CN111378020A - 通道视蛋白-2(Chop2)突变的鉴定及使用方法 - Google Patents
通道视蛋白-2(Chop2)突变的鉴定及使用方法 Download PDFInfo
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- C07K14/405—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from algae
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- A61P27/00—Drugs for disorders of the senses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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| CN202010025519.0A Pending CN111378020A (zh) | 2012-03-05 | 2013-03-05 | 通道视蛋白-2(Chop2)突变的鉴定及使用方法 |
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| EP2019588A4 (en) | 2006-05-04 | 2010-11-24 | Univ Wayne State | RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN |
| US9453241B2 (en) | 2010-05-04 | 2016-09-27 | Wayne State University | AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
| CN104334575A (zh) * | 2012-03-05 | 2015-02-04 | 韦恩州立大学 | 通道视蛋白-2(Chop2)突变的鉴定及使用方法 |
| CA2903545C (en) | 2013-03-14 | 2022-09-06 | Wayne State University | Method of enhancing delivery of therapeutic compounds to the eye |
| US10234761B2 (en) | 2013-07-08 | 2019-03-19 | Basf Se | Oxime ester photoinitiators |
| EP3117002B1 (en) | 2014-03-11 | 2025-12-03 | Wayne State University | A modified mglur6 promoter and methods of use |
| CA3022634A1 (en) | 2016-05-03 | 2017-11-09 | Wayne State University | Method of enhancing viral-mediated gene delivery in the eye using proteosome inhibitors |
| US20190218256A1 (en) * | 2016-06-03 | 2019-07-18 | MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. | Mutant light-inducible ion channel of channelrhodopsin |
| CN119979612A (zh) * | 2016-08-29 | 2025-05-13 | 韦恩州立大学 | 在具有改善光敏感性的通道视蛋白变体中突变的识别及其使用方法 |
| AU2017372351B2 (en) * | 2016-11-06 | 2019-12-12 | Nanoscope Technologies Llc | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
| CA3059652A1 (en) * | 2017-04-12 | 2018-10-18 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | New optogenetic tool |
| KR102756155B1 (ko) * | 2017-12-04 | 2025-01-20 | 라보라토리오스 에스에이엘브이에이티, 에스.에이. | 도베실산을 포함하는 후안부 질환 치료를 위한 안과용 국소 조성물 |
| JP6567153B1 (ja) * | 2018-09-28 | 2019-08-28 | 学校法人東北工業大学 | 対象化合物の特性の予測を行うための方法、コンピュータシステム、プログラム |
| WO2024226667A2 (en) * | 2023-04-24 | 2024-10-31 | Nanoscope Therapeutics Inc. | Optogenetic modulation by multi-characteristic opsins for vision restoration and other applications thereof |
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| US4554101A (en) | 1981-01-09 | 1985-11-19 | New York Blood Center, Inc. | Identification and preparation of epitopes on antigens and allergens on the basis of hydrophilicity |
| US4498919A (en) | 1983-10-31 | 1985-02-12 | Corning Glass Works | Method for making colored photochromic prescription ophthalmic lenses |
| US6610287B1 (en) | 1990-04-16 | 2003-08-26 | The General Hospital Corporation | Transfer and expression of gene sequences into nervous system cells using herpes simplex virus mutants with deletions in genes for viral replication |
| US5827702A (en) | 1994-10-31 | 1998-10-27 | Genentech, Inc. | Ocular gene therapy |
| CA2287495A1 (en) | 1997-04-21 | 1998-10-29 | University Of Florida | Materials and methods for treatment of retinal diseases |
| AU775245B2 (en) | 1998-09-17 | 2004-07-22 | Catholic University Nijmegen | Methods for treatment of degenerative retinal diseases |
| AU2001255575B2 (en) | 2000-04-28 | 2006-08-31 | The Trustees Of The University Of Pennsylvania | Recombinant aav vectors with aav5 capsids and aav5 vectors pseudotyped in heterologous capsids |
| WO2002082904A2 (en) | 2001-04-13 | 2002-10-24 | The Trustees Of The University Of Pennsylvania | Method of treating or retarding the development of blindness |
| US7144733B2 (en) | 2001-08-16 | 2006-12-05 | Sloan-Kettering Institute For Cancer Research | Bio-synthetic photostimulators and methods of use |
| DE10216005A1 (de) | 2002-04-11 | 2003-10-30 | Max Planck Gesellschaft | Verwendung von biologischen Photorezeptoren als direkt lichtgesteuerte Ionenkanäle |
| AU2003249318A1 (en) | 2002-07-18 | 2004-02-09 | The General Hospital Corp. | Method for augmenting vision in persons suffering from photoreceptor cell degeneration |
| US7186699B2 (en) | 2003-06-03 | 2007-03-06 | Cell Genesys, Inc. | Method for treating cancer by vector-mediated delivery of one or more anti-angiogenic or pro-apoptotic genes |
| WO2005044096A2 (en) | 2003-11-05 | 2005-05-19 | Neurovision, Inc. | Method for improving visual perception |
| US8906360B2 (en) | 2005-07-22 | 2014-12-09 | The Board Of Trustees Of The Leland Stanford Junior University | Light-activated cation channel and uses thereof |
| EP2019588A4 (en) | 2006-05-04 | 2010-11-24 | Univ Wayne State | RESTORATION OF VISUAL RESPONSES BY IN VIVO ADMINISTRATION OF NUCLEIC ACIDS OF RHODOPSIN |
| US9453241B2 (en) | 2010-05-04 | 2016-09-27 | Wayne State University | AAV-mediated subcellular targeting of heterologous rhodopsins in retinal ganglion cells |
| BR112013005634A2 (pt) * | 2010-09-08 | 2017-06-27 | Max Planck Gesellschaft | canal-rodopsina 2 mutante |
| CN104334575A (zh) * | 2012-03-05 | 2015-02-04 | 韦恩州立大学 | 通道视蛋白-2(Chop2)突变的鉴定及使用方法 |
| KR101639859B1 (ko) | 2014-03-06 | 2016-07-14 | 포항공과대학교 산학협력단 | 광 자극에 의한 미토콘드리아 활성의 시공간적 가역 조절 방법 |
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2017
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2018
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2019
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2021
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2024
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| ANDRÉ BERNDT等: "High-efficiency channelrhodopsins for fast neuronal stimulation at low light levels", 《PNAS》 * |
| SONJA KLEINLOGEL等: "Ultra light-sensitive and fast neuronal activation with the Ca2+-permeable channelrhodopsin CatCh", 《NATURE NEUROSCIENCE》 * |
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