JPH0366606A - Hair tonic of compound crude drug - Google Patents

Abstract

PURPOSE:To obtain hair tonic of compound crude drug having accelerating effect of hair growth to alopecia areata containing cooled decocted solution of compound crude drug containing Ginseng Radix, Astragali Radix, BUSHI, KANKYO, Persicae Semen, TANJIN, HOKOTSUYU, KOSHO, Carthami Flos, Angelicae Radix and Cnidii Rhizoma and alcohol extract of Swertiae Herba. CONSTITUTION:The subject hair tonic contains 100 pts.wt. Swertiae Herba and individually 5-40 pts.wt. Ginseng Radix, Astragali Radix, BUSHI, KANKYO, Persicae Semen, TANJIN, HOKOTSUYU, KOSHO, Carthami Flos, Angelicae Radix and Cnidii Rhizoma. As preparing, complex crude drug of Ginseng Radix and Astragali Radix, etc., is decocted with water and cooled to about room temperature to obtain cooled decocted solution, then resultant solution is mixed with extract solution obtained by extracting Swertiae Herba with ethyl alcohol, etc., preferably having <=20% concentration, thus readily settling substance is removed. Said hair tonic exhibits excellent hair growing effect with improving depression of physiological function of local skin in alopecia areata, especially circulation of blood and nutritive conditions.

Description

Detailed Description of the Invention (Industrial Field of Application) The present invention relates to a complex herbal hair growth agent, specifically for alopecia areata, which promotes the advancement of skin physiological functions, promotes local blood circulation, and improves skin growth. This invention relates to a complex herbal medicine hair growth agent that has the medicinal effect of promoting hair growth by imparting nourishing and moisturizing effects to hair.

[Prior art and problems to be solved by the invention] Many theories have been proposed regarding the causes of alopecia areata.

In the past, theories such as the virus theory, focal infection theory, neurological disorder theory, internal secretion theory, and mental stress theory were popular, but recently, theories such as genetic factors and autoimmunity have been gaining support. .

However, a definitive theory regarding the causes of alopecia areata has not yet been established.

Conventionally, there have been many treatments for alopecia areata using herbal medicines such as pepper tincture, cantharis tincture (animal herbal medicine), garlic extract, and cephalanthine alcohol solution.

However, all of them used simple herbal medicines, and almost none of them used fundamental therapeutic drugs that improved the physiological function of the hair loss area from a constitutional perspective and promoted hair growth.

In order to confirm the therapeutic effects of single herbal medicines, the present inventors conducted a clinical trial on a 30% ethanol solution with a cephalanthine concentration of 0.05% (Table 1) and a 30% ethanol extract of this drug (Table 1). Table 2) was attempted.

(Hereafter, blank space) As is clear from the chart, even when using simple herbal medicines,
It can be seen that although a certain degree of therapeutic effect can be obtained, a fully satisfactory effect cannot be obtained.

Therefore, as shown below, the present inventors examined the factors of hair growth and hair loss in alopecia areata from a skin physiological perspective, and also determined that there is a medicinal effect that improves the skin physiological abnormality of alopecia areata from a herbal pharmacological perspective. We searched for herbal hair growth agents.

(Hair growth and hair loss factors in alopecia areata) In order for hair to grow healthy, it is necessary that the hair be firmly rooted in the skin and difficult to fall off.

In order for hair to firmly take root in the skin, it is necessary that (11) the hair bulb and the hair follicle wall are in close contact, and (2) the hair matrix and dermal papilla are tightly connected. be.

In order to satisfy the requirements (1) and (2) above,
Blood circulation to the dermal papilla must also be maintained smoothly.
Another important factor in hair growth is that the trophic nerve functions normally without inhibiting hair growth or adversely affecting anagen hair follicles.

Therefore, if any of the above hair growth factors are impaired, hair loss will inevitably occur.

Although there are various opinions regarding the factors that inhibit hair growth and the pathological mechanism, the present inventors believe that the mechanism of hair loss that occurs during skin transplantation shows a pathological phenomenon similar to that of alopecia areata. We focused on

Therefore, in order to elucidate the developmental mechanism of alopecia areata,
The following animal experiments were conducted to examine the mechanism of hair growth in transplanted skin and changes in skin physiology.

