CN111298072A

CN111298072A - A Chinese medicinal composition for resisting venom from Pallas pit Viper

Info

Publication number: CN111298072A
Application number: CN202010340013.9A
Authority: CN
Inventors: 高云水; 晏根贵
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-04-26
Filing date: 2020-04-26
Publication date: 2020-06-19

Abstract

The invention discloses a traditional Chinese medicine composition for resisting viper venom, which consists of the following raw materials: rhizoma paridis, herba Lobeliae chinensis, herba Bidentis Bipinnatae, herba Hedyotidis Diffusae, rhizoma Chuanxiong, radix Angelicae Dahuricae, radix Et rhizoma Rhei, rhizoma Curcumae Longae, caulis Spatholobi, and radix Saposhnikoviae. The traditional Chinese medicine composition is suitable for patients bitten by the viper, has no adverse reaction and has quick curative effect.

Description

A Chinese medicinal composition for resisting venom from Pallas pit Viper

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for resisting agkistrodon halys venom.

Background

Currently, an estimated 200 million people are bitten by vipers each year worldwide, which can result in about 12 million deaths and hundreds of thousands of disabilities. It has been reported that vipers are mainly used in the middle Yangtze river basin and north areas of China, the vipers are locally in midstream of the Yangtze river basin, the terrain is mainly on hills, the climate is warm and humid, the propagation of snakes is facilitated, and poisonous snakes are more in variety, particularly vipers are more common, and the number of cases of snake bite is more every year. The viper venom belongs to mixed venom, clinical manifestations of nerve venom and blood circulation venom can be presented simultaneously, local symptoms and general symptoms are obvious, but the viper venom mainly takes the blood circulation venom as main part, and the disease condition is rapidly developed after the viper venom is bitten, so that the viper venom is life threatening. The blood circulation toxin in the venom of the Agkistrodon halys is capable of causing tissue edema, hemorrhage and necrosis, and the symptoms at the late stage of poisoning are particularly marked by swelling. The reason for swelling is related to enzymes contained in snake venom, and proteolytic enzyme can damage the vascular wall and dissolve muscle tissue, increase the permeability of the vascular wall, thus causing local muscle necrosis, hemorrhage and edema of snake wound, and seriously causing deep tissue ulceration. Hyaluronidase can destroy the integrity of connective tissue, and promote the snake venom to diffuse and absorb. Generally, 2-4 days after the bite is in the edema peak stage, the ecchymosis can spread to the periphery and even spread to the whole injured limb, the swelling process generally lasts for about 4 weeks, if the treatment is not timely, complications such as periosteum syndrome and the like can be frequently caused, and the labor capacity and the life quality of a patient are seriously influenced. At present, the anti-snake venom serum has no other medicine for treating snake bite poisoning, and the anti-pit viper serum has irreplaceable effect in treating pit viper bite, can separate snake venom in vivo to the maximum extent, but has no protective effect on snake venom and anti-snake venom serum combined with tissues and organs, and cannot relieve poisoning symptoms. Meanwhile, the anti-snake venom serum has no effect on snake-bite swelling, and after poisoning control, symptoms such as local bruising and swelling, pain and the like still appear in the later period of a patient, so that great pain is brought to the patient.

Therefore, there is a need to provide a Chinese medicinal composition against venom of Pallas pit Viper to solve the above problems.

Disclosure of Invention

In order to solve the technical problems, the invention provides a traditional Chinese medicine composition for resisting viper venom, which is suitable for viper bite patients, has no adverse reaction and stable curative effect.

The invention provides a traditional Chinese medicine composition for resisting agkistrodon halys venom, which comprises the following raw materials: rhizoma paridis, herba Lobeliae chinensis, herba Bidentis Bipinnatae, herba Hedyotidis Diffusae, rhizoma Chuanxiong, radix Angelicae Dahuricae, radix Et rhizoma Rhei, rhizoma Curcumae Longae, caulis Spatholobi, and radix Saposhnikoviae.

