CN111388646A - Traditional Chinese medicine composition for improving male sexual function and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for improving male sexual function and preparation method and application thereof Download PDFInfo
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Abstract
The invention provides a traditional Chinese medicine composition for improving male sexual function and a preparation method and application thereof, belonging to the technical field of traditional Chinese medicines, wherein the traditional Chinese medicine composition comprises the following raw materials in parts by weight: 10-30 parts of fennel, 20-30 parts of folium artemisiae argyi, 10-20 parts of gallnut, 15-30 parts of fructus evodiae, 15-30 parts of cinnamon, 10-20 parts of baked ginger, 5-10 parts of rhizoma corydalis and 5-10 parts of mint. Wherein, the folium artemisiae argyi and the cinnamon are taken as monarch drugs, the fennel, the baked ginger and the gallnut are taken as ministerial drugs, and the corydalis tuber and the evodia rutaecarpa are taken as adjuvant drugs; the mint is used as a guiding drug and zhu guo drug are combined to play the effects of tonifying kidney, replenishing essence, regulating qi and strengthening body. The experimental result shows that the external traditional Chinese medicine composition has the significant efficiency of 50 percent and the total effective rate of up to 90 percent in the aspect of improving the male sexual function, and compared with the oral yohimbine kidney-strengthening medicine, the external traditional Chinese medicine composition has the significant efficiency of 66.7 percent and the total effective rate of 12.5 percent.
Description
Technical Field
The invention belongs to the technical field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine composition for improving male sexual function, and a preparation method and application thereof.
Background
With the continuous improvement of the national standard of living, more and more men begin to pay attention to their health problems, and meanwhile, the intercourse between couples is more and more emphasized, wherein the most important factor influencing the intercourse between couples is the sexual dysfunction of men. The male sexual dysfunction is mainly clinically manifested as impotence, premature ejaculation, spermatorrhea and the like, which leads to the inability to complete sexual life satisfactorily, and the symptoms not only cause great trouble to the normal life of patients, but also can lead to infertility in severe cases. How to find a scientific and effective method to improve the renal function of a patient and improve the sexual life quality of the patient is one of the key points of the current research.
In the prior art, the main methods for treating male sexual dysfunction include western medicine treatment and traditional Chinese medicine treatment, wherein the western medicine treatment has large side effects, the symptoms are treated, the root causes are not treated, and the sexual dysfunction is aggravated or even the sexual function is completely lost by taking hormone medicines; although the traditional Chinese medicine has less effect than western medicines, the traditional Chinese medicine has the advantages of less adverse reaction, suitability for long-term administration, safety, reliability, low price and the like, and is more and more widely applied to the clinical treatment of the disease. However, the traditional Chinese medicine for treating male sexual dysfunction is mainly an oral traditional Chinese medicine, and the traditional Chinese medicine for external application can be obviously improved wholly, and the treatment effect is not obvious.
Disclosure of Invention
In view of the above, the present invention aims to provide a traditional Chinese medicine composition for improving male sexual function, a preparation method and an application thereof, the prepared traditional Chinese medicine composition has the effects of tonifying kidney, replenishing essence, regulating qi and strengthening body, the significant efficiency is 50% in improving male sexual function, and the total effective rate is up to 90%.
In order to achieve the above purpose, the invention provides the following technical scheme:
the invention provides a traditional Chinese medicine composition for improving male sexual function, which comprises the following raw materials in parts by weight: 10-30 parts of fennel, 20-30 parts of folium artemisiae argyi, 10-20 parts of gallnut, 15-30 parts of fructus evodiae, 15-30 parts of cinnamon, 10-20 parts of baked ginger, 5-10 parts of rhizoma corydalis and 5-10 parts of mint.
Preferably, 15 parts of fennel, 20 parts of folium artemisiae argyi, 15 parts of Chinese gall, 30 parts of fructus evodiae, 30 parts of cinnamon, 15 parts of baked ginger, 10 parts of rhizoma corydalis and 5 parts of mint.
The invention provides a preparation method of the traditional Chinese medicine composition in the technical scheme, which comprises the following steps: extracting the raw materials with ethanol solution, and filtering to obtain filtrate as Chinese medicinal composition.
