CN111329912A

CN111329912A - Application of radix paeoniae alba and peach kernel syrup in preparation of product for improving postpartum lochiorrhea

Info

Publication number: CN111329912A
Application number: CN202010108840.5A
Authority: CN
Inventors: 李伏君; 张鹏; 凌勇根; 白璐
Original assignee: Zhuzhou Qianjin Pharmaceutical Co Ltd
Current assignee: Zhuzhou Qianjin Pharmaceutical Co Ltd
Priority date: 2018-01-22
Filing date: 2018-01-22
Publication date: 2020-06-26
Also published as: CN110063998A

Abstract

The application is a divisional application with the application number of 201810060154.8, the application date of 2018, 01 and 22, and the invention name of 'syrup for promoting postpartum recovery and a preparation method and application thereof'. The invention relates to application of white paeony root-peach kernel syrup in preparing a product for improving postpartum lochiorrhea. The radix paeoniae alba and peach kernel syrup is prepared from the following raw materials in parts by weight: 5-50 parts of angelica sinensis, 2-20 parts of motherwort, 2-20 parts of peach kernels, 2-20 parts of white paeony roots, 2-20 parts of honey-fried licorice roots, 0.1-1 part of dried orange peels and 100-250 parts of auxiliary materials. The radix paeoniae alba and peach kernel syrup is reasonable in compatibility of raw materials, active ingredients are fully enriched through the extraction method, the synergistic effect is fully exerted after the extracts are mixed, and the overall curative effect of the syrup is improved. The radix paeoniae alba and peach kernel syrup can achieve the effects of enriching blood and tonifying qi, activating blood and removing blood stasis, can promote lochia to be discharged, has a promoting effect on quick recovery of uterus, can effectively treat postpartum anemia, is mild in effect but remarkable in effect, and is beneficial to quick recovery after childbirth.

Description

Application of radix paeoniae alba and peach kernel syrup in preparation of product for improving postpartum lochiorrhea

The application is a divisional application with the application number of 201810060154.8, the application date of 2018, 01 and 22, and the invention name of 'syrup for promoting postpartum recovery and a preparation method and application thereof'.

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to application of white paeony root and peach kernel syrup in preparation of a product for improving postpartum lochiorrhea.

Background

Postpartum refers to a period of time after childbirth of a pregnant woman. After birth, women lose a lot of nutrients and suffer many injuries, so that diet, nursing and recovery are very important for women during the period of time after birth. For example, postpartum hemorrhage, postpartum anemia, poor uterine recovery and other symptoms which are easy to appear after childbirth, such as the inability to quickly treat and recover, can seriously affect the health of women, even accompany with lifetime, and make it difficult for infants to obtain the full care of mothers.

At present, there is a need to develop a medicine or health care product capable of promoting postpartum recovery comprehensively to improve the physical health and living standard of modern women after birth.

Disclosure of Invention

The invention aims to overcome the defects and shortcomings of the existing product for promoting postpartum recovery, and provides application of white paeony root-peach kernel syrup in preparing the product for promoting postpartum recovery. The radix paeoniae alba and peach kernel syrup can achieve the effects of enriching blood and tonifying qi, and promoting blood circulation and removing blood stasis, and is beneficial to all-round rapid recovery of a lying-in woman.

The above purpose of the invention is realized by the following technical scheme:

specifically, the invention relates to a white peony root and peach kernel syrup. The radix paeoniae alba and peach kernel syrup is prepared from the following raw materials in parts by weight: 5-50 parts of angelica sinensis, 2-20 parts of motherwort, 2-20 parts of peach kernels, 2-20 parts of white paeony roots, 2-20 parts of honey-fried licorice roots, 0.1-1 part of dried orange peels and 100-250 parts of auxiliary materials.

The invention provides application of the white peony root-peach kernel syrup in preparation of a medicine or a health-care product for promoting postpartum recovery.

Specifically, the promotion of postpartum recovery comprises shortening of postpartum lochia excretion time, promotion of postpartum uterine recovery and/or treatment of postpartum anemia.

