CN111337683A

CN111337683A - Portable HIV detection device

Info

Publication number: CN111337683A
Application number: CN202010212883.8A
Authority: CN
Inventors: 邱宪波; 辛培; 王东; 张晓磊; 乔杉; 朱家君; 李双双; 杨殿龙; 杨文博; 董晓斌; 李益民
Original assignee: Beijing University of Chemical Technology; Beijing WanTai Biological Pharmacy Enterprise Co Ltd
Current assignee: Beijing University of Chemical Technology; Beijing WanTai Biological Pharmacy Enterprise Co Ltd
Priority date: 2020-03-24
Filing date: 2020-03-24
Publication date: 2020-06-26
Anticipated expiration: 2040-03-24
Also published as: CN111337683B

Abstract

The present disclosure relates to a portable HIV detection apparatus, comprising: a detection box (1) with a hollow inner cavity; a card slot (2) arranged in the hollow inner cavity and configured to receive an HIV urine colloidal gold immunochromatographic strip (A) to be tested; the shooting unit (3) is arranged in the hollow inner cavity, is positioned on the opposite side of the clamping groove (2), and is configured to acquire an image of the HIV urine colloidal gold immunochromatographic strip (A) in the clamping groove (2) and perform image processing; the controller is arranged in the hollow inner cavity, is in signal connection with the shooting unit (3), and is configured to receive the image processing data provided by the shooting unit (3) and perform qualitative judgment; the hollow inner cavity can form a closed darkroom for the shooting unit (3) to acquire images, and a paper slip inserting hole (16) is formed in the outer wall of the detection box (1) corresponding to the clamping groove (2). The embodiment of the disclosure has compact structure and occupies less space.

Description

Portable HIV detection device

Technical Field

The present disclosure relates to the field of medical detection, and in particular, to a portable Human Immunodeficiency Virus (HIV) detection apparatus.

Background

The current mainstream detection methods for HIV comprise nucleic acid detection and immunodetection, wherein the nucleic acid detection is used for detecting HIV virus and has high detection sensitivity; and the immunoassay is used for detecting HIV antibodies, has low detection sensitivity, but is more convenient to implement. Whether nucleic acid detection or immunoassay detection, the detection sample is mainly blood.

When the blood sample is used for HIV detection, besides the blood drawing operation needs specialized personnel, a plurality of complex operation steps are involved, and the blood sample is often completed by operating a plurality of detection instruments in specialized medical institutions such as hospitals. Therefore, this type of HIV detection that relies on blood as the test sample is difficult to perform in a rapid field environment (e.g., community or home).

In order to improve the detection efficiency of HIV and effectively control the prevalence of acquired immunodeficiency syndrome (namely AIDS), the development of a rapid HIV detection method aiming at urine or saliva samples has important practical significance.

Since the urine or saliva sample is obtained in a non-invasive manner, this facilitates the transfer of HIV testing from medical facilities to non-medical settings. In some related technologies, rapid detection Of HIV urine test paper strips is achieved on-site by a lateral flow chromatography (Point-Of-care testing, POCT).

Disclosure of Invention

Research shows that the equipment for detecting the HIV urine detection paper slip in the related technology occupies a large space, has high cost and is not beneficial to popularization and portable use of the detection device.

In view of this, the embodiments of the present disclosure provide a portable HIV detection apparatus, which occupies less space.

In one aspect of the present disclosure, there is provided a portable HIV detection apparatus comprising:

a detection box having a hollow inner cavity;

the clamping groove is arranged in the hollow inner cavity and is configured to receive an HIV urine colloidal gold immunochromatographic paper strip to be detected;

the shooting unit is arranged in the hollow inner cavity, is positioned at the opposite side of the clamping groove, and is configured to acquire an image of the HIV urine colloidal gold immunochromatographic strip in the clamping groove and perform image processing;

the controller is arranged in the hollow inner cavity, is in signal connection with the shooting unit, and is configured to receive the image processing data provided by the shooting unit and perform qualitative judgment;

the hollow inner cavity can form a closed darkroom for the shooting unit to acquire images, and a paper slip insertion hole is formed in the outer wall of the detection box corresponding to the clamping groove.

In some embodiments, the card slot is fixed on an inner side surface of a first side wall of the detection box, and the slip insertion port is located on a second side wall of the detection box, adjacent to the first side wall, and connected with the first side wall.

