CN105902880A

CN105902880A - Medicine composition for treating diabetes mellitus due to qi-yin deficiency

Info

Publication number: CN105902880A
Application number: CN201610357028.XA
Authority: CN
Inventors: 张喜均; 甘铁汉; 陈治伟; 韩宇强
Original assignee: GUANGXI BAIQI PHARMACEUTICAL Co Ltd
Current assignee: GUANGXI BAIQI PHARMACEUTICAL Co Ltd
Priority date: 2016-05-25
Filing date: 2016-05-25
Publication date: 2016-08-31

Abstract

The invention discloses a medicine composition for treating diabetes mellitus due to qi-yin deficiency. The medicine composition is prepared from the following raw materials in parts by weight: American ginseng, radix scrophulariae, dendrobe, radix ophiopogonis, asparagus cochinchinensis, red ginseng, astragalus membranaceus, schisandra chinensis, Chinese wolfberry fruits, radix polygonati officinalis, rehmannia, radix rehmanniae praeparata, radix polygonum multiflorum preparata, donkey-hide gelatin, radix paeoniae alba, rhizoma polygonati, longan pulp, rhizoma atractylodis macrocephalae, rhizoma atractylodis, coix seeds (roasted), Chinese yam, cornus officinalis, radix achyranthis bidentatae, rhizoma cibotii, coptis chinensis, cortex phellodendri, cortex lycii radicis, cynanchum atratum, selfheal, tribulus terrestris, radices trichosanthis, kudzu vine roots, indigo naturalis, concha meretricis sea cyclinae, salvia miltiorrhiza and herba lycopi serving as active ingredients. The medicine composition with a good effect of treating diabetes mellitus due to qi-yin deficiency can be used for overcoming the defect of existing medicines for treating diabetes mellitus due to qi-yin deficiency.

Description

A kind of pharmaceutical composition treating deficiency of both QI and YIN disease diabetes

Technical field

The present invention relates to technical field of Chinese medicines, be specifically related to a kind of pharmaceutical composition treating deficiency of both QI and YIN disease diabetes.

Background technology

Diabetes spp traditional Chinese medical science diabetes category.Being universally acknowledged common disease, this disease state of an illness is complicated, touching is difficult to resolve, and treats the most thorny.Become the 3rd reason of developed country's patient death at present.According to incompletely statistics, the prevalence of China's diabetes is 2-3%, more than 4 years old up to 4%, the health of serious harm people.Therefore, the study on prevention of diabetes has become key subjects of China's public health work.

Theory of Chinese medical science illustrates indication pathogenesis and the rule for the treatment of: diabetes is with polydipsia, polyphagia, polyuria, and health gradually disappears, or turbid urine, the pleasantly sweet disease being characterized of urine.The name of disease quenched one's thirst, head sees "Nei Jing"." bier five becomes " piece is said: " the most soft weak person of the five internal organs, kind disease disappears ".The vertical special piece of quenching one's thirst of Eastern Han Dynasty's Zhang Zhongjing " Medical Treasures of the Golden Chamber ", proposes three eliminating mass shapes and is in harmony treatment side's medicine.The Tang Dynasty Wang Tao " medical secrets of official is quenched one's thirst in a disappearing " piece draws " at all times record test " and says: " thirsty and drinking a lot of water, frequent micturition, have fat, like the sweet person of oatmeal, be all diabetes also ", add: " every is that urine is the sweetest ", " shrivelled become thin." Sui Dynasty Chao Yuanfang (550-630 A.D.) " General Treatise on the Cause and Symptoms of Diseases quench one's thirst time " says: " the multiple carbuncle of its pathological changes ".Gold dollar Liu's interchannel " Confucian's Duties to Their Parents interchannel three disappear an opinion " piece is said: " the husband person of quenching one's thirst, changeable deaf blind, skin ulcer tinea, Cuo etc ".Above discussion, illustrates that ancient medicine, to the clinical characters of diabetes and double disease thereof, is recognized already.And the Clinical symptoms and accompanied symptoms thereof according to diabetes shows, primary disease is similar to the diabetes of modern medicine.

The etiology and pathogenesis of primary disease, how due to eating and drinking without temperance, property will is lacked of proper care, and impairment of the kidney due to indulgence in sexual activities, congenital defect etc., is pathogenetic key factor of quenching one's thirst.YIN fluid deficiency, production of dryness-heat in the interior is pathogenetic basic pathology of quenching one's thirst, and delays with the passing of time, deficiency of YIN affecting YANG, then the card of deficiency of both QI and YIN occurs.Its diseased region mainly at lung, spleen (stomach), kidney, is attached most importance to kidney especially.The kidney being the origin of congenital constitution for lid, main store essential substances.Suffer from a deficiency of the kidney and be difficult to retrain urine, therefore frequent micturition Dong is many.Losing astringency inducing, essence of water and grain is betted, therefore turbid urine like grease, pleasantly sweet.Deficiency of kidney-YIN, deficiency-fire stirring up, then to see thirsty, dysphoria with feverish sensation in the chest palms and soles, red tongue Tianjin is few, stringy and thready pulse or the disease such as count accurately.The spleen and stomach provide the material basis of the acquired.Fat meat and fine grain thickness is hidden, diet, forfeit one's integrity, taste be wound.Deficiency of spleen-YIN, the most thirsty polydipsia, polyphagia polyphagia；The board deficiency of vital energy can not transfer essence of water and grain, then essence of water and grain is dirty for urine, therefore urine taste is sweet；Essence of water and grain can not moisten foster muscle. therefore fade body day.Lung governing qi, for source on water, compress body fluid, issues and is hindered by hot and dry, lack of lung-YIN. then can not compress body fluid and directly become descending.Discharge with urine, therefore frequent micturition amount is many.Lung does not apply Tianjin. the most thirsty polydipsia.Below all the deficiency of YIN and in have scorching as, with the passing of time the most sick delay, by deficiency of YIN affecting YANG, must cause the deficiency of vital energy syndrome of lung, spleen, stomach, kidney, forms the card of deficiency of both QI and YIN.Deficiency of vital energy person, has the most again fatigue and weakness, and disease be shown in lazy speech etc. of breathing hard.

Therefore the treatment of syndrome of deficiency of both qi and yin, should be with supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid is method.A kind of pure Chinese medicinal preparation of exploitation, takes and carries the pharmaceutical composition treating deficiency of both QI and YIN disease diabetes the most very easily, can be necessarily to encircle and suppress diabetes to add superior weapon, contribute for medicinal career.

Summary of the invention

The technical problem to be solved in the present invention is the deficiency overcoming existing treatment deficiency of both QI and YIN disease diabetes medicament, it is provided that one treats the deficiency of both QI and YIN disease preferable pharmaceutical composition of diabetes effect.

In pharmaceutical composition of the present invention, the consumption of each component is that inventor draws through a large amount of practice summaries, is made up of the crude drug of following weight parts:

Preferably, it is made up of the crude drug of following weight parts:

The dosage form of pharmaceutical composition of the present invention can be the medically acceptable dosage forms such as capsule, tablet, oral liquid, decoction, and their preparation method, supplementary product consumption are carried out by existing common process.

Pharmaceutical composition of the present invention is prepared the most in accordance with the following methods:

Take Radix Panacis Quinquefolii, Radix Ginseng Rubra, Colla Corii Asini, Semen Coicis, Concha Meretricis Seu Cyclinae five kinds of Chinese medicine, it is ground into fine powder, remaining raw material, boiling secondary, add water 5 times amount for the first time, decoct 2 hours, add water 4 times amount for the second time, decoct 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.15-1.20 (60 DEG C), let cool, adding ethanol makes alcohol content reach 75%, stirring, stand 30 hours, filter, filtrate recycling ethanol, and it is concentrated into the thick paste that relative density is 1.30-1.35 (60 DEG C), let cool, add above-mentioned powder and starch, mixing, it is dried, pulverize, add Indigo Naturalis, add with starch again, mixing, pelletize, it is dried, add magnesium stearate, mixing, load capsule, obtain.

Present invention additionally comprises aforementioned pharmaceutical compositions application in the medicine of preparation treatment deficiency of both QI and YIN disease diabetes, supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid, it is applicable to the auxiliary treatment of deficiency of both QI and YIN disease diabetes, fatigue and weakness can be improved, lazy speech of breathing hard, polyorexia, excessive thirst polydipsia, dry mouth and tougue, the symptom such as urinary micturition.

