CN105031219B - A kind of compound Chinese medicinal preparation and its preparation method and application for treating syndrome of deficiency of both qi and yin diabetes - Google Patents
A kind of compound Chinese medicinal preparation and its preparation method and application for treating syndrome of deficiency of both qi and yin diabetes Download PDFInfo
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Abstract
The invention discloses a kind of compound Chinese medicinal preparations for treating syndrome of deficiency of both qi and yin diabetes, are made of Radix Astragali, Radix Ophiopogonis, rhizoma anemarrhenae, root of Chinese trichosanthes, dogwood fruit, Schisandra chinensis, Chinese yam, the membrane of a chicken's gizzard, pueraria lobata；The present invention also provides the preparation methods of the compound preparation：Mixing Ultramicro-powder is made in root of Chinese trichosanthes, Chinese yam, the membrane of a chicken's gizzard, dogwood fruit；By remaining drug decocting, concentrate is made；Ultramicro-powder and concentrate mixing will be mixed to obtain the final product.The compound Chinese medicinal preparation of the present invention, prescription science, it is significant in efficacy, prepare it is reasonable, it is at low cost, good effect, quick, have no toxic side effect, the symptom for the diabetes that can be significantly improved.The present invention using Modern preparations technique and carries out depth optimization on the basis of traditional medicine prescription, and using dynamic decocting process, a step granulating technique, novel technique has many advantages, such as that preparation method is easy, efficient, energy saving, active ingredient destruction is few.
Description
Technical field
The present invention relates to a kind of compound Chinese medicinal preparations and its preparation method and application for treating syndrome of deficiency of both qi and yin diabetes, belong to
In technical field of Chinese medicine.
Background technology
Diabetes are a kind of chronic diseases caused by insulin deficit or islet function defect.Diabetes can lead to blood glucose
It increases, hyperglycemia can damage all multisystems of human body, especially nervous system and vascular system, and the whole world has nearly 300 every year
Ten thousand diabetics die of diabetic complication, and with the quickening pace of modern life, the factors such as unhealthy of life style will cause
Diabetic's number is increasing.
Diabetes medical history elder is with syndrome of deficiency of both qi and yin for common, national 1504 diabetes of Chinese medicine diabetes study cooperative groups
Statistics, syndrome of deficiency of both qi and yin account for 27.1%.Syndrome of deficiency of both qi and yin diabetes clinical manifestation is spiritlessness and weakness, thirst and liking drink, shortness of breath lazyness are sayed,
Dry mouth and throat, dysphoria in chestpalms-soles, soreness and weakness of waist and knees, the partially dry, frequent urination of stool, pink tongue or it is light red, tongue is few, thready and rapid pulse without strength.
The treatment of diabetes, Western medicine mostly with it is simple it is hypoglycemic based on, work rapid, but dependence is strong, it is palliative,
Prolonged application can be such that body drug resistance improves, and cannot still prevent the appearance of diabetic complication.Chinese patent drug is then emphasized to effect a permanent cure, though
It so works slow, but takes for a long time up to treating both manifestation and root cause of disease.Currently, it is no lack of the Chinese patent drug for the treatment of diabetes in the market, but still
Lack the Chinese patent drug of effectively treatment syndrome of deficiency of both qi and yin diabetes.
Chinese patent literature CN 1634279A (application number 200410044035.1) disclose a kind of treat in diabetes
Medicine, it is made of the bulk pharmaceutical chemicals of following weight：50 grams of Rhizoma Dioscoreae, raw 25 grams of Radix Astragali, 30 grams of radix scrophulariae, 15 grams of ginseng, Radix Ophiopogonis 30
Gram, 25 grams of dogwood fruit, 30 grams of rhizoma anemarrhenae, 25 grams of radix rehmanniae preparata, 15 grams of Schisandra chinensis, 15 grams of root of Chinese trichosanthes, 20 grams of pueraria lobata, 20 grams of asparagus fern, rhizoma alismatis
10 grams, 10 grams of Radix Glycyrrhizae.Drug matching of the present invention has benefiting qi and nourishing yin, promotes the production of body fluid to quench thirst, thirsty for drinking more, eats gluttony, diuresis more
And three eliminating masses become thin, effect stability does not recur and of low cost, medication convenience, efficient up to 100%.
