CN111388401A - Facial mask and preparation method and application thereof - Google Patents
Facial mask and preparation method and application thereof Download PDFInfo
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- CN111388401A CN111388401A CN201911285253.7A CN201911285253A CN111388401A CN 111388401 A CN111388401 A CN 111388401A CN 201911285253 A CN201911285253 A CN 201911285253A CN 111388401 A CN111388401 A CN 111388401A
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- mask
- nucleic acid
- acid solution
- polysaccharide nucleic
- facial mask
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- 238000002360 preparation method Methods 0.000 title claims description 7
- -1 polysaccharide nucleic acid Chemical class 0.000 claims abstract description 52
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 49
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 49
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 49
- 239000005017 polysaccharide Substances 0.000 claims abstract description 49
- 235000015097 nutrients Nutrition 0.000 claims abstract description 19
- 230000000694 effects Effects 0.000 claims abstract description 14
- 230000002087 whitening effect Effects 0.000 claims abstract description 8
- 239000000243 solution Substances 0.000 claims description 58
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims description 10
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 10
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- 238000000034 method Methods 0.000 claims description 8
- 239000008215 water for injection Substances 0.000 claims description 7
- KIUKXJAPPMFGSW-DNGZLQJQSA-N (2S,3S,4S,5R,6R)-6-[(2S,3R,4R,5S,6R)-3-Acetamido-2-[(2S,3S,4R,5R,6R)-6-[(2R,3R,4R,5S,6R)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2-carboxylic acid Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-DNGZLQJQSA-N 0.000 claims description 5
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- BIVBRWYINDPWKA-VLQRKCJKSA-L Glycyrrhizinate dipotassium Chemical group [K+].[K+].O([C@@H]1[C@@H](O)[C@H](O)[C@H](O[C@@H]1O[C@H]1CC[C@]2(C)[C@H]3C(=O)C=C4[C@@H]5C[C@](C)(CC[C@@]5(CC[C@@]4(C)[C@]3(C)CC[C@H]2C1(C)C)C)C(O)=O)C([O-])=O)[C@@H]1O[C@H](C([O-])=O)[C@@H](O)[C@H](O)[C@H]1O BIVBRWYINDPWKA-VLQRKCJKSA-L 0.000 claims description 5
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- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims description 4
- ZAKOWWREFLAJOT-CEFNRUSXSA-N D-alpha-tocopherylacetate Chemical compound CC(=O)OC1=C(C)C(C)=C2O[C@@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-CEFNRUSXSA-N 0.000 claims description 4
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims description 4
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims description 4
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- 230000003110 anti-inflammatory effect Effects 0.000 claims description 3
- ZAKOWWREFLAJOT-UHFFFAOYSA-N d-alpha-Tocopheryl acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C ZAKOWWREFLAJOT-UHFFFAOYSA-N 0.000 claims description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 claims description 3
- FOYKKGHVWRFIBD-UHFFFAOYSA-N gamma-tocopherol acetate Natural products CC(=O)OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1 FOYKKGHVWRFIBD-UHFFFAOYSA-N 0.000 claims description 3
- 229960003966 nicotinamide Drugs 0.000 claims description 3
- 235000005152 nicotinamide Nutrition 0.000 claims description 3
- 239000011570 nicotinamide Substances 0.000 claims description 3
- CLAHOZSYMRNIPY-UHFFFAOYSA-N 2-hydroxyethylurea Chemical compound NC(=O)NCCO CLAHOZSYMRNIPY-UHFFFAOYSA-N 0.000 claims description 2
- 229940031575 hydroxyethyl urea Drugs 0.000 claims description 2
- 239000011259 mixed solution Substances 0.000 claims description 2
- 239000004615 ingredient Substances 0.000 claims 4
- 230000003255 anti-acne Effects 0.000 claims 2
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 1
- NCZPCONIKBICGS-UHFFFAOYSA-N 3-(2-ethylhexoxy)propane-1,2-diol Chemical compound CCCCC(CC)COCC(O)CO NCZPCONIKBICGS-UHFFFAOYSA-N 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 239000004909 Moisturizer Substances 0.000 claims 1
- 229940100524 ethylhexylglycerin Drugs 0.000 claims 1
- 235000011187 glycerol Nutrition 0.000 claims 1
- 230000001333 moisturizer Effects 0.000 claims 1
- 235000016709 nutrition Nutrition 0.000 claims 1
- 208000020154 Acnes Diseases 0.000 abstract description 9