In some embodiments, the card slot comprises a rectangular frame comprising:

the accommodating cavity is configured to accommodate the HIV urine colloidal gold immunochromatographic strip and limit the HIV urine colloidal gold immunochromatographic strip in the vertical direction of the first side wall;

the first opening is arranged adjacent to the paper slip inserting opening and communicated between the accommodating cavity and the paper slip inserting opening; and

the second opening faces the shooting unit and is communicated with the accommodating cavity along the vertical direction of the second side wall.

In some embodiments, the rectangular frame further comprises:

a third opening located on at least one side of the accommodation chamber in a direction parallel to the first side wall and the second side wall, and communicating with the accommodation chamber;

the card slot further includes:

the elastic limiting piece is positioned in the third opening and is configured to limit the HIV urine colloidal gold immunochromatographic strip in the accommodating cavity in the direction parallel to the first side wall and the second side wall; and

the touch switch is connected with the elastic limiting part and is in signal connection with the controller, and the touch switch is configured to determine whether the HIV urine colloidal gold immunochromatographic strip is in place or not through the movement of the elastic limiting part and send a signal of in place to the controller.

In some embodiments, the photographing unit includes:

the first circuit board is configured to process the acquired image through a prestored image processing algorithm;

the camera is arranged on the surface of one side, close to the card slot, of the first circuit board, is in signal connection with the controller, and is configured to acquire an image of the HIV urine colloidal gold immunochromatographic strip in the card slot; and

the backlight plate is provided with a mounting hole matched with the outer contour shape and the size of the lens of the camera, sleeved on the lens of the camera through the mounting hole, connected with the first circuit board and configured to provide illumination light for the camera during image acquisition.

In some embodiments, the portable HIV detection apparatus further includes a display screen, disposed on a side of the first circuit board away from the card slot, in signal connection with the controller, and configured to display a qualitative determination result of the HIV urine colloidal gold immunochromatographic strip;

the third side wall of the detection box, which is far away from one side of the clamping groove, is provided with a through hole matched with the display screen in shape and size, the first circuit board and the display screen are fixedly arranged on the inner side surface of the third side wall, and at least part of the display screen is embedded in the through hole and exposed to the outer side of the third side wall.

In some embodiments, the portable HIV detection apparatus further comprises: a power supply module located within the hollow interior configured to supply power to the camera unit and the controller; the power supply module comprises a battery bin for containing a battery, the battery bin is located on the same side of the clamping groove and the shooting unit, and supports the surface, close to the clamping groove, of the first circuit board in a propping mode.

In some embodiments, the portable HIV detection apparatus further comprises:

the fixing frame is fixedly arranged in the hollow inner cavity, is positioned on one side, far away from the battery bin, of the shooting unit, is configured to abut against and support the surface, close to the clamping groove, of one side of the first circuit board together with the battery bin, and limits the backlight plate to slide.

In some embodiments, the controller comprises:

the single chip microcomputer control board is fixed on the inner side surface of a fourth side wall of the detection box through a plurality of connecting blocks, a preset gap is formed between the single chip microcomputer control board and the fourth side wall, and the fourth side wall is adjacent to a first side wall used for arranging the clamping groove in the detection box and a third side wall used for arranging the shooting unit;

in some embodiments, the portable HIV detection apparatus further comprises:

and the radio frequency identification module is arranged on the single chip microcomputer control board and is positioned between the single chip microcomputer control board and the inner side surface of the fourth side wall, and the radio frequency identification module is electrically connected with the single chip microcomputer control board and is configured to read data in a radio frequency identification card of a detected person so as to be convenient for the single chip microcomputer control board to carry out qualitative judgment according to the read data and the image processing data provided by the shooting unit.

In some embodiments, the single chip microcomputer control board comprises a Bluetooth module which is configured to communicate with the intelligent mobile terminal through a Bluetooth wireless link.

In some embodiments, the portable HIV detection apparatus further comprises:

the fixing frame is fixedly arranged in the hollow inner cavity, is positioned on one side, far away from the battery bin, of the shooting unit, is clamped with the single chip microcomputer control board, is configured to be abutted against and supported by the surface, close to one side of the clamping groove, of the first circuit board together with the battery bin, and limits the backlight board and the single chip microcomputer control board to slide.

In some embodiments, the power supply module further comprises a USB power supply line, and the controller is configured to stop supplying power to the battery compartment when the USB power supply line is powered on, and supply power to the battery compartment when the USB power supply line is not powered on.

