CN111298124A - Anti-acne composition containing antibiotics and vegetable oil - Google Patents
Anti-acne composition containing antibiotics and vegetable oil Download PDFInfo
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- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
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- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
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- A61K36/88—Liliopsida (monocotyledons)
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- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
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- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/107—Emulsions ; Emulsion preconcentrates; Micelles
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
Abstract
The invention provides an anti-acne composition containing antibiotics and vegetable oil, wherein the antibiotics and the vegetable oil are defined in the specification. In vitro test results show that the composition can generate a synergistic antibacterial effect (the combined medication index is less than 1) on the clindamycin-resistant propionibacterium acnes, and animal tests further prove that the composition can generate a synergistic therapeutic effect on a rat acne model caused by propionibacterium acnes.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to an anti-acne composition containing antibiotics and vegetable oil.
Background
Acne is a chronic inflammatory dermatosis which is good in puberty and mainly affects the pilosebaceous unit of the face, and the section statistics of Chinese population shows that the incidence rate of the acne is 8.1%. However, researches find that more than 95% of people have acnes with different degrees, and 3% -7% of acne patients leave scars, which bring great influence on physical and mental health of the patients. The pathogenesis of acne has not yet been fully elucidated. Hormone-induced excessive secretion of lipids from sebaceous glands in genetic background, follicular sebaceous gland dyskeratosis, hair follicle microorganism proliferation such as Propionibacterium acnes, inflammation, immune response and the like are related to the above.
The university of Changchun science 2014's university of Master graduate Yan Si nan in his Master thesis prokaryotic expression of lipase gene in Propionibacterium acnes and its application quotes related documents that Propionibacterium acnes, which are gram-positive anaerobic bacilli, mainly live in human skin hair follicles and sebaceous gland follicles, are opportunistic pathogens. The special physiological and biochemical properties of the Chinese herbal medicine determine the complex pathogenic mechanism of the Chinese herbal medicine, and further cause various clinical symptoms such as acne, surgical infection and the like. It is clear that the occurrence of acne occultation is related to excessive sebum secretion, hyperkeratosis at the opening of the duct of pilosebaceous glands, the propagation of propionibacterium acnes and the major factors of inflammatory reaction, but the role of the factors in the pathogenesis process and the real starting mechanism of acne are uncertain. Although Propionibacterium acnes are thought to be involved in the pathogenesis of acne, there is some evidence that Propionibacterium acnes only cause inflammation that masks acne and not are the true cause of acne. However, the esterase isolated and purified from the culture of Propionibacterium acnes can hydrolyze various triacylglycerols to produce free fatty acids having a multiple carbon chain length of carbon atoms, which can cause acne to produce inflammatory stimuli, and thus Propionibacterium acnes can produce a wide variety of extracellular enzymes, including lipases.
Chinese guidelines for acne treatment (2019 revision) indicate that antibiotics with anti-propionibacterium acnes and anti-inflammatory effects can be used for the treatment of acne. Common topical antibiotics include erythromycin, lincomycin and its derivatives clindamycin, chloramphenicol, clindamycin, fusidic acid, and the like. However, with the increasing spread of antibiotic abuse, the problem of resistance of Propionibacterium acnes to antibiotics is becoming more severe ([1] Zhangli, Wangcha, Zhu Li Yi, Lulechun, Yanfei, Yanshi, Lisining, Wangyilan, Limoni, Liquejie, Lijinju, Sun Dongjie. Meta analysis of resistance of Propionibacterium acnes to antibiotics in skin lesions of acne patients in China [ J ]. China Meja dermatosis J2019, 35(09): 515) -519, Kong-Wenking, Bilan. Propionibacterium acnes antibiotic resistance research progress [ J ]. China dermatosis J2018, 32(12): 1459-1463; Xuehong. acne patients' Propionibacterium acnes to macrolides and tetracyclic antibiotic resistance analysis [ J ]. clinical medicine literature electronics, 2018,5(54): 143.).
The vegetable oil is rich in active ingredients with antibacterial effect on the propionibacterium acnes, for example, 10 vegetable oils disclosed by Zu Y et al (polymers.2010Apr30; 15(5):3200-10.doi: 10.3390/polymers 15053200.) have MIC value of 0.016-0.500% (v/v) on the propionibacterium acnes; orchard et al (International Journal of Cosmetic Science,2018,40, 226-243) disclose Propionibacterium acnes activity against various vegetable oils with MIC values between 130-1500 mg/L.
A study by Ghosh SJ et al (Invest Dermatol.2018 Jun; 138(6):1400-1408.) states that CCARM9010 is a clindamycin-resistant Propionibacterium acnes strain and that the MIC of erythromycin for this strain is > 200.00. mu.g/mL.