Therefore, the invention provides the application of the radix paeoniae alba and peach kernel syrup in preparing a medicine or health product for shortening the discharge time of postpartum lochia.

The invention provides application of the white peony root-peach kernel syrup in preparation of a medicine or a health-care product for promoting postpartum uterus recovery.

The invention provides application of white peony root-peach kernel syrup in preparation of a medicine or a health-care product for treating postpartum anemia.

Further preferably, the white peony root and peach kernel syrup is prepared from the following raw materials in parts by weight: 30-45 parts of angelica sinensis, 15-30 parts of motherwort, 10-25 parts of peach kernels, 12-18 parts of white paeony roots, 10-16 parts of honey-fried licorice roots, 0.2-0.8 part of dried orange peels and 100-250 parts of auxiliary materials.

More preferably, the radix paeoniae alba and peach kernel syrup is prepared from the following raw materials in parts by weight: 38-42 parts of angelica sinensis, 20-24 parts of motherwort, 18-22 parts of peach kernels, 12-16 parts of white paeony roots, 10-14 parts of honey-fried licorice roots, 0.4-0.6 part of dried orange peels and 100-250 parts of auxiliary materials.

The angelica used in the invention is the root of the perennial herb angelica of the Umbelliferae. The herba leonuri adopted by the invention is the whole herb of the herba leonuri of the genus leonurus of the family labiatae, namely the dry overground part. The peach seeds adopted by the invention are dry mature seeds of roses or wild peaches. Harvesting after the fruits are ripe, removing the pulp and the nucleocapsid, taking out the seeds, and drying in the sun to obtain the peach kernels. The white peony root adopted by the invention is a plant of the genus Paeonia in the family Ranunculaceae, and is a dried root of Paeonia lactiflora pall. The honey-fried licorice root adopted by the invention is prepared by processing liquorice of leguminous plants with honey; as a specific preparation method, the honey is placed in a pot to be refined into medium honey, the raw licorice slices are added with slow fire to be uniformly stirred and fried, the mixture is taken out of the pot after 3-5 min, and is placed in a baking room or an oven to be baked until the mixture is not sticky, and then the mixture is taken out and cooled. The dried orange peel adopted by the invention is dry mature peel of Rutaceae plant orange or cultivated varieties thereof.

The formula of the white peony root-peach kernel syrup is skillfully designed, and the traditional Chinese medicines are mixed according to a specific proportion, so that the effects of enriching blood and benefiting qi and activating blood and removing stasis are balanced, qi stagnation and blood stasis are avoided while enriching blood, and postpartum recovery and lochia discharge are promoted. In addition, as the puerpera is easy to have symptoms of yin deficiency, high fever, thirst and the like after the puerpera is born, and the heat symptoms of the puerpera are easy to aggravate by traditional qi tonifying medicines such as astragalus and the like, the formula is skillfully adjusted, all the raw materials fully play the role of tonifying qi and blood under the synergistic action, and the traditional qi tonifying medicine is mild but has obvious effect, thereby being very beneficial to the puerpera to carry out postpartum recovery.

The white peony root and peach kernel syrup provided by the invention contains auxiliary materials for preparing the white peony root and peach kernel syrup. The auxiliary materials can be selected from sucrose and deionized water. As a preferred scheme of the invention, the white peony root and peach kernel syrup comprises 50-100 parts of sucrose and 50-100 parts of deionized water as auxiliary materials.

The radix paeoniae alba and peach kernel syrup provided by the invention can be prepared by the following method: extracting radix Angelicae sinensis, herba Leonuri, semen Persicae, radix Paeoniae alba, radix Glycyrrhizae Preparata and pericarpium Citri Tangerinae respectively to obtain herba Leonuri extract, radix Angelicae sinensis extract, semen Persicae extract, radix Paeoniae alba extract, radix Glycyrrhizae Preparata extract and pericarpium Citri Tangerinae extract, and mixing the above extracts with adjuvants.

