CN111372945A - 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗特发性肺间质纤维化 - Google Patents
基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗特发性肺间质纤维化 Download PDFInfo
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/26—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
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- Organic Chemistry (AREA)
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Abstract
一类具有胰高血糖素样肽‑1受体(Glucagon‑like peptide‑1 receptor，GLP‑1R)和胰高血糖素受体(Glucagon receptor，GCGR)双激动效应的多肽化合物的用途，其具有高酶解稳定性、高生物活性、无不良反应等特点，能够明显抑制TGF‑β1诱导的人肺上皮细胞成纤维化转化增殖，能明显改善博莱霉素诱导的小鼠肺纤维化程度。该类双靶点激动剂多肽可用于预防或治疗以纤维化症状为指症的肺病。
Description
PCT国内申请，说明书已公开。
Claims (10)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2017110801851 | 2017-11-06 | ||
| CN201711080185 | 2017-11-06 | ||
| PCT/CN2018/111034 WO2019085773A1 (zh) | 2017-11-06 | 2018-10-19 | 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗特发性肺间质纤维化 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN111372945A true CN111372945A (zh) | 2020-07-03 |
| CN111372945B CN111372945B (zh) | 2024-02-02 |
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| Application Number | Title | Priority Date | Filing Date |
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| CN201880069847.1A Active CN111372945B (zh) | 2017-11-06 | 2018-10-19 | 基于胃泌酸调节素类似物glp-1r/gcgr双靶点激动剂多肽治疗特发性肺间质纤维化 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN111372945B (zh) |
| TW (1) | TW201918259A (zh) |
| WO (1) | WO2019085773A1 (zh) |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112791178A (zh) * | 2021-01-22 | 2021-05-14 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双激动剂多肽衍生物预防或治疗肾纤维化 |
| WO2024008058A1 (zh) * | 2022-07-04 | 2024-01-11 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物及其应用 |
| CN112791178B (zh) * | 2021-01-22 | 2024-10-29 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双激动剂多肽衍生物预防或治疗肾纤维化 |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN114585640B (zh) * | 2020-09-28 | 2024-06-14 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双靶点激动剂多肽衍生物治疗病毒性肝炎相关的肝纤维化 |
| CN115932139B (zh) * | 2022-10-14 | 2024-05-28 | 上海吉奉生物科技有限公司 | 芴甲氧羰基-s-二棕榈酰-l-半胱氨酸纯度检测方法 |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104926934A (zh) * | 2014-09-23 | 2015-09-23 | 蒋先兴 | 胃泌酸调节素类似物 |
| CN105792851A (zh) * | 2013-09-13 | 2016-07-20 | 加州生物医学研究所 | 修饰的治疗剂及其组合物 |
| CN106046145A (zh) * | 2016-04-22 | 2016-10-26 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双靶点激动剂多肽治疗脂肪肝病、高脂血症和动脉硬化 |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2471811B1 (en) * | 2006-02-22 | 2015-09-16 | Merck Sharp & Dohme Corp. | Oxyntomodulin derivatives |
| KR102321339B1 (ko) * | 2013-07-18 | 2021-11-02 | 맨카인드 코포레이션 | 열-안정성 건조 분말 약제학적 조성물 및 방법 |
| TWI802396B (zh) * | 2014-09-16 | 2023-05-11 | 南韓商韓美藥品股份有限公司 | 長效glp-1/高血糖素受體雙促效劑治療非酒精性脂肝疾病之用途 |
| MA41794A (fr) * | 2015-03-18 | 2018-01-23 | The California Institute For Biomedical Res | Agents thérapeutiques modifiés et compositions associées |
| JP2018530319A (ja) * | 2015-09-03 | 2018-10-18 | ナチュラル シールド イスラエル ２０１６ リミテッドＮａｔｕｒａｌ Ｓｈｉｅｌｄ Ｉｓｒａｅｌ ２０１６ Ｌｔｄ | 血糖値の制御、肝保護、及び関連する病状の予防及び治療のための組み合わせられた組成物 |
-
2018
- 2018-10-19 CN CN201880069847.1A patent/CN111372945B/zh active Active
- 2018-10-19 WO PCT/CN2018/111034 patent/WO2019085773A1/zh active Application Filing
- 2018-11-06 TW TW107139333A patent/TW201918259A/zh unknown
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105792851A (zh) * | 2013-09-13 | 2016-07-20 | 加州生物医学研究所 | 修饰的治疗剂及其组合物 |
| CN104926934A (zh) * | 2014-09-23 | 2015-09-23 | 蒋先兴 | 胃泌酸调节素类似物 |
| WO2016045400A1 (zh) * | 2014-09-23 | 2016-03-31 | 蒋先兴 | 胃泌酸调节素类似物 |
| CN106046145A (zh) * | 2016-04-22 | 2016-10-26 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双靶点激动剂多肽治疗脂肪肝病、高脂血症和动脉硬化 |
| CA3021933A1 (en) * | 2016-04-22 | 2017-10-26 | Shenzhen Turier Biotech Co., Ltd. | Glp-1r/gcgr dual target agonist polypeptide for treatment of fatty liver diseases, hyperlipemia and arteriosclerosis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112791178A (zh) * | 2021-01-22 | 2021-05-14 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双激动剂多肽衍生物预防或治疗肾纤维化 |
| CN112791178B (zh) * | 2021-01-22 | 2024-10-29 | 深圳市图微安创科技开发有限公司 | Glp-1r/gcgr双激动剂多肽衍生物预防或治疗肾纤维化 |
| WO2024008058A1 (zh) * | 2022-07-04 | 2024-01-11 | 北京惠之衡生物科技有限公司 | 一种glp-1受体和gcg受体共激动多肽衍生物及其应用 |
Also Published As
| Publication number | Publication date |
|---|---|
| CN111372945B (zh) | 2024-02-02 |
| TW201918259A (zh) | 2019-05-16 |
| WO2019085773A1 (zh) | 2019-05-09 |
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