CN107115349A - A kind of vitaminAD E microemulsion injections for animals and preparation method thereof - Google Patents
A kind of vitaminAD E microemulsion injections for animals and preparation method thereof Download PDFInfo
- Publication number
- CN107115349A CN107115349A CN201710310433.0A CN201710310433A CN107115349A CN 107115349 A CN107115349 A CN 107115349A CN 201710310433 A CN201710310433 A CN 201710310433A CN 107115349 A CN107115349 A CN 107115349A
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- parts
- vitamin
- vitaminad
- preparation
- microemulsion
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
- A61K31/07—Retinol compounds, e.g. vitamin A
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
- A61K9/1075—Microemulsions or submicron emulsions; Preconcentrates or solids thereof; Micelles, e.g. made of phospholipids or block copolymers
Abstract
The invention belongs to the technical field of field of veterinary medicine preparation, specifically Liposoluble Vitamin Injection, it is related to vitaminAD E microemulsion injections for animals and preparation method thereof.It is made up of by weight following raw materials：5 10 parts of Retinol Palmitate；Vitamin D30.1 1 parts of oil；20 50 parts of vitamin e acetate；1 part of BHA0.5；1 part of BHT0.5；12 parts of phenmethylol；2 10 parts of Tween 80；10 30 parts of absolute ethyl alcohol；10 60 parts of injection soybean oil；The present invention additionally provides the preparation method of above-mentioned parenteral solution simultaneously.The present invention is by vitamin A, vitamin D, vitamin E compound use, using the newest vitamin dosage that recommends in the world as foundation in terms of drug content, grease is selected to be used as solvent according to its dissolution properties, compound a certain amount of surfactant and cosurfactant, it is prepared for clear and bright vitaminAD E parenteral solutions, the hydrophily and dispersiveness of product are added, is conducive to body to absorb rapidly, improves bioavilability.
Description
Technical field
The invention belongs to the technical field of field of veterinary medicine preparation, specifically Liposoluble Vitamin Injection, it is related to dimension for animals
Raw element ADE microemulsion injections and preparation method thereof.
Background technology
Although vitamin is not energy matter, nor constituting the raw material of tissue or organ, they are for thing in body
Being normally carried out for matter metabolism, plays an important role in terms of the transformation of energy and the maintenance of physiological function.Vitamin A, dimension
Raw element D and vitamin E belong to liposoluble vitamin.Vitamin A can not only maintain normal vision, maintain epithelial cell complete
Property and promote normal development of skeleton, improve immunity of organisms, suppress tumour, and contribute to body eubolism regulate and control.Dimension life
Plain D is nutrient necessary to maintaining higher mammal life, is one of most important regulatory factor of alcium and phosphor metabolization, for maintaining
The life processes such as calcium phosphorus balance, skeleton development, myoneural conduction effect and cellular activity information transmission are all required.Dimension
Raw element E physiological function is to promote the secretion of pituitary gonadotropic hormone, improves lipid-metabolism, reduces the generation of lipid peroxide
Deng.
Liposoluble vitamin is almost insoluble in water, and the bioavilability of liquid preparation is low, therefore clinical practice is by one
Definite limitation.With the development of medical sci-tech, vast pharmacy worker has continually developed micro-capsule, inclusion compound, liposome and nano-emulsion
Deng vitamin novel form and new technology, hence it is evident that improve the stability and bioavilability of vitamin preparation.Conventional this of clinic
Composite vitamin injection accounts for larger proportion in class injection, can meet patient daily to various vitamins under pathological state
Demand or the auxiliary treatment as some diseases.Have between B B-complex class drug prescription complicated component, each component directly
Or indirect interactively, stability is poor.Therefore improve solubility in water of preparation stability and liposoluble vitamin into
To develop the emphasis and difficult point of such preparation.
The content of the invention
In order to overcome the above-mentioned deficiencies of the prior art, the present invention intends providing a kind of vitaminAD E microemulsion injections for animals, its
It is made up of by weight following raw materials：
Vitamin A is usually coexisted with D in nature, and both, which combine, has antagonism, and oral vitamin A can excessively be done
The normal absorption of vitamin D is disturbed, makes blood calcium and Phos level on a declining curve, so to control vitamin A and vitamin D
Consumption is to proper ratio；When vitamin A and vitamin E are shared, vitamin E can promote body to the absorption of vitamin A, using and
Liver is stored, curative effect enhancing, with synergy, and when can overcome the shortcomings of alone.