A study by Holland KT et al (Br J Dermatol. 1992May; 126(5):505-9.) showed that erythromycin in combination with zinc significantly reduced the MIC values of erythromycin against erythromycin-resistant Propionibacterium acnes; however, there is no technical suggestion in the prior art that antibiotic in combination with vegetable oil synergistically act to reduce the MIC of the antibiotic for drug-resistant Propionibacterium acnes.
Disclosure of Invention
It is an object of the present invention to provide an anti-acne composition comprising an antibiotic and a vegetable oil, said composition being capable of exerting a synergistic antibacterial effect against propionibacterium acnes.
In order to achieve the above objects, the present invention provides an anti-acne composition comprising an antibiotic and a vegetable oil, wherein the antibiotic is one selected from the group consisting of tetracycline antibiotics, amide alcohol antibiotics, macrolide antibiotics, lincomycin or an analog thereof, and fusidic acid or a pharmaceutically acceptable salt thereof; the vegetable oil is selected from PEG-10 hydrogenated castor oil, PEG-100 hydrogenated castor oil, PEG-2 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-200 hydrogenated castor oil, PEG-25 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-35 hydrogenated castor oil, PEG-36 castor oil, PEG-40 hydrogenated castor oil, PEG-45 hydrogenated castor oil, PEG-5 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-7 hydrogenated castor oil, PEG-75 white chinlon oil, PEG-75 lanolin oil, PEG-8 hydrogenated castor oil, PEG-80 hydrogenated castor oil, PEG-35 hydrogenated castor oil, PEG-36 castor oil, PEG-40 hydrogenated castor oil, PPG-12-PEG-65 lanolin oil, PPG-3 hydrogenated castor oil, pistachio seed oil, blumea balsamifera oil, macadamia nut oil, macadamia blue cedar oil, illicium verum fruit oil, illicium verum seed oil, illicium verum oil, babassu seed oil, Brazilian myrtle fruit oil, meadowfoam seed oil, chamomile oil, birch oil, alband leaf oil, cajeput oil, meadowfoam oil, meadowrue root oil, white leaf spicebush flower oil, white lupin seed oil, lily oil, oldenlandia spot grass oil, mint leaf oil, peppermint oil, geranium oil, feverfew cedar bark oil, northern cedar oil, petitgrain oil, tea leaf oil, thistle seed oil, hemlock parsley oil, tea seed oil, Japanese thistle oil, hemlock parsley seed oil, pistia seed oil, pistachio nut oil, pistachi, Mentha pulegium oil, Aralia mandshurica kernel oil, soybean oil, Vaccinium macrocarpon oil, Fortunella margarita peel oil, Alnus crenata Maxim seed oil, hempseed oil, Atlantic chest sea bream oil, rice bran oil, rice germ oil, canola oil, Selaginella moellendorfii leaf oil, Selaginella moellensis nut oil, Selaginella moellensis stem oil, Selaginella moellensis wood oil, Camellia yunnanensis seed oil, mink oil, clove bud oil, clove flower oil, clove leaf oil, oregano majoram flower oil, multibstemmed Orlmax oil, goose oil, avocado oil unsaponifiable matter, emu oil, France rose flower oil, crocus sativus oil, papaya seed oil, tomato fruit oil, tomato seed oil, Passifloranthus glans seed oil, raspberry seed oil, oregano origana majoram flower oil, oregano leaf oil, caraway seed oil, caraway oil, rose hip oil, dog rose hip oil, rose flower oil, rose, Patchouli oil, patchouli peel oil, patchouli oil, morinda citrifolia oil, crabapple seed oil, synthetic patchouli oil, bougainvillea fusca oil, ribes nigrum seed oil, safflower seed oil, myrrh oil, red sedge seed oil, rosewood seed oil, red pine seed oil, Paeonia japonica seed oil, piper nigrum oil, pepper seed oil, carrot seed oil, walnut seed oil, melaleuca alternifolia oil, peanut oil, cucumber oil, Mortierella fulva oil, kalanchoe oil, anise oil, fennel oil, volcanic mud, jojoba seed oil, egg seed oil, tribulus terrestris oil, lindera fragrans oil, zingiberis officinalis oil, ginger root oil, turmeric root oil, gum-bark maple oil, cibotium oil, calendula officinalis seed oil, belladonis oil, palusta seed oil, pistachios chinensis oil, kadsura pepper oil, kaempferia root oil, peach seed oil, orange peel oil, bitter orange leaf oil, and the like orange oil, Bitter orange twig oil, bitter orange leaf oil, bitter orange oil, bitter oil tree seed oil, kula bitter orange peel oil, quinoa seed oil, peppermint oil, moringa seed oil, lime oil, eucalyptus globulus leaf