the mass ratio of the garlic extract in the extract is 50%, and the balance of the soybean extract and the corn extract is 50% to 50%.
Embodiment 7 is an anhydrous hand sanitizer, which is prepared from the following components in percentage by mass: 50% of extraction liquid, 0.8% of graphene, 0.8% of glycerol, 30% of ethanol, 20% of carbomer 940 and the balance of water; the extracting solution is a mixture of garlic extract, soybean extract and corn extract, wherein the mass ratio of the garlic extract in the extract is 50%, and the balance of the soybean extract and the corn extract is 50% to 50%.
Embodiment 8 is an anhydrous hand sanitizer, which is prepared from the following components in percentage by mass: 50% of extraction liquid, 0.8% of graphene, 0.8% of glycerol, 20% of ethanol, 16.8% of carbomer 940 and the balance of water; the extraction solution is a mixture of garlic extract, soybean extract and corn extract, wherein the mass ratio of the garlic extract in the extract is 50%, and the balance of the soybean extract and the corn extract is 50% to 50%.
EXAMPLE 9 preparation of Water-free hand lotions (appropriate amounts of starting materials were used according to different examples)
1) Preparing an extracting solution: taking one or two of corn and soybean and garlic as raw materials, wherein the mass ratio of the garlic to the soybean and/or the corn is 1:1, washing and crushing the raw materials, mixing the raw materials with 95% ethanol according to the mass ratio of 1:1 at normal temperature, carrying out ultrasonic vibration leaching for 50-80 minutes for 2-3 times, filtering, and combining leaching solutions; distilling the leaching liquor, and collecting 80-85 ℃ fractions as extracting solution;
2) adding graphene into deionized water, stirring at high speed of 5000-10000 rpm at room temperature, and continuously stirring for 30-60 min to form uniform aqueous dispersion;
3) and mixing the water dispersion and the extracting solution, adjusting the pH to 5.5-6.5, adding glycerol, ethanol and carbomer 940, and stirring for 20-30 min at the homogenization speed of 1000-2000 rpm to obtain the hand sanitizer.
Example 10 evaluation of Performance
1) And (3) microbial detection: microorganism detection is carried out on the sterilized water-free hand sanitizer prepared in the embodiments 1 to 8 according to the technical safety specifications for cosmetics (2015 edition), and the test result shows that the total number of strains in the embodiments 1 to 8 is less than 10 CFU/g; the total number of moulds and yeasts is less than 10 CFU/g; pseudomonas aeruginosa, staphylococcus aureus and heat-resistant escherichia coli are not detected;
2) bacteriostatic experiments: according to GB 15979-;
3. and (3) testing physical and chemical properties: the appearance, smell, cold resistance stability and heat resistance stability of the samples of examples 1-8 are measured according to QB/T2654-2013 hand sanitizer; the pH of example 5; tests show that the sterilizing and water-free hand sanitizer obtained in examples 1-8 is colorless and transparent jelly-shaped, and has no peculiar smell or peculiar smell (the alcohol smell exists in examples 6-8); keeping the temperature at (-5 +/-2) deg.C for 24h, and returning to room temperature or keeping the temperature at (40 +/-2) deg.C for 24h, and returning to room temperature without obvious change; the pH of the antiseptic and water-free hand sanitizer obtained in example 5 was 6.1.
The above description is only an embodiment of the present invention, and not intended to limit the scope of the present invention, and all modifications of equivalent structures and equivalent processes, or direct or indirect applications in other related fields of technology, which are made by the present specification, are included in the scope of the present invention.
Claims (10)
1. The water-free hand sanitizer is characterized by being prepared from the following components in percentage by mass: 30 to 60 percent of extracting solution, 0.1 to 2 percent of graphene, 0.5 to 2 percent of glycerol and the balance of water; the extractive solution contains Bulbus Allii extract, and also contains one or two of semen Maydis extract and semen glycines extract; the weight ratio of the garlic extract in the extract is 50%, and the balance is corn extract and/or soybean extract.
2. The hand sanitizer according to claim 1, wherein the hand sanitizer is prepared from the following components in percentage by mass: 45 to 55 percent of extracting solution, 0.5 to 1 percent of graphene, 0.5 to 1 percent of glycerol and the balance of water.
3. The hand sanitizer according to claim 2, wherein the hand sanitizer is prepared from the following components in percentage by mass: 50% of extracting solution, 0.8% of graphene, 0.8% of glycerol and the balance of water.
4. The hand sanitizer according to claim 1, wherein the extract is a mixture of garlic extract, corn extract and soybean extract; the weight percentage of the garlic extract in the mixed solution is 50 percent, and the balance is corn extract and soybean extract.
5. The hand sanitizer according to claim 1, wherein the graphene is graphene oxide.
6. The hand sanitizer according to claim 1, further comprising ethanol, wherein the ethanol is present in an amount of 10% to 30% by mass.
7. The hand sanitizer according to claim 6, wherein the ethanol is present in an amount of 20% by mass.
8. The hand sanitizer according to claim 1, further comprising carbomer 940, wherein the weight percentage of carbomer 940 is 10-20%.
9. The hand sanitizer of claim 8, wherein the carbomer 940 is present in an amount of 16.8% by weight.
10. A method of preparing a hand sanitizer according to claim 1, comprising the steps of:
10-1) preparation of extract: taking one or two of corn and soybean and garlic as raw materials, wherein the mass ratio of the garlic to the soybean and/or the corn is 1:1, washing and crushing the raw materials, mixing the raw materials with 95% ethanol according to the mass ratio of 1:1 at normal temperature, carrying out ultrasonic vibration leaching for 50-80 minutes for 2-3 times, filtering, and combining leaching solutions; distilling the leaching liquor, and collecting 80-85 ℃ fractions as extracting solution;
10-2) adding graphene into deionized water, stirring at high speed of 5000-10000 rpm at room temperature, and continuously stirring for 30-60 min to form uniform water dispersion;
10-3) mixing the water dispersion and the extracting solution, adjusting the pH to 5.5-6.5, adding glycerol, ethanol and carbomer 940, and stirring for 20-30 min under the condition that the homogenization speed is 1000-2000 rpm to obtain the hand sanitizer.
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| CN202010292561.9A CN111407710A (en) | 2020-04-15 | 2020-04-15 | Water-free hand sanitizer and preparation method thereof |
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| CN105769640A (en) * | 2014-12-26 | 2016-07-20 | 冒玉兰 | Garlic oil active cleaning hand sanitizer |
| CN106214522A (en) * | 2016-08-31 | 2016-12-14 | 苏州宝丽洁日化有限公司 | A kind of mild handwashing liquid and preparation method thereof |
| CN106491375A (en) * | 2016-12-14 | 2017-03-15 | 拜东辰 | A kind of feature Graphene handwashing liquid and preparation method thereof |
-
2020
- 2020-04-15 CN CN202010292561.9A patent/CN111407710A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR101427640B1 (en) * | 2014-03-28 | 2014-08-08 | (재)남해마늘연구소 | Method for manufacturing of soap using deep sea rock floor water |
| CN105769640A (en) * | 2014-12-26 | 2016-07-20 | 冒玉兰 | Garlic oil active cleaning hand sanitizer |
| CN106214522A (en) * | 2016-08-31 | 2016-12-14 | 苏州宝丽洁日化有限公司 | A kind of mild handwashing liquid and preparation method thereof |
| CN106491375A (en) * | 2016-12-14 | 2017-03-15 | 拜东辰 | A kind of feature Graphene handwashing liquid and preparation method thereof |
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Application publication date: 20200714 |