- 206010061218 Inflammation Diseases 0.000 abstract description 7
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- 239000002075 main ingredient Substances 0.000 abstract 1
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- 208000024891 symptom Diseases 0.000 description 4
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- 238000012360 testing method Methods 0.000 description 3
- 230000001225 therapeutic effect Effects 0.000 description 3
- ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
- 206010020751 Hypersensitivity Diseases 0.000 description 2
- DFPAKSUCGFBDDF-ZQBYOMGUSA-N [14c]-nicotinamide Chemical compound N[14C](=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-ZQBYOMGUSA-N 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- CDQSJQSWAWPGKG-UHFFFAOYSA-N butane-1,1-diol Chemical compound CCCC(O)O CDQSJQSWAWPGKG-UHFFFAOYSA-N 0.000 description 2
- 229960005188 collagen Drugs 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
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- 239000007924 injection Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
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- 230000001954 sterilising effect Effects 0.000 description 2
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 description 1
- ANZUDYZHSVGBRF-UHFFFAOYSA-N 3-ethylnonane-1,2,3-triol Chemical compound CCCCCCC(O)(CC)C(O)CO ANZUDYZHSVGBRF-UHFFFAOYSA-N 0.000 description 1
- WTJXVDPDEQKTCV-UHFFFAOYSA-N 4,7-bis(dimethylamino)-1,10,11,12a-tetrahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4h-tetracene-2-carboxamide;hydron;chloride Chemical compound Cl.C1C2=C(N(C)C)C=CC(O)=C2C(O)=C2C1CC1C(N(C)C)C(=O)C(C(N)=O)=C(O)C1(O)C2=O WTJXVDPDEQKTCV-UHFFFAOYSA-N 0.000 description 1
- 208000032544 Cicatrix Diseases 0.000 description 1
- 201000004624 Dermatitis Diseases 0.000 description 1
- 206010054107 Nodule Diseases 0.000 description 1
- 206010033733 Papule Diseases 0.000 description 1
- 206010037888 Rash pustular Diseases 0.000 description 1
- 208000035999 Recurrence Diseases 0.000 description 1
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 description 1
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 230000001914 calming effect Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 239000002537 cosmetic Substances 0.000 description 1
- 208000031513 cyst Diseases 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 238000007865 diluting Methods 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 229960003276 erythromycin Drugs 0.000 description 1
- 238000011156 evaluation Methods 0.000 description 1
- 238000013401 experimental design Methods 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 229960002421 minocycline hydrochloride Drugs 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 208000029561 pustule Diseases 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 231100000241 scar Toxicity 0.000 description 1
- 230000037387 scars Effects 0.000 description 1
- 238000007789 sealing Methods 0.000 description 1
- 210000002374 sebum Anatomy 0.000 description 1
- 230000003997 social interaction Effects 0.000 description 1
- 238000004659 sterilization and disinfection Methods 0.000 description 1
- 239000011550 stock solution Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 229940042585 tocopherol acetate Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 239000011719 vitamin A Substances 0.000 description 1
- 235000019155 vitamin A Nutrition 0.000 description 1
- 229940045997 vitamin a Drugs 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 238000009736 wetting Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/99—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from microorganisms other than algae or fungi, e.g. protozoa or bacteria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dermatology (AREA)
- Birds (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Biotechnology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to a facial mask, the main ingredients are BCG polysaccharide nucleic acid and basic nutrient solution, the BCG polysaccharide nucleic acid and the basic facial mask solution are mixed and added into the facial mask, which can play a role in diminishing inflammation and removing acnes on acnes, improve the immune function of the skin, prevent the acnes from recurring and improve the allergic skin quality; also has effects of keeping moisture and whitening skin.