The invention further optimizes the preparation method of each extract, and can fully enrich the components with good activity, thereby ensuring that each extract can more fully play the synergistic effect after being mixed and improving the overall curative effect of the white paeony root-peach kernel syrup. Specifically, the method comprises the following steps:

the invention optimizes the extraction method of angelica, particularly, the carbon dioxide supercritical extraction is carried out by using the mixed entrainer with specific composition, so that the angelica essential oil with ligustilide as a core component can be fully extracted, and the angelica polysaccharide with the function of promoting hematopoiesis can be fully enriched, thereby fully exerting the synergistic effect among all effective components and realizing the effect of promoting postpartum recovery. Specifically, the angelica sinensis extract is preferably extracted by the following method: crushing angelica, performing carbon dioxide supercritical extraction at the temperature of 25-40 ℃ and under the pressure of 6-8 MPa, extracting for 1.5-2.5 hours by using a mixed solvent of petroleum ether and ethanol as an entrainer, collecting extract, and concentrating to obtain an extract (namely the angelica extract). The volume ratio of the petroleum ether to the ethanol is preferably 1-3: 1 to 3, and more preferably 1: 3.

The invention optimizes the extraction method of motherwort, and particularly adopts high-concentration ethanol containing hydrochloric acid with certain concentration for soaking, and then uses water for dilution and extraction, so that alkaloids represented by leonurine and stachydrine can be fully dissolved and enriched, and can perform synergistic action after being mixed with other active ingredients. Specifically, the motherwort extract is preferably extracted by the following method: pulverizing motherwort, and soaking in 85-95% ethanol water solution containing 1-5% hydrochloric acid and 1-3 times of the mass of motherwort for 12-24 hours to obtain soaking solution; adding water with the volume 1-2 times of that of the soaking solution into the soaking solution, and performing reflux extraction to obtain an extracting solution; concentrating the extractive solution to obtain extract (herba Leonuri extract).

The invention optimizes the extraction method of peach kernel, and particularly adopts ethanol solution containing petroleum ether to soak and then adds ethyl acetate to extract, so that the components (such as triolein and the like) with the efficacy of promoting blood circulation and removing blood stasis in peach kernel can be fully enriched, and the components and other active components can be mixed to play a role in synergy so as to promote postpartum recovery. Specifically, the peach kernel extract is preferably extracted by the following method: crushing peach kernels, and soaking the peach kernels in 75-85% ethanol aqueous solution containing 1-5% of petroleum ether, wherein the mass of the ethanol aqueous solution is 1-3 times that of the peach kernels, for 12-24 hours to obtain soaking solution; adding ethyl acetate which is 1-2 times of the volume of the soaking solution into the soaking solution, and performing ultrasonic treatment to obtain an extracting solution; concentrating the extractive solution to obtain extract (semen Persicae extract).

The method for extracting the white paeony root is optimized, and particularly, the white paeony root is extracted by adopting an ethanol solution containing a certain amount of acetone, so that effective components with the effects of enriching the blood, benefiting qi and nourishing the blood in the white paeony root can be fully enriched, and the optimal treatment effect is realized. Specifically, the white paeony root extract is preferably extracted by the following method: crushing radix paeoniae alba, soaking the radix paeoniae alba in 65-75% ethanol water solution containing 1-5% acetone for 12-24 hours, and performing reflux extraction to obtain an extracting solution; concentrating the extractive solution to obtain extract (radix Paeoniae alba extract).

The extraction method of the honey-fried licorice root is optimized, and particularly, the honey-fried licorice root is soaked in warm water and then is extracted by adding ethanol, so that the components with the warming and tonifying effects in the honey-fried licorice root can be fully enriched, and the optimal treatment effect is realized. The honey-fried licorice extract is preferably extracted by the following method: crushing honey-fried licorice roots, and soaking in water at the temperature of 30-50 ℃ for 6-12 hours to obtain a soaking solution; adding ethanol into the soak solution to enable the final concentration of the ethanol to be 60-70%, and performing ultrasonic treatment to obtain an extracting solution; concentrating the extractive solution to obtain extract (radix Glycyrrhizae Preparata extract).

The dried orange peel extract is preferably extracted by the following method: crushing dried orange peel, soaking in 65-75% ethanol water solution containing 1-5% petroleum ether for 12-24 h, percolating, collecting percolate, and concentrating to obtain extract (i.e. dried orange peel extract).

