CN111265666A - Tea tree oil preparation for treating acarid blepharitis and preparation method thereof - Google Patents

Tea tree oil preparation for treating acarid blepharitis and preparation method thereof Download PDF

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Publication number
CN111265666A
CN111265666A CN202010201006.0A CN202010201006A CN111265666A CN 111265666 A CN111265666 A CN 111265666A CN 202010201006 A CN202010201006 A CN 202010201006A CN 111265666 A CN111265666 A CN 111265666A
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tea tree
tree oil
parts
preparation
blepharitis
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王婷
贾艳妮
史伟云
鹿秀海
王姝婷
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Shandong Eye Hospital
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Shandong Eye Hospital
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Priority to CN202210473777.4A priority patent/CN114931646A/en
Publication of CN111265666A publication Critical patent/CN111265666A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A61K31/5383—1,4-Oxazines, e.g. morpholine ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/702—Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/61—Myrtaceae (Myrtle family), e.g. teatree or eucalyptus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/14—Ectoparasiticides, e.g. scabicides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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Abstract

The invention provides a tea tree oil preparation for treating acarid blepharitis and a preparation method thereof, and belongs to the technical field of acarid blepharitis treatment. According to the records of the examples, for patients who have positive microscopic examination of demodex lash and are accompanied with eye discomfort symptoms, 79 cases (79.0%) of the patients with positive microscopic examination of demodex lash disappear, 12 cases (12%) of the patients with positive microscopic examination of demodex lash are obviously relieved by using the tea tree oil preparation provided by the invention, the effective treatment rate reaches 91%, the microscopic examination positive rate of demodex before treatment is 100%, the microscopic examination positive rate after 3 months of treatment is 10%, and all the patients do not have allergy or adverse reaction.