Pharmaceutical composition of the present invention, prescription is motivated, and prescription composition is with theory of Chinese medical science and modern pharmacology, clinical research as foundation.Pharmaceutical composition function of the present invention: supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid.Seeing fatigue and weakness with the diabetes of dry gas Yin bivacuity, lazy speech of breathing hard, polyphagia polyphagia, thirst and liking drink, health gradually becomes thin, dysphoria with feverish sensation in the chest palms and soles, palpitation and insomnia, urinary micturition, or turbid urine is pleasantly sweet, and corpulent tongue is big, thin fur or flower stripping, stringy and thready pulse or the disease person such as count accurately.Above-mentioned all medicines share plays supplementing QI and nourishing YIN altogether, effect of clearing away heat and promoting production of body fluid.Diabetes in the diabetes of deficiency of both QI and YIN, i.e. modern medicine.Diabetes in modern medicine are shown in above-mentioned patient, also can use it.

In pharmaceutical composition of the present invention:

Radix Panacis Quinquefolii, is called for short Radix Panacis Quinquefolii, has another name called U.S.'s ginseng, Radix Panacis Quinquefolii etc..In one's early years it is sold to the whole nation through Guangdong, therefore the another name of also panacis quinquefolii radix.Radix Panacis Quinquefolii main product is in the U.S. and Canada.The flat phase in 13rd century, based on wild.To 19 end of the centurys, the virgin forest in sub-Radix Panacis Quinquefolii original producton location cut down and through more than 150 years dig, resource was destroyed, and the most gradually has artificial culture.In recent years, Radix Panacis Quinquefolii uses domestic Radix Panacis Quinquefolii in China's successful introduction this product.The world of medicine of China uses Radix Panacis Quinquefolii on the whole to start from for 18 beginnings of the century, and the pharmaceutical texts of the most flat record Radix Panacis Quinquefolii is supplementary Amplifications of the Compendium of Materia Medica." Bencao Congxin " is said: " relieving restlessness is tired for tonifying the lung pathogenic fire reducing, born fluid.Empty face has fire person suitable." " property of medicine is examined " load: " nourishing YIN is brought down a fever." " book on Chinese herbal medicine asks former " carry: " lung heat clearing kidney, cool heart spleen, with pathogenic fire reducing, is relieved summer heat, relieved the effect of alcohol " it is cool in nature, sweet and slightly bitter taste.GUIXIN, lung, kidney channel.Tool lung benefiting is cloudy, clear asthenic fire, effect of promoting the production of body fluid to quench thirst.For chronic cough of deficiency lung, lose blood, dry throat and mouth, deficiency-heat is tired of tired ".Modern age, pharmacological research showed: ginsenoside's (for the main component of Radix Panacis Quinquefolii) can make cancer patient r-globin, and specific IgM increases, and accelerates antibody and produces, promotes lymphocyte transformation, strengthens net and knits endothelial system function.And then cGMP in rising osteocyte, reduce cAMP, favorably breed.Adrenal cells cAMP level can be increased and strengthen body nonspecific resistance.

Radix Scrophulariae, for conventional Chinese medicine, begins to be loaded in Shennong's Herbal, is classified as middle product.Compendium of Material Medica carries: " nourishing YIN to lower pathogenic fire solves speckle poison, throat, diuresis stasis." " book on Chinese herbal medicine justice " say: " treat chest and diaphragm cardiopulmonary pathogenic heat, clear bladder Liver and kidney accumulation of heat, treat the pharyngalgia of wind heat, let out the conjunctival congestion of liver-yang, only spontaneous perspiration antiperspirant, control haematemesis hematemesis." its cold nature, sweet in the mouth, hardship, salty.Return lung, stomach, kidney channel.Tool removing heat from blood YIN nourishing, effect of eliminating fire and detoxication.For consumption of YIN caused by febrile disease, crimson tongue quenches the thirst, maculae caused by violent heat pathogen, and constipation, hectic fever due to YIN-deficiency chronic cough, conjunctival congestion, pharyngalgia, scrofula, diphtheria, carbuncle sore tumefacting virus are hindered in Tianjin ".Modern pharmacological research shows, Radix Scrophulariae has: (1) hypotensive effect；(2) antibacterial action；(3) hypoglycemic activity；(4) refrigeration function.

Herba Dendrobii, this product is more common Chinese medicine, begins to be loaded in Shennong's Herbal, is classified as top grade property of medicine opinion and carries: " QI invigorating heat extraction cures mainly man's waist foot weak.Strong sun, by musculus cutaneus migratory arthralgia, the coldest in bone, deficient, the long-pending essence of the kidney invigorating, waist cancer, support kidney qi, benefit power." " Japan hanako materia medica " say: " controlling deficient bad weak, strengthening bone and muscle, warming the kidney, Fructus Alpiniae Oxyphyllae, flat gastric qi, by exogenous pathogen." supplementary Amplifications of the Compendium of Materia Medica carry: " clearing stomach remove deficiency-heat, promote the production of body fluid, strain, with for tea, appetite promoting and the spleen strengthening.Wind is treated in arresting convulsion, can prolong expectorant, expelling summer-heat, sweet virtue sending down the abnormal ascending QI in town." its cold nature, sweet in the mouth.Return stomach, kidney channel.Tool supplementing QI for promoting the production of body fluid, effect of nourishing YIN and clearing away heat.For cloudy body fluid deficiency, xerostomia excessive thirst, lack of appetite retch, deficiency-heat after being ill, mesh is silent not clear.Modern pharmacological research shows, 1, effect to digestive system.Herba Dendrobii decoct is administered orally can promote the secretion of gastric juice, contribute to digestion.2, the impact on cardiovascular system.Dendrobine reduces blood pressure, weakens the effects such as mental and physical efforts.3, Herba Dendrobii energy yin nourishing, can in clear kidney excess-fire and take the photograph vigour, except deficiency-heat and relieving thirst and restlessness in stomach, clear in have benefit, invigorating middle warmer to have clearly.

Radix Ophiopogonis, for conventional Chinese medicine.Put down and just record at Shennong's Herbal, be classified as top grade." property of medicine opinion " carries: " control pyretic toxicity, only excessive thirst.Main flood appearance podomere edema, lower water, control consumptive lung disease vomiting pus, master lets out essence.". amplification on Canon of Materia Medica carries: " control cardiopulmonary deficiency-heat." its cold nature, sweet in the mouth, micro-hardship.GUIXIN, lung, stomach warp.Tool YIN nourishing and the production of body fluid promoting, effect of moistening lung and clearing heat.For dryness of the lung dry cough, chronic consumptive disease is coughed, and Tianjin wound is thirsty, vexed insomnia, and interior-heat is quenched one's thirst, dryness of the intestine constipation, pharyngeal diphtheria.Modern pharmacological research shows: have heart tonifying diuresis, antitussive Radix Ophiopogonis, eliminates chyluria and recovers renal function effect.It is used for clinically treating (1) diabetes；(2) pulmonary tuberculosis hemoptysis；(2) cough caused by dryness；(4) xerostomia.

Radix Asparagi, for few conventional Chinese medicine.Begin to be loaded in Shennong's Herbal.Compendium of Material Medica carries: " moisturize YIN nourishing, clearing and descending lung-fire." " property of medicine opinion " load: " main lung qi cough with dyspnea, rush of panting is anxious, heat extraction, logical kidney qi, treats pulmonary fistula life carbuncle vomiting pus, controls scabies humida, only quenches one's thirst." it is cold in nature, sweet in the mouth, hardship.Return lung, kidney channel.Tool nourishing YIN to relieve dryness, effect of clearing away heat and promoting production of body fluid.For dryness of the lung dry cough, pertussis expectorant glues, dry throat and mouth, dryness of the intestine constipation.Modern pharmacological research shows: the main component 3-sitosterol in Radix Asparagi has cholesterol reducing effect.Its hereby kidney yin hold concurrently clearing away lung-heat and moistening for dryness.