Therefore, according to the embodiment of the disclosure, the hollow inner cavity of the detection box is provided with the clamping groove for receiving the HIV urine colloidal gold immunochromatographic paper strip, the shooting unit for collecting and analyzing the image of the paper strip in the clamping groove and the controller for qualitative judgment, the clamping groove and the shooting unit are oppositely arranged in the closed darkroom formed in the hollow inner cavity, the paper strip inserting hole communicated with the clamping groove is formed in the outer wall of the detection box, and the clamping groove, the shooting unit and the controller are arranged in the compact space in the detection box, so that the size of the device is effectively reduced, less space is occupied, and the portability is also improved.

Drawings

The accompanying drawings, which are incorporated in and constitute a part of this specification, illustrate embodiments of the disclosure and together with the description, serve to explain the principles of the disclosure.

The present disclosure may be more clearly understood from the following detailed description, taken with reference to the accompanying drawings, in which:

FIG. 1 is a schematic external structural view of some embodiments of a portable HIV detection device according to the present disclosure;

FIG. 2 is a schematic view of an internal mounting structure of some embodiments of a portable HIV detection device according to the present disclosure;

FIG. 3 is an exploded schematic view of the internal structure of some embodiments of a portable HIV detection device according to the present disclosure;

FIG. 4 is a schematic view of a mounting configuration of a card slot in some embodiments of the portable HIV detection device according to the present disclosure;

FIG. 5 is a schematic view of a portion of a camera unit in some embodiments of the portable HIV detection apparatus according to the present disclosure;

FIG. 6 is a schematic diagram of the construction of a backlight panel in some embodiments of portable HIV detection devices according to the present disclosure.

It should be understood that the dimensions of the various parts shown in the figures are not drawn to scale. Further, the same or similar reference numerals denote the same or similar components.

Detailed Description

Various exemplary embodiments of the present disclosure will now be described in detail with reference to the accompanying drawings. The description of the exemplary embodiments is merely illustrative and is in no way intended to limit the disclosure, its application, or uses. The present disclosure may be embodied in many different forms and is not limited to the embodiments described herein. These embodiments are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the disclosure to those skilled in the art. It should be noted that: the relative arrangement of parts and steps, the composition of materials, numerical expressions and numerical values set forth in these embodiments are to be construed as merely illustrative, and not as limitative, unless specifically stated otherwise.

The use of "first," "second," and similar terms in this disclosure is not intended to indicate any order, quantity, or importance, but rather are used to distinguish one element from another. The word "comprising" or "comprises", and the like, means that the element preceding the word covers the element listed after the word, and does not exclude the possibility that other elements are also covered. "upper", "lower", "left", "right", and the like are used merely to indicate relative positional relationships, and when the absolute position of the object being described is changed, the relative positional relationships may also be changed accordingly.

In the present disclosure, when a specific device is described as being located between a first device and a second device, there may or may not be intervening devices between the specific device and the first device or the second device. When a particular device is described as being coupled to other devices, that particular device may be directly coupled to the other devices without intervening devices or may be directly coupled to the other devices with intervening devices.

All terms (including technical or scientific terms) used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this disclosure belongs unless specifically defined otherwise. It will be further understood that terms, such as those defined in commonly used dictionaries, should be interpreted as having a meaning that is consistent with their meaning in the context of the relevant art and will not be interpreted in an idealized or overly formal sense unless expressly so defined herein.

Techniques, methods, and apparatus known to those of ordinary skill in the relevant art may not be discussed in detail but are intended to be part of the specification where appropriate.

FIG. 1 is a schematic diagram showing the external structure of some embodiments of the portable HIV detection device according to the present disclosure. Referring to fig. 1, in combination with fig. 2-6, in some embodiments, a portable HIV detection device includes: the detection box 1, the card slot 2, the shooting unit 3 and the controller. The cartridge 1 has a hollow inner cavity. The card slot 2 is arranged in the hollow inner cavity and is configured to receive an HIV urine colloidal gold immunochromatographic paper strip A to be tested. The shooting unit 3 is arranged in the hollow inner cavity, is positioned at the opposite side of the clamping groove 2, and is configured to acquire an image of the HIV urine colloidal gold immunochromatographic strip A in the clamping groove 2 and perform image processing. The shooting unit 3 can acquire the detection lines of the paper slip a, the control lines and the gray values of the background area through an image processing algorithm carried by the shooting unit, and provide the data as original detection data to the controller.