Description

Tea tree oil preparation for treating acarid blepharitis and preparation method thereof
Technical Field
The invention belongs to the technical field of treatment of acarid blepharitis, and particularly relates to a tea tree oil preparation for treating acarid blepharitis and a preparation method thereof.
Background
The acarid blepharitis is a special form of blepharitis caused by acarid infection, and demodex folliculorum and sebaceous gland mites infecting eyelids respectively parasitize eyelash follicles and sebaceous glands, which can cause eyelash follicles and meibomian gland lesions when the infection quantity is large or affected by various local factors. The conjunctiva and cornea complications are caused seriously by the typical clinical manifestations of itching eyes, dry eyes, blepharal rim congestion, scales, eyelash root sleeve-shaped secretion and the like. For treatment, physiological saline is generally adopted to clean eyelashes, carry out hot compress massage on meibomian glands, and locally use 2% metronidazole eye ointment and the like.
The wet tissue containing tea tree oil (such as OCUSOFT Olympic mites-removing tea tree essential oil eyelid cleaning mite-removing wet tissue) is used for wiping eyelid margin for treatment, the method has short drug action time, and the wet tissue may contact the ocular surface in the treatment process and has obvious stimulation symptoms.
At present, no effective tea tree oil preparation capable of continuously playing a role in acarid blepharitis is available.
Disclosure of Invention
In view of the above, the present invention provides a tea tree oil preparation for treating acarid blepharitis and a preparation method thereof, wherein the tea tree oil preparation can be uniformly applied to the blepharitis, the medicine stays for a long time on the blepharitis and continuously acts, and the tea tree oil preparation contains antibiotics, so that the tea tree oil preparation has a direct treatment effect on the blepharitis.
The invention provides a tea tree oil preparation for treating acarid blepharitis, which comprises the following components in parts by weight: 75-98.9 parts of yellow vaseline matrix, 1-20 parts of tea tree oil and 0.1-5 parts of antibiotic.
Preferably, the composition comprises the following components in parts by weight: 82-94.5 parts of yellow vaseline matrix, 5-15 parts of tea tree oil and 0.5-3 parts of antibiotic.
Preferably, the antibiotic comprises one of azithromycin, ofloxacin, gatifloxacin, tobramycin and erythromycin.
Preferably, when the antibiotic is ofloxacin, gatifloxacin or tobramycin, the weight part of the antibiotic is 0.1-3 parts.
Preferably, the tea tree oil preparation is a paste preparation.
Preferably, the yellow vaseline matrix comprises medical yellow vaseline, liquid paraffin and lanolin; the mass ratio of the medical yellow vaseline to the liquid paraffin to the lanolin is (6-10): (0.1-2): (0.1-2).
The invention also provides a preparation method of the tea tree oil preparation, which comprises the following steps: mixing yellow vaseline matrix, tea tree oil and antibiotics, and heating at 40-60 ℃ for 1-3 min.
Preferably, the heating temperature is 45-55 ℃.
Preferably, the heating time is 2 min.
Preferably, the heating is accompanied by stirring.
The invention has the beneficial effects that: the tea tree oil preparation provided by the invention comprises yellow vaseline matrix, tea tree oil and antibiotics, can be directly coated on the eyelid margin, has long retention time and can continuously play a role, and meanwhile, the tea tree oil preparation contains the antibiotics, so that the tea tree oil preparation has a direct treatment effect on blepharitis. According to the records of the examples, for patients who have positive microscopic examination of demodex eyelashes and are accompanied with eye discomfort symptoms, the tea tree oil preparation provided by the invention is applied to the edges of double eyelids, 1 time per night, 1 time of repeated diagnosis per week and 3 months of follow-up; results after treatment for 4 weeks, 79 (79.0%) of 100 patients have no uncomfortable symptoms, 12 (12%) of the patients have obvious remission, the effective rate of the treatment reaches 91%, the microscopic positive rate of demodex before treatment is 100%, the microscopic positive rate after treatment for 3 months is 10%, and all patients have no allergy or adverse reaction. Therefore, the tea tree oil preparation provided by the invention can effectively treat acarid blepharitis.
Drawings
FIG. 1 is a graph showing the treatment of anterior eyelid margin and eyelash root scales and mites with the tea tree oil formulation of the present invention, where A and B show that a large amount of scales are visible on the eyelid margin and eyelash root, and C and D show that a large amount of mites are visible on the eyelash root by microscopic examination;
FIG. 2 is a graph showing the appearance of scales and mites on the eyelid margin and eyelash roots after 3 months of treatment with the tea tree oil formulation of the present invention, wherein A and B show that the eyelid margin and eyelash roots are clear and no obvious scales are seen, and C and D show that no mites are seen on the eyelash roots by microscopic examination.
Detailed Description
The invention provides a tea tree oil preparation for treating acarid blepharitis, which comprises the following components in parts by weight: 75-98.9 parts of yellow vaseline matrix, 1-20 parts of tea tree oil and 0.1-5 parts of antibiotic.
In the present invention, the tea tree oil preparation preferably comprises the following components in parts by weight: 82-94.5 parts of yellow vaseline matrix, 5-15 parts of tea tree oil and 0.5-3 parts of antibiotic. In the present invention, the antibiotic preferably includes one of azithromycin, ofloxacin, gatifloxacin, tobramycin and erythromycin. When the antibiotic is ofloxacin, gatifloxacin or tobramycin, the weight part of the antibiotic is preferably 0.1-3 parts.
In the present invention, the yellow petrolatum base is preferably selected from the group consisting of medical yellow petrolatum, liquid paraffin and lanolin; the mass ratio of the medical yellow vaseline, the liquid paraffin and the lanolin is preferably (6-10): (0.1-2): (0.1-2), and more preferably 8:1: 1. The sources of the medical yellow vaseline, the liquid paraffin and the lanolin are not particularly limited, and the medical yellow vaseline, the liquid paraffin and the lanolin are conventional commercial products in the field. The source of the tea tree oil is not particularly limited in the present invention, and any commercially available product that is conventional in the art may be used. In the present invention, the antibiotic may be any commercially available product that is conventional in the art.
In the present invention, the tea tree oil preparation is preferably a cream preparation.
The invention also provides a preparation method of the tea tree oil preparation, which comprises the following steps: mixing yellow vaseline matrix, tea tree oil and antibiotics, and heating at 40-60 ℃ for 1-3 min.
In the invention, the heating temperature is preferably 45-55 ℃, more preferably 50 ℃, and the heating time is preferably 2 min. In the present invention, the heating is preferably performed in a water bath, and the heating is preferably accompanied by stirring.
The technical solutions provided by the present invention are described in detail below with reference to examples, but they should not be construed as limiting the scope of the present invention.
The yellow vaseline matrix in the following examples is prepared by mixing medical yellow vaseline, liquid paraffin and lanolin according to the mass ratio of 8:1: 1.
Example 1
94.5 parts of yellow vaseline matrix, 5 parts of tea tree oil and 0.5 part of azithromycin, and heating in a water bath kettle at 50 ℃ for 2min and uniformly mixing to obtain the tea tree oil preparation.
Example 2
75 parts of yellow vaseline matrix, 20 parts of tea tree oil and 5 parts of azithromycin, and heating the mixture in a water bath kettle at the temperature of 50 ℃ for 2min and uniformly mixing to obtain the tea tree oil preparation.
Example 3
94.5 parts of yellow vaseline matrix, 5 parts of tea tree oil and 0.5 part of azithromycin, and heating in a water bath kettle at 50 ℃ for 3min and uniformly mixing to obtain the tea tree oil preparation.
Example 4
84.5 parts of yellow vaseline matrix, 15 parts of tea tree oil and 0.5 part of ofloxacin, and heating in a water bath kettle at 50 ℃ for 2min and uniformly mixing to obtain the tea tree oil preparation.
Example 5
Heating 92 parts of yellow vaseline matrix, 5 parts of tea tree oil and 3 parts of ofloxacin in a water bath kettle at 50 ℃ for 2min, and uniformly mixing to obtain the tea tree oil preparation.
Example 6
94.9 parts of yellow vaseline matrix, 5 parts of tea tree oil and 0.1 part of gatifloxacin, and heating in a water bath kettle at 50 ℃ for 2min and mixing uniformly to obtain the tea tree oil preparation.
Example 7
94.9 parts of yellow vaseline matrix, 5 parts of tea tree oil and 0.1 part of tobramycin, and heating in a water bath kettle at 50 ℃ for 2min to obtain the tea tree oil preparation.
Example 8
94.9 parts of yellow vaseline matrix, 5 parts of tea tree oil and 0.1 part of tobramycin, and heating in a water bath kettle at 50 ℃ for 2min to obtain the tea tree oil preparation.
Example 9
Heating 90 parts of yellow vaseline matrix, 5 parts of tea tree oil and 5 parts of erythromycin in a water bath kettle at 50 ℃ for 2min, and mixing uniformly to obtain the tea tree oil preparation.
Example 10
Patients who were positive to demodex mascara under microscopic examination and were accompanied by ocular discomfort were treated with the tea tree oil preparation prepared in example 1.
The using method comprises the following steps: applied to the edge of double eyelid 1 time per night, and is followed by 1 time per week for 3 months.
Results after treatment for 4 weeks, 79 (79.0%) of 100 patients have no uncomfortable symptoms, 12 (12%) of the patients have obvious remission, the effective rate of the treatment reaches 91%, the microscopic positive rate of demodex before treatment is 100%, the microscopic positive rate after treatment for 3 months is 10%, and all patients have no allergy or adverse reaction. One example of a patient treated the condition of scales and mites on the eyelid margin and eyelash roots before using the tea tree oil formulation of the present invention is shown in fig. 1, where a and B show a large amount of scales visible on the eyelid margin and eyelash roots, and C and D show a large amount of mites visible on the eyelash roots after microscopic examination; the conditions of the scales and mites on the eyelid margin and the eyelash root after 3 months of treatment by using the tea tree oil preparation are shown in figure 2, wherein A and B show that the eyelid margin and the eyelash root are clean and no obvious scales are seen, and C and D show that no mites are seen on the eyelash root after microscopic examination.
The tea tree oil preparation provided by the invention has the advantages of long action time and convenience in operation, and can effectively treat acarid blepharitis.
The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and decorations can be made without departing from the principle of the present invention, and these modifications and decorations should also be regarded as the protection scope of the present invention.