The further scheme is that the feed is prepared from the following raw materials in parts by weight: 30-40g of rhizoma paridis, 30-40g of Chinese lobelia, 15-30g of sticktight, 30-40g of oldenlandia, 15-30g of ligusticum wallichii, 10-20g of radix angelicae, 15-30g of rheum officinale, 12-25g of turmeric, 20-30g of caulis spatholobi and 10-20g of radix sileris.

The further scheme is that the feed is prepared from the following raw materials by weight: 30g of rhizoma paridis, 30g of Chinese lobelia herb, 15g of sticktight, 30g of oldenlandia diffusa, 15g of ligusticum wallichii, 10g of radix angelicae, 15g of rheum officinale, 12g of turmeric, 20g of caulis spatholobi and 10g of radix sileris.

The further scheme is that the feed is prepared from the following raw materials by weight: 40g of rhizoma paridis, 40g of Chinese lobelia herb, 30g of spanishneedles herb, 40g of spreading hedyotis herb, 30g of szechuan lovage rhizome, 20g of dahurian angelica root, 30g of rhubarb, 25g of turmeric, 30g of suberect spatholobus stem and 20g of divaricate saposhnikovia root.

The further scheme is that the feed is prepared from the following raw materials by weight: 35g of rhizoma paridis, 35g of Chinese lobelia herb, 20g of sticktight, 35g of oldenlandia diffusa, 20g of ligusticum wallichii, 15g of radix angelicae, 20g of rheum officinale, 18g of turmeric, 25g of caulis spatholobi and 15g of divaricate saposhnikovia root.

The traditional Chinese medicine composition can be prepared into various applicable formulations such as decoction, powder, pills or capsules.

The invention has the beneficial effects that:

the traditional Chinese medicine composition can detoxify, detumescence, promote blood circulation and relieve pain, is suitable for patients bitten by the agkistrodon halys, has no adverse reaction and stable curative effect.

Detailed Description

In order to make the aforementioned objects, features and advantages of the present invention comprehensible, specific embodiments thereof are described in detail below. In the following description, numerous specific details are set forth in order to provide a thorough understanding of the present invention. This invention can be embodied in many different forms than those herein described and many modifications may be made by one skilled in the art without departing from the spirit and scope of the invention.

The present invention will be further described with reference to the following embodiments.

Example 1

Taking the following raw materials by weight: 30g of rhizoma paridis, 30g of Chinese lobelia, 15g of sticktight, 30g of oldenlandia diffusa, 15g of ligusticum wallichii, 10g of radix angelicae, 15g of rheum officinale, 12g of turmeric, 20g of caulis spatholobi and 10g of radix sileris.

Example 2

Taking the following raw materials by weight: 40g of rhizoma paridis, 40g of Chinese lobelia, 30g of sticktight, 40g of oldenlandia diffusa, 30g of ligusticum wallichii, 20g of radix angelicae, 30g of rheum officinale, 25g of turmeric, 30g of caulis spatholobi and 20g of divaricate saposhnikovia root, and the traditional Chinese medicine composition is prepared.

Example 3

Taking the following raw materials by weight: 35g of rhizoma paridis, 35g of Chinese lobelia herb, 20g of sticktight, 35g of spreading hedyotis herb, 20g of szechuan lovage rhizome, 15g of dahurian angelica root, 20g of rhubarb, 18g of turmeric, 25g of suberect spatholobus stem and 15g of divaricate saposhnikovia root, and the traditional Chinese medicine composition is prepared.

The Chinese medicinal composition can be prepared into various applicable formulations such as decoction, powder, pills or capsules, and can also be added into drinks.

The traditional Chinese medicine composition comprises the following components:

paris polyphylla, the essential herb for snake bite, has the functions of relieving swelling and pain. The book of Shen nong Ben Cao Jing (Shen nong's herbal) has a main expression: "governing erosion of the vulva, expelling three worms and removing snake venom. "

Lobelia chinensis can induce diuresis, relieve swelling and remove toxicity. Compendium of materia Medica: for snake poisonous snake bite, pounded juice is drunk and applied around the feces. "