The controller is arranged in the hollow inner cavity, is in signal connection with the shooting unit 3, and is configured to receive the image processing data provided by the shooting unit 3 and make qualitative judgment based on a lateral flow chromatography technology. The controller may implement the qualitative determination process using existing lateral flow tomography, which is not described herein in view of the fact that lateral flow tomography is not the subject of the present disclosure. The hollow inner cavity can form a closed darkroom for the shooting unit 3 to acquire images, and a paper slip inserting hole 16 is formed in the outer wall of the detection box 1 corresponding to the clamping groove 2.

The embodiment sets up the draw-in groove of receiving HIV urine colloidal gold immunochromatography note in the cavity inner chamber of detection box, gather and the camera unit of the image of the interior note of analysis draw-in groove and the controller of carrying out qualitative judgement, make draw-in groove and camera unit set up relatively in the closed darkroom that the cavity inner chamber formed, and set up the note inserted hole with the draw-in groove intercommunication on the detection box outer wall, set up the draw-in groove through the compact space in the detection box, camera unit and controller, the device size has been compressed effectively, occupy less space, the portability has also been improved.

Referring to FIGS. 1 and 2, in some embodiments, the cartridge 1 may be a square or rectangular parallelepiped cartridge, and the cartridge may be made of an opaque material, such as plastic or metal. The hollow inner chamber of the detection box 1 can form a closed darkroom to avoid light outside the detection box 1 from entering the hollow inner chamber, thereby preventing adverse effects of light leakage on image acquisition of the shooting unit 3.

In fig. 2, the card slot 2 is fixed to the inner surface of the first side wall 11 of the cartridge 1, and the slip insertion slot 16 is located at a position on the second side wall 12 of the cartridge 1 adjacent to the first side wall 11 and in contact with the first side wall 11. Therefore, an operator can conveniently insert the HIV urine colloidal gold immunochromatographic paper strip A into the clamping groove 2 from the paper strip inserting port 16 directly, and the position for effective image acquisition is reached. And the draw-in groove is fixed at the inboard surface of first lateral wall 11 for inserted HIV urine colloidal gold immunochromatography note A can support under the limiting displacement of draw-in groove and lean on the inboard surface of first lateral wall 11, thereby can keep the position stability of note when image acquisition, avoids the note not hard up in the draw-in groove and influences the image acquisition effect.

Referring to fig. 3 and 4, in some embodiments, the card slot 2 includes a rectangular frame 21. The rectangular frame 21 includes: a receiving cavity, a first opening 22 and a second opening 23. The accommodating cavity is configured to accommodate the HIV urine colloidal gold immunochromatographic strip A and limit the HIV urine colloidal gold immunochromatographic strip A in the vertical direction of the first side wall 11. The first opening 22 is disposed adjacent to the slip insertion opening 16 and communicates between the accommodating chamber and the slip insertion opening 16. The second opening 23 is provided toward the photographing unit 3 and communicates with the accommodating chamber in a vertical direction of the second side wall 12. Thus, the shooting unit 3 can clearly shoot the image of the HIV urine colloidal gold immunochromatographic strip A in the containing cavity through the second opening.

In addition to the limiting effect on the HIV urine colloidal gold immunochromatographic strip a in the vertical direction of the first side wall 11, in order to prevent the HIV urine colloidal gold immunochromatographic strip a from loosening in other directions, referring to fig. 3 and 4, in some embodiments, the card slot 2 further includes an elastic limiting member 24. The elastic stopper 24 is configured to limit the HIV urine colloidal gold immunochromatographic strip a in the containing cavity in a direction parallel to the first side wall 11 and the second side wall 12.

In fig. 3 and 4, the rectangular frame 21 further includes: and a third opening located at least one side of the accommodation chamber in a direction parallel to the first side wall 11 and the second side wall 12, and communicating with the accommodation chamber. The elastic limiting piece 24 can be arranged at the third opening, so that interference in and out of the HIV urine colloidal gold immunochromatographic strip A can be avoided, and lateral extrusion force can be applied after the HIV urine colloidal gold immunochromatographic strip A enters, so that the HIV urine colloidal gold immunochromatographic strip A is prevented from shaking or falling out. In some embodiments, the rectangular frame 21 has two oppositely disposed third openings, and an elastic limiting member is disposed in each third opening, so as to obtain a more stable paper strip limiting effect.

Referring to fig. 4, in some embodiments, the card slot 2 may further include a touch switch 25. The touch switch 25 may be connected to the elastic limiting member 24 and connected to the controller via signals. The HIV urine colloidal gold immunochromatographic strip A can be determined whether to be in place or not through the movement of the elastic limiting piece 24, and an in-place signal is sent to the controller. Therefore, the controller can know the in-place condition of the HIV urine colloidal gold immunochromatographic paper strip A in time so as to determine whether the test preparation is finished.