Radix Ginseng (Leptoradix Ginseng Rubra), begins to be loaded in Shennong's Herbal and says: " Radix Ginseng, sweet in the mouth is slightly cold.Main benefit five is hidden, peace spirit, determines soul, and spasmolytic is throbbed with fear, evil removing gas, obviously mesh, happy Fructus Alpiniae Oxyphyllae.Clothes, make light of one's life by commiting suicide and prolong life for a long time ".History tree is the most on the books." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " controlling negative and positive not enough, insufficiency of lung-QI "." book on Chinese herbal medicine covers and signs " carries: " relieving asthma and cough, unobstructed blood vessels, rush down YIN-fire, nourishes Yuanyang "." medicine origin " carries: " controlling taste YANG QI deficiency and lung qi to promote, lose heart, few gas, during invigorating middle warmer is slow, pathogenic fire in eliminating the pathogens from the lung taste, " cure mainly secret will " carries: " invigorating primordial QI, antidiarrheal, born fluid." its sweet in the mouth, micro-hardship, property is put down, is returned spleen, lung, heart channel.Tool strongly invigorating primordial QI, multiple arteries and veins takes off admittedly, and invigorating the spleen to benefit the lung promotes the production of body fluid, the function calmed the nerves.For weak body and prostration, cold extremities faint pulse, insufficiency of the spleen lack of appetite, the deficiency of the lung breathes with cough, and Tianjin wound is thirsty, and interior-heat is quenched one's thirst, prolonged illness weakness with emaciation, palpitation with fear insomnia. sexual impotence cold womb；Heart failure, cardiogenic shock.Modern pharmacological research shows: Radix Ginseng can improve the efficiency of muscle power and mental work, has obvious antifatigue effect.Certain Saponin contained therein has calmness, stable and analgesic activity to mice.Radix Ginseng has anti-stress effect, can improve body to various destructive stimuluses (too high, too low such as temperature or air pressure.Various poisonous chemical substances, microorganism, lonizing radiation or transplant cancer etc.) non-specific resistivity, make pathological change tend to and to recovering normal.Can slightly reduce blood glucose.Saponin mixture is named albumen synthesis promotive factor (Prostisol), can promote hepatocellular ribose core, protein and the biosynthesis of lipid, promotes the biosynthesis of erythrocyte DNA (deoxyribonucleic acid) in bone marrow, can improve the immunocompetence of body.Medical research confirms: control furuncle diabetes with Radix Ginseng clinically, senile diabetes patient blood glucose can be made to reduce, and blood glucose reduces 40-50 milligram %, imitates to maintain more than 2 weeks after drug withdrawal；In after isocratic diabetic takes Radix Ginseng, although dropping and hypoglycemic make rotten inconspicuous, but most overall health of patients makes moderate progress, such as thirsty sense, the transference cure such as weak or alleviate.

The Radix Astragali is conventional Chinese medicine, begins to be loaded in Shennong's Herbal and carries: " quench the thirst, stomachache, let out dysentery, QI invigorating, the cloudy gas of system." " medicine origin " load: " and control asthenia the coldest (" trembling with fear " work " antiperspirant "), enriching spleen-QI, real fur, eliminating the pathogens from the lung moderate heat, stringy pulse spontaneous perspiration, be apt to control weakness of the spleen and stomach, the medicine that expelling the toxic substance from the body with tonic the moon disease skin ulcer must be used ".It is warm in nature, sweet in the mouth.Return lung, spleen channel.Tool invigorating QI to consolidate the body surface resistance, diuresis poison holding, evacuation of pus, effect of expelling pus and promoting granulation.Weak for the deficiency of vital energy, anorexia and loose stool, sinking of QI of middle-JIAO, chronic diarrhea proctoptosis, (more metrorrhagia is leaked, exterior deficiency spontaneous perspiration, deficiency of vital energy water calf, and carbuncle difficulty is burst, and bursts for a long time and does not holds back, and blood deficiency dull yellowish colored skin, interior-heat is quenched one's thirst；Chronic nephritis proteinuria, diabetes.Modern pharmacological research shows, the Radix Astragali has: (1) diuresis；(2) hypotensive effect；(3) to action of the heart；(4) improve and promote the immunologic function of body: the Radix Astragali can put forward the level of cAMP in mice plasma, people take the Radix Astragali after in blood cAMP, IgM, IgE all have significantly increase；(5) effect to nephritis；(6) effect to hepatopathy；(7) effect to gastric ulcer；(8) toxicity: to mice coloclysis (being equivalent to crude drug 100g/kg) without bad toxic reaction.

Fructus Schisandrae Chinensis, for more common Chinese medicine.Begin to be loaded in Shennong's Herbal, be classified as top grade." herbal classic " carries: " main QI invigorating, cough with dyspnea, impairment caused by overstrain weakness and emaciation, tonifying for the deficiency, reinforcing YIN-essence, benefit man's essence." not Lu " carries: " support the five internal organs, heat extraction, flesh in raw the moon." Lee fruit say: " promoting the production of body fluid to quench thirst.Controlling dysentery, invigorating primordial QI is not enough, receives the gas of dissipation, platycoria ", it is warm in nature, sour in the mouth, sweet.Return lung, the heart, kidney channel.Bearberry Extract is astringent or styptic treatment for spontaneous sweating, supplementing QI for promoting the production of body fluid, effect of kidney calming.Sliding for chronic cough dyspnea due to deficiency, nocturnal emission, lose dung frequent micturition, incessant chronic diarrhea, spontaneous perspiration, night sweat, Tianjin wound is thirsty, deficient pulse of losing heart, and interior-heat is quenched one's thirst, palpitation and insomnia；Modern pharmacological research shows: Fructus Schisandrae Chinensis can affect carbohydrate metabolism, promotes liver glycogen heteroplasia, accelerates glycogenolysis, and the Phosphorylation events making brain, liver and muscle knit middle fructose and glucose is strengthened.

Fructus Lycii, for conventional Chinese medicine, begins to be loaded in Shennong's Herbal, is classified as top grade.TAO Hong-Jing is said: " nourishing the essence and strengthening QI, prosperous and powerful vagina." " property of medicine opinion ": " energy tonification essence various symptoms and signs of deficiency, easy color, bleach, and improving eyesight is calmed the nerves." Wang Haozhan says: " main cardiopathia dry sensation in the pharynx, pained, thirsty and taking fluids profusely, during nephropathy disappears." Compendium of Material Medica load: " nourishing kidney, lung moistening, improving eyesight." its property put down, sweet in the mouth.Return liver, kidney channel.Tool nourishing the liver and kidney, effect of replenishing vital essence to improve eyesight.For asthenia damage of essence, soreness of waist and knee joint, vertigo and tinnitus, interior-heat quenches one's thirst, and blood deficiency and yellow complexion, blurred vision is failed to understand.Modern pharmacological research shows: Fructus Lycii has: (1) hemoposieis；(2) enhancing non-specific immunity effect；(3) hepatoprotective effect；(4) hypoglycemic activity etc..

Rhizoma Polygonati Odorati, for conventional Chinese medicine, it begins to be loaded in Shennong's Herbal with the name of Rhizoma Polygonati Odorati, history tree records." four tones of standard Chinese pronunciation book on Chinese herbal medicine " carries: " invigorating the spleen and replenishing QI." " Japan hanako materia medica " load: " relieving restlessness is vexed, quenches the thirst, and moistens cardiopulmonary, mends five kinds of strain and seven kinds of impairment, deficient, and waist chest pain pain, sky row is fanatical." " the southern regions of the Yunnan Province book on Chinese herbal medicine " load: " and fill blood, invigorating middle warmer spleen invigorating." " Guangxi Chinese medicinal herbal " load: " nourishing YIN and clearing away lung-heat profit is quick-fried.Control the deficiency of YIN, hyperhidrosis, cough caused by dryness, lung beach wormwood." its cold nature, sweet in the mouth, attach to the lung and stomach meridians.Tool nourishing YIN to relieve dryness, effect of promoting the production of body fluid to quench thirst.Hinder for lung stomach-Yin.Cough caused by dryness-heat, dry throat and mouth, interior-heat is quenched one's thirst.Treat hyperlipidemia with Rhizoma Polygonati Odorati clinically, achieve good results.

Radix Rehmanniae (Radix Rehmanniae, Radix Rehmanniae Preparata) is conventional Chinese medicine, begins to be loaded in Shennong's Herbal.Having Radix Rehmanniae and Radix Rehmanniae Preparata two kinds in commodity, the two effect is different, and Radix Rehmanniae is cold in nature, sweet in the mouth.GUIXIN, liver, kidney channel.The tool cool heart of heat clearing away, yin nourishing, effect of promoting the production of body fluid.For calentura crimson tongue excessive thirst, yin asthenia generating intrinsic heat, hectic fever due to YIN-deficiency consumptive fever, interior-heat quenches one's thirst, hematemesis and epistaxis, sends out speckle dermexanthesis.Radix Rehmanniae Preparata slightly warm in nature, sweet in the mouth.Return liver, kidney channel.Tool nourishing YIN and supplementing blood, benefit essence fills out effect of marrow.For the hepatic and renal YIN deficiency, soreness of the waist and knees, osteopyrexia and fever, night sweat passes out semen, and interior-heat is quenched one's thirst, and blood deficiency and yellow complexion, severe palpitation, menoxenia, metrostaxis, dizziness, tinnitus, beard and hair is for no reason.Modern pharmacological research shows: Radix Rehmanniae has hypoglycemic effect, and rabbit hemostasis Radix Rehmanniae alcohol extractum solution 2g/kg or gavage 4g/kg all can make blood glucose decline, especially more apparent with drug administration by injection, and after being administered, 4 hours blood glucoses are preferably minimized level.Clinical report six drugs containing rehmanniae pill for curing two example diabetes, effect is obvious.Glucose in urine, blood glucose all can recover normally, and all clinical symptoms rapidly disappear, and body weight increases day by day, energetic, be quite a different person, simultaneously pulmonary tuberculosis also get better turn.