oil, lotus oil, rush oil, spearmint leaf oil, sulfated castor oil, sulfated olive oil, piper leaf oil, basil oil, quercus rosea seed oil, camellia oleifera seed oil, melaleuca viridis leaf oil, verbena oil, maleated soybean oil, mango seed oil, coleus forskohlii root oil, serenoa repens fruit oil, myrrh oil, rose flower oil, palmarosa oil, rosewood oil, american walnut seed oil, mezopyrum oil, hazelnut oil, rosemary oil, ylang oil, russia oil, mugwort seed oil, jasmine, jalapachy prickly oil, chamomile oil, peony seed oil, litsea-buckthorn seed oil, litsea-fruit oil, selfheal oil, prunella oil, ylang oil, turpinia oil, pen, Lemon seed oil, lemon eucalyptus oil, lemon balm leaf oil, lemon citronella leaf oil, burdock seed oil, shea butter oil, oregano leaf oil, oregano oil, Norway spruce leaf oil, juniper berry oil, parsley seed oil, yarrow oil, pinus koraiensis fruit oil, pinus koraiensis leaf oil, pinus koraiensis oil, Tilia oil, fir leaf oil, pluma seed oil, woad seed oil, cerasus humilis oil, sweet cherry seed oil, bilberry seed oil, hazel nut oil, hop berry oil, gaultheria mellea leaf oil, apple seed oil, grape leaf oil, grape seed oil, grapefruit peel oil, grapefruit seed oil, citron peel oil, rose oil, hydroxylated jojoba oil, zanthoxylum oil, prinsepium oil, hydrogenated macadamia nut oil, hydrogenated castor oil, hydrogenated soybean oil, hydrogenated yolk oil, hydrogenated egg oil, hydrogenated olive oil, parsley seed oil, hydrogenated avocado oil, hydrogenated olive oil unsaponifiables, hydrogenated safflower seed oil, hydrogenated peanut oil, hydrogenated jojoba oil, hydrogenated sunflower seed oil, hydrogenated rice bran oil, hydrogenated cottonseed oil, hydrogenated grape seed oil, hydrogenated sweet almond oil, hydrogenated wheat germ oil, hydrogenated almond oil, hydrogenated coconut oil, hydrogenated rapeseed oil, hydrogenated palm kernel oil, hydrogenated palm oil, macadamia integrifolia seed oil, ginseng seed oil, japanese cypress oil, japanese torreya seed oil, nutmeg kernel oil, cinnamon leaf oil, mastic oil, thyme oil with opalescence, macadamia broom-leaf oil, sea buckthorn fruit oil, sea buckthorn seed oil, camellia seed oil, Japanese pepper fruit oil, mountain sesame seed oil, snake oil, thyme leaf oil, thyme oil, musk rose seed oil, sea buckthorn seed oil, sea buckthorn, Hyssop oil, eriodictyon root oil, eriodictyon rhodiola oil, shiqua seed oil, pomegranate seed oil, melaleuca oleracea leaf oil, egypnia vegetable oil, silybum marianum seed oil, allium sativum seed oil, luffa seed oil, vegetarian flower oil, tamarind oil, garlic bulb oil, santalum spicatum oil, gardenia flower oil, sandalwood seed oil, peach kernel oil, sweet almond oil unsaponifiable, sweet almond seed oil, sweet orange peel oil, sweet orange flower oil, sweet orange seed oil unsaponifiable, pelargonium odorum oil, damascena rose oil, ostrich oil, tall oil acid, tall oil sterol, wenzhou mandarin fruit oil, hairless buffalo peel oil, spanish sage seed oil, siberian fir oil, watermelon seed oil, pumpkin seed oil, elderberry oil, cassia oil, cinnamon oil, sweet wormwood oil, sage oil, orange peel oil, orange fruit oil, Melissa leaf oil, Viola officinalis oil, bergamot fruit oil, bergamot leaf oil, myrtle oil, Pelargonium graveolens leaf oil, Pelargonium graveolens oil, Plectrium myrcia leaf oil, citron fruit peel oil, citron fruit oil, citron flower oil, citron leaf oil, citron stem oil, oleum Rapae, sunflower seed oil unsaponifiable matter, Cardamom seed oil, Coffea arabica seed oil, wheat germ oil unsaponifiable matter, Thamnolia flower oil, valerian root oil, Serenoa repens fruit oil, Aster palm kernel oil, Rubus davidianus seed oil, almond oil unsaponifiable matter, apricot seed oil, Rosa tenuisorba oil, Cedar oil, lavender oil, sage leaf oil, linseed oil, shepherdspurse herb oil, vetiver oil, sago oil, sagebia oil, sagebrush oil, sago oil, sagebrush oil, etc Elytrigia repens leaf oil, oat germ oil, oat kernel oil, lanolin oil, thyme oil, calabash seed oil, artichoke fruit oil, dog rose oil, oxidized corn oil, cashew seed oil, sage oil, coconut oil, wild soybean oil, unsaponifiable wild soybean oil, wild carrot oil, dog rose fruit oil, ylang flower oil, acetylated castor oil, Italian cabbage seed oil, Italian chrysanthemum oil, Italian pine kernel oil, winged seed moringa seed oil, neem seed oil, Chinese soapberry seed oil, Indian