Due to the unstability of vitamin A, when the antioxidant of proper proportion, BHT and BHA compoundings are added in preparation, effect
There is best protecting effect to vitamin A.
From absolute ethyl alcohol and Tween 80 compound use as solubilizer, the solubility of medicine can be increased, improved in preparation
The content of main ingredient, and the absorption of enhancing medicine, so as to improve the bioavilability of medicine.
Phenmethylol is the conventional additive of injection.The purpose of phenmethylol is added, primarily to playing certain analgesia
And antisepsis, and certain protective effect is played to the stability of fat-soluble injection.
Further, it is preferable to, 6.5 parts of Retinol Palmitate, vitamin D30.25 part of oil, vitamin e acetate 30
Part, 0.9 part of BHA, 0.6 part of BHT, 2 parts of phenmethylol, 4.5 parts of Tween 80,20 parts of absolute ethyl alcohol, 35 parts of injection soybean oil.
Meanwhile, the invention provides the preparation method of above-mentioned vitaminAD E microemulsion injections for animals, it includes following step
Suddenly：
Retinol Palmitate, vitamin D are taken respectively by above-mentioned weight ratio3Oil, vitamin e acetate, BHA, BHT and
Appropriate injection soybean oil is put into miscible in high-speed homogenization machine, formation oil phase；Added to above-mentioned oil phase and take place by above-mentioned weight ratio
Side's amount Tween 80, absolute ethyl alcohol and phenmethylol, add injection soybean oil to full dose, high speed homogenization 2-5 minutes, with 2000-
5000rpm homogeneous forms colostrum in 3-5 minutes；Then, using high pressure homogenizer, under 20-100MPa pressure, N is led to2Protection,
By 1-10 circulation, homogeneous emulsion is formed, the emulsion prepared is successively added using 0.45 μm and 0.22 μm of miillpore filter
Press filtration, is sterilized after packing using flowing steam, and flowing steam sterilization condition is 100 DEG C, 30 minutes.
Further, whole logical N in above-mentioned preparation method2Protection.
In whole production process, protected using nitrogen, prevent the oxidation of vitamin.
The beneficial effects of the invention are as follows：By vitamin A, vitamin D, vitamin E compound use, in terms of drug content with
The international newest vitamin dosage that recommends selects grease as solvent, compounded a certain amount of for foundation according to its dissolution properties
Surfactant and cosurfactant, are prepared for clear and bright vitaminAD E parenteral solutions, add the hydrophily of product and disperse
Property, be conducive to body to absorb rapidly, improve bioavilability.
Embodiment
The present invention is improves the solubility of preparation stability and liposoluble vitamin in water, using microemulsion technology, design
VitaminAD E microemulsion injections and preparation method thereof.With reference to specific embodiment, the invention will be further described.
The vitaminAD E microemulsion injections for animals of embodiment 1., are made up of following raw material, by weight calculating：
5 parts of Retinol Palmitate, vitamin D30.1 part of oil, 20 parts of vitamin e acetate, BHA0.75 parts, BHT
0.5 part, 1 part of phenmethylol, 2 parts of Tween 80,12 parts of absolute ethyl alcohol, 59 parts of injection soybean oil.
The vitaminAD E microemulsion injections for animals of embodiment 2., are made up of following raw material, by weight calculating：
5.5 parts of Retinol Palmitate, vitamin D30.15 part of oil, 25 parts of vitamin e acetate, BHA0.9 parts, BHT
0.6 part, 1 part of phenmethylol, 3 parts of Tween 80,15 parts of absolute ethyl alcohol, 49 parts of injection soybean oil.
The vitaminAD E microemulsion injections for animals of embodiment 3., are made up of following raw material, by weight calculating：
6 parts of Retinol Palmitate, vitamin D30.2 part of oil, 28 parts of vitamin e acetate, BHA0.9 parts, BHT 0.6
Part, 1.5 parts of phenmethylol, 4 parts of Tween 80,18 parts of absolute ethyl alcohol, 41 parts of injection soybean oil.