Radix Polygoni Multiflori Preparata, for conventional Chinese medicine, begins to be loaded in Song's " Kaibao Bencao ", and " the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " arresting seminal emission. hard kidney qi, the most red white turbid urine, urine, enter blood system, the expectorant Qin." " medicineization justice " carry: " the liver benefiting, hold back blood, YIN nourishing, control waist knee joint weak, muscles and bones is ached, and cuts deficient syndrome, and only kidney rushes down, and except metrorrhagia, solves leukorrhagia " " book on Chinese herbal medicine is the newest " carries: " tonifying the lung is empty, emesis blood ".It is warm in nature, bitter in the mouth, sweet, puckery.Return liver, the heart, kidney channel.Tool invigorating the liver and kidney, benefiting essence-blood, crow beard and hair, effect of bone and muscle strengthening.For blood deficiency and yellow complexion, vertigo and tinnitus, for no reason, waist knee joint is soft, numb limbs and tense tendons, bleeding not during menses for beard and hair, and chronic malaria body is empty；Blood fat disease.Modern pharmacological research shows: Radix Polygoni Multiflori has blood fat, hypoglycemic effect.

Colla Corii Asini, for conventional Chinese medicine.Putting down and just record at Shennong's Herbal, be classified as top grade, Compendium of Material Medica carries: " grow phase, except the wind phase is dry, lung heat clearing of reducing phlegm, diuresis with blood." its property put down, sweet in the mouth.Return lung, liver, kidney channel.Have YIN nourishing of enriching blood, moisturize, effect of hemostasis.Yellow for blood deficiency beach wormwood, dizziness cardiopalmus, flesh flaccidity is unable, dysphoria and insomnia, stirring-up of pathogenic wind in the interior resulting from deficiency, xeropulmonary cough, and labor ouch is spat blood, haematemesis hematuria, metrorrhagia of having blood in stool, vaginal bleeding during pregnancy.Modern pharmacological research shows: the dog Colla Corii Asini solution gavage to hemorrhagic anemia, and the speed that its erythrocyte and hemoglobin increase is faster than matched group, and another Colla Corii Asini can improve calcium balance in animal body.

The Radix Paeoniae Alba, for conventional Chinese medicine, begins to be loaded in Shennong's Herbal and is classified as middle product." Treatise on Febrile Disease with Notes " carries: Radix Paeoniae, white benefit and red rush down, white receipts and red dissipate also." " the acid receipts of Radix Paeoniae, hold back body fluid and benefit is flourish." " deficiency of vital QI, receives and on row, the acid of Radix Paeoniae is to receive healthy energy." " acid, receives also, let out also, the acid of Radix Paeoniae, receives cloudy gas and enters pathogen." its cold nature, bitter in the mouth, acid.Return liver, spleen channel.Tool suppressing the hyperactive liver pain relieving, nourishing blood for regulating menstruation, effect of astringing YIN to stop sweating.For dizziness of having a headache, hypochondriac pain, stomachache, limb pain twin, blood deficiency beach wormwood is yellow, menoxenia, spontaneous perspiration, night sweat.Modern pharmacological research shows: the Radix Paeoniae Alba has (1) spasmolysis；(2) effect to blood circulation；(3) analgesia, calm, anticonvulsant action；(4) antiinflammatory, antiulcer action；(5) antibacterial, refrigeration function.

Rhizoma Polygonati, for conventional Chinese medicine, begins to plant in " Mingyi Bielu ".Say: " main invigorating the spleen and replenishing QI, except rheumatism, settling five organs." " Japan hanako materia medica " carries: " and mend five kinds of strain and seven kinds of impairment, help muscles and bones, only famine, cold-resistant administration, strengthening the spleen stomach, moistens cardiopulmonary." " the southern regions of the Yunnan Province book on Chinese herbal medicine " load: " qi-restoratives adds essence." Compendium of Material Medica load: " mend all void, only cold and heat, fill out grain marrow." " Bencao Congxin " load: " the flat face profit that fills blood." its property put down, sweet in the mouth.Return spleen, lung, kidney channel.Tool boosting qi and nourishing yin, spleen invigorating, lung moistening, kidney tonifying.For weakness of the spleen and stomach, fatigue and asthenia, xerostomia lack of appetite, deficiency of the lung cough caused by dryness, asthenia of essence and blood, interior-heat is quenched one's thirst.Modern efficacy of a drug research report: rabbit is administered orally Rhizoma Polygonati extractum, its blood sugar content is originally normal, gradually increases, then reduces.And the blood glucose that causes upper parathyrine is too high in significant inhibitory action.

Arillus Longan, for more common Chinese medicine, begins to be loaded in Shennong's Herbal, lists middle product in." Kaibao Bencao " carries: return spleen and can Fructus Alpiniae Oxyphyllae." daily book on Chinese herbal medicine " carries: " Fructus Alpiniae Oxyphyllae mind calming." " the southern regions of the Yunnan Province book on Chinese herbal medicine " sanction: " nourishing blood to tranquillize the mind, long intelligence benefit antiperspirant, whet the appetite strengthening the spleen." " explaining abstruseness of the canon of materia medica " load: " profit issues cough-relieving "." must join book on Chinese herbal medicine " carries: " strengthening the spleen preserves painstaking effort, moistening five ZANG-organs, controls seized with terror stretching." it is warm in nature, sweet in the mouth, GUIXIN, spleen channel.Tool invigorating the heart and spleen, effect of nourishing blood to tranquillize the mind.For insufficiency of vital energy and blood, severe palpitation, forgetful insomnia, blood deficiency beach wormwood is yellow.Modern pharmacological research shows: (1) Arillus Longan can stimulate hemopoietic system, promotes erythrocyte and hemoglobin, thrombocytosis.

The Rhizoma Atractylodis Macrocephalae, for conventional Chinese medicine, begin to be loaded in Shennong's Herbal be classified as top grade, " medicine origin " carry: " dehumidifying benefit is dry, and middle QI invigorating, warming middle-JIAO; go in taste wet, and except gastric heat, strong taste spout diet, stomach function regulating, born fluid, main flesh heat; extremity are sleepy, and mesh is not intended to out, and tiredness with somnolence quenches the thirst." Lee fruit say: " go wet in all warps and manage taste." it is warm in nature, bitter in the mouth, sweet.Return spleen, stomach warp.Tool invigorating the spleen and benefiting QI, dampness diuretic, hidroschesis, antiabortive effect.For insufficiency of the spleen lack of appetite, abdominal distention is had loose bowels, phlegm retention vertigo and palpitation, edema, spontaneous perspiration, and frequent fetal movement modern pharmacological research shows: the Rhizoma Atractylodis Macrocephalae has reduction blood glucose effect.It is in a slight decrease that rabbit gavages decoct or preserved material, blood glucose.Rats gavaged decoct, has the assimilation of glucose in acceleration bodies thus drops hypoglycemic effect.The liver glycogen minimizing effect that mice is taken decoct the liver protecting orally, prevents carbon tetrachloride from causing.

Rhizoma Atractylodis, for conventional Chinese medicine, begin to be loaded in Shennong's Herbal and are classified as top grade." the Margarita foot of a hill or mountain " carries: " can stomach invigorating peace spleen. non-this of all wet wealth can not remove." it is warm in nature, acrid in the mouth, bitter.Return spleen, stomach, Liver Channel.Have drying damp and strengthening spleen, dispel the wind, cold expelling, effect of improving eyesight.For distension and fullness in the abdomen, having loose bowels, edema, tinea pedis fistula, rheumatic arthralgia, wind and cold sense is rich, nyctalopia nyctalopia.Modern pharmacological research shows, Rhizoma Atractylodis extractum subcutaneous injection has hypoglycemic activity to rabbit, and Rhizoma Atractylodis decoct, to rabbit gavage, has reduction blood glucose effect to four gas pyrimidine diabetes, during administration, blood glucose after 410mg% is gradually decreased to 160mg%, drug withdrawal 4-17 days, has no that blood glucose goes back up to be administered front level.

Semen Coicis, for conventional Chinese medicine, original name Semen Coicis people, Shennong's Herbal is classified as top grade.Supplement to the Herbal carries: " wet, master quenches one's thirst." Compendium of Material Medica load: " wind prevailing over dampness is removed in invigorating spleen and reinforcing stomach, tonifying the lung heat clearing away ", it is cool in nature, sweet in the mouth, light.Return spleen, stomach lung meridian.Tool spleen invigorating is wet, eliminating impediment antidiarrheal, effect of clearing away heat and discharging pus.For edema, tinea pedis, dysuria.Arthralgia chiefly caused by damp pathogen contracture, insufficiency of the spleen slag book, whirlpool carbuncle, acute appendicitis；Verruca plana.Modern pharmacological research shows: dream Semen Coicis (parched) has effect that spleen invigorating is wet.Semen Coicis have hypotensive effect.