The extract is an extract with a relative density of 1.10-1.25 at 50-90 ℃.

Because the white peony root and peach kernel syrup contains a large amount of traditional Chinese medicine extracts, the white peony root and peach kernel syrup is very easy to flocculate, precipitate and even deteriorate in the storage process after being mixed with the sucrose solution prepared by the conventional method. In order to ensure that the radix paeoniae alba and peach kernel syrup has good physical properties and stability, sucrose is preferably dissolved in deionized water at the temperature of 80-100 ℃, 0.5-1% of active carbon is added while stirring, and after 10-15 min, the active carbon is removed by filtration to obtain a sugar solution; adding the motherwort extract, the angelica extract, the peach kernel extract, the white paeony root extract, the honey-fried licorice root extract and the tangerine peel extract into the sugar solution, and fully mixing to obtain the beverage. After the sugar solution which is dissolved at high temperature and treated by active carbon is mixed with the extract, the finally obtained white paeony root and peach kernel syrup has good stability.

The invention has the following beneficial effects:

the invention provides application of radix paeoniae alba and peach kernel syrup in preparation of products for promoting postpartum recovery, the radix paeoniae alba and peach kernel syrup is reasonable in raw material compatibility, and an optimized extraction method enables active ingredients to be fully enriched, so that extracts are guaranteed to be mixed and then a synergistic effect is fully exerted, and the overall curative effect of the radix paeoniae alba and peach kernel syrup is improved; the traditional Chinese medicine composition has the effects of enriching blood and tonifying qi, activating blood and dissolving stasis, can promote lochia to be discharged, has a promoting effect on quick recovery of uterus, can effectively treat postpartum anemia, is mild in effect but remarkable in effect, and is beneficial to quick recovery after childbirth.

Detailed Description

The present invention is further illustrated by the following specific examples, which are not intended to limit the invention in any way. Reagents, methods and apparatus used in the present invention are conventional in the art unless otherwise indicated. Unless otherwise indicated, reagents and materials used in the following examples are commercially available.

Example 1

A radix paeoniae alba and peach kernel syrup is prepared from the following raw materials: 400g of angelica sinensis, 220g of motherwort, 200g of peach kernel, 140g of white paeony root, 120g of honey-fried licorice root, 5g of dried orange peel, 100g of cane sugar and 50g of deionized water.

The preparation method of the white peony root and peach kernel syrup specifically comprises the following steps:

(1) taking a Chinese angelica medicinal material according to the dosage, crushing, and then performing carbon dioxide supercritical extraction at the temperature of 35 ℃ and under the pressure of 7MPa, wherein the volume ratio of petroleum ether to ethanol is 1:3 as entrainer, wherein the amount of the entrainer is 1/2 of the mass of the Chinese angelica medicinal material, after 2 hours of extraction, collecting extract liquor, and concentrating the extract liquor to obtain an extract with the relative density of 1.15 at 90 ℃;

(2) taking a motherwort herb according to the dosage, crushing, and soaking in 90% ethanol water solution containing 2% hydrochloric acid, which is 1.5 times of the mass of the motherwort herb, overnight to obtain a soaking solution; adding water with the volume 1.5 times of the soaking solution into the soaking solution, performing reflux extraction to obtain an extracting solution, and concentrating the extracting solution to obtain an extract with the relative density of 1.15 at 90 ℃;

(3) taking a peach seed medicinal material according to the dosage, crushing, and soaking in 80% ethanol water solution containing 2% petroleum ether, which is 1.5 times of the mass of the peach seed medicinal material, overnight to obtain soaking solution; adding ethyl acetate with the volume 1.5 times of the soaking solution into the soaking solution, performing ultrasonic treatment to obtain an extracting solution, and concentrating the extracting solution to obtain an extract with the relative density of 1.15 at 90 ℃;

(4) taking a white paeony root medicinal material according to the dosage, crushing, soaking overnight by using 70% ethanol water solution containing 2% acetone, performing reflux extraction to obtain an extracting solution, and concentrating the extracting solution to an extract with the relative density of 1.15 at 90 ℃;