Herba Hedyotidis Diffusae: clearing heat, promoting diuresis, and removing toxicity, for example, Guangxi TCM J: treating infantile malnutrition, venomous snake bite, and cancer;

bidens pilosa L: clearing away heat and toxic materials, removing blood stasis, and promoting blood circulation;

ligusticum wallichii: promoting blood circulation for removing blood stasis, and dispersing blood stasis;

radix angelicae: dispersing qi stagnation, combined with Chuan Xiong, can enhance the actions of promoting qi and blood circulation;

rhubarb: cool blood and remove toxicity, dispel stasis and dredge meridians;

turmeric: dispelling pathogenic wind, promoting blood circulation, dredging channels and collaterals and relieving pain;

caulis spatholobi: blood-red color entering blood, moistening and dispersing, and has effects of promoting blood circulation, relaxing muscles and tendons, nourishing blood, and regulating menstruation;

wind prevention: it is a "wind-damp-clearing moistening agent" and a wind-damp-removing herb, and can dispel wind, remove dampness and alleviate pain.

In the composition, the paris polyphylla, which is also called paris rhizome and paris polyphylla, is a key medicine for treating snake bite and has the functions of relieving swelling and pain; herba Hedyotidis Diffusae, herba Lobeliae chinensis, and herba Bidentis Bipinnatae have effects of clearing away heat and toxic materials and relieving swelling; rhizoma Ligustici Chuanxiong, radix Angelicae Dahuricae, radix et rhizoma Rhei, Curcuma rhizome, caulis Spatholobi, and radix Saposhnikoviae for promoting blood circulation and relieving swelling; the whole formula has the effects of detoxifying, relieving swelling, activating blood and relieving pain.

The traditional Chinese medicine composition has scientific and reasonable components and safe compatibility and medication, 60 cases of clinical observation data of patients are provided by screening in order to show the treatment effect of the traditional Chinese medicine composition, the 60 cases are divided into two groups according to the random distribution principle, the two groups of patients are respectively a treatment group 30 cases and a control group 30 cases, the two groups of patients have no statistical significance in comparison in the aspects of disease conditions, personal basic conditions and the like, and the two groups of patients have comparability.

Firstly, selecting a standard:

the patients with agkistrodon halys bite can be used as the standard of the selected cases.

II, diagnosis standard:

has definite history of venomous snake bite; local symptoms: generally, there are two teeth marks, the distance is small, deep and clear, the wound is not bleeding much, and there are stabbing pain and numbness feeling. The injured limb has severe swelling, blood and water bubbles with different sizes can be arranged near the wound, the tissue is ulcerated after ulceration to generate inflammatory ulcer, and the inflammatory ulcer is often accompanied with swelling and pain of nearby lymph nodes; systemic symptoms: dizziness and headache appear 1-6 h after general bite, or have fever, chest distress, palpitation, dysphoria, shortness of breath, flutter of the nasal wings, drooping eyelids, blurred vision, diplopia, miosis, nausea and vomiting, weakness of limbs, and general muscle ache and discomfort. Severe patients may experience impaired liver function, electrolyte disturbance, impaired or depleted kidney function, impaired or depleted heart function, paralysis of the respiratory muscles and cessation of breathing.

Third, embodiment

The treatment group is prepared into powder for external use according to requirements in conventional western medicine treatment (wound treatment, tetanus prevention, toxin neutralization by antivenin, infection prevention by antibiotics, cytotoxicity reaction reduction by hormones, stress ulcer prevention by proton pump inhibitors, diuresis and detumescence, and snake venom excretion acceleration), and the specific method comprises the following steps: after conventional treatment, the wound is exposed, then the wound is disinfected by an iodophor cotton ball, and then the ground snake wound swelling powder is mixed with honey into paste to be externally applied to a swelling part, the paste is externally applied to the swelling part to be about 5cm above the swelling part, the paste is wrapped and fixed by using the plaster cotton after the application is finished, the dressing change is performed once a day, 7 days are a treatment course, and statistics is carried out after 1 treatment course.

The control group is treated according to the requirements by Western medicine routine treatment (wound treatment, tetanus prevention, toxin neutralization by antivenin, infection prevention by antibiotics, cytotoxicity reaction reduction by hormones, stress ulcer prevention by proton pump inhibitor, diuresis and detumescence, and snake venom excretion acceleration), 7 days is a treatment course, and statistics is carried out after 1 treatment course.