Preferably, the raw material further comprises, before extraction with an ethanol solution: and crushing the raw materials to obtain a crushed material, wherein the particle size of the crushed material is less than or equal to 830 mu m.
Preferably, the ethanol solution extraction is carried out after the radiation sterilization of the crushed material, the radiation dose of the radiation sterilization is 10KGY to 15KGY, and the radiation sterilization time is 13 hours to 18 hours.
Preferably, the extraction conditions include: the extraction time is 1-2 hours, the extraction times are 1-2 times, the extraction temperature is 80-100 ℃, and the volume percentage content of the ethanol solution is 55-70%.
Preferably, when the particle size of the pulverized material is 48 μm to 830 μm, the total time of the extraction is 2 hours, and the number of the extractions is 2.
Preferably, when the particle size of the pulverized material is less than 48 μm, the extraction time is 1 hour, and the number of times of extraction is 1.
Preferably, the mass ratio of the total mass of the raw materials to the ethanol solution is 1: 10.
The invention provides application of the traditional Chinese medicine composition in the technical scheme in preparing a medicine for improving male sexual function.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a traditional Chinese medicine composition for improving male sexual function, which comprises the following raw materials in parts by weight: 10-30 parts of fennel, 20-30 parts of folium artemisiae argyi, 10-20 parts of gallnut, 15-30 parts of fructus evodiae, 15-30 parts of cinnamon, 10-20 parts of baked ginger, 5-10 parts of rhizoma corydalis and 5-10 parts of mint. In the invention, the folium artemisiae argyi warms the channels and activates the collaterals, dispels yin cold and restores yang to restore collapse; cortex Cinnamomi has effects in invigorating primordial yang, warming spleen and stomach, removing cold accumulation, promoting blood circulation, and treating decline of fire from the gate of life, cold limbs, slight pulse, yang exhaustion, abdominal pain, diarrhea, cold hernia, and cold pain of waist and knee; fructus Foeniculi has effects of warming kidney, dispelling cold, regulating stomach function, and regulating qi-flowing, and can be used for treating lumbago due to kidney deficiency; the baked ginger has the effects of warming middle-jiao and dispelling cold, warming channels and stopping bleeding, and is used for treating deficiency-cold of spleen and stomach, abdominal pain, vomiting and diarrhea, hematemesis, metrorrhagia and metrostaxis, and yang deficiency and blood loss; galla chinensis has effects of astringing lung, arresting sweating, astringing intestine, arresting seminal emission, stopping bleeding, and removing toxic substance, and can be used for treating lung deficiency, chronic cough, spontaneous sweat, night sweat, chronic dysentery, chronic diarrhea, rectocele, nocturnal emission, whitish and turbid urine, various hemorrhage, carbuncle, sore, and furuncle; the fructus evodiae has the effects of warming the middle-jiao, dispelling cold, descending qi and relieving depression; yan Hu Suo can ascend and descend, and yin and yang can also regulate kidney qi and unblock meridians; menthol in peppermint has transdermal absorption effect. In the traditional Chinese medicine composition, the folium artemisiae argyi and the cinnamon are used as monarch drugs, the fennel, the baked ginger and the Chinese gall are used as ministerial drugs, the corydalis tuber and the evodia rutaecarpa are used as adjuvant drugs, the mint is used as a conductant drug, and the zhu drug is combined to play the effects of tonifying the kidney, replenishing essence, regulating qi and strengthening the body.
The experimental result shows that the external traditional Chinese medicine composition has the significant efficiency of 50 percent and the total effective rate of up to 90 percent in the aspect of improving the male sexual function, and compared with the oral yohimbine kidney-strengthening medicine, the external traditional Chinese medicine composition has the significant efficiency of 66.7 percent and the total effective rate of 12.5 percent.