(5) taking radix Glycyrrhizae Preparata according to the amount, pulverizing, and soaking in 40 deg.C water for 8 hr to obtain soaking solution; adding ethanol into the soak solution to make the final concentration of the ethanol be 65%, performing ultrasonic treatment to obtain an extracting solution, and concentrating the extracting solution to obtain an extract with the relative density of 1.15 at 90 ℃;

(6) taking pericarpium Citri Tangerinae according to dosage, pulverizing, soaking with 70% ethanol water solution containing 3% petroleum ether overnight, percolating (the specific operation can refer to percolation method under fluid extract and extract item of Chinese pharmacopoeia 2010), collecting percolate, and concentrating to obtain extract with relative density of 1.15 at 90 deg.C;

(7) dissolving sucrose in deionized water at 100 deg.C, adding 0.5% active carbon under stirring, filtering after 15min to remove active carbon to obtain sugar solution; and (3) mixing the extracts obtained in the steps (1) to (6), adding the mixed extracts into the sugar solution, uniformly mixing, and filtering to remove precipitates to obtain the sugar-free sugar.

Example 2

A radix paeoniae alba and peach kernel syrup is prepared from the following raw materials: 300g of angelica, 150g of motherwort, 150g of peach kernel, 120g of white paeony root, 100g of honey-fried licorice root, 2g of tangerine peel, 100g of cane sugar and 50g of deionized water.

The preparation method is the same as example 1.

Example 3

A radix paeoniae alba and peach kernel syrup is prepared from the following raw materials: 450g of angelica, 300g of motherwort, 250g of peach kernel, 180g of white paeony root, 160g of honey-fried licorice root, 8g of tangerine peel, 100g of cane sugar and 50g of deionized water.

The preparation method is the same as example 1.

Example 4

A radix paeoniae alba and peach kernel syrup is prepared from the following raw materials: 500g of angelica, 200g of motherwort, 200g of peach kernel, 200g of white paeony root, 200g of honey-fried licorice root, 10g of dried orange peel, 100g of cane sugar and 50g of deionized water.

The preparation method is the same as example 1.

Example 5

A white paeony root and peach kernel syrup which has the same formula as that of the syrup in the example 1; the preparation methods differ only in that: in the step (1), when the angelica extract is prepared, the entrainer is only ethanol, and diethyl ether is not used.

Example 6

A white paeony root and peach kernel syrup which has the same formula as that of the syrup in the example 1; the preparation methods differ only in that: in the step (2), when the leonurus extract is prepared, a 90% ethanol aqueous solution containing 2% hydrochloric acid and water with the volume of 1.5 of the hydrochloric acid are directly mixed as a solvent for reflux extraction without soaking.

Example 7

A white paeony root and peach kernel syrup which has the same formula as that of the syrup in the example 1; the preparation methods differ only in that: and (3) when the peach kernel extract is prepared in the step (3), directly mixing 80% ethanol aqueous solution and ethyl acetate with the volume 1.5 times of that of the ethanol aqueous solution as a solvent for ultrasonic extraction without soaking and using petroleum ether.

Example 8

A white paeony root and peach kernel syrup which has the same formula as that of the syrup in the example 1; the preparation methods differ only in that: and (4) when the white paeony root extract is prepared, soaking the white paeony root extract in 70 percent ethanol water solution overnight and extracting the white paeony root extract under reflux without using acetone.

Example 9

A white paeony root and peach kernel syrup which has the same formula as that of the syrup in the example 1; the preparation methods differ only in that: and (5) when the honey-fried licorice extract is prepared, directly carrying out ultrasonic extraction on 65% ethanol without soaking.

Example 10

A white paeony root and peach kernel syrup which has the same formula as that of the syrup in the example 1; the preparation methods differ only in that: and (6) when the dried orange peel extract is prepared, petroleum ether is not used, and the dried orange peel extract is directly soaked overnight by 70% ethanol water solution and percolated for extraction.