Above-mentioned prescription seems reasonable, there is many places deficiency actually：1. prescription flavour of a drug are various, the monarch and his subjects are unknown, are unfavorable for drug effect
Collaboration play；2. reusing radix rehmanniae preparata in side, radix rehmanniae preparata property sticks greasy, hinders digestion, long-term use is being unfavorable for diabetic just
Normal diet；3. ginseng is the product of big benefit, heat symptom-complex avoids clothes, and diabetic has the symptoms such as dry mouth and throat, dysphoria in chestpalms-soles more, if long
Phase takes the product containing ginseng, can aggravate the state of an illness.
Invention content
In view of the deficiencies of the prior art, the present invention provides a kind of compound Chinese medicinal preparations for treating syndrome of deficiency of both qi and yin diabetes
And preparation method thereof.
It is an object of the present invention to provide a kind of compound Chinese medicinal preparations for treating syndrome of deficiency of both qi and yin diabetes, by following heavy
Measure the bulk pharmaceutical chemicals composition of number：
100~600 parts of Radix Astragali, 30~300 parts of Radix Ophiopogonis, 100~600 parts of rhizoma anemarrhenae, 80~500 parts of root of Chinese trichosanthes, dogwood fruit 50
~400 parts, 10~200 parts of Schisandra chinensis, 80~500 parts of Chinese yam, 5~200 parts of the membrane of a chicken's gizzard, 100~600 parts of pueraria lobata；
Preferably, a kind of compound Chinese medicinal preparation for treating syndrome of deficiency of both qi and yin diabetes, by the bulk pharmaceutical chemicals of following parts by weight
Composition：
200~400 parts of Radix Astragali, 60~200 parts of Radix Ophiopogonis, 200~400 parts of rhizoma anemarrhenae, 120~300 parts of root of Chinese trichosanthes, dogwood fruit
100~200 parts, 30~120 parts of Schisandra chinensis, 100~300 parts of Chinese yam, 10~100 parts of the membrane of a chicken's gizzard, 200~400 parts of pueraria lobata；
It is further preferred that a kind of compound Chinese medicinal preparation for treating syndrome of deficiency of both qi and yin diabetes, by following parts by weight
Bulk pharmaceutical chemicals form：
300 parts of Radix Astragali, 120 parts of Radix Ophiopogonis, 300 parts of rhizoma anemarrhenae, 240 parts of root of Chinese trichosanthes, 150 parts of dogwood fruit, 80 parts of Schisandra chinensis, Chinese yam
210 parts, 45 parts of the membrane of a chicken's gizzard, 300 parts of pueraria lobata.
It is a further object to provide a kind of preparations of compound Chinese medicinal preparation that treating syndrome of deficiency of both qi and yin diabetes
Method：
A kind of preparation method of compound Chinese medicinal preparation that treating syndrome of deficiency of both qi and yin diabetes, includes the following steps：
A. root of Chinese trichosanthes, Chinese yam, the membrane of a chicken's gizzard, dogwood fruit are mixed into ultramicro grinding, mixing Ultramicro-powder is made；
B. add water to decoct pueraria lobata, Radix Astragali, rhizoma anemarrhenae, Schisandra chinensis, Radix Ophiopogonis, filtered after decocting 1~2 hour for the first time
First-time filtrate, filter residue add water to decoct again 0.8~1.2 hour, filter to obtain secondary filtrate, merge first-time filtrate and secondary filtrate,
It is concentrated, concentrate is made；
C. Ultramicro-powder will be mixed made from step a to be added in concentrate made from step b, be uniformly mixed, treatment is made
The medicinal preparation for oral administration of syndrome of deficiency of both qi and yin diabetes；Or：
Make bottom material by Ultramicro-powder is mixed made from step a, spray into concentrate made from step b, be granulated through a step, mixing,
The granule for the treatment of syndrome of deficiency of both qi and yin diabetes is made.
Preferably, in the step a, the fineness of ultramicro grinding is 200 mesh.
It is further preferred that in the step b, decocts 1.5 hours, decoct 1 hour again for the first time.
Another object of the present invention is above-mentioned compound Chinese medicinal preparation in the drug for preparing treatment syndrome of deficiency of both qi and yin diabetes
In application.The dosage form of the drug is granule, tablet, oral solutions or capsule.