fruit seed oil, rapeseed oil, camellia seed oil, olive shell oil, olive fruit oil, olive oil unsaponifiable oil, cyperus oil, pomelo peel oil, pomelo fruit oil, pomelo seed oil unsaponifiable matter, haematococcus pluvialis oil, magnolia oil, corn germ oil, corn oil, unsaponifiable corn oil, coriander fruit oil, coriander seed oil, corn germ oil, corn oil, thyme oil, corn oil unsapo, Root oil of Angelica rotundifolia, seed oil of Angelica rotundifolia, bay leaf oil, evening primrose oil, cowberry seed oil, lavandula angustifolia oil, black grass seed oil, camphor tree bark oil, pinus sylvestris oil, olive gum oil, sesame oil unsaponifiable matter, sesame seed oil, gardenia oil, Chilean hazel nut oil, Chinese gooseberry seed oil, perilla seed oil, palm kernel oil and palm oil.
In one preferred aspect, the antibiotic of the present invention is one selected from the group consisting of tetracycline, oxytetracycline, doxycycline, minocycline, chloramphenicol, thiamphenicol, erythromycin ethylsuccinate, roxithromycin, clarithromycin, azithromycin, telithromycin, dirithromycin, kitasamycin, midecamycin, acetyl midecamycin, josamycin, milbemycin, romycin, acetyl spiramycin, lincomycin, clindamycin and sodium fusidate.
On one hand, the mass ratio of the antibiotic to the vegetable oil is preferably 0.01: 1-100: 1.
In one preferred aspect, the acne described herein is acne caused by propionibacterium acnes.
On the other hand, the composition can be prepared into external medicines.
More preferably, the external medicine of the present invention is a liquid preparation for external use; further preferably, the liquid preparation for external use is one selected from an emulsion for external use and a suspension for external use.
More preferably, the external medicine of the present invention is an external semisolid preparation; further preferably, the semisolid preparation for external use of the present invention is one selected from ointments and gels.
In a further aspect of the invention there is provided the use of a composition as hereinbefore described in the manufacture of a medicament for the treatment of acne.
In vitro test results show that the composition can generate a synergistic antibacterial effect (the combined medication index is less than 1) on the clindamycin-resistant propionibacterium acnes, and animal tests further prove that the composition can generate a synergistic therapeutic effect on a rat acne model caused by propionibacterium acnes.
Detailed Description
The present invention will be further described below by way of specific embodiments, but the present invention is not limited to only the following examples.
Test example 1 synergistic antibacterial action of the composition against clindamycin-resistant Propionibacterium acnes (CCARM 9010)
The inhibition of the test substances ① - ③ on the clindamycin-resistant propionibacterium acnes (CCARM 9010) is measured by a method disclosed by Lemna and the like (food and fermentation industry, 2017,43(02): 232-238.).
(1) The tested drugs are:
① antibiotic, ② vegetable oil, ③ antibiotic and vegetable oil in a mass ratio R (indicated as "-" connecting antibiotic and vegetable oil)
(2) Test method
① preparing test sample solution by taking a certain amount of test substance, using DMF as solvent, and adopting a specific multiple continuous dilution method to prepare test sample solution with 6 concentrations.
② bacterial suspension is prepared by inoculating activated strain to liquid culture medium (no agar), shake-culturing, calculating bacterial colony number by plate dilution method, and adjusting bacterial suspension concentration to 10 with sterile physiological saline7CFU/mL。
③ agar-hole diffusion method for determining antibacterial activity comprises cooling the sterilized culture medium to 50 deg.C, adding 6mL of bacterial suspension, mixing, pouring into a culture dish with diameter of 9cm, standing for 45min, uniformly perforating (diameter of 7mm) on the cured culture medium with an aseptic perforator, marking, adding 40 μ L of sample solution into each hole, DMF as blank control, culturing at 37 deg.C for 18h, measuring and recording the diameter (mm) of the zone of inhibition, repeating for 3 times, averaging to obtain the result, and calculating the Inhibition Ratio (IR) of the strain to be tested according to the following formula.
