JP7335874B2 - 血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株 - Google Patents

血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株 Download PDF

Info

Publication number
JP7335874B2
JP7335874B2 JP2020520777A JP2020520777A JP7335874B2 JP 7335874 B2 JP7335874 B2 JP 7335874B2 JP 2020520777 A JP2020520777 A JP 2020520777A JP 2020520777 A JP2020520777 A JP 2020520777A JP 7335874 B2 JP7335874 B2 JP 7335874B2
Authority
JP
Japan
Prior art keywords
fim3
vaccine
functional
strain
live attenuated
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
JP2020520777A
Other languages
English (en)
Japanese (ja)
Other versions
JP2021500325A (ja
JP2021500325A5 (enExample
Inventor
デブリ，アン－ソフィー
レイズ，ドミニク
ロヒト，カミーレ
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Original Assignee
Institut Pasteur de Lille
Institut National de la Sante et de la Recherche Medicale INSERM
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale INSERM filed Critical Institut Pasteur de Lille
Publication of JP2021500325A publication Critical patent/JP2021500325A/ja
Publication of JP2021500325A5 publication Critical patent/JP2021500325A5/ja
Priority to JP2023089684A priority Critical patent/JP2023109996A/ja
Application granted granted Critical
Publication of JP7335874B2 publication Critical patent/JP7335874B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/235—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Bordetella (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/099—Bordetella
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/523—Bacterial cells; Fungal cells; Protozoal cells expressing foreign proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
JP2020520777A 2017-10-18 2018-10-18 血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株 Active JP7335874B2 (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2023089684A JP2023109996A (ja) 2017-10-18 2023-05-31 血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762574068P 2017-10-18 2017-10-18
US62/574,068 2017-10-18
PCT/EP2018/078522 WO2019077028A1 (en) 2017-10-18 2018-10-18 BORDETELLA STRAINS EXPRESSING SERO-TYPE FIMBRIAE 3

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2023089684A Division JP2023109996A (ja) 2017-10-18 2023-05-31 血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株

Publications (3)

Publication Number Publication Date
JP2021500325A JP2021500325A (ja) 2021-01-07
JP2021500325A5 JP2021500325A5 (enExample) 2021-10-07
JP7335874B2 true JP7335874B2 (ja) 2023-08-30

Family

ID=64664226

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2020520777A Active JP7335874B2 (ja) 2017-10-18 2018-10-18 血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株
JP2023089684A Pending JP2023109996A (ja) 2017-10-18 2023-05-31 血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2023089684A Pending JP2023109996A (ja) 2017-10-18 2023-05-31 血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株

Country Status (8)

Country Link
US (2) US11446372B2 (enExample)
EP (1) EP3697439A1 (enExample)
JP (2) JP7335874B2 (enExample)
CN (2) CN111278456B (enExample)
AU (1) AU2018353409B2 (enExample)
CA (1) CA3077428A1 (enExample)
SG (1) SG11202003333WA (enExample)
WO (1) WO2019077028A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0707102B1 (pt) * 2006-03-10 2022-05-31 Institut Pasteur De Lille Composição imunogênica
CA2759280C (en) 2009-04-28 2016-09-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
CA3077428A1 (en) * 2017-10-18 2019-04-25 Institut Pasteur De Lille Bordetella strains expressing serotype 3 fimbriae
CN116635517A (zh) 2020-11-17 2023-08-22 伊利亚德生物技术有限公司 与神经退行性疾病相关的神经病理的治疗和预防

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529338A (ja) 2006-03-10 2009-08-20 アンスティテュ パストゥール ドゥ リル 百日咳に対する単一用量ワクチンとしての生弱毒化ボルデテラ株