This preparation is made of Radix Astragali, Radix Ophiopogonis, rhizoma anemarrhenae, root of Chinese trichosanthes, dogwood fruit, Schisandra chinensis, Chinese yam, the membrane of a chicken's gizzard, pueraria lobata.Radix Astragali
There is rising Yang QI invigorating, temper is helped to rise, multiple its dissipates the work(that essence reaches lung；Radix Ophiopogonis nourishing Yin and promoting production of body fluid, solution is tired to quench the thirst, and is altogether monarch drug in a prescription.
Root of Chinese trichosanthes, which quenches the thirst, moistens withered, slight bitter fall fire；Rhizoma anemarrhenae supernatant lung heat, in rush down stomach fire, drop kidney fire, and nourishing Yin and moistening dryness promotes the production of body fluid
Quench the thirst, it is compatible with Radix Astragali, as《Records of Tradition Chinese and Western Medicine in Combination》It says：" the big tonifying lung gas of Radix Astragali energy keeps gas prosperous with source on kidney-nourishing water
Self energy unboiled water, and rhizoma anemarrhenae can grow greatly body fluid in lung, in order to the unlikely inclined victory of negative and positive, and the work(of unboiled water benefit is general ", match with root of Chinese trichosanthes
5, heat-clearing enriching yin is focused on, profit is vehement to quench the thirst.Above-mentioned two medicine is all ministerial drug, and principal drug assistance supplementing qi and nourishing yin, clearing heat and moistening dryness promote the production of body fluid to quench thirst altogether
Work(.
Cloudy strengthening the essence, five viscera settling lead to nine orifices, only small facility to Fructus Corni by force, item, strength；The main QI invigorating of Schisandra chinensis, tonifying for the deficiency,
Qiang Yin, two medicine phases are closed, and have nourshing kidney tonifying lung, supplementing qi and nourishing yin, the work(for contracting urine of promoting the production of body fluid.Fang Zhongyong Chinese yams, Gan Ping and moisten, can moistening lung and production of body fluid
Quench the thirst, to control deficiency of both vital energy and Yin, the key medicine quenched one's thirst.The membrane of a chicken's gizzard is sweet in flavor mild-natured, reinforcing spleen to promote digestion, with tonic phase 5, has benefit without stagnant, taste
And oiliness work(.
Pueraria lobata acrid flavour is mild-natured, and the Fang Zhongyong medicines rise the gas for lifting the clear sun of taste, and compress body fluid is to irrigate the five internal organs, to make medicine.
All medicines share, gas Tianjin is clear and rich to have both sample and control with raw, is association of activity and inertia, and mends without stagnant, grows and oiliness, plays benefit altogether
Gas yin-nourishing, clearing heat and promoting fluid moisturize the work(to quench the thirst, must be answered in order to gas is cloudy, and scorching clearly, body fluid obtains cloth, and quench one's thirst from only, and sincere is treatment
The good recipe quenched one's thirst based on deficiency of both qi and yin.
Beneficial effects of the present invention are：
1, the compound Chinese medicinal preparation for the treatment of syndrome of deficiency of both qi and yin diabetes of the present invention, prescription science, significant in efficacy, preparation
Rationally, at low cost, good effect, quick, it has no toxic side effect, the symptom for the diabetes that can be significantly improved.
2, the present invention using Modern preparations technique and carries out depth optimization on the basis of traditional medicine prescription, using dynamic
State decocting process, a step granulating technique, novel technique have preparation method is easy, efficient, energy saving, active ingredient destruction is few etc.
Advantage.
Specific implementation mode
Technical scheme of the present invention is described further with reference to embodiment, but institute's protection domain of the present invention is not limited to
This.
Embodiment 1
A kind of compound Chinese medicinal preparation for treating syndrome of deficiency of both qi and yin diabetes, includes the bulk pharmaceutical chemicals of following parts by weight：
300 parts of Radix Astragali, 120 parts of Radix Ophiopogonis, 300 parts of rhizoma anemarrhenae, 240 parts of root of Chinese trichosanthes, 150 parts of dogwood fruit, 80 parts of Schisandra chinensis, Chinese yam
210 parts, 45 parts of the membrane of a chicken's gizzard, 300 parts of pueraria lobata.
