CN111280185A - Anti-virus disinfectant and preparation method thereof - Google Patents

Anti-virus disinfectant and preparation method thereof Download PDF

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Publication number
CN111280185A
CN111280185A CN202010212436.2A CN202010212436A CN111280185A CN 111280185 A CN111280185 A CN 111280185A CN 202010212436 A CN202010212436 A CN 202010212436A CN 111280185 A CN111280185 A CN 111280185A
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moxa
disinfectant
extract
tar
percent
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柳馨
铁健
铁生年
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Qinghai University
Qinghai Normal University
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Qinghai University
Qinghai Normal University
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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N31/00Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
    • A01N31/02Acyclic compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N43/00Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
    • A01N43/34Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom
    • A01N43/36Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings
    • A01N43/38Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one nitrogen atom as the only ring hetero atom five-membered rings condensed with carbocyclic rings
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N47/00Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
    • A01N47/08Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
    • A01N47/10Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
    • A01N47/18Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing a —O—CO—N< group, or a thio analogue thereof, directly attached to a heterocyclic or cycloaliphatic ring
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N59/00Biocides, pest repellants or attractants, or plant growth regulators containing elements or inorganic compounds
    • A01N59/08Alkali metal chlorides; Alkaline earth metal chlorides
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N63/00Biocides, pest repellants or attractants, or plant growth regulators containing microorganisms, viruses, microbial fungi, animals or substances produced by, or obtained from, microorganisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01NPRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
    • A01N65/00Biocides, pest repellants or attractants, or plant growth regulators containing material from algae, lichens, bryophyta, multi-cellular fungi or plants, or extracts thereof
    • A01N65/08Magnoliopsida [dicotyledons]
    • A01N65/12Asteraceae or Compositae [Aster or Sunflower family], e.g. daisy, pyrethrum, artichoke, lettuce, sunflower, wormwood or tarragon

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Environmental Sciences (AREA)
  • Agronomy & Crop Science (AREA)
  • Plant Pathology (AREA)
  • Dentistry (AREA)
  • Pest Control & Pesticides (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Chemical & Material Sciences (AREA)
  • Inorganic Chemistry (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Botany (AREA)
  • Virology (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

The invention relates to the technical field of disinfectant production, in particular to a preparation method of an anti-virus disinfectant. The invention provides the following technical scheme: the antivirus disinfectant consists of the following raw materials in concentration ratio: ethanol: 1-30% (w/w); sodium chloride: 0.001 to 1 percent (w/w); sodium bicarbonate: 0.001 to 2 percent (w/w); moxa combustion product extract: 1-10% (w/w); complex enzyme: 0.001 to 5 percent (w/w). The invention provides an antiviral disinfectant with plant extracts as main components, which aims to fully utilize various products generated in the burning process of wormwood so that the antiviral disinfectant can be applied to the production of antiviral disinfectant, and provides a disinfectant which is nontoxic and harmless and can be used for human bodies.

