CN111201241A - 用C5a活性抑制剂治疗炎性疾病 - Google Patents

用C5a活性抑制剂治疗炎性疾病 Download PDF

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Publication number
CN111201241A
CN111201241A CN201880041303.4A CN201880041303A CN111201241A CN 111201241 A CN111201241 A CN 111201241A CN 201880041303 A CN201880041303 A CN 201880041303A CN 111201241 A CN111201241 A CN 111201241A
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CN
China
Prior art keywords
antibody
antigen
binding
binding fragment
compound
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Pending
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CN201880041303.4A
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English (en)
Chinese (zh)
Inventor
郭仁峰
尼尔斯·R·里德曼
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InflaRx GmbH
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InflaRx GmbH
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Application filed by InflaRx GmbH filed Critical InflaRx GmbH
Publication of CN111201241A publication Critical patent/CN111201241A/zh
Pending legal-status Critical Current

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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/10Anti-acne agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/545Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Dermatology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Compounds Of Unknown Constitution (AREA)
CN201880041303.4A 2017-06-23 2018-06-13 用C5a活性抑制剂治疗炎性疾病 Pending CN111201241A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP17177657 2017-06-23
EP17177657.8 2017-06-23
EP17189938 2017-09-07
EP17189938.8 2017-09-07
PCT/EP2018/065676 WO2018234118A1 (en) 2017-06-23 2018-06-13 TREATMENT OF INFLAMMATORY DISEASES BY INHIBITORS OF C5A ACTIVITY

Publications (1)

Publication Number Publication Date
CN111201241A true CN111201241A (zh) 2020-05-26

Family

ID=62636193

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880041303.4A Pending CN111201241A (zh) 2017-06-23 2018-06-13 用C5a活性抑制剂治疗炎性疾病

Country Status (10)

Country Link
EP (1) EP3642230A1 (ja)
JP (1) JP2020524696A (ja)
KR (1) KR20200020727A (ja)
CN (1) CN111201241A (ja)
AU (1) AU2018286754A1 (ja)
CA (1) CA3066689C (ja)
IL (1) IL271074A (ja)
SG (1) SG11201912882QA (ja)
TW (1) TWI786132B (ja)
WO (1) WO2018234118A1 (ja)

Cited By (1)

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Publication number Priority date Publication date Assignee Title
CN114364695A (zh) * 2020-06-24 2022-04-15 舒泰神(北京)生物制药股份有限公司 特异性识别c5a的抗体及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MA45235A (fr) 2016-06-14 2019-04-17 Regeneron Pharma Anticorps anti-c5 et leurs utilisations
EP3724226A1 (en) 2017-12-13 2020-10-21 Regeneron Pharmaceuticals, Inc. Anti-c5 antibody combinations and uses thereof
CA3132771A1 (en) * 2019-03-14 2020-09-17 Morphosys Ag Antibodies targeting c5ar
TW202140553A (zh) 2020-01-13 2021-11-01 美商威特拉公司 C5ar1抗體分子及其用途
CA3173944A1 (en) 2021-01-13 2022-07-21 Visterra, Inc. Humanized complement 5a receptor 1 antibodies and methods of use thereof

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CN1604909A (zh) * 2001-10-17 2005-04-06 昆士兰大学 作为g蛋白-偶联受体拮抗剂的环肽
CN1997384A (zh) * 2004-03-26 2007-07-11 普罗米克斯有限公司 使用补体C5a受体调节剂治疗神经系统病症
CN105392803A (zh) * 2013-05-08 2016-03-09 诺和诺德股份有限公司 C5aR拮抗剂的用途
WO2016102877A1 (fr) * 2014-12-23 2016-06-30 Galderma Research & Development Nouveaux composés antagonistes des récepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies médiées par des chimiokines
CN106132982A (zh) * 2014-03-20 2016-11-16 因弗拉克斯有限责任公司 用于治疗病毒性肺炎的C5a抑制剂
CN111108118A (zh) * 2017-04-03 2020-05-05 因弗拉克斯有限责任公司 用C5a活性抑制剂治疗炎性疾病