For antibiotics and vegetable oils, IR was plotted against the log (c)) of the test concentrations (μ g/mL) of antibiotics and vegetable oils, and the concentration of each test substance at which the inhibition of specific fa occurred was calculated from the linear regression equation and is designated as ICfa(A)And ICfa(B). For mixtures, the concentration of antibiotic in the mixture at which inhibition of a particular fa occurs is calculated from a linear regression equation using IR plotted against the logarithm of the antibiotic concentration (. mu.g/mL) and reported as ICfa(mixA)。
The Combination Index (CI) at which a specific fa inhibitory rate is produced is calculated according to the following formula.
CI＝ICfa(mixA)/ICfa(A)+ICfa(mixA)/(R×ICfa(B))
When CI <1, it means that there is synergism, the smaller the CI, the stronger the synergism. The results are shown in Table 1
Table 1(fa ═ 40.24%)
EXAMPLE 1 preparation of a suspension for external use containing a combination of antibiotics and vegetable oils
[ prescription ] medecamycin 5.00g, hop berry oil 2.40g, camphor spirit 250mL, sodium carboxymethyl cellulose 5g, glycerin 100g, adding purified water to 1000mL.
[ PREPARATION ] Medidycin is put into a mortar, and glycerin is added to the mortar to be ground into fine paste. And preparing sodium carboxymethylcellulose into mucilage with 200mL of water, slowly adding into mortar under stirring, transferring into a measuring vessel, adding Camphora spirit and Ceratonia strigaea fruit oil under stirring, adding purified water to full volume, and stirring.
EXAMPLE 2 preparation of emulsion for external use containing a combination of antibiotics and vegetable oils
[ prescription ] sodium fusidate 0.16g, rice germ oil 9.84g, acacia gum fine powder 125g, tragacanth gum fine powder 7g, saccharin sodium 0.1g, volatile almond oil 1mL, ethylparaben 0.5g, purified water added to 1000mL.
[ preparation ] sodium fusidate, rice germ oil and Arabic gum are ground uniformly, 250mL of purified water is added at a time, the mixture is ground in one direction forcibly to prepare primary emulsion, sodium saccharin aqueous solution, volatile almond oil and ethylparaben alcohol solution are added, then tragacanth mucilage is slowly added, the purified water is added to the full amount, and the mixture is stirred uniformly, thus obtaining the composition.
EXAMPLE 3 preparation of an ointment containing a combination of antibiotics and vegetable oils
[ prescription ] 6.13g of meleumycin, 3.87g of black grass seed oil, 12.5g of stearic acid, 17.0g of glyceryl monostearate, 5.0g of beeswax, 67.0g of white vaseline, 10.0g of aluminum distearate, 75.0g of ozokerite, 410.0mL of liquid paraffin, 1.0g of ethylparaben, 1.0g of calcium hydroxide and distilled water till 1000g.
[ preparation method ] Mebaimycin, black grass seed oil, stearic acid, glyceryl monostearate, beeswax and ceresin are heated and melted in water bath, then liquid paraffin, white vaseline and aluminum distearate are added, and the mixture is heated to 85 ℃ (oil phase); dissolving calcium hydroxide and ethylparaben in distilled water, and heating to the same temperature (water phase); slowly adding the water phase into the oil phase under stirring, and condensing to obtain the final product.
Example 4 preparation of a gel containing a combination of antibiotics and vegetable oils
[ prescription ] erythromycin ethylsuccinate 0.38g, coriander seed oil 9.62g, carbopol 94010 g, glycerin 50g, polysorbate 802g, ethylparaben 0.5g, ethanol 50g, sodium hydroxide 4g, and distilled water to 1000g.
[ preparation method ] mixing erythromycin ethylsuccinate, coriander seed oil, carbopol, glycerol and polysorbate 80 with 300mL of distilled water, dissolving sodium hydroxide in 100mL of distilled water, adding into the above liquid, stirring, dissolving ethylparaben in ethanol, gradually adding, and stirring to obtain transparent gel.
Comparative example 1 preparation of antibiotic-containing gel
[ prescription ] erythromycin ethylsuccinate 0.38g, carbopol 94010 g, glycerin 50g, polysorbate 802g, ethylparaben 0.5g, ethanol 50g, sodium hydroxide 4g, and distilled water added to 1000g.
[ preparation method ] mixing erythromycin ethylsuccinate, carbopol, glycerin and polysorbate 80 with 300mL of distilled water, dissolving sodium hydroxide in 100mL of distilled water, adding into the above liquid, stirring, dissolving ethylparaben in ethanol, and gradually adding and stirring to obtain transparent gel.