In fig. 4, the elastic limiting member 24 may include a metal sheet bent at a certain angle (e.g., 120 ° to 150 °), one end of which may be fixed outside the rectangular frame 21, and the other end of which is close to or abuts against the touch switch 25 on a side away from the rectangular frame 21. The bending part between the two ends of the elastic limiting part 24 enters the third opening and can be tightly propped against the side edge of the paper slip when the HIV urine colloidal gold immunochromatographic paper slip A is inserted into the accommodating cavity.

Referring to fig. 2-3 and 5-6, in some embodiments, the photographing unit 3 includes: a first circuit board 31, a camera 32 and a backlight plate 34. The first circuit board 31, the camera 32 and the backlight plate 34 are compactly integrated, and can occupy less space and consume less power, thereby having a longer operation time.

The camera 32 is disposed on the surface of the first circuit board 31 adjacent to one side of the card slot 2, is in signal connection with the controller, and is configured to acquire an image of the HIV urine colloidal gold immunochromatographic strip a in the card slot 2. The first circuit board 31 can process the captured image through a pre-stored image processing algorithm. The relative position of the camera 32 and the card slot 2 is fixed, and when the camera 32 is installed, the focal length of the camera 32 can be set to a value capable of clearly shooting the surface of the paper slip.

The backlight 34 may employ a uniform green or white light source. In some embodiments, the backlight 34 specifically includes LED light sources, circuit boards, light guide plates, reflective films, diffusion films, light shielding films, and the like. Light emitted from the LED light source can be emitted in the direction of the card slot 2 via the light guide plate and the diffusion film. The backlight plate 34 can provide illumination light to the camera 32 during image capture, so that the camera 32 captures a clearer image.

In fig. 3, the backlight plate 34 has a mounting hole 34a that matches the shape and size of the outer contour of the lens of the camera 32. The backlight plate 34 can be sleeved on the lens of the camera 32 through the mounting hole 34a and can be connected with the first circuit board 31 through a wire 34 b. The backlight plate 34 sleeved on the lens can be closer to the surface of the detected paper slip, so that shadows generated in the illumination process can be effectively eliminated, and the detection effect is ensured.

Referring to fig. 2 and 3, in some embodiments, the portable HIV detection apparatus further comprises: a display screen 8. The display screen 8 may be a liquid crystal display screen, an organic light emitting diode display screen, or the like. The display screen 8 is arranged on one side of the first circuit board 31 far away from the card slot 2, is in signal connection with the controller, and is configured to display the qualitative judgment result of the HIV urine colloidal gold immunochromatographic strip A.

In fig. 1 and 3, a third side wall 13 of the detection box 1 on the side far away from the card slot 2 is provided with a through hole 15 matching with the shape and size of the display screen 8. The first circuit board 31 and the display screen 8 are both fixedly arranged on the inner side surface of the third side wall 13, and the display screen 8 is at least partially embedded in the through hole 15 and exposed to the outer side of the third side wall 13. Since the display screen 8 itself is thin and is attached to the third side wall 13 and partially embedded in the through hole 15, it occupies only a small amount of space inside the cartridge 1 in its thickness direction. In addition, the display screen 8 can also form abutting support of surface contact with the first circuit board 31 of the shooting unit 3, and the mounting stability of the display screen 8 is improved.

Referring to fig. 2 and 3, in some embodiments, the portable HIV detection apparatus further comprises: a power supply module 4 located within the hollow interior. The power supply module 4 can supply power to the photographing unit 3 and the controller. To improve portability, the power module 4 may include a battery compartment 41 for housing a battery. The battery compartment 41 may be disposed on the same side of the card slot 2 and the photographing unit 3, and may support against a surface of the first circuit board 31 adjacent to the side of the card slot 2. A cover plate 42 may be disposed outside the battery compartment 41 to enclose the battery compartment 41, and a replaceable battery 43 (e.g., an alkaline battery) or a rechargeable battery (e.g., a lithium battery) may be disposed inside the battery compartment 41.

In other embodiments, the power supply module 4 may also include other power supply lines, such as USB power supply lines, to implement dual or multiple power management functions. The controller may stop the power supply to the battery compartment 41 when the USB power supply line is powered on, and may supply the power to the battery compartment 41 when the USB power supply line is not powered on. Therefore, the portable HIV detection device is more flexible to use and is suitable for various different power supply environments.