Comparative example 1

The composition of example 6 of patent document CN1872150A is prepared from the following raw materials: 200g of angelica, 200g of astragalus, 60g of donkey-hide gelatin, 300g of motherwort, 6g of dried orange peel and 450g of cane sugar; the preparation method comprises the following steps:

(1) soaking radix astragali and herba Leonuri in 3kg water for 1 hr, decocting for 2 hr, filtering to obtain decoction, decocting 2.5kg water for 1.5 hr, filtering to obtain decoction, mixing the decoctions, filtering, and concentrating the filtrate to obtain fluid extract with relative density of 1.12 at 70 deg.C;

(2) pulverizing radix Angelicae sinensis and pericarpium Citri Tangerinae into coarse powder, soaking in 1.03kg 70% ethanol as solvent for 48 hr, percolating according to fluid extract and percolation method under extract item (appendix I O of first part of 2005 edition in Chinese pharmacopoeia), collecting percolate, and concentrating under reduced pressure to obtain fluid extract with relative density of 1.14 at 70 deg.C;

(3) dissolving colla Corii Asini in the above extractive solution, adding the extractive solution of radix Angelicae sinensis and pericarpium Citri Tangerinae, mixing, concentrating to obtain fluid extract with relative density of 1.22(70 deg.C), adding sucrose, heating to dissolve, filtering, adding appropriate amount of distilled water to 1000ml, and stirring thoroughly.

Comparative example 2

Commercially available motherwort particles.

Comparative example 3

A composition, which differs from example 1 only in that: the preparation method comprises dissolving sucrose in deionized water at 100 deg.C to obtain sugar solution directly, and treating without activated carbon.

Experimental example 1

The experimental example explains the influence of the white peony root and peach kernel syrup on the discharge time of postpartum lochia.

1. Subject: the products of examples 1-10 and comparative examples 1, 2;

2. the experimental method comprises the following steps: selecting 120 parturient women in normal labor, and randomly dividing into 12 groups of 10 persons; the average time of each group (rounded to the whole day) is calculated by recording the time required for discharging lochia for the puerpera after 1 time of each group in the morning and at night every day from the first day of postpartum.

3. The experimental results are as follows: as shown in table 1.

Table 1: lochia elimination time (unit: day)

Experimental example 2

The experimental example illustrates the effect of the white peony root and peach kernel syrup on uterine recovery.

1. Subject: the products of examples 1-10 and comparative examples 1, 2;

2. the experimental method comprises the following steps: selecting 120 parturient women in normal labor, and randomly dividing into 12 groups of 10 persons; the parturient can take the products 1 time every morning and evening since the first day of parturition, and perform B-ultrasonic examination around the day (day 28) to determine whether uterus is normal (based on the standard that the sum of the three diameters of uterus is less than 18 cm), and find out the percentage of people in each group whose uterus is normal.

3. The experimental results are as follows: as shown in table 2.

Table 2: percentage of persons recovering normal uterus

Experimental example 3

The experimental example explains the treatment effect of the white peony root and peach kernel syrup on postpartum anemia.

1. Subject: the products of example 1, example 2, example 6, comparative example 1 and comparative example 2;

2. the experimental method comprises the steps of collecting 100 postpartum anemic puerperae, wherein all cases accord with the diagnosis standards of nutritional anemia and hemorrhagic anemia of adult women, and the diagnosis standards have no statistical significance in the aspects of age, disease conditions, nutritional conditions and the like, randomly dividing the postpartum anemic puerperae into 5 groups, taking the products of example 1, example 2, example 6, comparative example 1 and comparative example 2 for each group, twice a day in the morning and evening, taking the postpartum anemic puerperae for 1 month in a treatment course, and judging the cure rate according to the diagnosis standards of the anemia of the adult women (the red cell count is less than 3.5 × 1012/L, and the hemoglobin is less than 110 g/L).

3. The experimental results are as follows: as shown in Table 3, no obvious adverse reaction was observed between the mother and the infant during the treatment period.

Table 3: anemia cure rate (%)

Experimental group	Cure rate (%)
		Example 1	85
Example 2	85
		Example 6	80
Comparative example 1	70
		Comparative example 2	65

According to the results of the experimental examples 1-3, the radix paeoniae alba and peach kernel syrup can promote lochia to be discharged, has a promoting effect on quick recovery of uterus, can effectively treat postpartum anemia, and is beneficial to comprehensive recovery of puerperae in postpartum.