Comparative example 2 preparation of gel of vegetable oil-containing composition
[ prescription ] 9.62g of coriander seed oil, 94010 g of carbopol, 50g of glycerol, 802g of polysorbate, 0.5g of ethylparaben, 50g of ethanol, 4g of sodium hydroxide and distilled water till 1000g.
[ preparation method ] mixing coriander seed oil, carbopol, glycerin, polysorbate 80 and 300mL of distilled water, dissolving sodium hydroxide in 100mL of distilled water, adding into the above liquid, stirring, dissolving ethylparaben in ethanol, gradually adding, and stirring to obtain transparent gel.
Test example 2 therapeutic effect of a gel comprising a combination of antibiotics and vegetable oils on a model of acne in rats caused by Propionibacterium acnes
The treatment of the gels prepared in example 4, comparative example 1 and comparative example 2 on a Propionibacterium acnes-induced rat model of acne was examined using the method disclosed in Liyuan et al (Hainan medicine, 2017,28(21): 3446-3448), wherein the swelling rates of auricles after administration are shown in Table 2.
TABLE 2
| Group of | Number of examples | Dosage to be administered | Swelling Rate (%) |
| Normal control group | 10 | ―― | 8.24±1.27 |
| Model control group | 10 | ―― | 76.96±11.78 |
| Example 4 gel administration group | 10 | 0.01g of propionibacterium acnes injection area is smeared on the auricle | 7.89±1.01 |
| Comparative example 1 gel administration group | 10 | 0.01g of propionibacterium acnes injection area is smeared on the auricle | 55.53±7.48 |
| Comparative example 1 gel administration group | 10 | 0.01g of propionibacterium acnes injection area is smeared on the auricle | 47.15±5.05 |
As can be seen from table 2, the rate of decrease of the propionibacterium acnes-induced swelling of the rat acne model after application of the gel of example 4 with respect to the model control group was higher than the sum of the rates of decrease of comparative example 1 and comparative example 2.
Claims (10)
1. An anti-acne composition comprising an antibiotic and a vegetable oil, wherein the antibiotic is one selected from the group consisting of tetracycline antibiotics, amidol antibiotics, macrolide antibiotics, lincomycin or analogs thereof, and fusidic acid or a pharmaceutically acceptable salt thereof; the vegetable oil is selected from PEG-10 hydrogenated castor oil, PEG-100 hydrogenated castor oil, PEG-2 hydrogenated castor oil, PEG-20 hydrogenated castor oil, PEG-200 hydrogenated castor oil, PEG-25 hydrogenated castor oil, PEG-30 hydrogenated castor oil, PEG-35 hydrogenated castor oil, PEG-36 castor oil, PEG-40 hydrogenated castor oil, PEG-45 hydrogenated castor oil, PEG-5 hydrogenated castor oil, PEG-50 hydrogenated castor oil, PEG-60 hydrogenated castor oil, PEG-7 hydrogenated castor oil, PEG-75 white chinlon oil, PEG-75 lanolin oil, PEG-8 hydrogenated castor oil, PEG-80 hydrogenated castor oil, PEG-35 hydrogenated castor oil, PEG-36 castor oil, PEG-40 hydrogenated castor oil, PPG-12-PEG-65 lanolin oil, PPG-3 hydrogenated castor oil, pistachio seed oil, blumea balsamifera oil, macadamia nut oil, macadamia blue cedar oil, illicium verum fruit oil, illicium verum seed oil, illicium verum oil, babassu seed oil, Brazilian myrtle fruit oil, meadowfoam seed oil, chamomile oil, birch oil, alband leaf oil, cajeput oil, meadowfoam oil, meadowrue root oil, white leaf spicebush flower oil, white lupin seed oil, lily oil, oldenlandia spot grass oil, mint leaf oil, peppermint oil, geranium oil, feverfew cedar bark oil, northern cedar oil, petitgrain oil, tea leaf oil, thistle seed oil, hemlock parsley oil, tea seed oil, Japanese thistle oil, hemlock parsley seed oil, pistia seed oil, pistachio nut oil, pistachi, Mentha pulegium oil, Aralia mandshurica kernel oil, soybean oil, Vaccinium macrocarpon oil, Fortunella margarita peel oil, Alnus crenata Maxim seed oil, hempseed oil, Atlantic chest sea bream oil, rice bran oil, rice germ oil, canola oil, Selaginella moellendorfii leaf oil, Selaginella moellensis nut oil, Selaginella moellensis stem oil, Selaginella moellensis wood oil, Camellia yunnanensis seed oil, mink