Rhizoma Dioscoreae, for conventional Chinese medicine.Shennong's Herbal is listed in top grade." herbal classic " carries: " main damaging the spleen and stomach, qi-restoratives, except cold and heat pathogen, invigorating the spleen and replenishing QI power, long muscle, take normal hearing and eyesight for a long time." " typhoid fever accumulate will " carry: " tonifying for the deficiency, clearind deficient heat ".Compendium of Material Medica carries: " kidney tonifying gas, strengthening the spleen and stomach, stopping leak dysentery, reduce phlegm saliva, moistens fur." its property put down, sweet in the mouth, return spleen, lung, kidney channel.Tool spleen reinforcing nourishing the stomach, promote the production of body fluid lung benefiting, effect of the kidney invigorating arresting seminal emission.For insufficiency of the spleen lack of appetite, incessant chronic diarrhea.The deficiency of the lung is breathed with cough, emission due to deficiency of the kidney, leukorrhagia, frequent micturition, and deficiency-heat is quenched one's thirst.Modern pharmacological research shows: Rhizoma Dioscoreae can be promoted the production of body fluid the kidney invigorating, the moon of lung benefiting kidney and control and quench one's thirst.

Fructus Corni, for conventional Chinese medicine, beginning load gives Shennong's Herbal." not Lu " carries: " ..., reinforcing YIN-essence, benefit essence, settling five organs, logical nine orifices, only normal urination, improving eyesight, strongly." " property of medicine opinion " cultivation: " ..., the kidney invigorating gas, emerging yang-energy, add marrow, treat tinnitus, only old man's urine does not saves." its slightly warm in nature, sour in the mouth, return liver, tool tonification liver, puckery solid mu effect.For dizzy obstinate ear, knee joint soreness, sexual impotence something lost, free and unfettered frequency of urinating, bleeding not during menses, profuse sweating collapse, interior-heat is quenched one's thirst ".Modern pharmacological research shows: Fructus Corni can make anaesthetized dog blood pressure reduce, on normal Rabbits ' Blood Sugar without impact.

Radix Achyranthis Bidentatae, for conventional Chinese medicine, the most flat sees Shennong's Herbal." not Lu " carries: " few gas in curing the wound, man's kidney yin disappears, and old man loses excessive, and invigorating middle warmer is continuous absolutely.Filling out bone, except carbuncle and stamen rachiagia in brain, married woman's moon water is obstructed, blood agglomeration, benefit essence.Li Yin gas, only poliosis." " property of medicine opinion " load: " control impotence, mend virtuous replenishing essence.Tie by stagnant blood stream, the rib twelve regular channels ".Its property is put down, bitter in the mouth, acid.Return liver, kidney channel.Tool invigorating the liver and kidney, bone and muscle strengthening, eliminating blood stasis and inducing menstruation, effect of conducting blood to flow downwards.For soreness of waist and knee joint, muscles and bones is unable, amenorrhea minister in ancient times, dizziness due to hyperactivity of liver-YANG.Modern pharmacological research shows, Radix Achyranthis Bidentatae decoct has of short duration hypotensive effect.

Testis et Pentis Canis, for more common Chinese medicine, begins to carry Shennong's Herbal, is classified as middle product, and Compendium of Material Medica carries: " is Liver and kidney, strong bone, controls wind void." book on Chinese herbal medicine is the newest " carries: " hard kidney supports body, QI invigorating." it is warm in nature, bitter in the mouth, sweet.Return liver, kidney channel.Tool invigorating the liver and kidney, strong waist kidney, effect of wind-damp dispelling, aching and limp for spinal column, lower limb are weak, rheumatism numbness crust.

Rhizoma Coptidis, conventional Chinese medicine, begins to be loaded in Shennong's Herbal, is classified as top grade." Japan hanako materia medica " carries, and controls five kinds of strain and seven kinds of impairment, QI invigorating, only cardiac and abdominal pain.Palpitate with fear fidgety, moisten cardiopulmonary, put on flesh, hemostasis, and skin ulcer scabies, night sweat, sky row heat-phlegm." " pearl sac " load: " eliminating heart-fire, epigastric oppression." it is cold in nature for sun, bitter in the mouth.GUIXIN, spleen, stomach, liver, gallbladder, large intestine channel.Tool heat clearing and damp drying, effect of eliminating fire and detoxication.For damp and hot feeling of fullness, vomiting, dysentery.Jaundice, unconsciousness due to high fever, hyperactivity of heart-fire, dysphoria and insomnia, heat in blood tells nosebleed, conjunctival congestion acid regurgitation, and toothache is quenched one's thirst, and carbuncle treats skin ulcer；Modern pharmacological research shows that Rhizoma Coptidis has: (1) antimicrobial and protozoacide effect；(2) effect to blood circulation；(3) effect to acetylcholine etc.；(4) effect to smooth muscle；(5) on bile secretion and the impact of blood；(6) radiation anticancer, anti-and the impact etc. on cellular metabolism.

Cortex Phellodendri, for conventional Chinese medicine, with the name of bark of a cork tree wood, begins to be loaded in Shennong's Herbal, is classified as top grade " herbal classic " and carries: " stagnation of pathogenic heat, jaundice, perianal abscess in main the five internal organs the intestines and stomach." " not Lu " carry: " and treat frightened gas between skin, red of skin heat, the hot swelling pain of mesh, aphtha." supplement to the Herbal load: " decoction, master quenches one's thirst." " pearl sac " cultivation: " control kidney water, bladder is not enough, and all fistulas are fainted, weakness of the waist and knees ".It is cold in nature, bitter in the mouth, returns kidney, bladder warp.Tool heat clearing and damp drying, pathogenic fire purging is except steaming, effect of detoxification sore treatment.For damp-heat dysentery, jaundice, leukorrhagia. pyretic stranguria, tinea pedis, hectic fever due to YIN-deficiency consumptive fever, night sweat, seminal emission, sore swollen toxin, eczema pruritus.Cortex Phellodendri contains more little berberine as Rhizoma Coptidis, therefore its pharmacological action is substantially similar to Rhizoma Coptidis.But content is low compared with Rhizoma Coptidis, and containing other compositions, the most also there is antibacterial action, hypotensive effect etc..

Cortex Lycii, for conventional Chinese medicine, begins to be loaded in Shennong's Herbal, it is classified as top grade " herbal classic ": " in main five, pathogen, hankers quenching one's thirst, general arthralgia." " Treatise on Dietetic Therapy " load: " heat of boning is quenched one's thirst." Wang Haogu says: " rushing down kidney fire, in fall lung, Fu fire, removes born of the same parents' moderate heat, brings down a fever, the gas Compendium of Material Medica that make corrections load: " go part of the body cavity below the umbilicus, housing the bladder, kidneys and bowels Liver and kidney deficiency-heat.It is cold in nature, sweet in the mouth.Return lung, liver, kidney channel.Tool removing heat from blood is except steaming, and effect of fire drops in lung heat clearing.For deficiency of YIN hectic fever, hectic fever due to YIN-deficiency night sweat, cough due to lung-heat.Slightly blood, holds back blood, and interior-heat is quenched one's thirst.Modern pharmacological research shows that Cortex Lycii has: (1) to Cardiovascular System；(2) hypoglycemic activity；(3) effect for reducing blood fat；(4) refrigeration function；(5) antibacterial and antivirus action etc..Clinical it is administered orally with Cortex Lycii decoct, Hypertension, has obvious curative effect.

Radix Cynanchi Atrati, for more common Chinese medicine, begins to be loaded in Shennong's Herbal, it is classified as middle product. history tree all records." herbal classic " carries: " main sudden and violent apoplexy, fever of the body limb is full, before we notice it does not know people, mad puzzled pathogen.Cold and heat acid nevus, disease washes, disease appearing at regular intervals." " key medicine divides agent " load: clearind deficient heat, except heat in blood." it is cold in nature, bitter in the mouth, salty.Return stomach, liver, kidney channel.Tool clearing away heat and cooling blood, inducing diuresis for treating stranguria syndrome, effect of detoxification sore treatment.Heating, fever due to yin deficiency, hectic fever due to YIN-deficiency consumptive fever is sought for pathogenic warmth wound.Puerperal fever due to deficiency of blood, pyretic stranguria, stranguria with blood.Swollen ulcer drug.Modern pharmacological research shows: Radix Cynanchi Atrati can enter punching one wantonly two arteries and veins, and the heat purified the blood point is for heat in blood, and dark coloured urine, pouring is bitterly etc..

