CN111359002A - RuCu2O光热促愈合创可贴的制备方法 - Google Patents

RuCu2O光热促愈合创可贴的制备方法 Download PDF

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CN111359002A
CN111359002A CN202010352378.3A CN202010352378A CN111359002A CN 111359002 A CN111359002 A CN 111359002A CN 202010352378 A CN202010352378 A CN 202010352378A CN 111359002 A CN111359002 A CN 111359002A
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郑斌
郭明明
明东
甘霖
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Tianjin University
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Abstract

本发明涉及一种RuCu2O光热促愈合创可贴的制备方法，具体为：依次加入RuCl3·xH2O的TEG溶液、PVP的TEG溶液、CTAB的T EG溶液。加入TEG使反应液总体积为8mL充分搅拌,得酒红色透明液体。170℃加热搅拌,溶液颜色由酒红至墨绿再至浅黄,最后得到棕黑色透明胶体溶液。所制得的Ru胶体溶液长时间放置无沉淀，通过改变CTAB的加入量可以得到不同的Ru纳米颗粒，Ru胶体溶液经丙酮处理，得Ru纳米颗粒沉淀,用乙醇重新分散后备用。然后将Ru胶体加入到PVP和Cu(NO3)2的混合溶液中。将所制得的RuCu2O粘贴在创可贴的内层，即RuCu2O光热促愈合创可贴。该创可贴在近红外照射下可以有效去除外伤处的细菌，铜离子可以促进伤口的愈合，为外伤的治疗提供了新的方法。

Description

RuCu2O光热促愈合创可贴的制备方法
技术领域
本发明属于纳米医学领域，涉及一种RuCu2O光热促愈合创可贴的制备方法，该创可贴可在近红外下有高效率的杀菌功能和促进伤口愈合的功能。
背景技术
细菌依旧是引起一些疾病的重要因素，细菌感染对人类健康、食品安全等带来了重大威胁。目前，抗生素是杀菌的一种较为常用的手段，而抗生素的广泛使用使大部分细菌进化出耐药性，使灭菌的效率大大降低。目前创可贴中药物部分对于杀菌起到的作用很小，促伤口愈合作用远达不到预想的结果。
金属抗菌早在细菌被发现时就出现了，已经被人类使用了近四百年。大部分金属虽有抗菌性能，但效率较低，因此金属光热杀菌被广泛应用。钌(Ru)是一种硬而脆呈浅灰色的多价稀有金属元素，是铂族金属中的一员。钌的性质很稳定，耐腐蚀性很强，常温即能耐盐酸、硫酸、硝酸以及王水的腐蚀，具有良好的光热效果。Cu+可以促进伤口愈合。
因此，我们设计了一种方便携带的RuCu2O光热促愈合创可贴，一方面，可以较好的光热杀菌，另一方面Cu+促进伤口愈合。此创可贴可以达到杀菌与促愈合一体化的目的。
发明内容
本发明目的在于克服现有技术的不足，提供一种RuCu2O光热促愈合创可贴的制备方法。
本发明的技术方案是RuCu2O光热促愈合创可贴的制备方法，包括如下步骤：
1)依次加入RuCl3·xH 2O的TEG溶液(20mmol·L-1)1ml、PVP的TEG溶液(200mmol·L-1)2mlCTAB的T EG溶液(200mmol·L-1)0.1m l；
2)加入TEG使反应液总体积为8mL充分搅拌,得酒红色透明液体；
3)170℃加热搅拌＝溶液颜色由酒红至墨绿再至浅黄,最后得到棕黑色透明胶体溶液；
4)所制得的Ru胶体溶液长时间放置无沉淀，通过改变CTAB的加入量＝得到不同的Ru纳米颗粒，Ru胶体溶液经丙酮处理，得Ru纳米颗粒沉淀,用乙醇重新分散后备用；
5)然后将Ru胶体加入到10mL PVP(5mg/mL)和Cu(NO3)2(0.1M)的混合溶液中，大力搅拌＝后,加入10μL N2H4·3H2O(35wt％)；
6)将所制得的RuCu2O粘贴在创可贴的内层，即RuCu2O光热促愈合创可贴。
制备出的创可贴有以下几大优点：
1)Ru具有较好的光热性能，更高效的杀灭细菌；
2)铜离子具有促进伤口愈合的功能，在治疗外伤的过程中还促进伤口的愈合，具有双重功能；3)制作成为创可贴的形式方便携带。
具体实施方式
以下结合实施例对本发明作进一步的说明。
实施例1：
RuCu2O光热促愈合创可贴的制备方法：
1)在50ml圆底烧瓶中依次加入RuCl3·xH 2O的TEG溶液(20mmol·L-1)1ml、PVP的TEG溶液(200mmol·L-1)2ml CTAB的T EG溶液(200mmol·L-1)0.1m l。
2)加入适量TEG使反应液总体积为8mL.充分搅拌,得酒红色透明液体。
3)170℃油浴加热搅拌24h,溶液颜色由酒红至墨绿再至浅黄,最后得到棕黑色透明胶体溶液。
4)所制得的Ru胶体溶液长时间放置无沉淀，通过改变CTAB的加入量可以得到不同的Ru纳米颗粒，Ru胶体溶液经丙酮处理，得Ru纳米颗粒沉淀,用乙醇重新分散后备用。
5)然后将Ru胶体加入到10mL PVP(5mg/mL)和Cu(NO3)2(0.1M)的混合溶液中。大力搅拌30分钟后,加入10μL N2H4·3H2O(35wt％)。
6)将所制得的RuCu2O粘贴在创可贴的内层，即RuCu2O光热促愈合创可贴。
实施例2：
RuCu2O光热促愈合创可贴的制备方法：
1)在50ml圆底烧瓶中依次加入RuCl3·xH2O的TEG溶液(20mmol·L-1)1ml、PVP的TEG溶液(200mmol·L-1)2ml CTAB的T EG溶液(200mmol·L-1)0.1m l。
2)加入适量TEG使反应液总体积为8mL.充分搅拌,得酒红色透明液体。
3)270℃油浴加热搅拌24h,溶液颜色由酒红至墨绿再至浅黄,最后得到棕黑色透明胶体溶液。
4)所制得的Ru胶体溶液长时间放置无沉淀，通过改变CTAB的加入量可以得到不同的Ru纳米颗粒，Ru胶体溶液经丙酮处理，得Ru纳米颗粒沉淀,用乙醇重新分散后备用。
5)然后将Ru胶体加入到10mL PVP(5mg/mL)和Cu(NO3)2(0.1M)的混合溶液中。大力搅拌30分钟后,加入10μL N2H4·3H2O(35wt％)。
6)将所制得的RuCu2O粘贴在创可贴的内层，即RuCu2O光热促愈合创可贴。
实施例3：
RuCu2O光热促愈合创可贴的制备方法：
1)在50ml圆底烧瓶中依次加入RuCl3·xH2O的TEG溶液(20mmol·L-1)1ml、PVP的TEG溶液(400mmol·L-1)2ml CTAB的TEG溶液(200mmol·L-1)0.1m l。
2)加入适量TEG使反应液总体积为8mL.充分搅拌,得酒红色透明液体。
3)170℃油浴加热搅拌24h,溶液颜色由酒红至墨绿再至浅黄，最后得到棕黑色透明胶体溶液。
4)所制得的Ru胶体溶液长时间放置无沉淀，通过改变CTAB的加入量可以得到不同的Ru纳米颗粒，Ru胶体溶液经丙酮处理，得Ru纳米颗粒沉淀,用乙醇重新分散后备用。
5)然后将Ru胶体加入到10mL PVP(5mg/mL)和Cu(NO3)2(0.1M)的混合溶液中。大力搅拌30分钟后,加入10μL N2H4·3H2O(35wt％)。
6)将所制得的RuCu2O粘贴在创可贴的内层，即RuCu2O光热促愈合创可贴。