Specifically, autologous skin grafts were performed on rabbit ears, and the relationship between the engraftment of the grafted skin and changes in the physiological function of the skin tissue until hair growth normalized was investigated.

As a result, the grafted skin took root around 10 to 14 days after skin transplantation, and at this time, there was a high degree of neogenesis of subcutaneous reticular vessels, and cell infiltration of lymphocytes was observed (hereinafter referred to as "this period"). (referred to as the ``angiogenesis phase'').

Furthermore, about 30 days after the skin transplantation, the skin was completely engrafted, the texture pattern became normal, the infiltration of lymphocytes decreased, and hair growth in the anagen phase was observed.

When the physiological functions of the skin in the above two periods were examined by methylene plow resolution time and QRZ absorption test, the methylene plow resolution time also shortened during the QRZ absorption point tube formation stage, and both showed normal values during the skin engraftment stage. Ta. Incidentally, this tendency for changes in physiological functions due to skin transplantation was similarly observed in human skin transplantation.

The above-mentioned methylene plow disappearance time and QRZ absorption contraction in the angiogenesis period during skin transplantation demonstrate that the angiogenesis period is a period of strong skin metabolism and active physiological functions.

On the other hand, as a result of measuring the methylene plow disappearance time and the QRZ absorption point on the bald area and the head of hair of patients with alopecia areata, there was a tendency for both to be longer in the bald area. From this fact, the skin in the affected area of alopecia areata has a normal wave s.
e It was found that the physiological function of the skin was lower than that of the skin on the head.

It was also found that blood circulation in the hair removal area was significantly poor. That is, when comparing the skin temperature of the bald area and the healthy area, it was found that the skin temperature of the healthy area was higher, and as hair growth progressed and the medical condition improved, the skin temperature of the bald area gradually increased. These facts indicate that inhibition of blood circulation in the local area of alopecia areata has an adverse effect on the hair growth mechanism.

Therefore, it can be said that the best way to promote hair growth in the treatment of alopecia areata is to improve the decline in the physiological functions of the skin in the area affected by alopecia, especially the blood circulation and nutritional status.

The present invention was made based on such knowledge and as a result of intensive search for complex herbal medicines that have excellent medicinal effects on alopecia areata.The present invention aims to provide excellent hair growth effects on alopecia areata. The object of the present invention is to provide a complex herbal medicine hair growth agent having the following properties.

[! Means to solve problem I]

The complex herbal medicine hair growth agent according to the present invention to achieve the above object contains ginseng, Astragalus, Fuzi, Qianjiang, Taojin, Danshen, bone fat, silk, safflower, Dangki, Chuan, and this drug. It will be done.

In addition, for 100 parts by weight of the three drugs, ginseng, Astragalus, Tsuzi,
It is preferable that the composition contains 5 to 40 parts by weight of each of dangan, peach nin, danshen, bone fat, mingjing, safflower, dangki, and chuan.

The above-mentioned herbal medicines are classified into (1) supplementary medicines, (2) warm medicines, and (3) medicinal effects of active blood, and their medicinal effects are shown.

(1) Tii Health Medicine ■ Ginseng Ginseng has a nourishing and tonic effect on the whole body, but among the vitamins contained in it, B and B7 act as hair growth promoters. It is known to have medicinal effects related to antihistamine effects, and suppresses allergic inflammation caused by the autoimmune phenomenon of alopecia areata.

■ Astragalus Since ancient times, Astragalus has been said to be a healing herbal medicine, and is often used for skin diseases. Improves blood circulation on the body surface and enhances the nutritional status of the skin.

■Bone repair fat It has the effect of nourishing the skin and dilating blood vessels, and its alcoholic extract has the effect of increasing melanin.

■Go home It has blood supplementation and blood circulation effects, improving blood circulation.

It has an antagonizing effect on vitamin E deficiency, and when used in combination with Astragalus, local blood circulation is improved.