Spica Prunellae, for conventional Chinese medicine, begins to be loaded in Shennong's Herbal, it is classified as low-grades." herbal classic " carries: " main cold and heat, scrofula, scrofula, head sore, moth eliminating stagnation gas, swelling of the feet arthralgia chiefly caused by damp pathogen." " Amplification on Materia Medica addendum " sanction: " taking a tonic or nourishing food to build up one's health blood vessels " " the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " liver-wind of dispelling, network of passing through.It is in harmony facial hemiparalysis, row irritability, open stagnation of liver-QI, only muscles and bones nevus pain, ophthal malgia, dissipate scrofula, tuberculosis all over the body." it is cold in nature, acrid in the mouth, hardship, returns liver, gallbladder meridian.Tool relieves inflammation or internal heat, improving eyesight, eliminating stagnation, detumescence.For conjunctival congestion and swelling pain, mesh pearl nyctalgia, dizziness of having a headache, scrofula.Flaccidity tumor, acute mastitis swells and ache；Thyromegaly, lymphoid tuberculosis, cyclomastopathy, vascular hypertension.Modern pharmacological research shows: Spica Prunellae has (1) antibacterial action；(2) antifungic action；(3) hypotensive effect, (4) are to key role；(5) to blood vessel function；(6) antiinflammatory action；(7) antitumor action etc..

Fructus Tribuli, for more common Chinese medicine, the name given with Fructus Tribuli begins to be loaded in Shennong's Herbal, is classified as top grade." can about cure mirror " carry: " eliminating the pathogens from the lung gas and dissipate liver-wind, except conjunctivitis, pulse carbuncle, breast carcinoma, eczema." " book on Chinese herbal medicine is the newest " carry: " QI invigorating reduces phlegm for town liver-wind, removing fire from the liver, wet dissipation removing blood stasis, eliminating carbuncle subcutaneous ulcer, the San Chuan Qin." tool slightly warm in nature, acrid in the mouth, hardship.Return Liver Channel.Tool Pingyin resolving depression, promoting blood circulation by removing wind, effect that improving eyesight is antipruritic, it being used for having a headache dizzy, distending pain in the chest and hypochondrium, breast closes breast numbness, cataract, rubella pruritus.Modern pharmacological research shows that Fructus Tribuli has the effect reduced blood pressure.

Radix Trichosanthis, for conventional Chinese medicine, begins to be loaded in Shennong's Herbal, is classified as middle product." herbal classic " carries: " master quenches one's thirst, fever of the body, tired, the hottest, qi-restoratives regulating the spleen and stomach, continuous wound absolutely." " not Lu " carry: " except tumor heat, eight subcutaneous ulcer body yellowish complexion, dry lip, dry mouth in the intestines and stomach, lose heart." " book on Chinese herbal medicine is just " carry: " cool cardiopulmonary, antipyretic yearningly.Heat-phlegm on fall diaphragm, the acute mastitis that disappears toxic swelling." medical center admire will " carries: tonifying the lung, astringing QI, pathogenic fire reducing, mind calming, and eliminating pathogen in the liver of holding concurrently is strongly fragrant, and slow liver is anxious, clear bladder heat, only pyretic stranguria urine short number, except sun is bright damp and hot." its cold nature, sweet in the mouth, micro-hardship, attach to the lung and stomach meridians.Tool clearing away heat and promoting production of body fluid, effect of detumescence and apocenosis.For calentura excessive thirst, lung-heat type cough, interior-heat quenches one's thirst, sore swollen toxin.Go Rhizoma Alismatis to add Radix Trichosanthis with LIUWEI DIHUANG TANG clinically, or and be basic side plus-minus treatment diabetes 3 example with Radix Trichosanthis, patient takes medicine after 0-24 agent, the most cures, and follows up a case by regular visits to 13-14 month, has no multiple.

Radix Puerariae, for conventional Chinese medicine, begins to be loaded in Shennong's Herbal, is classified as middle product." herbal classic " load: master quenches one's thirst, high fever of the body, vomiting, all numbness, play cloudy gas, solve all poison " " Japan hanako materia medica " load: " controlling chest and diaphragm hot, vexed sultry mad "." medicine origin " carries: thirsty except taste deficiency-heat.Compendium of Material Medica carries: " dissipate stagnated fire." it is cool in nature, sweet in the mouth, pungent.Return spleen, stomach warp.Tool expelling pathogenic factors from muscles for reducing heat, promotes the production of body fluid, rash, effect of yang invigorating antidiarrheal.For locating to feel fever and headache, stiffness of the nape, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea, have loose bowels；Hypertension neck pain.Clinically with the strong pain of kudzuvine root for treating hypertension neck, angina pectoris, receive blunt good effect.

Indigo Naturalis, for conventional Chinese medicine.The name of Indigo Naturalis begins to be loaded in Tang's " property of medicine opinion ", records thereafter Song's Yu " Kaibao Bencao " and says: " palpitation with fear heating, pestilent headache cold and heat, pan-fried water grinds and takes it for principal solution small piece of land surrounded by water poison of drug, infantile pyretic diseases." " key medicine divides agent " carry: " the heat extraction solution Qin, hold concurrently can removing heat from blood " it be cold in nature, salty in the mouth.Return Liver Channel.Tool heat clearing away solution is given, removing heat from blood, arresting convulsion.For maculae caused by violent heat pathogen, heat in blood tells nosebleed, chest pain hemoptysis, aphtha, mumps, sore throat, pediatric epilepsy scared.Modern pharmacological research shows that Indigo Naturalis has: (1) antitumaous effect: (2) hepatoprotective effect；(3) impact on leukocyte；(4) antibacterial action etc..

Concha Meretricis Seu Cyclinae, for few conventional Chinese medicine, Shennong's Herbal is classified as top grade." herbal classic " carries: " main child, against upper gas, pants, stuffy sensation with restlessness, chest pain cold and heat." " four tones of standard Chinese pronunciation book on Chinese herbal medicine " load: " and only quench one's thirst, moistening five ZANG-organs, Compendium of Material Medica carries: " clearing away heat-damp and promoting diuresis, reduce phlegm drink, and removing food stagnancy gathers ... " it is cold in nature. and hide hardship, salty.Return lung, kidney, stomach warp.Tool heat clearing away disease, hard masses softening and resolving, effect of relieving gastric hyperacidity to alleviate stomachache.Ouch, pain in chest and hypochondrium, sputum mixed with blood, scrofula tumor is coughed, acid regurgitation of having a stomachache for phlegm-fire.

Radix Salviae Miltiorrhizae, for conventional Chinese medicine, begins to be loaded in Shennong's Herbal, it is classified as top grade." the southern regions of the Yunnan Province book on Chinese herbal medicine " carries: " reinforcing the heart sedate, calming heart and tranquilizing mind.Controlling forgetful palpitation with a distress feeling, palpitation with fear is insomnia." Compendium of Material Medica load: " and invigorate blood circulation, logical pericardium channel.Control colic." " choosing of Yunnan Chinese herbal medicine " load: " promoting blood circulation to remove blood stasis, sedation-analgesia ", its cold nature, bitter in the mouth.GUIXIN, Liver Channel.Tool stasis-dispelling and pain-killing, promoting blood circulation to restore menstrual flow, the effect of the relieving restlessness that clears away heart-fire.For menoxenia, amenorrhea dysmenorrhea, abdominal mass accumulation, chest and abdomen twinge, pyretic arthralgia nevus pain, skin infection swells and ache, dysphoria and insomnia；Hepatosplenomegaly, angina pectoris.Modern pharmacological research shows that the injection of Radix Salviae Miltiorrhizae rabbit muscle has obvious hypoglycemic activity.

Herba Lycopi, this product is more common Chinese medicine, begins to be loaded in Shennong's Herbal, it is classified as middle product.Lei Gong's Treatise on Preparation and Broiling of Materia Medica carries: " energy removing blood stasis, logical the most long-pending." " Japan hanako materia medica " carry: " and nourish blood gas for logical nine orifices, profit GUAN-pulse, broken stagnated blood, and disappear broken abdominal mass, antenatal puerperal all kinds of diseases and ailments, logical small intestinal, granulation promoting of putting on flesh, disappear and flutter damage blood stasis, control serious epistaxis and spit blood, wind syndrome of head ophthalmalgia, married woman's labor is thin, husband's yellowish complexion.Its slightly warm in nature, bitter in the mouth, pungent.Return liver spleen channel.Tool blood circulation promoting and blood stasis dispelling, effect of line water detumescence.For menoxenia, amenorrhea, pain is light, and postnatal blood stasis is suffered from abdominal pain, edema.