Description
Technical Field
The invention relates to the technical field of cosmetics, and particularly relates to a facial mask.
Background
Acne, a chronic inflammatory skin disease of the pilosebaceous unit, is frequently found in the face and other parts rich in sebum, is mainly found in teenagers, has great influence on the psychology and social interaction of the teenagers, and is very troublesome in treatment. The 24 th volume of volume 8, observation of therapeutic effects of BCG polysaccharide nucleic acid for treating moderate and severe acne, of volume 24 of the report of the armed police 'Hospital's school of logistics (medical edition) 2015, records BCG polysaccharide nucleic acid injection in combination with minocycline hydrochloride for treating acne; chinese dermatologic impurities in 2004, volume 11, 18, volume 11 of "BCG polysaccharide nucleic acid and other medicines for treating severe clustered acne" also records that BCG polysaccharide nucleic acid is combined with oral erythromycin, vitamins, vitamin A, lipid and other medicines for treating acne, but no report is available for external use of BCG polysaccharide nucleic acid for relieving acne.
The prior mask for calming, diminishing inflammation and removing acnes uses plant extracts and has the following defects: 1. whereas plant extracts are currently under-or functional; 2. the addition amount is not controlled enough, and the extract has complex components, so people are easy to be allergic, and the like; 3. the existing facial mask is prepared by matching all raw materials, is opened before use, and has the possibility that the effective components react with other added raw materials during the period from production to use, so that the efficacy is insufficient or allergy is caused. At present, no report of the application of BCG polysaccharide nucleic acid to the facial mask is found.
Disclosure of Invention
The invention aims to provide a mask which has the effects of diminishing inflammation and removing acnes, has the function of improving immunity, can promote the immune function of the skin to be improved, prevents acnes from recurring and improves allergic skin.
The purpose of the invention is realized by the following technical scheme:
a facial mask is prepared from BCG polysaccharide nucleic acid and facial mask paper.
The solution of the BCG polysaccharide nucleic acid is prepared by using water for injection, and 2-5ml of each solution is filled in a plastic bottle after the preparation is finished; the concentration of the solution of the BCG polysaccharide nucleic acid is 0.35mg/ml-3.50 mg/ml.
The BCG polysaccharide nucleic acid solution and the facial mask paper are packaged separately before use.
The use method of the facial mask comprises the following steps: before use, the facial mask paper is placed in BCG polysaccharide nucleic acid solution, and is applied to the face after being sufficiently absorbed.
The invention also provides application of the mask in preparing a skin care product with anti-inflammation and acne-removing effects.
The invention also aims to provide another facial mask which has the effects of moisturizing and whitening besides the effects of the facial mask.
A facial mask is prepared from BCG polysaccharide nucleic acid solution, basic nutrient solution and facial mask paper.
The BCG polysaccharide nucleic acid solution is prepared by using water for injection, and 2-5ml of each BCG polysaccharide nucleic acid solution is filled in a plastic bottle after the preparation is finished; the concentration of the BCG polysaccharide nucleic acid solution is 0.35mg/ml-3.50 mg/ml.
The basic nutrient solution comprises a moisturizing component, a soothing component and a whitening component.
The moisture keeping component is one or more of dipropylene glycol, butanediol, glycerol, hydrolyzed hyaluronic acid, sorbitol, hydrolyzed collagen, polyethylene glycol-32, polyethylene glycol-6, hydroxyethyl urea, and ethylhexyl glycerol.
The soothing component is dipotassium glycyrrhizinate.
The whitening component is one or more of niacinamide, vitamin C and tocopherol acetate.
