CN111278456B - 表达血清3型菌毛的鲍特菌属菌株 - Google Patents

表达血清3型菌毛的鲍特菌属菌株 Download PDF

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Publication number
CN111278456B
CN111278456B CN201880067004.8A CN201880067004A CN111278456B CN 111278456 B CN111278456 B CN 111278456B CN 201880067004 A CN201880067004 A CN 201880067004A CN 111278456 B CN111278456 B CN 111278456B
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functional
live attenuated
strain
fim3
vaccine
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Chinese (zh)
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CN111278456A (zh
Inventor
阿内-索菲·德布里
多米尼克·拉兹
卡米尔·洛赫特
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Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
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Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
CN201880067004.8A 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株 Active CN111278456B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202411102248.9A CN118979003A (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574068P 2017-10-18 2017-10-18
US62/574,068 2017-10-18
PCT/EP2018/078522 WO2019077028A1 (en) 2017-10-18 2018-10-18 BORDETELLA STRAINS EXPRESSING SERO-TYPE FIMBRIAE 3

Related Child Applications (1)

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CN202411102248.9A Division CN118979003A (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株

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CN111278456A CN111278456A (zh) 2020-06-12
CN111278456B true CN111278456B (zh) 2024-08-09

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CN201880067004.8A Active CN111278456B (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株
CN202411102248.9A Pending CN118979003A (zh) 2017-10-18 2018-10-18 表达血清3型菌毛的鲍特菌属菌株

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US (2) US11446372B2 (enExample)
EP (1) EP3697439A1 (enExample)
JP (2) JP7335874B2 (enExample)
CN (2) CN111278456B (enExample)
AU (1) AU2018353409B2 (enExample)
CA (1) CA3077428A1 (enExample)
SG (1) SG11202003333WA (enExample)
WO (1) WO2019077028A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0707102B1 (pt) * 2006-03-10 2022-05-31 Institut Pasteur De Lille Composição imunogênica
CA2759280C (en) 2009-04-28 2016-09-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
CA3077428A1 (en) * 2017-10-18 2019-04-25 Institut Pasteur De Lille Bordetella strains expressing serotype 3 fimbriae
CN116635517A (zh) 2020-11-17 2023-08-22 伊利亚德生物技术有限公司 与神经退行性疾病相关的神经病理的治疗和预防

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5395764A (en) * 1989-11-03 1995-03-07 Eniricerhce S.P.A. Promoter of the gene which codes for the pilinic subunit fim3 of Bordetella pertussis and its use for the expression in Bordetella of the genes which code for a protein of interest
CN101400783A (zh) * 2006-03-10 2009-04-01 巴斯德研究院里尔分院 包特氏菌减毒活菌株作为抗百日咳的单剂量疫苗

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US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
US6713072B1 (en) 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
GB9115332D0 (en) 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
FR2718750B1 (fr) 1994-04-19 1996-06-14 Pasteur Institut Protéines recombinantes de l'hémagglutinine filamenteuse de Bordetella, notamment, B. Pertussis, production et application à la production de protéines étrangères ou de principes actifs vaccinants.
FR2754543B1 (fr) 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
FR2840319B1 (fr) 2002-05-30 2004-08-20 Pasteur Institut Souches de bordetella rendues deficientes par attenuation genetique
EP1617805A4 (en) 2003-04-11 2012-07-04 Medimmune Llc METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2008058396A1 (en) 2006-11-15 2008-05-22 Folia Biotech Inc. Papaya mosaic virus-based vaccines for influenza
EP2134359A4 (en) 2007-02-23 2010-06-16 Penn State Res Found USE OF A NONVIRULENT BORDETELLA MUTANT AS LIVING VACCINE VECTOR
CN100537767C (zh) * 2007-04-29 2009-09-09 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
US20100104533A1 (en) 2007-06-18 2010-04-29 Carter William A Early intervention of viral infection with immune activators
CA2759280C (en) * 2009-04-28 2016-09-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
JP5551774B2 (ja) 2009-06-15 2014-07-16 ナショナル ユニヴァーシティー オブ シンガポール インフルエンザワクチン、組成物、および使用方法
US9415077B2 (en) * 2011-11-02 2016-08-16 Institut National De La Sante Et De La Recherche Medicale Effect of an attenuated Bordetella strain against allergic disease
JP2015525794A (ja) * 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
EP2722338A1 (en) 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel recombinant Bordetella strains
US9655959B2 (en) * 2014-10-01 2017-05-23 National University Of Singapore Adenylate cyclase deficient bordetella strains
AU2017242541B2 (en) * 2016-03-29 2022-06-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Mutant bordetella strains and methods for use
US10799573B2 (en) * 2016-03-30 2020-10-13 Regents Of The University Of Minnesota Pertussis vaccines and methods of making and using
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JP7404226B2 (ja) * 2017-07-18 2023-12-25 セラム インスティテュート オブ インディア プライベート リミティド 向上した安定性、高度の免疫原性、及び減少した反応源性を有する免疫原性組成物、並びにその調製プロセス
CA3077428A1 (en) * 2017-10-18 2019-04-25 Institut Pasteur De Lille Bordetella strains expressing serotype 3 fimbriae
US12036405B2 (en) * 2018-03-23 2024-07-16 The Board Of Regents Of The University Of Oklahoma System and method of electric-induced acoustic tomography for electrotherapy monitoring
WO2020049133A1 (en) 2018-09-05 2020-03-12 National University Of Singapore Adenylate cyclase catalytic domain deficient bordetella strains

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US5395764A (en) * 1989-11-03 1995-03-07 Eniricerhce S.P.A. Promoter of the gene which codes for the pilinic subunit fim3 of Bordetella pertussis and its use for the expression in Bordetella of the genes which code for a protein of interest
CN101400783A (zh) * 2006-03-10 2009-04-01 巴斯德研究院里尔分院 包特氏菌减毒活菌株作为抗百日咳的单剂量疫苗

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"Construction and evaluation of Bordetella pertussis live attenuated vaccine strain BPZE1 producing Fim3";Anne-Sophie Debrie et al.;《Vaccine》;第36卷;第1345-1352页 *
"Live Attenuated B. pertussis as a Single-Dose Nasal Vaccine against Whooping Cough";Nathalie Mielcarek et al.;《PLoS Pathogens》;第2卷(第2期);第662-670页 *

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Publication number Publication date
CN118979003A (zh) 2024-11-19
CA3077428A1 (en) 2019-04-25
JP2021500325A (ja) 2021-01-07
US11446372B2 (en) 2022-09-20
WO2019077028A4 (en) 2019-06-27
US20220362369A1 (en) 2022-11-17
AU2018353409A1 (en) 2020-04-16
EP3697439A1 (en) 2020-08-26
US12403188B2 (en) 2025-09-02
JP7335874B2 (ja) 2023-08-30
SG11202003333WA (en) 2020-05-28
AU2018353409B2 (en) 2025-07-17
WO2019077028A1 (en) 2019-04-25
CN111278456A (zh) 2020-06-12
US20200297833A1 (en) 2020-09-24
JP2023109996A (ja) 2023-08-08

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