Pharmaceutical composition of the present invention, by monarch principles of formulating prescriptions analysis prescription compatibility of medicines:

We are to set for the diabetes of syndrome of deficiency of both qi and yin, and with supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid is method.Radix Panacis Quinquefolii in side, sweet in the mouth are cool in nature, supplementing QI and nourishing YIN, nourishing the stomach to promote the production of body fluid；Radix Scrophulariae, bitter in the mouth are cold in nature, nourishing YIN to lower pathogenic fire, clearing away heat and cooling blood；Herba Dendrobii, sweet in the mouth is cold in nature, nourishing the stomach to promote the production of body fluid, YIN nourishing heat extraction；Radix Ophiopogonis, sweet in the mouth is cold in nature, nourishing YIN and moistening the lung, reinforcing stomach reg fluid；Radix Asparagi, bitter in the mouth is cold in nature, nourishing YIN and moistening the lung, lung heat clearing pathogenic fire reducing, lower foster kidney yin.Five medicines share, and become the merit of supplementing QI and nourishing YIN to grow the moon liquid of lung, spleen, stomach, kidney altogether, clear in raw scorching, promote the production of body fluid and only quench one's thirst, altogether for the monarch drug in side.

Leptoradix Ginseng Rubra, the Radix Astragali in side, sweet tepor, strongly invigorating primordial QI, tonifying the lung spleen invigorating；Fructus Schisandrae Chinensis sweet acid temperature, lung nourishing kidney, supplementing QI for promoting the production of body fluid, control the card of all gas the moon dissipation；Fructus Lycii, Gan Ping, nourishing YIN and supplementing blood, replenishing vital essence to improve eyesight；Rhizoma Polygonati Odorati, sweet is slightly cold, nourishing YIN and moistening the lung, reinforcing stomach reg fluid；Radix Rehmanniae, Gan Liang, nourishing YIN and clearing away heat；Radix Rehmanniae Preparata, Gan Weiyi, taste of enriching blood is bright, and benefit essence fills out marrow；Radix Polygoni Multiflori Preparata, sweet tepor, invigorating the liver and kidney, benefiting essence-blood；Colla Corii Asini, Gan Ping, enrich blood, nourshing Yin and drynsessmoistening prescription；Rhizoma Polygonati, Gan Ping, takes a tonic or nourishing food to build up one's health spleen the moon, the lung moistening and production of body fluid promoting；The Radix Paeoniae Alba, acid is slightly cold, and nourishes blood and blood, and each medicine of yin fluid astringing closes and with it, also becomes the merit of supplementing QI and nourishing YIN, nourishing lung, spleen, stomach, the moon of kidney, both selected the congenital foundation, also helped the foundation of acquired constitution, makes cloudy Tianjin sufficient, the Lei heat of interior life can be clear, quenches one's thirst and can stop, can strengthen effect of monarch drug, is for the ministerial drug in side.

The spleen and stomach provide the material basis of the acquired, therefore again with the sweet temperature of the Rhizoma Atractylodis Macrocephalae, invigorating the spleen and benefiting QI in side；Rhizoma Atractylodis, bitter temperature, drying damp and strengthening spleen；Semen Coicis, sweet light is slightly cold, and spleen invigorating is wet；Arillus Longan, Gan Wen, invigorating the heart and spleen, nourishing blood to tranquillize the mind；Rhizoma Dioscoreae, Gan Ping, supports spleen the moon and consolidating semen is micro-, closes and with it, helps the foundation of acquired constitution to grow its change source altogether.The kidney being the origin of congenital constitution, again with Radix Achyranthis Bidentatae, Rhizoma Cibotii liver and kidney tonifying in side；Fructus Corni liver and kidney tonifying, reinforcing the kindey to control nocturnal emission, do not make the micro-bet of foodstuff essence.Assistant helps all medicines of the monarch and his subjects to control the merit quenched one's thirst altogether, is for the adjuvant drug in side.

" the raw interior-heat of the deficiency of YIN ", therefore with Rhizoma Coptidis, Cortex Phellodendri, clearing up internal heat by using drugs of bitter in taste and cold in nature, eliminating fire and detoxication in side；Cortex Lycii, Gan Han, tonifying YIN, clearind deficient heat, let out lung-fire；Radix Cynanchi Atrati, bitter cold, replenishing YIN and removing heat；Spica Prunellae, hardship is slightly cold. liver heat removing and eyesight improving；Fructus Tribuli, Xin Ping, suppressing the hyperactive liver resolving depression, wind and heat dispersing；Radix Trichosanthis, sweet is slightly cold, and clearing away heat and promoting production of body fluid quenches the thirst；Radix Puerariae, Gan Xinping, heat clearing away, promoting the production of body fluid to quench thirst；Indigo Naturalis, salty-cold, heat clearing away., removing heat from blood, removing toxic substances；Concha Meretricis Seu Cyclinae, salty-cold, clearing away lung-heat.Yin asthenia generating intrinsic heat, consumption Tianjin liquid that burns forms the stasis of blood, therefore again with Radix Salviae Miltiorrhizae, Herba Lycopi, blood circulation promoting and blood stasis dispelling in side.The most each medicine also can be helped and be helped each medicine of the monarch and his subjects to control the merit quenched one's thirst, therefore the also adjuvant drug in the side of being.

The most all medicines share, and play supplementing QI and nourishing YIN altogether, the merit of clearing away heat and promoting production of body fluid, fatigue and weakness is seen for the diabetes of deficiency of both QI and YIN, lazy speech of breathing hard, polyphagia polyphagia, thirst and liking drink, health gradually becomes thin, dysphoria with feverish sensation in the chest palms and soles, palpitation and insomnia, dung frequency amount is many, or turbid urine is pleasantly sweet, and corpulent tongue is big, thin fur or flower stripping, stringy and thready pulse or the disease person such as count accurately.Diabetes in modern medicine are shown in above-mentioned patient, are also suitable for it.

Detailed description of the invention

With specific embodiment, the invention will be further described below, but the invention is not limited in these embodiments.

Embodiment 1

The most 36-flavor Glutinous, take Radix Panacis Quinquefolii, Radix Ginseng Rubra, Colla Corii Asini, Semen Coicis, the Concha Meretricis Seu Cyclinae five tastes.It is ground into fine powder, 30 tastes such as remaining Radix Scrophulariae, boiling secondary, add water 5 times amount for the first time, decoct 2 hours, add water 4 times amount for the second time, decoct 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.15-1.20 (60 DEG C), let cool, adding ethanol makes alcohol content reach 75%, stirring, stand 30 hours, filter, filtrate recycling ethanol, and it is concentrated into the thick paste that relative density is 1.30-1.35 (60 DEG C), let cool, add above-mentioned powder and starch 150g, mixing, it is dried, pulverize, add Indigo Naturalis, 450g is added to starch, mixing, pelletize, it is dried, add magnesium stearate 2.7g, add the cane sugar powder of conventional amount used, technique makes granule routinely.

Embodiment 2

The most 36-flavor Glutinous, take Radix Panacis Quinquefolii, Radix Ginseng Rubra, Colla Corii Asini, Semen Coicis, the Concha Meretricis Seu Cyclinae five tastes.It is ground into fine powder, 30 tastes such as remaining Radix Scrophulariae, boiling secondary, add water 5 times amount for the first time, decoct 2 hours, add water 4 times amount for the second time, decoct 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.15-1.20 (60 DEG C), let cool, adding ethanol makes alcohol content reach 75%, stirring, stand 30 hours, filter, filtrate recycling ethanol, and it is concentrated into the thick paste that relative density is 1.30-1.35 (60 DEG C), let cool, add above-mentioned powder and starch 150g, mixing, it is dried, pulverize, add Indigo Naturalis, 450g is added to starch, mixing, pelletize, it is dried, add magnesium stearate 2.7g, mixing, load capsule, make 1000, obtain.

Embodiment 3

The most 36-flavor Glutinous, take Radix Panacis Quinquefolii, Radix Ginseng Rubra, Colla Corii Asini, Semen Coicis, the Concha Meretricis Seu Cyclinae five tastes.It is ground into fine powder, 30 tastes such as remaining Radix Scrophulariae, boiling secondary, add water 5 times amount for the first time, decoct 2 hours, add water 4 times amount for the second time, decoct 1.5 hours, collecting decoction, filter, filtrate is concentrated into the clear paste that relative density is 1.15-1.20 (60 DEG C), let cool, adding ethanol makes alcohol content reach 75%, stirring, stand 30 hours, filter, filtrate recycling ethanol, and it is concentrated into the thick paste that relative density is 1.30-1.35 (60 DEG C), let cool, add above-mentioned powder and starch 150g, mixing, it is dried, pulverize, add Indigo Naturalis, 450g is added to starch, mixing, pelletize, it is dried, add magnesium stearate 2.7g, mixing, load capsule, make.