The BCG polysaccharide nucleic acid solution, the basic nutrient solution and the mask paper are packaged separately before use.
The invention also provides a using method of the mask, which is characterized in that: before use, the BCG polysaccharide nucleic acid solution and the basic nutrient solution are mixed uniformly, and then the facial mask paper is placed in the mixed solution and is applied to the face after being sufficiently absorbed.
The invention also provides application of the mask in preparing a skin care product with the effects of diminishing inflammation, removing acnes, whitening and relieving.
The invention has the beneficial effects that:
1. the BCG polysaccharide nucleic acid has the effects of diminishing inflammation and improving immunity, and can be used for diminishing inflammation and removing acnes when being added into the mask as an anti-inflammatory component, so that the immune function of the skin can be improved, the recrudescence of acnes can be prevented, and the allergic skin can be improved.
2. The BCG polysaccharide nucleic acid, the basic nutrient solution and the mask paper are packaged separately, so that the BCG polysaccharide nucleic acid and the basic nutrient solution such as moisturizing components, soothing components and the like can be effectively prevented from reacting in the process of placing before production and use, the effect is reduced or other substances are generated, and allergy or insufficient effect is caused.
Detailed Description
Example 1
A facial mask is prepared from BCG polysaccharide nucleic acid solution and facial mask paper.
Preparing a BCG polysaccharide nucleic acid solution:
(1) concentration and preparation: weighing BCG polysaccharide nucleic acid, placing in a concentrated cup, adding appropriate amount of water for injection, dissolving with a magnetic stirrer, adding water for injection to the undissolved part, and dissolving with the magnetic stirrer until completely dissolving.
(2) Centrifuging: centrifuging the concentrated solution to remove insoluble impurities.
(3) Diluting and preparing: adding the scale mark for injection to approximate batch, adding the concentrated solution, and adding water for injection to the scale mark for batch to finally make the concentration of the BCG polysaccharide nucleic acid solution be 1.0 mg/ml.
(4) And (3) filtering: the diluted stock solution was passed through a 0.45um filter.
(5) Filling: filling the BCG polysaccharide nucleic acid solution into cleaned bottles by using a filling and sealing machine, wherein 2-5ml of each bottle is sealed.
(6) And (3) sterilization: sterilizing at 121 deg.C under 0.11MPa for 20 min.
Before use, the facial mask paper is slightly soaked in water, then placed in BCG polysaccharide nucleic acid solution, and applied to the face after being sufficiently absorbed; if the facial mask paper is dry after being sufficiently absorbed, a proper amount of water can be added for application.
Example 2
A facial mask is prepared from BCG polysaccharide nucleic acid solution, basic nutrient solution and facial mask paper.
1. The BCG polysaccharide nucleic acid solution was prepared as in example 1.
2. The basic nutrient solution is prepared from dipropylene glycol, butanediol, glycerol, hydrolyzed hyaluronic acid, dipotassium glycyrrhizinate, nicotinamide and vitamin C by conventional method.
Before use, the BCG polysaccharide nucleic acid solution and the basic nutrient solution are mixed uniformly, the silk mask paper is placed in the mixture, and after the silk mask paper is sufficiently absorbed, the silk mask paper is applied to the face.
Example 3
A facial mask is prepared from BCG polysaccharide nucleic acid solution, basic nutrient solution and facial mask paper.
1. Preparing a BCG polysaccharide nucleic acid solution:
the BCG polysaccharide nucleic acid solution was prepared as in example 1.
2. The basic nutrient solution is prepared from double hydrolyzed hyaluronic acid, sorbitol, hydrolyzed collagen, dipotassium glycyrrhizinate, nicotinamide, vitamin C and tocopheryl acetate by conventional method.
Before use, the BCG polysaccharide nucleic acid solution and the basic nutrient solution are mixed uniformly, the silk mask paper is placed in the mixture, and after the silk mask paper is sufficiently absorbed, the silk mask paper is applied to the face.