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4883761A (en) * 1986-03-25 1989-11-28 The United States Of America As Represented By The Department Of Health And Human Services Pertussis toxin gene: cloning and expression of protective antigen
US6713072B1 (en) 1987-11-02 2004-03-30 Chiron S.R.L. Immunologically active polypeptides with altered toxicity useful for the preparation of an antipertussis vaccine
IT1236971B (it) * 1989-11-03 1993-05-07 Eniricerche Spa Regione promotore dei geni codificanti le subunita' piliniche fim2, fm3 e fimx di bordetella pertussis e loro impiego per l'espressione di geni che codificano una proteina di interesse.
GB9115332D0 (en) 1991-07-16 1991-08-28 Connaught Lab Manipulation of gene copy number in bordetella
FR2718750B1 (fr) 1994-04-19 1996-06-14 Pasteur Institut Protéines recombinantes de l'hémagglutinine filamenteuse de Bordetella, notamment, B. Pertussis, production et application à la production de protéines étrangères ou de principes actifs vaccinants.
FR2754543B1 (fr) 1996-10-11 1998-12-31 Pasteur Institut Souche de bordetella deficiente dans la production de toxine et exprimant une proteine hydride, liposomes comprenant de la fha et leurs utilisations comme vaccins, et utilisation de la fha pour stimuler les reponses immunitaires
FR2840319B1 (fr) 2002-05-30 2004-08-20 Pasteur Institut Souches de bordetella rendues deficientes par attenuation genetique
EP1617805A4 (en) 2003-04-11 2012-07-04 Medimmune Llc METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS
GB0402131D0 (en) * 2004-01-30 2004-03-03 Isis Innovation Delivery method
WO2008058396A1 (en) 2006-11-15 2008-05-22 Folia Biotech Inc. Papaya mosaic virus-based vaccines for influenza
EP2134359A4 (en) 2007-02-23 2010-06-16 Penn State Res Found USE OF A NONVIRULENT BORDETELLA MUTANT AS LIVING VACCINE VECTOR
CN100537767C (zh) * 2007-04-29 2009-09-09 中国药品生物制品检定所 百日咳疫苗保护性抗原的重组表达及其应用
US20100104533A1 (en) 2007-06-18 2010-04-29 Carter William A Early intervention of viral infection with immune activators
CA2759280C (en) * 2009-04-28 2016-09-20 Inserm (Institut National De La Sante Et De La Recherche Medicale) Vaccine for prophylaxis or treatment of an allergen-driven airway pathology
JP5551774B2 (ja) 2009-06-15 2014-07-16 ナショナル ユニヴァーシティー オブ シンガポール インフルエンザワクチン、組成物、および使用方法
US9415077B2 (en) * 2011-11-02 2016-08-16 Institut National De La Sante Et De La Recherche Medicale Effect of an attenuated Bordetella strain against allergic disease
JP2015525794A (ja) * 2012-08-06 2015-09-07 グラクソスミスクライン バイオロジカルズ ソシエテ アノニム 乳児においてｒｓｖ及び百日咳菌に対する免疫応答を惹起するための方法
EP2722338A1 (en) 2012-10-17 2014-04-23 INSERM (Institut National de la Santé et de la Recherche Médicale) Novel recombinant Bordetella strains
US9655959B2 (en) * 2014-10-01 2017-05-23 National University Of Singapore Adenylate cyclase deficient bordetella strains
AU2017242541B2 (en) * 2016-03-29 2022-06-30 Institut National De La Sante Et De La Recherche Medicale (Inserm) Mutant bordetella strains and methods for use
US10799573B2 (en) * 2016-03-30 2020-10-13 Regents Of The University Of Minnesota Pertussis vaccines and methods of making and using
WO2018213361A1 (en) * 2017-05-15 2018-11-22 Vanderbilt University LONG-CIRCULATING ZWITTERIONIC POLYPLEXES FOR siRNA DELIVERY
JP7404226B2 (ja) * 2017-07-18 2023-12-25 セラム インスティテュート オブ インディア プライベート リミティド 向上した安定性、高度の免疫原性、及び減少した反応源性を有する免疫原性組成物、並びにその調製プロセス
CA3077428A1 (en) * 2017-10-18 2019-04-25 Institut Pasteur De Lille Bordetella strains expressing serotype 3 fimbriae
US12036405B2 (en) * 2018-03-23 2024-07-16 The Board Of Regents Of The University Of Oklahoma System and method of electric-induced acoustic tomography for electrotherapy monitoring
WO2020049133A1 (en) 2018-09-05 2020-03-12 National University Of Singapore Adenylate cyclase catalytic domain deficient bordetella strains