Experimental example 4

This example illustrates the stability of the white peony root and peach kernel syrup.

1. Test subjects:

experimental group 1 is the white peony root and peach kernel syrup product obtained in example 1 of the present invention;

experiment group 2 is the radix paeoniae alba and peach kernel syrup product obtained in example 3 of the invention;

control 1 is the product of comparative example 1 of the present invention;

control 2 is the product of comparative example 3 of the present invention.

2. The test method comprises the following steps:

1) and (3) accelerated test: placing the mixture for 6 months under the conditions that the relative humidity is 75% RH +/-5% RH and the temperature is 40 +/-2 ℃, and periodically sampling and testing.

2) And (3) long-term test: placing the mixture for 12 months under the conditions of relative humidity of 60% RH +/-5% RH and temperature of 25 +/-2 ℃, and periodically sampling and testing.

3. The experimental results are as follows: see tables 4 and 5. In the following table, the active ingredient group A refers to total alkaloids in herba Leonuri extract (the sum of leonurine and stachydrine accounts for more than 90% of the total alkaloids), and the active ingredient group A refers to leonurine; the active ingredient group B is ligustilide extracted from radix Angelicae sinensis; the active component C is Angelica sinensis polysaccharide in Angelica sinensis extract; the active component D is triolein in semen Persicae extract.

Table 4: results of accelerated test

Table 5: long term test results

According to the experimental results, the radix paeoniae alba and peach kernel syrup has good stability.

Although the invention has been described in detail hereinabove by way of general description, specific embodiments and experiments, it will be apparent to those skilled in the art that many modifications and improvements can be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.

Claims

1. The application of the radix paeoniae alba and peach kernel syrup in the preparation of the medicine or the health care product for promoting postpartum recovery is characterized in that the radix paeoniae alba and peach kernel syrup is prepared from the following raw materials in parts by weight: 5-50 parts of angelica sinensis, 2-20 parts of motherwort, 2-20 parts of peach kernels, 2-20 parts of white paeony roots, 2-20 parts of honey-fried licorice roots, 0.1-1 part of dried orange peels and 100-250 parts of auxiliary materials.

2. The use of claim 1, wherein promoting postpartum recovery comprises reducing postpartum lochia elimination, promoting postpartum uterine recovery, and/or treating postpartum anemia.

3. The application of the white peony root-peach kernel syrup in preparing the medicine or the health-care product for shortening the discharge time of postpartum lochia is characterized in that the white peony root-peach kernel syrup is prepared from the following raw materials in parts by weight: 5-50 parts of angelica sinensis, 2-20 parts of motherwort, 2-20 parts of peach kernels, 2-20 parts of white paeony roots, 2-20 parts of honey-fried licorice roots, 0.1-1 part of dried orange peels and 100-250 parts of auxiliary materials.

4. The application of the white peony root-peach kernel syrup in the preparation of the medicine or the health care product for promoting postpartum uterus recovery is characterized in that the white peony root-peach kernel syrup is prepared from the following raw materials in parts by weight: 5-50 parts of angelica sinensis, 2-20 parts of motherwort, 2-20 parts of peach kernels, 2-20 parts of white paeony roots, 2-20 parts of honey-fried licorice roots, 0.1-1 part of dried orange peels and 100-250 parts of auxiliary materials.

5. The application of the white peony root-peach kernel syrup in preparing the medicine or the health-care product for treating postpartum anemia is characterized in that the white peony root-peach kernel syrup is prepared from the following raw materials in parts by weight: 5-50 parts of angelica sinensis, 2-20 parts of motherwort, 2-20 parts of peach kernels, 2-20 parts of white paeony roots, 2-20 parts of honey-fried licorice roots, 0.1-1 part of dried orange peels and 100-250 parts of auxiliary materials.