Description

Anti-virus disinfectant and preparation method thereof
Technical Field
The invention relates to the technical field of disinfectant production, in particular to a preparation method of an anti-virus disinfectant.
Background
The smoke generated by the burning of the moxa is commonly called moxa smoke. The folium Artemisiae Argyi cigarette has effects of sterilizing, killing bacteria, and enhancing immunity. In the research on the chemical components and pharmacological actions of the moxa, the moxa and the moxa extract have obvious inhibition and killing effects on various common bacteria, viruses and fungi. In the moxa smoking and staining antibacterial test, a layer of yellow oily matter is found on the surfaces of the culture dish and the dish flat plate, and the oily matter is generated during moxa smoking and burning and also has antibacterial and bactericidal effects. The moxa smoke contains trace elements such as selenium, iron, zinc, magnesium, sodium, potassium, calcium and the like, and can be absorbed by human bodies. However, in the prior art, the application of the moxa is limited to moxibustion and decoction of traditional Chinese medicines, so that the functions of the moxa are not completely developed, and meanwhile, the existing disinfectant or disinfection product has an erosion effect on human bodies or human skins and cannot be massively used for body disinfection for a long time. At present, the disinfection methods commonly used at home and abroad are a chemical method and a physical method, and the chemical preparations comprise 84 disinfectant, a chlorine trioxide disinfectant, a hydrogen peroxide disinfectant, a sodium hypochlorite disinfectant, a peracetic acid disinfectant, a formaldehyde disinfectant, a glutaraldehyde disinfectant, a phenol disinfectant, an iodine disinfectant, an ozone disinfectant, a double-chain quaternary ammonium salt disinfectant, a coal phenol soap disinfectant, a polyhexamethylene guanidine hydrochloride disinfectant, a thymol disinfectant, a cinnamon essential oil disinfectant, lactic acid and the like. The physical methods include ultraviolet irradiation, ozone generator, etc. The methods can quickly kill pathogenic microorganisms, have low effective concentration, but have a plurality of defects, such as toxicity, irritation, metal corrosivity, poor lasting effect and short stabilization time, a plurality of pollutants are formed, all personnel need to leave the field during disinfection, an operating system needs protective measures, peculiar smell cannot be quickly eliminated after disinfection, and the method has the risk of accumulated poisoning on a human body after long-term use.
Disclosure of Invention
The invention provides an antiviral disinfectant with plant extracts as main components, which aims to fully utilize various products generated in the burning process of wormwood so that the antiviral disinfectant can be applied to the production of antiviral disinfectant, and provides a disinfectant which is nontoxic and harmless and can be used for human bodies. In order to achieve the purpose, the invention provides the following technical scheme:
an antivirus disinfectant solution is prepared from water, ethanol, sodium chloride, sodium bicarbonate, enzyme, and folium Artemisiae Argyi extract by mixing.
Preferably, the antivirus disinfectant consists of the following raw materials in concentration ratio: ethanol: 1-30% (w/w); sodium chloride: 0.001 to 1 percent (w/w); sodium bicarbonate: 0.001 to 2 percent (w/w); moxa combustion product extract: 1-10% (w/w); complex enzyme: 0.001 to 5 percent (w/w).
Preferably, the water is deionized water.
Preferably, the moxa extract comprises moxa smoke, ash generated by burning moxa, and tar generated during burning of moxa.
Preferably, the enzyme is a complex enzyme.
Further preferably, the pharmaceutical composition further comprises one or two of arbidol and darunavir, and a hydrochloric acid solution.
Further preferably, the concentration of the arbidol is: 1-50 micromolar, the concentration of darunavir is: 1-500 micromolar concentration, and the concentration of hydrochloric acid is: 0.001 to 5 percent (w/w).
A preparation method of an antivirus disinfectant comprises the following steps: weighing moxa extract, complex enzyme, ethanol, sodium chloride and sodium bicarbonate according to the formula, mixing, and dissolving in deionized water to obtain the plant extract disinfectant.
Preferably, arbidol, darunavir and hydrochloric acid are weighed according to the formula and dissolved in deionized water to prepare a No. 2 solution, and the plant extract disinfectant and the No. 2 solution are mixed according to the mass ratio of 1:1 to prepare the anti-virus disinfectant.
Preferably, the preparation method of the moxa extract comprises the following steps: igniting the dry moxa in a burning tower to burn the moxa with a dark fire, generating a large amount of white smoke, and absorbing the generated white smoke, tar and ash by using an absorbent.
The moxa extract collecting device comprises a combustion tower and is characterized in that a first absorption cover is arranged above the combustion tower, an absorption bottle device is arranged at the outlet end of an air guide pipe connected with the first absorption cover, the air outlet end of the absorption bottle device is connected with a buffer bottle, and an absorbent is filled in the absorption bottle.
Preferably, the first absorption cover is in the shape of an inverted funnel, the absorption bottle is a U-shaped pipe device, and the U-shaped pipe device comprises a plurality of U-shaped pipes which are sequentially connected end to end.
The invention provides a using method of the moxa extract collecting device, which comprises the following steps:
(1) moxa smoke combustion product collection