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009529338A (ja) 2006-03-10 2009-08-20 アンスティテュ パストゥール ドゥ リル 百日咳に対する単一用量ワクチンとしての生弱毒化ボルデテラ株

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BMC Microbiology，2008年，8，162
Expert Review of Vaccines，2014年，13，1205-1214
平成27年度国立感染症研究所年報，2017年03月29日，５．細菌第二部

Also Published As

Publication number Publication date
CN118979003A (zh) 2024-11-19
CA3077428A1 (en) 2019-04-25
JP2021500325A (ja) 2021-01-07
US11446372B2 (en) 2022-09-20
WO2019077028A4 (en) 2019-06-27
US20220362369A1 (en) 2022-11-17
AU2018353409A1 (en) 2020-04-16
EP3697439A1 (en) 2020-08-26
US12403188B2 (en) 2025-09-02
SG11202003333WA (en) 2020-05-28
AU2018353409B2 (en) 2025-07-17
CN111278456B (zh) 2024-08-09
WO2019077028A1 (en) 2019-04-25
CN111278456A (zh) 2020-06-12
US20200297833A1 (en) 2020-09-24
JP2023109996A (ja) 2023-08-08

Similar Documents

Publication Publication Date Title
JP2023109996A (ja) 血清型３線毛を発現するボルデテラ（ｂｏｒｄｅｔｅｌｌａ）菌株
ES2771675T3 (es) Nuevas cepas recombinantes de Bordetella
AU2022221438B2 (en) Mutant bordetella strains and methods for use
Dharmasena et al. Stable expression of Shigella sonnei form I O-polysaccharide genes recombineered into the chromosome of live Salmonella oral vaccine vector Ty21a
WO2020049133A1 (en) Adenylate cyclase catalytic domain deficient bordetella strains
JP2001507568A (ja) ハイブリッドｆｈａを発現するボルデテラ株、リポソームおよびワクチン
HK40026630B (zh) 表达血清3型菌毛的鲍特菌属菌株
HK40026630A (en) Bordetella strains expressing serotype 3 fimbriae
JP6867623B2 (ja) 百日咳モデル動物およびその作製方法、ならびに百日咳モデル動物を用いた方法
Mukkur et al. Alternative whooping cough vaccines: A minireview
WO2012131066A1 (en) Vaccine against pasteurellaceae
JP2023545176A (ja) 高用量シゲラ属（Ｓｈｉｇｅｌｌａ）ワクチン製剤
Guzmàn et al. Use of Salmonella Spp. Carrier Strains to Deliver Bordetella Pertussis Antigens in Mice using the oral Route
HK1262896B (zh) 突变型博德特氏菌属菌株及其使用方法
HK1262896A1 (en) Mutant bordetella strains and methods for use

Legal Events

Date Code Title Description
A524 Written submission of copy of amendment under article 19 pct

Free format text: JAPANESE INTERMEDIATE CODE: A525

Effective date: 20200413

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20210830

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20210830

A977 Report on retrieval

Free format text: JAPANESE INTERMEDIATE CODE: A971007

Effective date: 20220617

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20220621

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20220912

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221219

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20221219

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20230131

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230531

A911 Transfer to examiner for re-examination before appeal (zenchi)

Free format text: JAPANESE INTERMEDIATE CODE: A911

Effective date: 20230630

TRDD Decision of grant or rejection written
A01 Written decision to grant a patent or to grant a registration (utility model)

Free format text: JAPANESE INTERMEDIATE CODE: A01

Effective date: 20230725

A61 First payment of annual fees (during grant procedure)

Free format text: JAPANESE INTERMEDIATE CODE: A61

Effective date: 20230818

R150 Certificate of patent or registration of utility model

Ref document number: 7335874

Country of ref document: JP

Free format text: JAPANESE INTERMEDIATE CODE: R150