CN111249202A - Application of hydrogel nano-carrier in anti-inflammation and anti-aging cream - Google Patents
Application of hydrogel nano-carrier in anti-inflammation and anti-aging cream Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
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- A61K8/678—Tocopherol, i.e. vitamin E
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
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- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
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- A61K8/733—Alginic acid; Salts thereof
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/927—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of insects, e.g. shellac
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- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
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- A61K2800/78—Enzyme modulators, e.g. Enzyme agonists
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Abstract
The invention discloses an application of a hydrogel nano-carrier in anti-inflammation and anti-aging cream, which comprises an anti-inflammation and anti-aging composition, hydroxyethyl cellulose-sodium alginate hydrogel and the like, wherein the anti-inflammation and anti-aging composition comprises a rosin leaf extract, gynostemma pentaphylla, ascorbyl glucoside, vitamin E, sorbitan monooleate, glycerol, allantoin and the like; the anti-inflammatory and anti-aging hydrogel is prepared by wrapping the anti-inflammatory component and the anti-aging component by the hydroxyethyl cellulose-sodium alginate hydrogel, is a nano-scale carrier, has the capability of being quickly absorbed by skin and penetrating cell membranes, loads the anti-inflammatory component and the anti-aging component into skin cells, goes deep into the muscle bottom to remove surplus free radicals, promotes the degradation of skin cutin and the hyperplastic metabolism of epidermal germinal layer cells, and makes the skin tender and elastic.
Description
Technical Field
The invention specifically relates to an application of a hydrogel nano-carrier in anti-inflammation and anti-aging cream, belonging to the technical field of cosmetics.
Background
The cosmetic is a chemical industrial product or a fine chemical product which is applied, sprayed or the like to any part of the surface of a human body to achieve the purposes of cleaning, maintaining, beautifying, decorating and changing the appearance, or correcting the smell of the human body and keeping a good state. With the development of economy and the continuous improvement of quality of life, the consciousness of the young Chinese for protecting the skin is increased year by year, the amount of the consumption products of cosmetics is increased year by year, and a trend of rapid rise is presented. But the effect of the cosmetic products on the market is not satisfactory, the products are difficult to penetrate through the skin, the water retention is poor, the functionalization is single, the allergy is easy to cause and the like.
Gynostemma pentaphyllum has antiaging effect. When age spots (also called lipofuscin) and speckle and freckle are formed, it is found that a large amount of lipid peroxide is accumulated and increased in the skin, and the ability of people to decompose and excrete lipid peroxide is strong in young age, and gradually weakened with age, so that skin cells are gradually aged. The gynostemma pentaphylla can effectively reduce and inhibit the generation of lipid peroxide, protect skin cell membranes from being damaged, and further prevent cell aging. Gynostemma pentaphylla has antiaging effect, because it can increase activity of antioxidant enzyme system such as superoxide dismutase (SOD) in epidermal cells of human body and skin, enhance elimination of active oxidation free radicals, and improve metabolism of organism.
The pine leaves have strong surplus free radical scavenging activity, so that the release of allergen histamine is inhibited, and the pine leaves have an antiallergic effect.
But the effective components of the gynostemma pentaphylla and the rosin leaves are difficult to enter deep skin cells to play the effects of the ginkgolides and the berberine.
Disclosure of Invention
The invention relates to an application of a hydrogel nano-carrier in anti-inflammation and anti-aging cream. The rosin leaf extract and the gynostemma pentaphylla are wrapped by the hydroxyethyl cellulose-sodium alginate hydrogel, the hydroxyethyl cellulose-sodium alginate hydrogel is a nano-scale carrier, the nano-scale carrier has the capability of being quickly absorbed by skin and penetrating cell membranes, the anti-inflammatory component and the anti-aging component are loaded into skin cells, and the specific disulfide bond of the hydroxyethyl cellulose-sodium alginate hydrogel is identified and melted by glutathione in the cells, so that the rosin leaf extract and the gynostemma pentaphylla in the hydrogel are released, can penetrate into the muscle bottom to remove surplus free radicals, promotes the degradation of skin cutin and the hyperplastic metabolism of epidermal germinal layer cells, and enables the skin to be tender and elastic.
In order to achieve the purpose, the invention adopts the technical scheme that.