Selecting absolute ethyl alcohol as a moxa smoke absorbent, utilizing the absorption device, respectively filling the absolute ethyl alcohol into a U-shaped tube device, putting dry moxa into a combustion tower, combusting with dark fire, collecting moxa smoke, roughly filtering the obtained moxa smoke collecting liquid, finely filtering with a microporous organic filter membrane with the pore diameter of 2 mu m, and collecting filtrate;
(2) preparation of moxa-ash crystals
Extracting the mugwort ashes generated by combustion in a combustion tower with methanol at a ratio of methanol to the mugwort ashes (500mL:10g) for 3 days, coarsely filtering the extract, filtering with a microporous organic filter membrane (pore size of 2um), distilling and concentrating, concentrating the filtrate to 50mL, placing in a fume hood for 12 hours, and filtering the concentrated solution to obtain a solid sample;
(3) tar preparation
Burning moxa in a combustion tower, leaving a large amount of black brown tar on the wall of a glass funnel, dissolving the tar on the glass funnel by using anhydrous methanol, filtering by using a microporous organic filter membrane after rough filtration, and carrying out distillation concentration to obtain black tar;
(4) mixing the collected filtrate, folium Artemisiae Argyi crystals and tar oil, heating in 45-60 deg.C water bath, and stirring for 20-60 min to obtain folium Artemisiae Argyi extract.
Drawings
Fig. 1 is a schematic structural diagram of an embodiment of the present invention.
Detailed Description
The technical solution of the present invention is further explained with reference to the accompanying drawings.
Example 1:
an antivirus disinfectant consists of the following raw materials in concentration ratio: ethanol: 1-30% (w/w); sodium chloride: 0.001 to 1 percent (w/w); sodium bicarbonate: 0.001-2% (w/w) moxa extract: 1-10% (w/w); complex enzyme: 0.001 to 5 percent (w/w).
Example 2:
the antivirus disinfectant consists of the following raw materials in concentration ratio: hydrochloric acid: 0.001 to 5 percent (w/w); ethanol: 1-30% (w/w); sodium chloride: 0.001 to 1 percent (w/w); sodium bicarbonate: 0.001 to 2 percent (w/w); moxa combustion product extract: 1-10% (w/w); complex enzyme: 0.001 to 5 percent (w/w); arbidol: 1-50 micromolar; darunavir: 1-500 micromolar; the balance being deionized water.
The preparation method comprises the following steps: the moxa extract, the complex enzyme, the ethanol, the sodium chloride and the sodium bicarbonate are weighed according to the formula content, mixed and dissolved in deionized water to prepare the plant extract disinfectant. The antivirus disinfectant is prepared by weighing arbidol, darunavir and hydrochloric acid according to the formula, dissolving the arbidol, the darunavir and the hydrochloric acid in deionized water to prepare a No. 2 solution, and mixing the plant extract disinfectant and the No. 2 solution according to the mass ratio of 1: 1.
Example 3:
the utility model provides a moxa extract collection device, includes combustion tower 1, 1 top of combustion tower is provided with first absorption cover 2, and 3 exit ends of air duct that link to each other with first absorption cover 2 are provided with absorption bottle device 4, and absorption bottle device 4 gives vent to anger the end and is connected with buffer bottle 5 and 6, be equipped with the absorbent in the absorption bottle device 4. The first absorption cover 2 is in an inverted funnel shape, the absorption bottle device 4 is a U-shaped pipe device, and the U-shaped pipe device comprises a plurality of U-shaped pipes which are sequentially connected end to end. Further connect the air duct behind the cushion flask with circulating water vacuum pump for adjust chinese mugwort cigarette rate of giving vent to anger.
The invention provides a using method of the moxa extract collecting device, which comprises the following steps:
(1) moxa smoke combustion product collection
Selecting absolute ethyl alcohol as a moxa smoke absorbent, utilizing the absorption device, respectively filling the absolute ethyl alcohol into a U-shaped tube device, putting dry moxa into a combustion tower, combusting with dark fire, collecting moxa smoke, roughly filtering the obtained moxa smoke collecting liquid, finely filtering with a microporous organic filter membrane with the pore diameter of 2 mu m, and collecting filtrate;
(2) preparation of moxa-ash crystals
Extracting the mugwort ashes generated by combustion in a combustion tower with methanol at a ratio of methanol to the mugwort ashes (500mL:10g) for 3 days, coarsely filtering the extract, filtering with a microporous organic filter membrane (pore size of 2um), distilling and concentrating, concentrating the filtrate to 50mL, placing in a fume hood for 12 hours, and filtering the concentrated solution to obtain a solid sample;
(3) tar preparation
Burning moxa in a combustion tower, leaving a large amount of black brown tar on the wall of a glass funnel, dissolving the tar on the glass funnel by using anhydrous methanol, filtering by using a microporous organic filter membrane after rough filtration, and carrying out distillation concentration to obtain black tar;
(4) mixing the collected filtrate, folium Artemisiae Argyi crystals and tar oil, heating in 50 deg.C water bath, and stirring for 30 min to obtain folium Artemisiae Argyi extract.
The arbidol chemical name mentioned in the invention is 6-bromo-5-hydroxy-1-methyl-4- ((dimethylamino) methyl) -2- (phenylthiomethyl) -1H-indole-3-carboxylic acid ethyl ester; the molecular formula is C22H25BrN2O 3S.
The darunavir is chemically [ (1R,5S,6R) -2, 8-dioxybicyclo [ 3.3.0-decane-6-yl-N- [ (2S,3R) -4- [ (4-aminophenyl) sulfonyl- (2-methylpropyl) amino ] -3-hydroxy-1-phenyl-butane-2-yl ] carbamate, and the molecular formula of the darunavir is C27H37N3O 7S.

