CN111212650A - 用于编码核糖核酸在组织中的靶向递送、表达和调节的组合物和方法 - Google Patents

用于编码核糖核酸在组织中的靶向递送、表达和调节的组合物和方法 Download PDF

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CN111212650A
CN111212650A CN201880066146.2A CN201880066146A CN111212650A CN 111212650 A CN111212650 A CN 111212650A CN 201880066146 A CN201880066146 A CN 201880066146A CN 111212650 A CN111212650 A CN 111212650A
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sequence
mrna
cells
cell
composition
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R·米科尔
S·安托斯奇克
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United Therapeutics Corp
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CN201880066146.2A 2017-09-07 2018-09-06 用于编码核糖核酸在组织中的靶向递送、表达和调节的组合物和方法 Pending CN111212650A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1714430.4A GB201714430D0 (en) 2017-09-07 2017-09-07 Compositions and processes for targeted delivery and expression and modulation of therapeutic components in tissue
GB1714430.4 2017-09-07
US201862632056P 2018-02-19 2018-02-19
US62/632,056 2018-02-19
PCT/US2018/049772 WO2019051100A1 (en) 2017-09-07 2018-09-06 COMPOSITIONS AND METHODS FOR TARGETED CODING ADMINISTRATION, EXPRESSION AND MODULATION OF RIBONUCLEIC ACIDS IN TISSUE

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CN111212650A true CN111212650A (zh) 2020-05-29

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CN201880066146.2A Pending CN111212650A (zh) 2017-09-07 2018-09-06 用于编码核糖核酸在组织中的靶向递送、表达和调节的组合物和方法

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US (3) US11359212B2 (enExample)
EP (2) EP4218770A3 (enExample)
JP (4) JP2020533411A (enExample)
KR (1) KR102741572B1 (enExample)
CN (1) CN111212650A (enExample)
AU (1) AU2018328289B2 (enExample)
CA (1) CA3074293A1 (enExample)
ES (1) ES2942890T3 (enExample)
GB (1) GB201714430D0 (enExample)
MX (2) MX2020002568A (enExample)
PL (1) PL3678673T3 (enExample)
PT (1) PT3678673T (enExample)
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WO (1) WO2019051100A1 (enExample)

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CN113444744A (zh) * 2021-06-28 2021-09-28 北京鼎成肽源生物技术有限公司 一种用于基因编辑NK细胞的mRNA模板及构建方法、mRNA的体外转录方法和应用
CN114107347A (zh) * 2021-11-24 2022-03-01 中国人民解放军空军军医大学 一种基于具有按需抗炎功能、装载炎症响应型mRNA的工程化外泌体及其构建方法和应用

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IL295724A (en) 2020-02-21 2022-10-01 Combined Therapeutics Inc Compositions and methods for organ-protective expression and modulation of coding ribonucleic acids
CA3187345A1 (en) 2020-07-31 2022-02-17 Romain MICOL Compositions and methods for improved vaccination
CA3171589A1 (en) 2021-05-03 2022-11-03 Moritz THRAN Improved nucleic acid sequence for cell type specific expression

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CN114107347A (zh) * 2021-11-24 2022-03-01 中国人民解放军空军军医大学 一种基于具有按需抗炎功能、装载炎症响应型mRNA的工程化外泌体及其构建方法和应用

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PT3678673T (pt) 2023-04-24
MX2020008606A (es) 2020-09-21
US20200255863A1 (en) 2020-08-13
EP4218770A3 (en) 2023-08-09
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US11359212B2 (en) 2022-06-14
EP3678673B1 (en) 2023-01-25
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US20250129383A1 (en) 2025-04-24
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RU2020112990A (ru) 2021-10-07
EP4218770A2 (en) 2023-08-02
CA3074293A1 (en) 2019-03-14
WO2019051100A1 (en) 2019-03-14
AU2018328289B2 (en) 2025-07-10
JP2020533411A (ja) 2020-11-19
KR102741572B1 (ko) 2024-12-10
KR20200104282A (ko) 2020-09-03
JP2023159160A (ja) 2023-10-31
ES2942890T3 (es) 2023-06-07
US20220220506A1 (en) 2022-07-14
AU2018328289A1 (en) 2020-03-19
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