oil, clove bud oil, clove flower oil, clove leaf oil, oregano majoram flower oil, multibstemmed Orlmax oil, goose oil, avocado oil unsaponifiable matter, emu oil, France rose flower oil, crocus sativus oil, papaya seed oil, tomato fruit oil, tomato seed oil, Passifloranthus glans seed oil, raspberry seed oil, oregano origana majoram flower oil, oregano leaf oil, caraway seed oil, caraway oil, rose hip oil, dog rose hip oil, rose flower oil, rose, Patchouli oil, patchouli peel oil, patchouli oil, morinda citrifolia oil, crabapple seed oil, synthetic patchouli oil, bougainvillea fusca oil, ribes nigrum seed oil, safflower seed oil, myrrh oil, red sedge seed oil, rosewood seed oil, red pine seed oil, Paeonia japonica seed oil, piper nigrum oil, pepper seed oil, carrot seed oil, walnut seed oil, melaleuca alternifolia oil, peanut oil, cucumber oil, Mortierella fulva oil, kalanchoe oil, anise oil, fennel oil, volcanic mud, jojoba seed oil, egg seed oil, tribulus terrestris oil, lindera fragrans oil, zingiberis officinalis oil, ginger root oil, turmeric root oil, gum-bark maple oil, cibotium oil, calendula officinalis seed oil, belladonis oil, palusta seed oil, pistachios chinensis oil, kadsura pepper oil, kaempferia root oil, peach seed oil, orange peel oil, bitter orange leaf oil, and the like orange oil, Bitter orange twig oil, bitter orange leaf oil, bitter orange oil, bitter oil tree seed oil, kula bitter orange peel oil, quinoa seed oil, peppermint oil, moringa seed oil, lime oil, eucalyptus globulus leaf oil, lotus oil, rush oil, spearmint leaf oil, sulfated castor oil, sulfated olive oil, piper leaf oil, basil oil, quercus rosea seed oil, camellia oleifera seed oil, melaleuca viridis leaf oil, verbena oil, maleated soybean oil, mango seed oil, coleus forskohlii root oil, serenoa repens fruit oil, myrrh oil, rose flower oil, palmarosa oil, rosewood oil, american walnut seed oil, mezopyrum oil, hazelnut oil, rosemary oil, ylang oil, russia oil, mugwort seed oil, jasmine, jalapachy prickly oil, chamomile oil, peony seed oil, litsea-buckthorn seed oil, litsea-fruit oil, selfheal oil, prunella oil, ylang oil, turpinia oil, pen, Lemon seed oil, lemon eucalyptus oil, lemon balm leaf oil, lemon citronella leaf oil, burdock seed oil, shea butter oil, oregano leaf oil, oregano oil, Norway spruce leaf oil, juniper berry oil, parsley seed oil, yarrow oil, pinus koraiensis fruit oil, pinus koraiensis leaf oil, pinus koraiensis oil, Tilia oil, fir leaf oil, pluma seed oil, woad seed oil, cerasus humilis oil, sweet cherry seed oil, bilberry seed oil, hazel nut oil, hop berry oil, gaultheria mellea leaf oil, apple seed oil, grape leaf oil, grape seed oil, grapefruit peel oil, grapefruit seed oil, citron peel oil, rose oil, hydroxylated jojoba oil, zanthoxylum oil, prinsepium oil, hydrogenated macadamia nut oil, hydrogenated castor oil, hydrogenated soybean oil, hydrogenated yolk oil, hydrogenated egg oil, hydrogenated olive oil, parsley seed oil, hydrogenated avocado oil, hydrogenated olive oil unsaponifiables, hydrogenated safflower seed oil, hydrogenated peanut oil, hydrogenated jojoba oil, hydrogenated sunflower seed oil, hydrogenated rice bran oil, hydrogenated cottonseed oil, hydrogenated grape seed oil, hydrogenated sweet almond oil, hydrogenated wheat germ oil, hydrogenated almond oil, hydrogenated coconut oil, hydrogenated rapeseed oil, hydrogenated palm kernel oil, hydrogenated palm oil, macadamia integrifolia seed oil, ginseng seed oil, japanese cypress oil, japanese torreya seed oil, nutmeg kernel oil, cinnamon leaf oil, mastic oil, thyme oil with opalescence, macadamia broom-leaf oil, sea buckthorn fruit oil, sea buckthorn seed oil, camellia seed oil, Japanese pepper fruit oil, mountain sesame seed oil, snake oil, thyme leaf oil, thyme oil, musk rose seed oil, sea buckthorn seed oil, sea buckthorn, Hyssop oil, eriodictyon root oil, eriodictyon rhodiola oil, shiqua seed oil, pomegranate seed oil, melaleuca oleracea leaf oil, egypnia vegetable oil, silybum marianum seed oil, allium sativum seed oil, luffa seed oil, vegetarian flower oil, tamarind oil, garlic bulb oil, santalum