Detailed Description
The invention provides a traditional Chinese medicine composition for improving male sexual function, which comprises the following raw materials in parts by weight: 10-30 parts of fennel, 20-30 parts of folium artemisiae argyi, 10-20 parts of Chinese gall, 15-30 parts of fructus evodiae, 15-30 parts of cinnamon, 10-20 parts of baked ginger, 5-10 parts of rhizoma corydalis and 5-10 parts of mint, and preferably comprises 15 parts of fennel, 20 parts of folium artemisiae argyi, 15 parts of Chinese gall, 30 parts of fructus evodiae, 30 parts of cortex cinnamomi, 15 parts of baked ginger, 10 parts of rhizoma corydalis and 5 parts of mint. The source of the traditional Chinese medicine raw materials is not particularly limited, and the traditional Chinese medicine is prepared by adopting a conventional commercially available product.
In the invention, folium artemisiae argyi and cinnamon are taken as monarch drugs, fennel, baked ginger and Chinese gall are taken as ministerial drugs, and rhizoma corydalis and fructus evodiae are taken as adjuvant drugs; the mint is used as a guiding drug and zhu guo drug are combined to play the effects of tonifying kidney, replenishing essence, regulating qi and strengthening body.
The invention also provides a preparation method of the traditional Chinese medicine composition in the technical scheme, which comprises the following steps: extracting the raw materials with ethanol solution, and filtering to obtain filtrate as Chinese medicinal composition.
In the invention, before the raw material is extracted by ethanol solution, the method also comprises the following steps: and crushing the raw materials to obtain a crushed material, wherein the particle size of the crushed material is less than or equal to 830 mu m. In the invention, the contact area between the raw material and the solvent can be increased by crushing the raw material, the diffusion surface is larger, the diffusion speed of the solvent in the raw material is increased, the extraction of the effective components of the raw material is further improved, and the invention has the advantages of time saving and efficiency improvement.
The radiation sterilization treatment is carried out on the crushed material to obtain the radiation material, the radiation dose of the radiation sterilization is preferably 10-15KGY, more preferably 13KGY, and the radiation sterilization time is preferably 13-18 hours, more preferably 16 hours. In the invention, the irradiation dose and time in the irradiation step have no obvious influence on the content and the effect of the effective components contained in the crushed material, and the crushed material can be ensured to achieve the sterilization effect.
The invention carries out ethanol solution extraction on the obtained irradiation, and the extraction conditions preferably comprise: the extraction time is preferably 1-2 hours, and the extraction times are preferably 1-2 times; preferably, when the particle size of the crushed material is preferably 48 μm to 830 μm, the total time of the extraction is preferably 2 hours, the number of the extractions is 2, and the time of each extraction is the same; when the particle size of the pulverized material is preferably less than 48 μm, the time for the extraction is preferably 1 hour, and the number of times of the extraction is preferably 1 time.
In the present invention, the temperature of the extraction is preferably 80 to 100 ℃, more preferably 90 ℃. In the invention, the extraction temperature is adopted to avoid the inactivation of the biological and physiological activities of the active ingredients in the raw materials and the dissolution of ineffective ingredients, thereby improving the extraction effect of the active ingredients of the raw materials.
In the present invention, the ethanol solution preferably has a volume percentage content of 55% to 70%, more preferably 60%.
In the present invention, the mass ratio of the total mass of the raw materials to the ethanol solution is preferably 1: 10.
In the invention, the ethanol solution extraction mode is preferably reflux extraction, the loss of volatilization of the ethanol solution caused by high temperature is avoided by adopting the reflux extraction, the extraction efficiency of the effective components of the traditional Chinese medicine is improved, and the method has the advantages of simple equipment and simple and convenient operation.
The invention also provides application of the traditional Chinese medicine composition in the technical scheme in preparing a medicine for improving male sexual function.
The application method of the traditional Chinese medicine composition comprises the steps of smearing the traditional Chinese medicine composition 2-5m L on the groin, massaging for 3-5 minutes for 3 times a day, using the composition once in the morning, at noon and at night, and continuously using the composition for half a year.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
Example 1
Weighing 10g of fennel, 20g of folium artemisiae argyi, 10g of Chinese gall, 15g of fructus evodiae, 15g of cinnamon, 10g of baked ginger, 5g of rhizoma corydalis and 5g of mint respectively, crushing the materials to obtain particles with the particle size of 830 microns, then carrying out irradiation sterilization with the irradiation dose of 10KGY for 13 hours, then carrying out reflux extraction on the ethanol solution, wherein the mass ratio of the total mass of the raw materials to the ethanol solution is 1:10, the concentration of the ethanol solution is 55%, the extraction temperature is 95 ℃, the extraction time is 2 hours, extracting for 2 times, filtering, and combining the filtrates for 2 times to obtain the traditional Chinese medicine composition.