The preparation of the anti-inflammation and anti-aging cream comprises the following components in percentage by weight:
5-15% of hydroxyethyl cellulose-sodium alginate hydrogel, 1-5% of a rosin leaf extract, 1-5% of gynostemma pentaphylla, 0.2-1% of ascorbyl glucoside, 0.1-1% of vitamin E, 1-5% of sorbitan monooleate, 1-10% of glycerol, 1-10% of allantoin, 0.1-1% of D-panthenol, 1-5% of shea butter, 1-5% of beeswax, 0.5-1.5% of erythritol, 0.3-3% of sodium citrate, 0.01-0.1% of phenoxyethanol and the balance of water to 100%, wherein the rosin leaf extract and the gynostemma pentaphylla are wrapped by the hydroxyethyl cellulose-sodium alginate hydrogel.
The structural formula of the hydroxyethyl cellulose-sodium alginate hydrogel is shown as the formula (I):
wherein n is 20-50; and m is 20-50.
The preparation method of the anti-inflammation and anti-aging cream comprises the following steps:
1) weighing the raw materials of the formula components, wrapping the rosin leaf extract and the gynostemma pentaphylla with hydroxyethyl cellulose-sodium alginate hydrogel, and then placing in a water bath at 55-65 ℃ for constant temperature for 20-30 min.
2) Adding water, ascorbyl glucoside, allantoin, D-panthenol, and erythritol into water phase dissolving kettle, heating to 65 deg.C, and maintaining constant temperature for 3 hr.
3) Adding sorbitan monooleate, glycerol, shea butter and beeswax into oil phase dissolving kettle, heating to 70 deg.C, mixing, and keeping constant temperature for 3 hr.
4) Cooling oil phase and water phase, folium Colophonium extract, and hydroxyethyl cellulose-sodium alginate of herba Gynostemmatis to 25 deg.C, delivering into emulsifying pan, adding vitamin E, heating to 55 deg.C, mixing, homogenizing and emulsifying for about 15 min; after emulsification is finished, cooling the temperature of the material body to normal temperature, adding phenoxyethanol preservative, finally adjusting the pH value to be neutral by using sodium citrate, and discharging.
Besides the specific requirements of the components, other auxiliary materials such as pH regulators, essences, pigments, surfactants and the like can be added or used within the range of not damaging the effects of the invention, and the ordinary content can be selected by the skilled in the art according to the conventional standard.
The folium Colophonium extract has strong scavenging activity of excessive free radicals, which is closely related to histamine as allergic factor, and can inhibit release of histamine as allergen, and has antiallergic effect, so as to make human skin tender and smooth, remove acne and speckle.
Vitamin E has antioxidant effect, thereby protecting sebum and cell membrane proteins and moisture in skin. It also can promote the regeneration and activity of human cells and delay the aging process of cells.
Gynostemma pentaphyllum has antiaging effect. In general, when age spots (also called lipofuscin) and speckle and freckle are formed, a large amount of lipid peroxide is accumulated in the skin and increased, and the ability of people to decompose and excrete lipid peroxide is strong in young age, and gradually weakened with age, so that skin cells are gradually aged. The gypenoside can effectively reduce and inhibit the generation of lipid peroxide, protect the cell membrane of the skin from being damaged, and further prevent the cell aging. Gynostemma pentaphylla has antiaging effect, because it can increase activity of antioxidant enzyme system such as superoxide dismutase (SOD) in epidermal cells of human body and skin, enhance elimination of active oxidation free radicals, and improve metabolism of organism.
Butyrospermum parkii is a rich moistening agent, is easy to absorb, is rich in unsaturated fatty acid, can enhance the moisturizing capability of skin, moistens dry and cutin-damaged skin, and is extracted from Kalit trees. Compared with other vegetable oils, the vegetable oil contains the highest proportion of fat concomitant substances, in particular triterpene alcohol, vitamin E, vitamin A and the like which are essential nutrients for growth, and is rich in nutrition. Can prevent the water loss of skin, help to heal wound, increase the defense capability and the smoothness of the skin, and is an inexhaustible natural skin-care component.
Beeswax is the substance secreted by four pairs of wax glands under the abdomen of the worker bee. The main components of the fatty acid ester comprise acids, free fatty acid, free fatty alcohol and carbohydrate. In addition, carotenoid, vitamin A, aromatic substances and the like are added, so that the skin is promoted to be firm and delicate.
The invention has the beneficial effects that:
the hydroxyethyl cellulose-sodium alginate hydrogel nano-carrier used in the invention carries a drug, after entering cells, glutathione in the cells specifically recognizes disulfide bonds of the hydrogel, the carrier is slowly decomposed, the rosin leaf extract in the carrier is released to achieve an anti-inflammatory effect, and the gynostemma pentaphylla in the carrier is released to achieve an anti-aging effect.