The vitaminAD E microemulsion injections for animals of embodiment 4., are made up of following raw material, by weight calculating：
6.5 parts of Retinol Palmitate, vitamin D30.25 part of oil, 30 parts of vitamin e acetate, BHA0.9 parts, BHT
0.6 part, 2 parts of phenmethylol, 4.5 parts of Tween 80,20 parts of absolute ethyl alcohol, 35 parts of injection soybean oil.
The vitaminAD E microemulsion injections for animals of embodiment 5., are made up of following raw material, by weight calculating：
7 parts of Retinol Palmitate, vitamin D30.3 part of oil, 32 parts of vitamin e acetate, BHA0.9 parts, BHT 0.6
Part, 2 parts of phenmethylol, 5 parts of Tween 80,22 parts of absolute ethyl alcohol, 30 parts of injection soybean oil.
The vitaminAD E microemulsion injections for animals of embodiment 6., are made up of following raw material, by weight calculating：
7.5 parts of Retinol Palmitate, vitamin D30.35 part of oil, 35 parts of vitamin e acetate, BHA0.9 parts, BHT
0.6 part, 2 parts of phenmethylol, 5.5 parts of Tween 80,25 parts of absolute ethyl alcohol, 25 parts of injection soybean oil.
The vitaminAD E microemulsion injections for animals of embodiment 7., are made up of following raw material, by weight calculating：
8 parts of Retinol Palmitate, vitamin D30.4 part of oil, 38 parts of vitamin e acetate, BHA0.9 parts, BHT 0.6
Part, 2 parts of phenmethylol, 6 parts of Tween 80,28 parts of absolute ethyl alcohol, 16 parts of injection soybean oil.
Specific preparation method (whole N2Protection)：
Retinol Palmitate, vitamin D are taken respectively by above-mentioned weight ratio3Oil, vitamin e acetate, BHA, BHT and
Appropriate injection soybean oil is put into miscible in high-speed homogenization machine, formation oil phase；；Added to above-mentioned oil phase and take place by above-mentioned weight ratio
Side's amount Tween 80, absolute ethyl alcohol and phenmethylol, add injection soybean oil to full dose, high speed homogenization 3 minutes is equal with 2000rpm
Matter forms colostrum in 3 minutes；；Then, using high pressure homogenizer, under 50MPa pressure, N is led to2Protection, by 5 circulations, shape
Into homogeneous emulsion, the emulsion prepared successively uses 0.45 μm and 0.22 μm of miillpore filter pressure filtration, is used after packing
Flowing steam is sterilized, and flowing steam sterilization condition is 100 DEG C, 30 minutes.The method of described sterilizing uses filtration sterilization
Mode, hundred grades of cleaning shops, i.e., after using 0.45 μm of filtering with microporous membrane, then using 0.22 μm of filtering with microporous membrane, fills
N2, it is filling.Pass through different embodiments, character, drug content measure, stability and scattered feature from preparation, it is determined that most preferably
Embodiment is embodiment 4.
Claims (4)
1. a kind of vitaminAD E microemulsion injections for animals, it is characterised in that：It is made up of by weight following raw materials：
2. a kind of vitaminAD E microemulsion injections for animals according to claim 1, it is characterised in that：Pressed by following raw materials
Weight is than composition：
6.5 parts of Retinol Palmitate, vitamin D30.25 part of oil, 30 parts of vitamin e acetate, 0.9 part of BHA, BHT 0.6
Part, 2 parts of phenmethylol, 4.5 parts of Tween 80,20 parts of absolute ethyl alcohol, 35 parts of injection soybean oil.
3. the preparation method of a kind of vitaminAD E microemulsion injections for animals described in claim 1, it is characterised in that including such as
Lower step：
Retinol Palmitate, vitamin D are taken respectively by above-mentioned weight ratio3Oil, vitamin e acetate, BHA, BHT and appropriate note
Penetrate and miscible in high-speed homogenization machine, formation oil phase is put into soybean oil；Added to above-mentioned oil phase takes recipe quantity to tell by above-mentioned weight ratio
Temperature 80, absolute ethyl alcohol and phenmethylol, add injection soybean oil to full dose, high speed homogenization 2-5 minutes is equal with 2000-5000rpm
Matter forms colostrum in 3-5 minutes；Then, using high pressure homogenizer, under 20-100MPa pressure, N is led to2Protection, by 1-10 times
Circulation, forms homogeneous emulsion, and the emulsion prepared successively uses 0.45 μm and 0.22 μm of miillpore filter pressure filtration, packing
Sterilized afterwards using flowing steam, flowing steam sterilization condition is 100 DEG C, 30 minutes.