Example 2
Weighing 30g of fennel, 30g of folium artemisiae argyi, 20g of Chinese gall, 30g of fructus evodiae, 30g of cinnamon, 20g of baked ginger, 10g of rhizoma corydalis and 10g of mint respectively, crushing the coarse powder to obtain a particle size of 48 mu m, then carrying out irradiation sterilization with the irradiation dose of 15KGY for 18 hours, carrying out reflux extraction on an ethanol solution, wherein the mass ratio of the total mass of the raw materials to the ethanol solution is 1:10, the concentration of the ethanol solution is 70%, the extraction temperature is 80 ℃, the extraction time is 2 hours, extracting for 2 times, filtering, and combining the filtrates for 2 times to obtain the traditional Chinese medicine composition.
Example 3
Respectively weighing 20g of fennel, 25g of folium artemisiae argyi, 15g of Chinese gall, 20g of fructus evodiae, 25g of cinnamon, 15g of baked ginger, 8g of rhizoma corydalis and 8g of mint, crushing the materials into superfine powder with the particle size of 36 mu m, then carrying out irradiation sterilization with the irradiation dose of 13KGY for 16 hours, then carrying out reflux extraction on the ethanol solution, wherein the mass ratio of the total mass of the raw materials to the ethanol solution is 1:10, the concentration of the ethanol solution is 60%, the extraction temperature is 90 ℃, the extraction time is 1 hour, extracting for 1 time, and filtering to obtain a filtrate, namely the traditional Chinese medicine composition.
Example 4
100 patients with kidney-yang deficiency type impotence, premature ejaculation and spermatorrhea were selected as the study subjects. All patients meet the diagnosis standard of kidney-yang deficiency, and all patients and their family members have informed consent and sign informed consent forms. The patients were divided into observation group and control group by random number table method, 50 cases each. The observation groups were 33-52 years old, with the mean age (41.5 + -9.5) years. The age of the control group is 35-57 years, and the average age (44.5 +/-8.5) is. All patients have different degrees of soreness and weakness of waist, dizziness, aversion to cold, impotence, premature ejaculation, spermatorrhea and other conditions to eliminate genital tract infection factors and organic diseases. The difference between the general data of age and disease state of two groups of patients is not statistically significant (P > 0.05).
Control group: the yohimbine kidney-invigorating product is orally taken for 1 time/2 days and 1 granule/time, and is continuously taken for half a year for renal function reexamination.
The observation group is that the Chinese medicinal composition 3m L prepared in the example 3 is smeared on the groin, massaged for 3-5 minutes 3 times a day, used once in the morning, noon and evening, continuously used for half a year, and the renal function is rechecked.
And (3) evaluating the curative effect:
the effect is shown: the clinical symptoms such as waist soreness and weakness, dizziness and chilliness disappear, the renal function recovers, the impotence and premature ejaculation condition disappears, and the sexual function completely recovers;
the method has the following advantages: the clinical symptoms such as waist soreness and weakness, dizziness and chilliness are improved, the renal function is improved, the impotence and premature ejaculation conditions are reduced, and the sexual function is basically recovered;
and (4) invalidation: the clinical symptoms such as waist soreness and weakness, dizziness and chilliness and the like do not improve, the renal function is not improved, the conditions of impotence and premature ejaculation still exist, and the sexual dysfunction even loses.
Observation indexes are as follows:
all patients were observed and recorded about soreness and weakness of waist, dizziness, aversion to cold, renal function, impotence, premature ejaculation, and other sexual function. The results of the treatment in the control and observation groups are shown in Table 1.