6. The use of any one of claims 1-5, wherein the radix Paeoniae alba and semen Persicae syrup is prepared from the following raw materials in parts by weight: 30-45 parts of angelica sinensis, 15-30 parts of motherwort, 10-25 parts of peach kernels, 12-18 parts of white paeony roots, 10-16 parts of honey-fried licorice roots, 0.2-0.8 part of dried orange peels and 100-250 parts of auxiliary materials.

7. The application of claim 6, wherein the radix paeoniae alba and peach kernel syrup is prepared from the following raw materials in parts by weight: 38-42 parts of angelica sinensis, 20-24 parts of motherwort, 18-22 parts of peach kernels, 12-16 parts of white paeony roots, 10-14 parts of honey-fried licorice roots, 0.4-0.6 part of dried orange peels and 100-250 parts of auxiliary materials.

8. The use according to any one of claims 1 to 7, wherein the excipients comprise sucrose and deionized water; preferably, the auxiliary materials comprise 50-100 parts of cane sugar and 50-100 parts of deionized water.

9. The use of any one of claims 1 to 7, wherein the preparation method of the radix paeoniae alba and peach kernel syrup comprises the following steps: extracting radix Angelicae sinensis, herba Leonuri, semen Persicae, radix Paeoniae alba, radix Glycyrrhizae Preparata and pericarpium Citri Tangerinae respectively to obtain herba Leonuri extract, radix Angelicae sinensis extract, semen Persicae extract, radix Paeoniae alba extract, radix Glycyrrhizae Preparata extract and pericarpium Citri Tangerinae extract, and mixing the above extracts with adjuvants;

preferably, sucrose is dissolved in deionized water at 80-100 ℃, 0.5-1% of activated carbon is added while stirring, and after 10-15 min, the activated carbon is removed by filtration to obtain sugar liquid; adding the motherwort extract, the angelica extract, the peach kernel extract, the white paeony root extract, the honey-fried licorice root extract and the tangerine peel extract into the sugar solution, and fully mixing to obtain the beverage.

10. The use as claimed in claim 9, wherein the angelica sinensis extract is obtained by extracting: crushing angelica, performing carbon dioxide supercritical extraction at the temperature of 25-40 ℃ and under the pressure of 6-8 MPa, extracting for 1.5-2.5 hours by using a mixed solvent of petroleum ether and ethanol as an entrainer, collecting extract, and concentrating to obtain the Chinese angelica extract; preferably, the volume ratio of the petroleum ether to the ethanol is 1-3: 1-3;

the motherwort herb extract is obtained by the following method: pulverizing motherwort, and soaking in 85-95% ethanol water solution containing 1-5% hydrochloric acid and 1-3 times of the mass of motherwort for 12-24 hours to obtain soaking solution; adding water with the volume 1-2 times of that of the soaking solution into the soaking solution, and performing reflux extraction to obtain an extracting solution; concentrating the extractive solution;

the peach kernel extract is obtained by the following method: crushing peach kernels, and soaking the peach kernels in 75-85% ethanol aqueous solution containing 1-5% of petroleum ether, wherein the mass of the ethanol aqueous solution is 1-3 times that of the peach kernels, for 12-24 hours to obtain soaking solution; adding ethyl acetate which is 1-2 times of the volume of the soaking solution into the soaking solution, and performing ultrasonic treatment to obtain an extracting solution; concentrating the extractive solution;

and/or the white paeony root extract is extracted by the following method: crushing radix paeoniae alba, soaking the radix paeoniae alba in 65-75% ethanol water solution containing 1-5% acetone for 12-24 hours, and performing reflux extraction to obtain an extracting solution; concentrating the extractive solution;

the honey-fried licorice extract is obtained by the following method: crushing honey-fried licorice roots, and soaking in water at the temperature of 30-50 ℃ for 6-12 hours to obtain a soaking solution; adding ethanol into the soak solution to enable the final concentration of the ethanol to be 60-70%, and performing ultrasonic treatment to obtain an extracting solution; concentrating the extractive solution;

and/or the dried orange peel extract is obtained by the following extraction method: crushing dried orange peel, soaking in 65-75% ethanol water solution containing 1-5% petroleum ether for 12-24 h, percolating, collecting percolate, and concentrating.