In fig. 2, the portable HIV detection apparatus may further include: and the fixing frame 7 is fixedly arranged in the hollow inner cavity. The fixing frame 7 may be located on a side of the shooting unit 3 away from the battery compartment 41, and configured to support, together with the battery compartment 41, a surface of the first circuit board 31 adjacent to the side of the card slot 2, and limit, together with the battery compartment 41, sliding of the backlight board 34. This makes full use of the battery compartment 41 and the holder 7 to achieve effective fixing of the components in the photographing unit 3, and eliminates the internal space occupied by a dedicated fixing structure for the photographing unit 3.

Referring to fig. 2 and 3, in some embodiments, the controller includes: a single chip microcomputer control board 51. The single chip microcomputer control board 51 can be fixed on the inner side surface of the fourth side wall 14 of the detection box 1 through a plurality of connecting blocks, and a preset gap is formed between the single chip microcomputer control board and the fourth side wall 14. In fig. 2, four corners of the one-chip microcomputer control board 51 may be provided with

connection blocks

52a, 52b, 52c, and 52d, respectively. Four screw holes 17 are provided in the fourth side wall 14 corresponding to the positions of the respective connector blocks, and the single chip microcomputer control board 51 can be reliably fixed to the inner side surface of the fourth side wall 14 by means of a connector such as a screw. The fourth side wall 14 here adjoins both the first side wall 11 and the third side wall 13.

Referring to fig. 2, in some embodiments, the portable HIV detection apparatus further includes a Radio Frequency Identification (RFID) module 6. The RFID module 6 may be disposed on the one-chip microcomputer control board 51 between the one-chip microcomputer control board 51 and the inner side surface of the fourth side wall 14. The RFID module 6 is disposed between the single chip microcomputer control board 51 and the fourth sidewall 14, occupies a small space in the vertical direction of the fourth sidewall 14, and is closer to the fourth sidewall 14, so that the signal is more sensitive when the RFID card is identified.

The RFID module 6 is electrically connected to the single chip microcomputer control board 51, and is configured to read data in an RFID card of a subject, so that the single chip microcomputer control board 51 performs qualitative judgment according to the read data and an image acquired by the shooting unit 3. For example, different detection standards may need to be used for different types and batches of paper strips to be detected. Accordingly, the data of the RFID card can be read by the RFID module 6 to determine the appropriate detection standard, so as to meet the detection requirements of different types of paper strips to be detected.

In fig. 3, the fixing frame can also be clamped with the single chip microcomputer control board 51. One side of the fixing frame adjacent to the fourth side wall 14 can be provided with a groove for clamping the end part of the singlechip control board 51 adjacent to one side of the shooting unit, so that the fixing frame and the singlechip control board 51 can be at least partially overlapped in the thickness direction, and the size of the inner space is further reduced. The fixing frame 7 and the battery compartment 41 can jointly support the surface of the first circuit board 31 adjacent to one side of the card slot 2 in a leaning manner, and limit the backlight board 34 and the singlechip control board 51 from sliding.

In some embodiments, the single chip microcomputer control board 51 includes a bluetooth module configured to communicate with the smart mobile terminal through a bluetooth wireless link. When the singlechip control board 51 obtains a detection result of qualitative judgment according to the image acquired by the shooting unit 3, the detection result can be transmitted to an intelligent mobile terminal (such as an intelligent mobile phone) in real time through the Bluetooth module, and further transmitted to a remote medical monitoring center as required.

In FIG. 1,

buttons

18a and 18b may be provided on the outside of the cartridge 1. Button 18a may be used to power the device on and off and button 18b may be used to detect the initiation of a procedure. When the button 18b is pressed, the one-chip microcomputer control board 51 can issue a control instruction to the photographing unit 3 to control the camera to take a photograph. The single chip microcomputer control board 51 can display the qualitative detection result through the liquid crystal screen 8 through image processing and analysis and judgment, and send the qualitative detection result to the intelligent mobile terminal through the Bluetooth module.

The operation of some embodiments of the portable HIV testing device will now be described with reference to FIGS. 1-6 and the foregoing embodiments.

The operator may first open the button 18a and bring the RFID card close to the RFID detection area (i.e., the fourth side wall 14), read the information stored in the RFID card through the RFID module, and display it on the display screen 8. Next, the operator may insert the fully reacted HIV urine colloidal gold immunochromatographic strip a into the card slot 2 through the strip insertion port 16. When the slip is inserted in place, the touch switch 25 can send an in-place signal to the single chip microcomputer control board 51. The single chip microcomputer control board 51 can display prompt information such as 'paper slip is completely inserted' through the display screen to indicate that the preparation work before the test is finished at the moment.