The hydroxyethyl cellulose-sodium alginate hydrogel disclosed by the invention has the advantages of biological non-toxicity, easiness in penetrating through cell membranes, small diameter and easiness in penetrating through the cell membranes, can be used for transporting anti-inflammatory and anti-aging components into cells to be slowly released, and has long-acting anti-inflammatory and anti-aging effects.
The invention provides an application of a hydrogel nano-carrier in anti-inflammation and anti-aging cream, which is prepared by adding mild plant extract components, namely a rosin leaf extract and gynostemma pentaphylla, and matching with basic raw materials, can penetrate deep layers of muscle bottoms to remove excessive free radicals, inhibit the formation of pockmarks, prevent skin allergy, regulate the water-oil balance of skin, inhibit the formation of lipid peroxide, enable the skin to be compact and smooth, eliminate wrinkles and fine pores, and be tender and smooth, healthy and beautiful.
Drawings
Figure 1 hydroxyethyl cellulose-sodium alginate hydrogel molecular formula.
FIG. 2 is a bar graph of cytotoxicity of hydroxyethylcellulose-sodium alginate hydrogel (1-50 mg/mL) and Hacat epidermal cells obtained in the present invention.
Detailed Description
To better illustrate the objects, aspects and advantages of the present invention, the present invention will be further described with reference to specific examples.
Examples 1-4 preparation of hydrogel nano-carrier in anti-inflammatory and anti-aging cream, example 5 is a control group, and each component is mass fraction
The preparation method of the long-acting nano hydrogel anti-inflammatory and anti-aging cream comprises the following steps:
1) weighing the raw materials of the formula components, wrapping the rosin leaf extract and the gynostemma pentaphylla with hydroxyethyl cellulose-sodium alginate hydrogel, and then placing in a water bath at 55-65 ℃ for constant temperature for 20-30 min;
2) putting water, ascorbyl glucoside, allantoin, D-panthenol and erythritol into a water phase dissolving kettle, heating to 65 ℃, and keeping constant temperature for 3 h;
3) putting sorbitan monooleate, glycerol, shea butter and beeswax into an oil phase dissolving kettle, heating to 70 ℃, uniformly mixing, and keeping constant temperature for 3 h;
4) cooling oil phase and water phase, folium Colophonium extract, and hydroxyethyl cellulose-sodium alginate of herba Gynostemmatis to 25 deg.C, delivering into emulsifying pan, adding vitamin E, heating to 55 deg.C, mixing, homogenizing and emulsifying for about 15 min; after emulsification is finished, cooling the temperature of the material body to normal temperature, adding phenoxyethanol preservative, finally adjusting the pH value to be neutral by using sodium citrate, and discharging.
Example 6
The test method comprises the following steps: the long-acting nano hydrogel anti-inflammatory and anti-aging cream obtained in the examples 1 to 4 is used as a test sample 1 to 4, and the cream obtained in the example 5 is used as a control sample 1; 300 female volunteers 30-50 years old, with more acne and mottle, more wrinkles and experiencing of using face cream in the same area are randomly selected, after test samples 1-4 and a control sample 1 are used respectively, a scoring standard is designed and scored, the maximum value and the minimum value of each group of data are removed, the average value is taken, and then the scoring result is recorded in a table 3.
Grading standard: the scoring criteria are referenced in table 2.
And (4) grading results: as can be seen from Table 3, the long-acting nano hydrogel anti-inflammatory and anti-aging facial cream obtained by the formula and the preparation method has the advantages of good luster, high apparent score, good compatibility of each component in the formula, no color difference and long retention time of over 2 hours.
TABLE 2 Scoring criteria
Example 7
Determination of solubility
Respectively adding 5 parts of 0.5g of rosin leaf extract and gynostemma pentaphylla into 50mL of deionized water to obtain turbid mixed liquid of the rosin leaf extract and the gynostemma pentaphylla, numbering 1-5, and respectively adding 1.5g, 2g, 2.5g, 3g and 3.5g of hydroxyethyl cellulose-sodium alginate hydrogel into the solution 1-5. Heating and stirring at 60 deg.C for 20 min. And after cooling to room temperature, observing the dissolution conditions of the rosin leaf extract and the gynostemma pentaphylla, wherein the turbid solution No. 1 is relatively turbid, the turbidity of the solution No. 2 is further reduced, and the turbid solution No. 3-5 becomes clear. Proved that the hydroxyethyl cellulose-sodium alginate hydrogel can remarkably enhance the solubility of the rosin leaf extract and the gynostemma pentaphylla in water.