Fourth, comparison results

In the treatment group, 13 healers account for 32.5 percent, 12 significant effects account for 43.3 percent, 5 significant effects account for 16.7 percent, and the total effective rate is 100 percent; in the control group, 3 cured patients account for 10 percent, 8 effective patients account for 26.7 percent, 12 effective patients account for 40 percent, 7 ineffective patients account for 23.3 percent, and the total effective rate is 76.7 percent; the treatment group was superior to the control group. The healing refers to that the swelling and pain of the patient are completely eliminated, the wound is healed, the limb function is recovered, and the integral of symptoms and signs is reduced by more than 90%. The obvious effect means that the swelling and pain of the affected part is obviously relieved, the limb function of the patient is basically recovered, and the integral of symptoms and signs is reduced by 60-89%. The effect means that the swelling and pain of the affected part are relieved, the wound is not completely healed, and the integral of symptoms and signs is reduced by 30 to 59 percent; the ineffectiveness means that the general symptoms and local symptoms are not obviously improved, and the integral of the symptoms and signs is reduced by less than 30%.

The observation result shows that the traditional Chinese medicine composition has good treatment effect on the patients bitten by the agkistrodon halys.

The traditional Chinese medicine composition is prepared into other dosage forms, the same or similar results are obtained in experiments, the listing is omitted, the description is prevented from being accumulated, and the application claims the traditional Chinese medicine composition (combination invention) rather than the dosage form or the preparation method, so that any dosage form prepared from the traditional Chinese medicine composition belongs to the protection scope of the application and medicines for treating the same diseases.

Claims

1. A traditional Chinese medicine composition for resisting viper venom comprises the following raw materials: rhizoma paridis, herba Lobeliae chinensis, herba Bidentis Bipinnatae, herba Hedyotidis Diffusae, rhizoma Chuanxiong, radix Angelicae Dahuricae, radix Et rhizoma Rhei, rhizoma Curcumae Longae, caulis Spatholobi, and radix Saposhnikoviae.

2. The traditional Chinese medicine composition for resisting viper venom according to claim 1, which is characterized by comprising the following raw materials in parts by weight: the feed is prepared from the following raw materials in parts by weight: 30-40g of rhizoma paridis, 30-40g of Chinese lobelia, 15-30g of sticktight, 30-40g of oldenlandia, 15-30g of ligusticum wallichii, 10-20g of radix angelicae, 15-30g of rheum officinale, 12-25g of turmeric, 20-30g of caulis spatholobi and 10-20g of radix sileris.

3. The traditional Chinese medicine composition for resisting viper venom according to claim 2, which is characterized by being prepared from the following raw materials in parts by weight: 30g of rhizoma paridis, 30g of Chinese lobelia herb, 15g of sticktight, 30g of oldenlandia diffusa, 15g of ligusticum wallichii, 10g of radix angelicae, 15g of rheum officinale, 12g of turmeric, 20g of caulis spatholobi and 10g of radix sileris.

4. The traditional Chinese medicine composition for resisting viper venom according to claim 2, which is characterized by being prepared from the following raw materials in parts by weight: 40g of rhizoma paridis, 40g of Chinese lobelia herb, 30g of spanishneedles herb, 40g of spreading hedyotis herb, 30g of szechuan lovage rhizome, 20g of dahurian angelica root, 30g of rhubarb, 25g of turmeric, 30g of suberect spatholobus stem and 20g of divaricate saposhnikovia root.

5. The traditional Chinese medicine composition for resisting viper venom according to claim 2, which is characterized by being prepared from the following raw materials in parts by weight: 35g of rhizoma paridis, 35g of Chinese lobelia herb, 20g of sticktight, 35g of oldenlandia diffusa, 20g of ligusticum wallichii, 15g of radix angelicae, 20g of rheum officinale, 18g of turmeric, 25g of caulis spatholobi and 15g of divaricate saposhnikovia root.

6. The anti-viper venom traditional Chinese medicine composition according to any one of claims 1-5, which is characterized in that: the Chinese medicinal composition is prepared into decoction, powder, pills or capsules.