The preparation of the Chinese medicine compound prescription medicinal preparation for oral administration of above-mentioned treatment syndrome of deficiency of both qi and yin diabetes, includes the following steps：
A. root of Chinese trichosanthes, Chinese yam, the membrane of a chicken's gizzard, dogwood fruit are mixed into ultramicro grinding, mixing Ultramicro-powder is made；
B. add water to decoct pueraria lobata, Radix Astragali, rhizoma anemarrhenae, Schisandra chinensis, Radix Ophiopogonis, filtered after decocting 1.5 hours for the first time
First-time filtrate, filter residue add water to decoct again 1 hour, filter to obtain secondary filtrate, merge first-time filtrate and secondary filtrate, concentrated,
Concentrate is made；
C. Ultramicro-powder will be mixed made from step a to be added in concentrate made from step b, be uniformly mixed, treatment is made
The tablet or granule of syndrome of deficiency of both qi and yin diabetes.
Embodiment 2
A kind of compound Chinese medicinal preparation for treating syndrome of deficiency of both qi and yin diabetes, includes the bulk pharmaceutical chemicals of following parts by weight：
200 parts of Radix Astragali, 200 parts of Radix Ophiopogonis, 200 parts of rhizoma anemarrhenae, 300 parts of root of Chinese trichosanthes, 100 parts of dogwood fruit, 120 parts of Schisandra chinensis, mountain
100 parts of medicine, 100 parts of the membrane of a chicken's gizzard, 200 parts of pueraria lobata；
The preparation method is the same as that of Example 1.
Embodiment 3
A kind of compound Chinese medicinal preparation for treating syndrome of deficiency of both qi and yin diabetes, includes the bulk pharmaceutical chemicals of following parts by weight：
400 parts of Radix Astragali, 60 parts of Radix Ophiopogonis, 400 parts of rhizoma anemarrhenae, 120 parts of root of Chinese trichosanthes, 200 parts of dogwood fruit, 30 parts of Schisandra chinensis, Chinese yam
300 parts, 10 parts of the membrane of a chicken's gizzard, 400 parts of pueraria lobata；
The preparation method is the same as that of Example 1.
Embodiment 4
A kind of compound Chinese medicinal preparation for treating syndrome of deficiency of both qi and yin diabetes, includes the bulk pharmaceutical chemicals of following parts by weight：
600 parts of Radix Astragali, 30 parts of Radix Ophiopogonis, 600 parts of rhizoma anemarrhenae, 80 parts of root of Chinese trichosanthes, 400 parts of dogwood fruit, 10 parts of Schisandra chinensis, Chinese yam
500 parts, 5 parts of the membrane of a chicken's gizzard, 600 parts of pueraria lobata；
The preparation method is the same as that of Example 1.
Embodiment 5
A kind of compound Chinese medicinal preparation for treating syndrome of deficiency of both qi and yin diabetes, includes the bulk pharmaceutical chemicals of following parts by weight：
100 parts of Radix Astragali, 300 parts of Radix Ophiopogonis, 100 parts of rhizoma anemarrhenae, 500 parts of root of Chinese trichosanthes, 50 parts of dogwood fruit, 200 parts of Schisandra chinensis, Chinese yam
80 parts, 200 parts of the membrane of a chicken's gizzard, 100 parts of pueraria lobata；
The preparation method is the same as that of Example 1.
Contrast experiment
Test apparatus：HEA-232 electronics blood sugar analyzer (Omron).
Experimental animal：Select the regular grade Wistar male rats of health, monthly age 6-8 month, weight (250 ± 20) g.
Modeling：Rat Fast be can't help into water 12h, then tail vein injection streptozotocin 35mg/kg, after injecting 5 days, from
Measuring blood sugar of blood extracting value in orbital venous plexus filters out the rat of blood glucose ＞ 16.7mmol/L, gavages Chinese herbal granules (green peel
15g, monkshood 10g), it is administered by 15.75g/kg weight, once a day, continuous 4 weeks.Institute's modeling type is syndrome of deficiency of both qi and yin glycosuria
Sick rat.Rat is grouped at random when experiment, every group 10.