Example 8
Cytotoxicity test
Inoculating Hacat epidermal cells into a cell culture flask, and placing at 37 deg.C and 5% CO2Culturing in environment, wherein the culture medium is selected from 1640 culture medium containing 10% fetal calf serum and 0.5% double antibody. The cultured cells were seeded in 96-well plates at a cell density of 8000 cells/mL, and continued at 37 ℃ with 5% CO2Culturing for 48h in the environment. Removing culture medium from 96-well plate, washing with precooled PBS for 3 times, adding 1640 complete culture medium containing hydroxyethyl cellulose-sodium alginate hydrogel with different gradients, and continuously maintaining at 37 deg.C and 5% CO2And culturing for 24 hours in the environment. The culture medium in the 96-well plate is removed, 200 μ L of MTT solution diluted to 5mg/ml with 1640 complete medium is added to each well, the solution is removed after incubation for 4h with tinfoil wrap, and 100 μ L of DMSO is added to fully dissolve the formazan that adheres to the 96-well plate. And transferring the 96-well plate into a microplate reader, setting the scanning wavelength to be 577nm, measuring the absorbance of the 96-well plate, and determining the cell survival rate according to the value of the absorbance.
FIG. 2 is a bar graph of cytotoxicity of hydroxyethylcellulose-sodium alginate hydrogel (1-50 mg/mL) and Hacat epidermal cells obtained in the present invention. As can be seen from FIG. 2, the hydroxyethyl cellulose-sodium alginate hydrogel obtained in the invention is non-toxic to normal cells and is a high-affinity cosmetic carrier.
Claims (5)
1. The application of the hydrogel nano-carrier in anti-inflammation and anti-aging cream is characterized in that: the anti-inflammation and anti-aging cream comprises the following components in percentage by weight: 5-15% of hydroxyethyl cellulose-sodium alginate hydrogel, 1-5% of a rosin leaf extract, 1-5% of gynostemma pentaphylla, 0.2-1% of ascorbyl glucoside, 0.1-1% of vitamin E, 1-5% of sorbitan monooleate, 1-10% of glycerol, 1-10% of allantoin, 0.1-1% of D-panthenol, 1-5% of shea butter, 1-5% of beeswax, 0.5-1.5% of erythritol, 0.3-3% of sodium citrate, 0.01-0.1% of phenoxyethanol and the balance of water to 100%, wherein the rosin leaf extract and the gynostemma pentaphylla are wrapped by the hydroxyethyl cellulose-sodium alginate hydrogel;
the hydroxyethyl cellulose-sodium alginate hydrogel is shown as a formula (I):
wherein n is 20-50; m is 20-50;
the preparation method of the anti-inflammation and anti-aging cream comprises the following steps:
1) weighing the raw materials of the formula components, wrapping the rosin leaf extract and the gynostemma pentaphylla with hydroxyethyl cellulose-sodium alginate hydrogel, and then placing in a water bath at 55-65 ℃ for constant temperature for 20-30 min;
2) putting water, ascorbyl glucoside, allantoin, D-panthenol and erythritol into a water phase dissolving kettle, heating to 65 ℃, and keeping constant temperature for 3 h;
3) putting sorbitan monooleate, glycerol, shea butter and beeswax into an oil phase dissolving kettle, heating to 70 ℃, uniformly mixing, and keeping constant temperature for 3 h;
4) cooling oil phase and water phase, folium Colophonium extract, and hydroxyethyl cellulose-sodium alginate of herba Gynostemmatis to 25 deg.C, delivering into emulsifying pan, adding vitamin E, heating to 55 deg.C, mixing, homogenizing and emulsifying for about 15 min; after emulsification is finished, cooling the temperature of the material body to normal temperature, adding phenoxyethanol preservative, finally adjusting the pH value to be neutral by using sodium citrate, and discharging.
2. The application of the hydrogel nano-carrier in anti-inflammatory and anti-aging cream is characterized in that the content of the rosin leaf extract and the gynostemma pentaphylla in the anti-aging cream is increased by the hydrogel nano-carrier.
3. The application of the hydrogel nano-carrier in anti-inflammatory and anti-aging cream is characterized in that the hydrogel nano-carrier delays the evaporation of water and has a long-term moisturizing effect on skin.
4. The application of the hydrogel nano-carrier in the anti-inflammation and anti-aging cream is characterized in that the hydrogel nano-carrier loads an anti-inflammation component and an anti-aging component into skin cells.
5. The use of the hydrogel nanocarrier in an anti-inflammatory and anti-aging cream as claimed in claim 4, wherein the skin cells are Hacat epidermal cells.
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