spicatum oil, gardenia flower oil, sandalwood seed oil, peach kernel oil, sweet almond oil unsaponifiable, sweet almond seed oil, sweet orange peel oil, sweet orange flower oil, sweet orange seed oil unsaponifiable, pelargonium odorum oil, damascena rose oil, ostrich oil, tall oil acid, tall oil sterol, wenzhou mandarin fruit oil, hairless buffalo peel oil, spanish sage seed oil, siberian fir oil, watermelon seed oil, pumpkin seed oil, elderberry oil, cassia oil, cinnamon oil, sweet wormwood oil, sage oil, orange peel oil, orange fruit oil, Melissa leaf oil, Viola officinalis oil, bergamot fruit oil, bergamot leaf oil, myrtle oil, Pelargonium graveolens leaf oil, Pelargonium graveolens oil, Plectrium myrcia leaf oil, citron fruit peel oil, citron fruit oil, citron flower oil, citron leaf oil, citron stem oil, oleum Rapae, sunflower seed oil unsaponifiable matter, Cardamom seed oil, Coffea arabica seed oil, wheat germ oil unsaponifiable matter, Thamnolia flower oil, valerian root oil, Serenoa repens fruit oil, Aster palm kernel oil, Rubus davidianus seed oil, almond oil unsaponifiable matter, apricot seed oil, Rosa tenuisorba oil, Cedar oil, lavender oil, sage leaf oil, linseed oil, shepherdspurse herb oil, vetiver oil, sago oil, sagebia oil, sagebrush oil, sago oil, sagebrush oil, etc Elytrigia repens leaf oil, oat germ oil, oat kernel oil, lanolin oil, thyme oil, calabash seed oil, artichoke fruit oil, dog rose oil, oxidized corn oil, cashew seed oil, sage oil, coconut oil, wild soybean oil, unsaponifiable wild soybean oil, wild carrot oil, dog rose fruit oil, ylang flower oil, acetylated castor oil, Italian cabbage seed oil, Italian chrysanthemum oil, Italian pine kernel oil, winged seed moringa seed oil, neem seed oil, Chinese soapberry seed oil, Indian fruit seed oil, rapeseed oil, camellia seed oil, olive shell oil, olive fruit oil, olive oil unsaponifiable oil, cyperus oil, pomelo peel oil, pomelo fruit oil, pomelo seed oil unsaponifiable matter, haematococcus pluvialis oil, magnolia oil, corn germ oil, corn oil, unsaponifiable corn oil, coriander fruit oil, coriander seed oil, corn germ oil, corn oil, thyme oil, corn oil unsapo, Root oil of Angelica rotundifolia, seed oil of Angelica rotundifolia, bay leaf oil, evening primrose oil, cowberry seed oil, lavandula angustifolia oil, black grass seed oil, camphor tree bark oil, pinus sylvestris oil, olive gum oil, sesame oil unsaponifiable matter, sesame seed oil, gardenia oil, Chilean hazel nut oil, Chinese gooseberry seed oil, perilla seed oil, palm kernel oil and palm oil.
2. The composition of claim 1, wherein said antibiotic is selected from the group consisting of tetracycline, oxytetracycline, doxycycline, minocycline, chloramphenicol, thiamphenicol, erythromycin ethylsuccinate erythromycin, roxithromycin, clarithromycin, azithromycin, telithromycin, dirithromycin, kitasamycin, medemycin, acetylmedemycin, josamycin, meleumycin, romycin, acetylspiramycin, lincomycin, clindamycin, and sodium fusidate.
3. Composition according to claim 1 or 2, characterized in that, in one aspect, the ratio of the antibiotic according to the invention to the vegetable oil is preferably between 0.01:1 and 100:1 by mass.
4. A composition according to claim 1 or 2, characterized in that said acne is acne caused by propionibacterium acnes.
5. The composition of claim 1 or 2, wherein said composition is formulated for topical administration.
6. The composition of claim 5, wherein said topical medicament is a topical liquid formulation.
7. The composition of claim 6, wherein the liquid preparation for external use is one selected from the group consisting of an emulsion for external use and a suspension for external use.
8. The composition of claim 5, wherein said topical medicament is a topical semisolid formulation.
9. The composition of claim 8, wherein said semi-solid formulation for external use is one selected from the group consisting of an ointment and a gel.
10. Use of a composition according to claim 1 or 2 in the manufacture of a medicament for the treatment of acne.
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