Experimental example 1
Preferred prescription (embodiment 1) is prepared into flat thirsty particle by preferred technique, as a control group；
It is available on the market, the same Chinese patent drug sugar-reducing comfort piece for treating syndrome of deficiency of both qi and yin diabetes and ginseng-astragalus blood-sugar lowering piece difference
As sample sets 1 and sample sets 2, above-mentioned 3 groups of samples are respectively acting on syndrome of deficiency of both qi and yin diabetes rat, dosage 1.0g/
Kg, successive administration 3 weeks measured blood glucose in the 21st day, count change of blood sugar percentage, the results are shown in Table 1：
Table 1
The above results show that the hypoglycemic effect for putting down thirsty particle is better than sugar-reducing comfort piece and ginseng-astragalus blood-sugar lowering piece.
Experimental example 2
Preferred prescription (embodiment 1) is prepared into flat thirsty particle by preferred technique, as a control group；
It changes Radix Astragali into equal numbers ginseng, particle is prepared by preferred technique, as sample sets 1；
The gypsum that rhizoma anemarrhenae is changed into equal numbers, is prepared into particle, as sample sets 2 by preferred technique；
It changes Schisandra chinensis into equal numbers prepared rehmannia root, particle is prepared by preferred technique, as sample sets 3；
It changes pueraria lobata into equal numbers Radix Glycyrrhizae, particle is prepared by preferred technique, as sample sets 4；
5 groups of samples, are respectively acting on syndrome of deficiency of both qi and yin diabetes rat, dosage 1.0g/kg, successive administration 3 weeks, in
It measures blood glucose within 21st day, counts change of blood sugar percentage, the results are shown in Table 2：
Table 2
The above results show that the hypoglycemic effect of control group is better than other sample sets, i.e. the technical program is preferably formulated drop
Sugared best results.
Experimental example 3
Preferred prescription (embodiment 1) is prepared into flat thirsty particle by preferred technique, as a control group；
On the basis of control group, change prescription ratio：
The prescription of embodiment 2 is prepared into particle by preferred technique, as sample sets 1；
The prescription of embodiment 3 is prepared into particle by preferred technique, as sample sets 2；
The prescription of embodiment 4 is prepared into particle by preferred technique, as sample sets 3；
The prescription of embodiment 5 is prepared into particle by preferred technique, as sample sets 4.
5 groups of samples, are respectively acting on syndrome of deficiency of both qi and yin diabetes rat, dosage 1.0g/kg, successive administration 3 weeks, in
It measures blood glucose within 21st day, counts change of blood sugar percentage, the results are shown in Table 3：
Table 3
The above results show that the hypoglycemic effect of control group is better than other sample sets, i.e. the technical program is preferably formulated drop
Sugared best results.
Claims (3)
1. a kind of compound Chinese medicinal preparation for treating syndrome of deficiency of both qi and yin diabetes, which is characterized in that by the raw material of following parts by weight
Medicine forms：
300 parts of Radix Astragali, 120 parts of Radix Ophiopogonis, 300 parts of rhizoma anemarrhenae, 240 parts of root of Chinese trichosanthes, 150 parts of dogwood fruit, 80 parts of Schisandra chinensis, Chinese yam 210
Part, 45 parts of the membrane of a chicken's gizzard, 300 parts of pueraria lobata；Preparation methods steps are as follows：
A. root of Chinese trichosanthes, Chinese yam, the membrane of a chicken's gizzard, dogwood fruit are mixed into ultramicro grinding, mixing Ultramicro-powder is made；
B. add water to decoct pueraria lobata, Radix Astragali, rhizoma anemarrhenae, Schisandra chinensis, Radix Ophiopogonis, filter once after decocting 1.5 hours for the first time
Filtrate, filter residue add water to decoct again 1 hour, filter to obtain secondary filtrate, merge first-time filtrate and secondary filtrate, concentrated, are made
Concentrate；
C. Ultramicro-powder being mixed made from step a to be added in concentrate made from step b, being uniformly mixed, it is cloudy that treatment gas is made
The medicinal preparation for oral administration of two asthenic symptoms diabetes；Or：
Make bottom material by Ultramicro-powder is mixed made from step a, sprays into concentrate made from step b, be granulated through a step, mixing, is made
Treat the granule of syndrome of deficiency of both qi and yin diabetes；
In step a, the fineness of the Ultramicro-powder is 200 mesh.
2. application of the compound Chinese medicinal preparation described in claim 1 in the drug for preparing treatment syndrome of deficiency of both qi and yin diabetes.
3. application according to claim 2, which is characterized in that the dosage form of the compound Chinese medicinal preparation is granule, piece
Agent, oral solutions or capsule.
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