(2) Onurasha Cold Remedies■ Combination of Fuzi Fuzi and Qiangang promotes blood circulation. Fuzi also has anti-pain and anti-inflammatory properties.

■Inui concubine Promote blood circulation.

■Kinu-sama Stimulates the local area and promotes blood circulation.

(3) A drug that restores live blood. ■Das ginseng dilates blood vessels, promotes blood circulation, improves local congestion and anemia, and has antibacterial, sedative, and nerve stabilizing effects.

■In addition to improving blood congestion and blood clots and promoting blood circulation, peaches have anti-inflammatory and detoxifying properties. Combination with safflower and yo 1 improves blood circulation.

■Safflower has the effect of removing blood congestion and blood clots. In particular, safflower oil and safflower wine have the effect of removing local internal bleeding and improving blood congestion.

It also has passion and anti-inflammatory properties.

■''] Adjusts blood circulation, dilates blood vessels, and improves nutritional status. MQ water soak extract has an antagonizing effect on vitamin deficiencies.

Next, a method for producing the complex crude drug hair growth agent according to the present invention will be explained.

The composite herbal medicine hair growth agent according to the present invention is prepared by, for example, decocting a composite herbal medicine consisting of the above-mentioned ginseng, Astragalus, Zhuzi, Qiangan, Peach Ren, Danshen, Bone Fat, Silky, Safflower, Danggui, and Yo 1 with water. After that, it can be obtained by mixing the cooled decoction which has been cooled to about room temperature and the infusion of the drug obtained by alcohol extraction.

This drug is formulated as a component of a complex herbal medicine because the swertiamarin contained therein has a hair growth effect.

The alcohol used in the alcohol extraction is not particularly limited in the present invention as long as it does not harm the human body, and for example, ethyl alcohol can be used. In addition, it is preferable that the concentration of alcohol used does not exceed 50%, and more preferably that it does not exceed 20%. If the alcohol concentration in the hair growth agent exceeds 50%,
This causes a decrease in the amount of water in the hair, resulting in hair breakage and the like, which may actually suppress hair growth.

In addition, it is preferable to use the preliquid of the composite herbal medicine that has been filtered by a filtering means such as Heatron paper or Japanese paper before cooling. The same applies to the alcoholic infusion solution.

In addition, if the obtained composite herbal hair growth agent is further subjected to a centrifuge to remove easily sedimentable substances, it is possible to obtain a complex herbal hair growth agent with high commercial value that does not produce sediment even after long-term storage. become.

The composite crude drug hair growth agent according to the present invention can be applied at an appropriate frequency depending on the degree of hair loss, but usually, it is applied to the hair loss area twice in the morning and twice while performing a pine surge. I can do it.

In addition, it is preferable to wash your hair once every three days and then apply the product.

〔Example〕

Hereinafter, the present invention will be explained in more detail based on Examples, but the present invention is not limited to the following Examples in any way, and can be modified as appropriate without changing the gist thereof.

(A) Preparation of complex herbal drug hair growth agent 30 grams of 9 drugs with the roots removed were kept at room temperature for 5 days.
After alcohol extraction by immersion in 500 rnl of 0% ethyl alcohol, the exudate of the drug was filtered using Heatron paper.

On the other hand, 6 grams of ginseng, 6 grams of Astragalus, 6 grams of Fuzi, 6 grams of dried ginger, 3 grams of peach kernels, 6 grams of Danseng, 3 grams of bone fat, 10 grams of Hu 4N, 6 grams of safflower, 6 grams of Dangki, Jll% 3 After pre-preparing the crude drug consisting of 1,400 g of water for 2 hours in 1,400 m of water, about 1,000 g of the preliminary solution of the composite crude drug was filtered using Heatron paper, and the filtrate was allowed to cool to room temperature.

Next, about 400 m of the infusion liquid of the above three drugs and about 1000 ae of the cooled liquid of the composite herbal medicine were mixed to give an alcohol concentration of 20.
% of tonic type complex herbal medicine hair growth agent 1400d at 1F11.