Example 4
A facial mask is prepared from BCG polysaccharide nucleic acid solution, basic nutrient solution and facial mask paper.
1. Preparing a BCG polysaccharide nucleic acid solution:
the BCG polysaccharide nucleic acid solution was prepared as in example 1.
2. The basic nutrient solution is prepared from double hydrolyzed hyaluronic acid, sorbitol, hydrolyzed collagen, dipotassium glycyrrhizinate, nicotinamide, vitamin C and tocopheryl acetate by conventional method.
Before use, the BCG polysaccharide nucleic acid solution and the basic nutrient solution are mixed uniformly, the silk mask paper is placed in the mixture, and after the silk mask paper is sufficiently absorbed, the silk mask paper is applied to the face.
Following is an examination of the acne removal test of examples 1-4
1. Test population selection
The experimental population is as follows: 80 people, who are clinically manifested by multiple damages such as papules, pustules, nodules, cysts, acne, blackhead, large pores, scars and the like on the face and are accompanied by greasy feeling of the facial skin, teenagers and middle-aged men and women in the population are divided into 4 groups, and 20 people in each group try out the facial masks obtained in the examples 1, 2, 3 and 4 respectively.
2. Mask for experiment: the masks prepared in examples 1 to 4 were prepared with the same amount of blank mask paper.
3. The using method comprises the following steps: examples 1-4 facial mask application methods the same as in examples 1-4, blank facial mask was applied by wetting the facial mask paper with water and applying to the face just before use.
4. The experimental method comprises the following steps: the left face of each experimental group experimenter was applied with the facial mask of the present invention (i.e., the facial mask prepared in example 1 was applied to experimental group 1, the facial mask prepared in example 2 was applied to experimental group 2, and so on), and the right face was applied with the blank facial mask, and the facial mask was torn off after 20 minutes of application. The experimenter applies the facial mask once every 72 hours, and as the experimental design, the left face is applied with the facial mask of the invention, the right face is applied with the blank facial mask, and after 30 times of facial mask application, the acne removing effect is observed once; after applying the mask for 60 times, the acne removing effect is observed again. Stopping applying the facial mask 60 times, and recording acne recurrence 30 days after stopping applying the facial mask; after 90 days after the mask application was stopped, the recurrence of pox was recorded again.
5. The evaluation standard of curative effect is as follows:
and (3) healing: the symptoms completely disappeared;
remarkably: the symptoms substantially disappear;
the method has the following advantages: the symptoms are obviously improved or improved;
and (4) invalidation: no improvement in symptoms.
The results are detailed in the following tables (the numbers in tables 1-3 refer to the number of people)
TABLE 1 acne-removing test results after applying facial mask 30 times
TABLE 2 acne-removing experimental results after applying the facial mask 60 times
From the experimental results in tables 1 and 2, it can be seen that after applying the facial mask 30 times, the total number of patients with therapeutic effect in the experimental groups 1-4 is 12, 14, 13 and 13 in sequence, the effective rate is 60%, 70%, 65% and 65% in sequence, and after applying the facial mask 60 times, the total number of patients with therapeutic effect in the experimental groups 1-4 is 15, 17, 16 and 16 in sequence, and the effective rate is 75%, 85%, 80% and 80% in sequence.
6. Relapse definition and grading:
recurrence of the disease: the condition was worse than the condition recorded after 60 times of mask application and all the conditions were relapse.
Stage I: slightly worse than the condition recorded after 60 times of mask application;
and II, stage: the moderate worsening was observed after 60 postings with mask.
Grade III: the degree of severity was worsened after 60 times of mask application, which was consistent with the condition before mask application.
TABLE 3 recurrent patient record chart for stopping face mask acne
Claims (16)
1. A facial mask is characterized in that the facial mask is prepared from BCG polysaccharide nucleic acid solution and facial mask paper.