The operator can press button 18b to initiate the testing process. In the detection process, the camera 32 collects the image information of the HIV urine colloidal gold immunochromatographic paper strip A, then the original data such as the gray values of the paper strip detection line, the control line and the background area are obtained through the image processing algorithm of the driving chip in the camera module, and then the data are sent to the singlechip control board 51. The singlechip control board 51 carries out qualitative judgment according to the data, displays the detection result of the qualitative judgment through the display screen 8, and simultaneously transmits the detection result to the smart phone of the operator through the Bluetooth module, so that the detection result can be conveniently checked through the smart phone. The process of detecting multiple slips can be performed by repeating the above steps.

By way of illustration of the above-described embodiments of the portable HIV detection device of the present disclosure, at least one of the above-described embodiments of the present disclosure has the following advantages:

1. the portable HIV detection device disclosed by the invention can realize the rapid qualitative detection of HIV by combining HIV colloidal gold immunochromatographic paper strips aiming at urine samples, thereby providing a non-invasive HIV rapid detection supporting instrument for HIV detection prevention and control of basic medical institutions, communities and even families;

2. for an operator, the portable HIV detection device can realize convenient detection operation by fewer keys without professional training on the operator;

3. the portable HIV detection device is compact in structural design, maximally reduces the size of the device, supports handheld use, and remarkably reduces the instrument cost while ensuring the detection effect through optimized integration of an optical mechanical electrical integration system;

4. the detection result of the portable HIV detection device can be displayed on the display screen of the detection box, the detection result transmitted by the Bluetooth module can be checked through the smart phone, and the detection structure can be further transmitted to a specialized medical monitoring data center, so that efficient real-time HIV prevention and control monitoring is realized.

Thus, various embodiments of the present disclosure have been described in detail. Some details that are well known in the art have not been described in order to avoid obscuring the concepts of the present disclosure. It will be fully apparent to those skilled in the art from the foregoing description how to practice the presently disclosed embodiments.

Although some specific embodiments of the present disclosure have been described in detail by way of example, it should be understood by those skilled in the art that the foregoing examples are for purposes of illustration only and are not intended to limit the scope of the present disclosure. It will be understood by those skilled in the art that various changes may be made in the above embodiments or equivalents may be substituted for elements thereof without departing from the scope and spirit of the present disclosure. The scope of the present disclosure is defined by the appended claims.

Claims

1. A portable HIV detection apparatus, comprising:

a detection box (1) with a hollow inner cavity;

a card slot (2) arranged in the hollow inner cavity and configured to receive an HIV urine colloidal gold immunochromatographic strip (A) to be tested;

the shooting unit (3) is arranged in the hollow inner cavity, is positioned on the opposite side of the clamping groove (2), and is configured to acquire an image of the HIV urine colloidal gold immunochromatographic strip (A) in the clamping groove (2) and perform image processing;

the controller is arranged in the hollow inner cavity, is in signal connection with the shooting unit (3), and is configured to receive the image processing data provided by the shooting unit (3) and perform qualitative judgment;

the hollow inner cavity can form a closed darkroom for the shooting unit (3) to acquire images, and a paper slip inserting hole (16) is formed in the outer wall of the detection box (1) corresponding to the clamping groove (2).

2. The portable HIV testing device according to claim 1, wherein the card slot (2) is fixed on the inner side surface of a first side wall (11) of the test case (1), and the paper slip insertion port (16) is located on a second side wall (12) of the test case (1) adjacent to the first side wall (11) and in contact with the first side wall (11).

3. The portable HIV detection device according to claim 2, characterized in that said card slot (2) comprises a rectangular frame (21), said rectangular frame (21) comprising:

a containing cavity configured to contain the HIV urine colloidal gold immunochromatographic strip (A) and limit the HIV urine colloidal gold immunochromatographic strip (A) in the vertical direction of the first side wall (11);

a first opening (22) disposed adjacent to the slip insertion opening (16) and communicating between the accommodating chamber and the slip insertion opening (16); and

and the second opening (23) is arranged towards the shooting unit (3) and communicated with the accommodating cavity along the vertical direction of the second side wall (12).