The obtained composite herbal hair growth agent was kept at a temperature of 5°C for one week to allow the easily sedimented substances to precipitate naturally, and then the supernatant liquid was mixed with approx.
200Id was placed in a centrifuge (rotation speed: 3000 rpm) for 30 minutes, and then filtered to prepare approximately 1200d of a complex herbal medicine from which easily sedimentable substances were substantially completely removed.

(B) Clinical trial A clinical trial was conducted on a total of 49 patients using the composite herbal hair growth agent prepared in (A) above.

The hair restorer was applied twice a day, once in the morning, to the hair loss area while performing a pine surge. I applied it once every three days after washing my hair.

The clinical types of alopecia areata are classified into normal type (this type is classified into single type and multi-type type), general type, and generalized type. It was classified into three levels, and the effects were evaluated for each category.

The results are shown in Table 3. In the same table, "remarkable response" means that the growth of terminal hair can be seen and the skin has completely healed to the extent that the scalp cannot be seen. "Effective" means that the development of terminal hair can be seen. The term "ineffective" refers to cases in which improvement was achieved, but the improvement was still only to the extent that the scalp was visible. Also, "ineffective" refers to cases in which improvement was achieved subjectively and objectively but only the appearance of 4 hairs, or new growth of terminal hairs was observed. However, this refers to those who still experience hair loss, and those who do not see any hair growth.

(The following is a blank space) Table 3 (C) Clinical trial results As is clear from Table 3, out of 14 cases of conventional (single) alopecia areata, 12 cases showed excellent response and 2 cases showed effective response, showing a 100% efficacy rate. The efficacy rate was 86% for only those with a good response, and the treatment period was one month for those with a quick response and five months for a slow response.

The average treatment period was about 2 months.

In 17 cases of normal type (multifocal) alopecia areata, 11 cases showed excellent response;
The efficacy rate was 100% in 6 cases, and the efficacy rate in only excellent cases was 67.5%.The treatment period was 3 months in cases where the effect was early, and nearly 1 year in cases where the effect was slow. It took. The average treatment period was approximately 7 months.

In 9 cases of alopecia areata cephalus, there were 4 cases of excellent response, 4 cases of good response, and 1 case of poor response, showing an efficacy rate of 88%, and the efficacy rate of only excellent response cases was 44%. The average treatment period was about seven and a half months.

In 9 cases of generalized alopecia areata, there were 4 cases of excellent response, 2 cases of good response, and 3 cases of no response, showing an efficacy rate of 66%, and the efficacy rate for only severe response was 4.
4%, and the average treatment period was about 10 months.

It can be seen that the effects of herbal hair restorers on alopecia areata are the longest compared to the normal type, and that only a short period of treatment is required.

Regarding gender, it can be seen that the effectiveness rate is higher for women than for men.

〔Effect of the invention〕

As explained above in detail, the complex crude drug hair growth agent according to the present invention was prepared based on clinical evidence regarding the relationship between changes in physiological function during hair growth and the medicinal efficacy of crude drugs. Therefore, by fundamentally improving skin physiological functions,
It has an excellent hair growth effect on alopecia areata.

As described above, the present invention has excellent and unique effects.

Claims (1)

[Scope of Claims] 1. A complex herbal medicine hair growth agent characterized by containing ginseng, Astragalus, Fuzi, Qianjiang, Taojin, Danshen, bone fat, pepper, safflower, Dangki, Chuan, and this drug. . 2. For 100 parts by weight of this drug, ginseng, Astragalus, Zhuzi, Qianjiang, Peach Ren, Danshen, bone fat, pepper, safflower, Dangki and Kawa■
The complex hair growth agent according to claim 1, containing 5 to 40 parts by weight of each of the following. 3. Mix the cooled decoction of a composite herbal medicine containing ginseng, Astragalus, Zhuzi, dried ginger, peach kernel, Danshen, bone fat, pepper, safflower, Danggui and Chuan ■ with the alcoholic extract of this medicine. Claim 1
or the complex herbal medicine hair growth agent described in 2. 4. A composite herbal medicine hair growth agent obtained by removing easily sedimentable substances from the composite herbal medicine hair growth agent according to any one of claims 1 to 3.