Clinical data:

Treatment group and matched group totally 180 example, 60 examples are respectively observed by attached institute of Colleges Of Traditional Chinese Medicine Of Guangxi one and Guangxi District the People's Hospital and No.1 Hospital Attached to Guangxi Medical Univ..

One, physical data:

The object of observation included in is diabetes (diabetes) patient in 18-65 year.Wherein treatment group 120 example, uses embodiment 3 capsule.Matched group 60 example, uses the JIANGTANGSHU JIAONANG that pharmaceutical factory of Tonghua, Jilin Province city produces.Two groups of sexes, age distribution, source of disease are constituted and before the course of disease, treatment, the state of an illness compares and is shown in Table 1.

Two, case selection:

(1) diagnostic criteria: (formulating according to " new Chinese medicine treatment diabetes (diabetes) guideline of clinical investigations ")

1, tcm diagnosis standard: all have thirsty polydipsia, and rapid digestion of food is the most hungry, frequent micturition and sweet, body is gradually shown in that the patient such as become thin can be made a definite diagnosis.

2, differential diagnosis in tcm syndrome of deficiency of both qi and yin: fatigue and weakness, spontaneous sweating, lazy speech of breathing hard, thirst and liking drink, dysphoria with feverish sensation in the chest palms and soles, palpitation and insomnia, red constipation of urinating, red tongue with a little fluid, corpulent tongue is big, thin fur or flower stripping, stringy and thready pulse or count accurately.

3, Western medicine diagnose standard: using WHO tentative standard (venous plasma very sugar method) in 1980, all one meeting following condition can examine Jin for diabetes:

(1) there is diabetic symptom, any time blood glucose >=11.1mmol/L (200mg/dl), or fasting glucose >=7.8mmol/L (140mg/dl).

(2) there is a diabetic symptom and blood glucose does not reaches above-mentioned standard, carry out 75g oral glucose to amount test (0GTT), 2 hours blood glucoses >=11.1mmol/L (200mg/dl).

(3) such as non-diabetic symptom, except above-mentioned standard exterior palpi separately adds a standard, i.e. 0GTT1 hour >=11.1mmol/L (200mg/dl), or another OGTT2 hours blood glucose >=11.1mmol/L (200mg/dl), or fasting glucose >=7.8mmol/L (140mg/dl).

(2) test case standard:

1, inclusive criteria: all meet above-mentioned diagnostic criteria and Chinese medical discrimination person, all can include in and now examine object.

2, exclusion standard:

(1) although patient's blood glucose before the test is higher than normal, but by rear fasting glucose < 7.8mmol/L (140mg/dl), or 2 hours blood glucoses < 11.1mmol/L (200mg/dl) after the meal such as diet control, increase activities.

(2) age is under-18s or over-65s, gestation or women breast-feeding their children, and those who are allergic to this drug.

(3) noncooperationist (refer to coordinate effect food to control or not the person of affecting the treatment by regulation medication).

(4) merge intentionally, liver, the complication such as kidney, or be associated with other severe primary diseases, cyclothymic.

(5) there are Diabetic ketosis, ketoacidosis and the infected in nearly 1 month.

(6) end completely specifies the observation period and therapy discontinued, it is impossible to judge the full person of curative effect or data.

Observational technique

Employing multicenter, district's group are random, compare, non-blind is observed.Observe 180 examples altogether, wherein treatment group 120 example, use embodiment 3 capsule, each 4, three times a day, be used in conjunction 1 month.Positive control 60 example, the JIANGTANGSHU limb capsule using pharmaceutical factory of Tonghua, Jilin Province city to produce, each 5, three times a day, it is used in conjunction 1 month.Experimenter is made detailed physical examination by routine, make fasting glucose, after the meal 2 hours blood glucoses, twenty-four-hour urine sugar and quantitatively etc. check, take the control value before 3 averages are treated (test first 4 weeks, every 10-14 days check fasting glucose, glucose in urine (quantitative or qualitative), continuous 3 times).Meet case selection standard person and i.e. include the object of observation in.Weekly with examining 1 time after taking medicine, inquire situation of taking medicine, the record state of an illness and side effect.Therapeutic effect scoring method is evaluated, each witness by without, light, in, remember 0,2,4,6 points the most respectively.Check fasting glucose, after the meal 2 hours blood glucoses, twenty-four-hour urine sugar after terminating the course for the treatment of and quantitatively etc. check.Outcome measure is directly made by now not examining person.Now examine period without other similar medicines.Can now examine insulin stop lapse rate to disabling the insulin person of having any problem.

Result

One, efficacy assessment standard:

(1) symptom weight grade scale and scoring method: be shown in Table 2.

(2) efficacy assessment standard:

1, effective: after treatment, symptom disappears substantially, fasting glucose < 7.2mmol/L (130mg/dl), after the meal 2 hours blood glucoses < 11.1mmol/L (200mg/dl), twenty-four-hour urine sugar quantitatively < 10.0g；Or decline more than 30% before the most relatively treatment of blood glucose, twenty-four-hour urine sugar.

2, effective: after treatment, symptom is obviously improved, fasting blood < 8.3mmol/L (150mg/dl), after the meal 2 hours blood glucoses < 10.0mmol/L (180mg/dl), twenty-four-hour urine sugar quantitatively < 25.0g；Or decline more than 10% before the most relatively treatment of blood glucose, twenty-four-hour urine sugar.

3, invalid: after treatment, symptom is not improved, the decline of blood glucose, glucose in urine does not reaches above-mentioned standard.

Two, efficacy analysis:

1, compare before and after the treatment of witness integration: be shown in Table 3.

2, compare before and after physico-chemical examination treatment: be shown in Table 3.

3, treatment group and matched group comparitive study: be shown in Table 4.

4, hospitalize group comparitive study: be shown in Table 5.

Table 1 treatment group is in matched group sex, age, the course of disease and the comparison controlling the front state of an illness (integration):

Note: two groups are compared, and every P is equal > 0.05.

Table 2 degrees of symptoms grade scale

Table 3 compares (t inspection) before and after witnessing integration and physico-chemical examination (X ± SD) treatment

Note: front and back compare, P all < 0.01.

Table 4 treatment group and matched group comparitive study (two groups of average Ridit analyze)

5 two hospitalize group comparitive study of table (two groups of average Ridit analyze)

Note: X²=1.44 X² _0.25<2>=2.77 P > 0.25.

Untoward reaction

Treatment group 120 example, matched group 60 example, during now examining, all do not find bright inner untoward reaction and toxic and side effects.

Discuss

1, the Chinese medicine preparation that embodiment 3 capsule system develops according to traditional Chinese medical theory and experience, this test and Selection 120 example patients carry out clinical observation, and the JIANGTANGSHU limb capsule produced with pharmaceutical factory of Tonghua, Jilin Province city makees positive control.Two groups of sexes, age distribution, the more equal no significant difference of the state of an illness (P > 0.05, be shown in Table 1) before source of disease composition, the course of disease and treatment, prompting data has comparability.

2, the case selected by this group is diabetes (diabetes) patient of syndrome of deficiency of both qi and yin, patient's fatigue and asthenia after treatment, breathe hard and seize speech, spontaneous perspiration, night sweat, thirst and liking drink, dysphoria with feverish sensation in the chest palms and soles, cardiopalmus, have a sleepless night, urinate the diseases such as red, constipation and fasting glucose, 2h-plasma glucose etc. check and all have clear improvement (P < 0.01 is shown in Table 2).Prompting embodiment 3 capsule has effect of supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid.

3, treatment group 120 example, total effective rate is 85.8%.Matched group 60 example, total effective rate is 86.7%.Two groups of comparitive study no significant differences (P > 0.05, be shown in Table 4), prompting embodiment 3 treats deficiency of both QI and YIN Diabetes (diabetes) curative effect of card is similar to the JIANGTANGSHU JIAONANG that pharmaceutical factory of Tonghua, Jilin Province city produces.

4, this group example clinical observation, does not all find obvious adverse reaction and toxic and side effects, and prompting this product is safe and reliable.

Claims

1. the pharmaceutical composition treating deficiency of both QI and YIN disease diabetes, it is characterised in that: this medicine Compositions is made up of the raw material of following weight parts:

The pharmaceutical composition for the treatment of deficiency of both QI and YIN disease diabetes the most according to claim 1, its It is characterised by: this pharmaceutical composition is made up of the raw material of following weight parts:

3. the pharmaceutical composition according to any one of claim 1-2 is preparation treatment deficiency of both QI and YIN disease Application in the medicine of diabetes.