2. The mask according to claim 1, wherein the BCG polysaccharide nucleic acid solution is prepared by using water for injection.
3. The mask according to claim 1, wherein the concentration of the BCG polysaccharide nucleic acid solution is 0.35mg/ml to 3.50 mg/ml.
4. The mask according to any one of claims 1 to 3, wherein the BCG polysaccharide nucleic acid solution and the mask paper are packaged separately before use.
5. The method of using a mask pack of claim 4, wherein: before use, the facial mask paper is placed in BCG polysaccharide nucleic acid solution, and is applied to the face after being sufficiently absorbed.
6. Use of the mask of any one of claims 1-3 for the preparation of a skin care product having anti-inflammatory and anti-acne effects.
7. A facial mask is characterized in that the facial mask is prepared from a BCG polysaccharide nucleic acid solution, a basic nutrient solution and facial mask paper.
8. The mask according to claim 7, wherein the BCG polysaccharide nucleic acid solution is prepared by using water for injection.
9. The mask according to claim 7, wherein the concentration of the BCG polysaccharide nucleic acid solution is 0.35mg/ml to 3.50 mg/ml.
10. The mask according to claim 7, wherein the base nutrient solution comprises a moisturizing ingredient, a comfort ingredient and a whitening ingredient.
11. The mask according to claim 10, wherein the moisturizing component is one or more of small alcohol moisturizers dipropylene glycol, butylene glycol, glycerin, hydrolyzed hyaluronic acid, sorbitol, hydrolyzed collagen, polyethylene glycol-32, polyethylene glycol-6, hydroxyethyl urea, and ethylhexyl glycerin.
12. The mask pack of claim 10, wherein said soothing component is dipotassium glycyrrhizinate.
13. The mask according to claim 10, wherein the whitening ingredient is one or more of niacinamide, vitamin C and tocopheryl acetate.
14. The mask according to any one of claims 7 to 13, wherein the bcg-polysaccharide nucleic acid solution, the base nutritional solution and the mask paper are packaged separately before use.
15. A method of using the mask pack of claim 14, wherein: before use, the BCG polysaccharide nucleic acid solution and the basic nutrient solution are mixed uniformly, and then the facial mask paper is placed in the mixed solution and is applied to the face after being sufficiently absorbed.
16. Use of the mask of any one of claims 7-13 for the preparation of a skin care product having anti-inflammatory, anti-acne, whitening, soothing effects.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201811532110 | 2018-12-14 | ||
| CN2018115321107 | 2018-12-14 | ||
| CN2018115348881 | 2018-12-14 | ||
| CN201811534888 | 2018-12-14 |
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| CN111388401A true CN111388401A (en) | 2020-07-10 |
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101686992A (en) * | 2008-01-07 | 2010-03-31 | 湖南九芝堂斯奇生物制药有限公司 | Application and injection and the preparation method of BCG polysaccharide nucleic acid extractive in the medicine of preparation treatment allergic skin disease |
| CN101820891A (en) * | 2007-12-14 | 2010-09-01 | 湖南九芝堂斯奇生物制药有限公司 | BCG polysaccharide nucleic acid extractive and preparation method thereof |
| CN105581974A (en) * | 2014-10-24 | 2016-05-18 | 熊慧 | External-use composition |
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2019
- 2019-12-13 CN CN201911285253.7A patent/CN111388401A/en active Pending
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101820891A (en) * | 2007-12-14 | 2010-09-01 | 湖南九芝堂斯奇生物制药有限公司 | BCG polysaccharide nucleic acid extractive and preparation method thereof |
| CN101686992A (en) * | 2008-01-07 | 2010-03-31 | 湖南九芝堂斯奇生物制药有限公司 | Application and injection and the preparation method of BCG polysaccharide nucleic acid extractive in the medicine of preparation treatment allergic skin disease |
| CN105581974A (en) * | 2014-10-24 | 2016-05-18 | 熊慧 | External-use composition |
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