4. The portable HIV detection device according to claim 3, characterized in that said rectangular frame (21) further comprises:

a third opening located on at least one side of the housing chamber in a direction parallel to the first side wall (11) and the second side wall (12) and communicating with the housing chamber;

the card slot (2) further comprises:

an elastic stopper (24) located in the third opening and configured to stop the HIV urine colloidal gold immunochromatographic strip (A) in the containing cavity in a direction parallel to the first side wall (11) and the second side wall (12); and

the touch switch (25) is connected with the elastic limiting piece (24) and is in signal connection with the controller, and is configured to determine whether the HIV urine colloidal gold immunochromatographic paper strip (A) is in place or not through the movement of the elastic limiting piece (24) and send a place signal to the controller.

5. The portable HIV detection device according to claim 1, characterized in that said shooting unit (3) comprises:

a first circuit board (31) configured to process the acquired image by a pre-stored image processing algorithm;

the camera (32) is arranged on the surface of one side, adjacent to the card slot (2), of the first circuit board (31), is in signal connection with the controller, and is configured to acquire an image of the HIV urine colloidal gold immunochromatographic paper strip (A) in the card slot (2); and

the backlight plate (34) is provided with a mounting hole (34a) matched with the outer contour shape and size of the lens of the camera (32), the backlight plate (34) is sleeved on the lens of the camera (32) through the mounting hole (34a), is connected with the first circuit board (31), and is configured to provide illumination light for the camera (32) during image acquisition.

6. The portable HIV detection device of claim 5, further comprising: the display screen (8) is arranged on one side, far away from the card slot (2), of the first circuit board (31), is in signal connection with the controller, and is configured to display the qualitative judgment result of the HIV urine colloidal gold immunochromatographic strip (A);

the detection box (1) is far away from third lateral wall (13) on one side of the clamping groove (2) is provided with a through hole (15) matched with the shape and the size of the display screen (8), the first circuit board (31) and the display screen (8) are fixedly arranged on the inner side surface of the third lateral wall (13), and the display screen (8) is at least partially embedded in the through hole (15) and exposed to the outer side of the third lateral wall (13).

7. The portable HIV detection device of claim 5, further comprising: a power supply module (4) located within the hollow interior configured to supply power to the camera unit (3) and the controller; the power supply module (4) comprises a battery bin (41) used for containing a battery, the battery bin (41) is located on the same side of the card slot (2) and the shooting unit (3), and supports the surface, close to the card slot (2), of the first circuit board (31) in an abutting mode.

8. The portable HIV detection device of claim 7, further comprising:

the fixing frame (7) is fixedly arranged in the hollow inner cavity, is positioned on one side, away from the battery bin (41), of the shooting unit (3), and is configured to support the surface, close to the clamping groove (2), of the first circuit board (31) in a propping mode together with the battery bin (41) and limit the backlight plate (34) to slide.

9. The portable HIV detection device of claim 1, wherein the controller comprises:

singlechip control board (51), fix through a plurality of connecting blocks detect the inboard surface of fourth lateral wall (14) of box (1), and with form between fourth lateral wall (14) and predetermine the clearance, fourth lateral wall (14) with be used for setting up in detecting box (1) first lateral wall (11) of draw-in groove (2) and be used for setting up third lateral wall (13) homogeneous phase of shooting unit (3) is adjoined.

10. The portable HIV detection device of claim 9, further comprising:

the radio frequency identification module (6) is arranged on the single chip microcomputer control board (51) and is positioned between the single chip microcomputer control board (51) and the inner side surface of the fourth side wall (14), the radio frequency identification module (6) is electrically connected with the single chip microcomputer control board (51) and is configured to read data in a radio frequency identification card of a detected person, so that the single chip microcomputer control board (51) can carry out qualitative judgment according to the read data and image processing data provided by the shooting unit (3).

11. The portable HIV detection device according to claim 9, characterized in that said single-chip microcomputer control board (51) comprises a Bluetooth module configured to communicate with an intelligent mobile terminal through a Bluetooth wireless link.

12. The portable HIV detection device of claim 9, further comprising:

the fixing frame (7) is fixedly arranged in the hollow inner cavity, is positioned on one side, away from the battery bin (41), of the shooting unit (3), is clamped with the single chip microcomputer control board (51), and is configured to be abutted against and supported by the surface, close to the clamping groove (2), of the first circuit board (31) together with the battery bin (41) and limit the backlight board (34) and the single chip microcomputer control board (51) to slide.

13. The portable HIV detection device according to claim 7, characterized in that said power supply module (4) further comprises a USB power supply line, said controller being configured to stop the power supply to said battery compartment (41) when said USB power supply line is powered, and to stop the power supply to said battery compartment (41) when said USB power supply line is not powered.