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AU6501390A (en) 1989-09-21 1991-04-18 Synergen, Inc. Method for transporting compositions across the blood brain barrier
EP0463151B1 (en) 1990-01-12 1996-06-12 Cell Genesys, Inc. Generation of xenogeneic antibodies
AUPO755097A0 (en) 1997-06-25 1997-07-17 University Of Queensland, The Receptor agonist and antagonist
US7754208B2 (en) 2001-01-17 2010-07-13 Trubion Pharmaceuticals, Inc. Binding domain-immunoglobulin fusion proteins
US20030133939A1 (en) 2001-01-17 2003-07-17 Genecraft, Inc. Binding domain-immunoglobulin fusion proteins
LT3385384T (lt) 2004-02-12 2020-09-25 Archemix Llc Aptamero terapija, naudinga su komplementu susijusių ligų gydymui
WO2008009062A1 (en) 2006-07-21 2008-01-24 Promics Pty Ltd Treatment for intimal hyperplasia and related conditions
GB0617734D0 (en) 2006-09-08 2006-10-18 Evolutec Ltd Method of treating peripheral nerve disorders
PL2381778T3 (pl) * 2008-12-22 2017-01-31 Chemocentryx, Inc. Antagoniści c5ar
GB0905790D0 (en) * 2009-04-03 2009-05-20 Alligator Bioscience Ab Novel polypeptides and use thereof
EP2327725A1 (en) 2009-11-26 2011-06-01 InflaRx GmbH Anti-C5a binding moieties with high blocking activity
JP2013529647A (ja) * 2010-06-24 2013-07-22 ケモセントリックス,インコーポレイティド C5aRアンタゴニスト
ES2649490T3 (es) * 2013-03-14 2018-01-12 Alnylam Pharmaceuticals, Inc. Composiciones de ARNi contra el componente C5 del complemento y métodos para su uso
EP3194596A1 (en) 2014-09-16 2017-07-26 Alnylam Pharmaceuticals, Inc. Complement component c5 irna compositions and methods of use thereof
WO2016061066A1 (en) 2014-10-15 2016-04-21 Alexion Pharmaceuticals, Inc. Methods of replicating a large scale eculizumab production cell culture
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CN1604909A (zh) * 2001-10-17 2005-04-06 昆士兰大学 作为g蛋白-偶联受体拮抗剂的环肽
CN1847261A (zh) * 2001-10-17 2006-10-18 昆士兰大学 作为g蛋白-偶联受体拮抗剂的环肽
CN1997384A (zh) * 2004-03-26 2007-07-11 普罗米克斯有限公司 使用补体C5a受体调节剂治疗神经系统病症
CN105392803A (zh) * 2013-05-08 2016-03-09 诺和诺德股份有限公司 C5aR拮抗剂的用途
CN106132982A (zh) * 2014-03-20 2016-11-16 因弗拉克斯有限责任公司 用于治疗病毒性肺炎的C5a抑制剂
WO2016102877A1 (fr) * 2014-12-23 2016-06-30 Galderma Research & Development Nouveaux composés antagonistes des récepteurs cxcr1 et cxcr2 aux chimiokines, et leur utilisation dans le traitement de pathologies médiées par des chimiokines
CN111108118A (zh) * 2017-04-03 2020-05-05 因弗拉克斯有限责任公司 用C5a活性抑制剂治疗炎性疾病

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"InflaRx initiates exploratory phase II trial with IFX-1, a first-in-class anti-complement C5a antibody, in patients with Hidradenitis Suppurativa", pages 1 - 2 *
AH-WENG A.等: "化脓性汗腺炎伴发坏疽性脓皮病", 世界核心医学期刊文摘·皮肤病学, vol. 2, no. 2, 28 February 2006 (2006-02-28), pages 46 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114364695A (zh) * 2020-06-24 2022-04-15 舒泰神(北京)生物制药股份有限公司 特异性识别c5a的抗体及其应用

Also Published As

Publication number Publication date
IL271074A (en) 2020-01-30
TW201904611A (zh) 2019-02-01
AU2018286754A1 (en) 2019-12-19
EP3642230A1 (en) 2020-04-29
SG11201912882QA (en) 2020-01-30
JP2020524696A (ja) 2020-08-20
KR20200020727A (ko) 2020-02-26
TWI786132B (zh) 2022-12-11
CA3066689C (en) 2024-01-16
CA3066689A1 (en) 2018-12-27
WO2018234118A1 (en) 2018-12-27

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