4. a kind of preparation method of vitaminAD E microemulsion injections for animals according to claim 2, it is characterised in that on
State whole logical N in preparation method2Protection.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710310433.0A CN107115349A (en) | 2017-05-05 | 2017-05-05 | A kind of vitaminAD E microemulsion injections for animals and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201710310433.0A CN107115349A (en) | 2017-05-05 | 2017-05-05 | A kind of vitaminAD E microemulsion injections for animals and preparation method thereof |
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| CN107115349A true CN107115349A (en) | 2017-09-01 |
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| CN201710310433.0A Pending CN107115349A (en) | 2017-05-05 | 2017-05-05 | A kind of vitaminAD E microemulsion injections for animals and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498607A (en) * | 2018-12-04 | 2019-03-22 | 宁夏智弘生物科技有限公司 | A kind of vitaminAD E injection for animals and preparation method |
| CN112121006A (en) * | 2020-11-02 | 2020-12-25 | 苏州素仕生物科技有限公司 | Vitamin ADE composition for injection livestock and preparation method thereof |
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| CN1596882A (en) * | 2004-07-22 | 2005-03-23 | 沈阳药科大学 | Vitamin K1 emulsion and its freeze-dried emulsion and preparation method |
| CN101073580A (en) * | 2007-06-22 | 2007-11-21 | 北京润德康医药技术有限公司 | Compsoite vitamin injection and its production |
| CN101703468A (en) * | 2009-11-30 | 2010-05-12 | 浙江大学 | Nano-emulsion of vitamin E oil and preparation method thereof |
| CN102552293A (en) * | 2011-12-31 | 2012-07-11 | 沈阳药科大学 | Compound vitamin submicron emulsion lyophilized powder for injection and preparation method of compound vitamin submicron emulsion lyophilized powder |
| CN104337829A (en) * | 2014-05-29 | 2015-02-11 | 西安力邦肇新生物科技有限公司 | Bottled grease micro emulsion freeze-dried preparation with 13 composite vitamins |
-
2017
- 2017-05-05 CN CN201710310433.0A patent/CN107115349A/en active Pending
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1596882A (en) * | 2004-07-22 | 2005-03-23 | 沈阳药科大学 | Vitamin K1 emulsion and its freeze-dried emulsion and preparation method |
| CN101073580A (en) * | 2007-06-22 | 2007-11-21 | 北京润德康医药技术有限公司 | Compsoite vitamin injection and its production |
| CN101703468A (en) * | 2009-11-30 | 2010-05-12 | 浙江大学 | Nano-emulsion of vitamin E oil and preparation method thereof |
| CN102552293A (en) * | 2011-12-31 | 2012-07-11 | 沈阳药科大学 | Compound vitamin submicron emulsion lyophilized powder for injection and preparation method of compound vitamin submicron emulsion lyophilized powder |
| CN104337829A (en) * | 2014-05-29 | 2015-02-11 | 西安力邦肇新生物科技有限公司 | Bottled grease micro emulsion freeze-dried preparation with 13 composite vitamins |
Non-Patent Citations (1)
| Title |
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| "《药剂学》" * |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN109498607A (en) * | 2018-12-04 | 2019-03-22 | 宁夏智弘生物科技有限公司 | A kind of vitaminAD E injection for animals and preparation method |
| CN112121006A (en) * | 2020-11-02 | 2020-12-25 | 苏州素仕生物科技有限公司 | Vitamin ADE composition for injection livestock and preparation method thereof |
| CN112121006B (en) * | 2020-11-02 | 2021-05-11 | 苏州素仕生物科技有限公司 | Vitamin ADE composition for injection livestock and preparation method thereof |
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Application publication date: 20170901 |