Claims (10)

1. An antivirus disinfectant solution is prepared from water, ethanol, sodium chloride, sodium bicarbonate, enzyme, and folium Artemisiae Argyi extract by mixing.
2. The anti-virus disinfectant as claimed in claim 1, which is characterized by comprising the following raw materials in concentration ratio: ethanol: 1-30% (w/w); sodium chloride: 0.001 to 1 percent (w/w); sodium bicarbonate: 0.001 to 2 percent (w/w); moxa extract: 1-10% (w/w); complex enzyme: 0.001 to 5 percent (w/w).
3. The anti-virus disinfectant as claimed in claim 2, wherein the water is deionized water and the enzyme is complex enzyme.
4. The anti-virus disinfectant as claimed in claim 3, wherein said moxa extract comprises moxa smoke, ash from the burning of moxa, and tar produced by the burning of moxa.
5. The anti-virus disinfectant as claimed in claim 4, further comprising one or two of arbidol and darunavir, and further comprising hydrochloric acid solution, wherein the concentration of arbidol is: 1-50 micromolar, the concentration of darunavir is: 1-500 micromolar concentration, and the concentration of hydrochloric acid is: 0.001 to 5 percent (w/w).
6. A preparation method of an antivirus disinfectant comprises the following steps: weighing moxa extract, complex enzyme, ethanol, sodium chloride and sodium bicarbonate according to the formula, mixing, and dissolving in deionized water to obtain the plant extract disinfectant.
7. The method for preparing an anti-virus disinfectant as claimed in claim 6, wherein arbidol, darunavir and hydrochloric acid are weighed according to the formula, and dissolved in deionized water to prepare solution No. 2, and the plant extract disinfectant and the solution No. 2 are mixed according to the mass ratio of 1:1 to prepare the anti-virus disinfectant.
8. The method for preparing an anti-virus disinfectant as claimed in claim 7, wherein the method for preparing the moxa extract comprises the following steps: igniting the dry moxa in a burning tower to burn the moxa with a dark fire, generating a large amount of white smoke, and absorbing the generated white smoke, tar and ash by using an absorbent.
9. The utility model provides a moxa extract collection device, includes the combustion tower, its characterized in that the combustion tower top is provided with first absorption cover, and the air duct exit end that links to each other with first absorption cover is provided with the absorption bottle device, and the absorption bottle device end of giving vent to anger is connected with the cushion flask, be equipped with the absorbent in the absorption flask, set up the air duct behind the cushion flask and link to each other with circulating water vacuum pump for adjust chinese mugwort cigarette rate of giving vent to anger, first absorption cover is inverted funnel shape, the absorption flask is the U-shaped pipe device, the U-shaped pipe device includes the U-shaped pipe that a plurality of end to end links to each other in.
10. The method of using a moxa extract collection device of claim 9, comprising:
(1) moxa smoke combustion product collection
Selecting anhydrous ethanol as folium Artemisiae Argyi absorbent, respectively loading anhydrous ethanol into U-shaped tube device by using the above collecting device, placing dry folium Artemisiae Argyi into combustion tower, burning with dark fire, collecting folium Artemisiae Argyi smoke, coarse filtering the obtained folium Artemisiae Argyi smoke collecting solution, fine filtering with organic filter membrane, and collecting filtrate;
(2) preparation of moxa-ash crystals
Extracting the mugwort ashes generated by combustion in a combustion tower by using methanol, then roughly filtering an extracting solution, filtering by using a microporous organic filter membrane, distilling and concentrating, concentrating the filtrate, standing in a fume hood, and filtering the concentrated solution to obtain a solid sample;
(3) tar preparation
Burning moxa in a combustion tower, leaving a large amount of black brown tar on the wall of a glass funnel, dissolving the tar on the glass funnel by using anhydrous methanol, filtering by using a microporous organic filter membrane after rough filtration, and carrying out distillation concentration to obtain black tar;
(4) mixing the collected filtrate, folium Artemisiae Argyi crystals and tar under heating in water bath, and stirring for a certain period to obtain folium Artemisiae Argyi extract.
CN202010212436.2A 2020-03-24 2020-03-24 Anti-virus disinfectant and preparation method thereof Pending CN111280185A (en)

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108485720A (en) * 2018-05-08 2018-09-04 中国华能集团清洁能源技术研究院有限公司 A kind of cooling system and cooling means for biological fuel gas
CN208553651U (en) * 2018-07-23 2019-03-01 国家电投集团远达环保工程有限公司重庆科技分公司 A kind of white cigarette elimination system
CN110012913A (en) * 2018-01-06 2019-07-16 张志红 A kind of compound disinfectant and preparation method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110012913A (en) * 2018-01-06 2019-07-16 张志红 A kind of compound disinfectant and preparation method thereof
CN108485720A (en) * 2018-05-08 2018-09-04 中国华能集团清洁能源技术研究院有限公司 A kind of cooling system and cooling means for biological fuel gas
CN208553651U (en) * 2018-07-23 2019-03-01 国家电投集团远达环保工程有限公司重庆科技分公司 A kind of white cigarette elimination system

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
洪宗国: "艾叶燃烧物的抑菌作用", 《中国针灸学会年会》 *

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