Claims (10)

1. The tea tree oil preparation for treating acarid blepharitis is characterized by comprising the following components in parts by weight: 75-98.9 parts of yellow vaseline matrix, 1-20 parts of tea tree oil and 0.1-5 parts of antibiotic.
2. The tea tree oil preparation according to claim 1, comprising the following components in parts by weight: 82-94.5 parts of yellow vaseline matrix, 5-15 parts of tea tree oil and 0.5-3 parts of antibiotic.
3. The tea tree oil formulation of claim 1 or 2, wherein the antibiotic comprises one of azithromycin, ofloxacin, gatifloxacin, tobramycin and erythromycin.
4. The tea tree oil preparation according to claim 3, wherein when the antibiotic is ofloxacin, gatifloxacin or tobramycin, the weight part of the antibiotic is 0.1-3 parts.
5. A tea tree oil formulation according to claim 1 or 2, wherein the tea tree oil formulation is a paste formulation.
6. The tea tree oil formulation of claim 1, wherein the yellow petrolatum base comprises medical yellow petrolatum, liquid paraffin, and lanolin; the mass ratio of the medical yellow vaseline to the liquid paraffin to the lanolin is (6-10): (0.1-2): (0.1-2).
7. A process for the preparation of a tea tree oil formulation as claimed in any one of claims 1 to 6, comprising the steps of: mixing yellow vaseline matrix, tea tree oil and antibiotics, and heating at 40-60 ℃ for 1-3 min.
8. The method according to claim 7, wherein the heating temperature is 45 to 55 ℃.
9. The method of claim 7 or 8, wherein the heating time is 2 min.
10. The method according to claim 7, wherein the heating is accompanied by stirring.
CN202010201006.0A 2020-03-20 2020-03-20 Tea tree oil preparation for treating acarid blepharitis and preparation method thereof Pending CN111265666A (en)

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CN202010201006.0A CN111265666A (en) 2020-03-20 2020-03-20 Tea tree oil preparation for treating acarid blepharitis and preparation method thereof
CN202210473777.4A CN114931646A (en) 2020-03-20 2020-03-20 Tea tree oil preparation for treating acarid blepharitis and preparation method thereof

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Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102727425A (en) * 2012-07-19 2012-10-17 厦门大学 Nitroimidazole oculentum and preparation method thereof
CN104189091A (en) * 2007-08-29 2014-12-10 蒂休特赫公司 Compositions and methods for treating demodex infestations
CN105326954A (en) * 2015-11-02 2016-02-17 北京市眼科研究所 Traditional Chinese medicine composition for treating blepharitis and preparing method thereof

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104189091A (en) * 2007-08-29 2014-12-10 蒂休特赫公司 Compositions and methods for treating demodex infestations
CN102727425A (en) * 2012-07-19 2012-10-17 厦门大学 Nitroimidazole oculentum and preparation method thereof
CN105326954A (en) * 2015-11-02 2016-02-17 北京市眼科研究所 Traditional Chinese medicine composition for treating blepharitis and preparing method thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
姜雷等: "蠕形螨睑缘炎的治疗进展", 《医学综述》 *

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