Claims (1)

1.RuCu2O光热促愈合创可贴的制备方法，其特征在于，包括如下步骤：
1)依次加入RuCl3·xH 2O的TEG溶液(20mmol·L-1)1ml、PVP的TEG溶液(200mmol·L-1)2mlCTAB的T EG溶液(200mmol·L-1)0.1m l；
2)加入TEG使反应液总体积为8mL充分搅拌,得酒红色透明液体；
3)170℃加热搅拌＝溶液颜色由酒红至墨绿再至浅黄,最后得到棕黑色透明胶体溶液；
4)所制得的Ru胶体溶液长时间放置无沉淀，通过改变CTAB的加入量＝得到不同的Ru纳米颗粒，Ru胶体溶液经丙酮处理，得Ru纳米颗粒沉淀,用乙醇重新分散后备用；
5)然后将Ru胶体加入到10mL PVP(5mg/mL)和Cu(NO3)2(0.1M)的混合溶液中，大力搅拌后,加入10μL N2H4·3H2O(35wt％)；
6)将所制得的RuCu2O粘贴在创可贴的内层，即RuCu2O光热促愈合创可贴。
CN202010352378.3A 2020-04-28 2020-04-28 RuCu2O光热促愈合创可贴的制备方法 Pending CN111359002A (zh)

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Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844258B1 (en) * 2003-05-09 2005-01-18 Novellus Systems, Inc. Selective refractory metal and nitride capping
US20070054047A1 (en) * 2005-09-06 2007-03-08 Tokyo Electron Limited Method of forming a tantalum-containing layer from a metalorganic precursor
CN1947801A (zh) * 2006-01-27 2007-04-18 邢宪生 复合功能液态创口敷料及其用途
CN106824223A (zh) * 2016-12-31 2017-06-13 浙江工业大学 Ru‑Cu2O包裹Cu纳米线及其制备方法与应用
CN107432932A (zh) * 2017-08-01 2017-12-05 暨南大学 纳米钌复合材料及其制备方法和在载药和制备抗肿瘤药物中的应用
CN110051837A (zh) * 2019-04-08 2019-07-26 南京师范大学 一种CuO/ZnO/Au纳米粒子及其制备方法和应用

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6844258B1 (en) * 2003-05-09 2005-01-18 Novellus Systems, Inc. Selective refractory metal and nitride capping
US20070054047A1 (en) * 2005-09-06 2007-03-08 Tokyo Electron Limited Method of forming a tantalum-containing layer from a metalorganic precursor
CN1947801A (zh) * 2006-01-27 2007-04-18 邢宪生 复合功能液态创口敷料及其用途
CN106824223A (zh) * 2016-12-31 2017-06-13 浙江工业大学 Ru‑Cu2O包裹Cu纳米线及其制备方法与应用
CN107432932A (zh) * 2017-08-01 2017-12-05 暨南大学 纳米钌复合材料及其制备方法和在载药和制备抗肿瘤药物中的应用
CN110051837A (zh) * 2019-04-08 2019-07-26 南京师范大学 一种CuO/ZnO/Au纳米粒子及其制备方法和应用

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