TABLE 1 treatment results for control and observation groups
As shown in table 1, the external application of the Chinese medicinal composition of the present invention has a significant efficiency of 50% and a total effective rate of 90% in improving male sexual function, and compared with the control group, the significant efficiency is increased by 66.7% and the total effective rate is increased by 12.5%.
Case one
After being cured as ED in 2 months in 2018 by Wang, 56 years old, Dongguan people in Dongguan city, the curative effect of the hospital is not obvious, and the function is basically lost, 4m L of the traditional Chinese medicine composition prepared in the embodiment 3 of the invention is used after 5 months in 2019, the traditional Chinese medicine composition is applied to the groin, and can erect after 2 months of treatment, and the function is basically recovered after 6 months of use.
Case two
If a chiffon is in 46 years old, a man, a Guangzhou city and premature ejaculation are not obvious in treatment effect in a hospital, the treatment effect can be maintained within 2 minutes basically, the traditional Chinese medicine composition prepared in the embodiment 2 of the invention is used in 2019, and 3m L is applied to the groin and can be maintained for 3-5 minutes after 1 month of treatment, and the function is basically recovered after 3 months of use.
Case three
The patient in Jiangzhi, 28 years old, Jiangxi, city, has a long-term masturbation history through the hospital, suffers from severe spermatorrhea, and has a poor multi-party treatment effect, 2m L is smeared in the groin by using the traditional Chinese medicine composition prepared in the embodiment 1 of the invention, the disease condition is improved after 1 month of treatment, and the function is basically recovered after 6 months of use.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.
Claims (10)
1. The traditional Chinese medicine composition for improving male sexual function is characterized by comprising the following raw materials in parts by weight: 10-30 parts of fennel, 20-30 parts of folium artemisiae argyi, 10-20 parts of gallnut, 15-30 parts of fructus evodiae, 15-30 parts of cinnamon, 10-20 parts of baked ginger, 5-10 parts of rhizoma corydalis and 5-10 parts of mint.
2. The traditional Chinese medicine composition according to claim 1, which is characterized by comprising the following raw materials in parts by weight: 15 parts of fennel, 20 parts of folium artemisiae argyi, 15 parts of Chinese gall, 30 parts of fructus evodiae, 30 parts of cinnamon, 15 parts of baked ginger, 10 parts of rhizoma corydalis and 5 parts of mint.
3. The method for preparing the traditional Chinese medicine composition of claim 1 or 2, which is characterized by comprising the following steps: extracting the raw materials with ethanol solution, and filtering to obtain filtrate as Chinese medicinal composition.
4. The method according to claim 3, wherein the raw material before being extracted with ethanol solution further comprises: and crushing the raw materials to obtain a crushed material, wherein the particle size of the crushed material is less than or equal to 830 mu m.
5. The method according to claim 4, wherein the pulverized material is subjected to irradiation sterilization and then to ethanol solution extraction, wherein the irradiation dose of the irradiation sterilization is 10 to 15KGY, and the irradiation sterilization time is 13 to 18 hours.
6. The method of claim 3, wherein the extraction conditions include: the extraction time is 1-2 hours, the extraction times are 1-2 times, and the extraction temperature is 80-100 ℃;
the volume percentage content of the ethanol solution is 55-70%.
7. The method according to claim 4 or 6, wherein when the pulverized material has a particle size of 48 μm to 830 μm, the total time of the extraction is 2 hours and the number of the extractions is 2.
8. The method according to claim 4 or 6, wherein when the particle size of the pulverized material is less than 48 μm, the extraction time is 1 hour, and the number of times of extraction is 1 time.
9. The production method according to claim 3, wherein the mass ratio of the total mass of the raw materials to the ethanol solution is 1: 10.
10. The use of the Chinese medicinal composition according to claim 1 or 2 in the preparation of a medicament for improving male sexual function.
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|---|---|---|---|---|
| CN1134303A (en) * | 1996-03-13 | 1996-10-30 | 王连俊 | Kidney-warming and yang-invigorating plaster |
| CN109172671A (en) * | 2018-11-19 | 2019-01-11 | 云南中医学院 | A kind of flue moxibustion traditional Chinese medicine powder and preparation method thereof for kidney yang deficiency syndrome patient |
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2020
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