CN111201234A - 新型化合物及其作为acc抑制剂的用途 - Google Patents

新型化合物及其作为acc抑制剂的用途 Download PDF

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Publication number
CN111201234A
CN111201234A CN201880053983.1A CN201880053983A CN111201234A CN 111201234 A CN111201234 A CN 111201234A CN 201880053983 A CN201880053983 A CN 201880053983A CN 111201234 A CN111201234 A CN 111201234A
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CN
China
Prior art keywords
compound
alkyl
haloalkyl
independently
cancer
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Pending
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CN201880053983.1A
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English (en)
Chinese (zh)
Inventor
张军波
廖红
王培培
王鹏
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Nanjing Ruijie Pharma Co ltd
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Nanjing Ruijie Pharma Co ltd
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Publication of CN111201234A publication Critical patent/CN111201234A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Epidemiology (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
CN201880053983.1A 2017-07-17 2018-07-17 新型化合物及其作为acc抑制剂的用途 Pending CN111201234A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CNPCT/CN2017/093106 2017-07-17
CNPCT/CN2017/093106 2017-07-17
PCT/CN2018/095973 WO2019015583A1 (en) 2017-07-17 2018-07-17 NOVEL COMPOUNDS AND THEIR USES AS ACC INHIBITORS

Publications (1)

Publication Number Publication Date
CN111201234A true CN111201234A (zh) 2020-05-26

Family

ID=65014996

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201880053983.1A Pending CN111201234A (zh) 2017-07-17 2018-07-17 新型化合物及其作为acc抑制剂的用途

Country Status (5)

Country Link
US (1) US10995099B2 (https=)
EP (1) EP3655409B1 (https=)
JP (1) JP7067725B2 (https=)
CN (1) CN111201234A (https=)
WO (2) WO2019015583A1 (https=)

Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114815020A (zh) * 2022-04-21 2022-07-29 岭南师范学院 一种高品质因数折射率传感器的设计方法及折射率传感器
WO2022166761A1 (zh) * 2021-02-07 2022-08-11 正大天晴药业集团股份有限公司 噻吩并嘧啶衍生物
CN116747321A (zh) * 2023-06-14 2023-09-15 厦门君德医药科技有限公司 一种接枝改性的介孔二氧化硅及其制备方法和应用

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2019020041A1 (zh) * 2017-07-26 2019-01-31 南京圣和药业股份有限公司 作为acc抑制剂的化合物及其应用
EP3995498A4 (en) 2019-07-02 2023-03-01 Sunshine Lake Pharma Co., Ltd. THIENOPYRIMIDI DERIVATIVES WITH STEREO CONFIGURATION AND THEIR USE IN MEDICINE
AR119594A1 (es) 2019-08-09 2021-12-29 Gilead Sciences Inc Derivados de tienopirimidina como inhibidores acc y usos de los mismos
JP7612682B2 (ja) 2019-10-15 2025-01-14 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 新規なテトラゾール
CN112778325A (zh) * 2019-11-07 2021-05-11 南京瑞捷医药科技有限公司 一种acc抑制剂及其用途
JP7565439B2 (ja) * 2020-10-14 2024-10-10 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング Ｔｒｐａ１阻害剤としてのテトラゾール誘導体
WO2022079091A1 (en) * 2020-10-14 2022-04-21 Boehringer Ingelheim International Gmbh Tetrazole derivatives as trpa1 inhibitors
CA3210965A1 (en) 2021-04-14 2022-10-20 Boehringer Ingelheim International Gmbh 3h,4h-thieno[2,3-d]pyrimidin-4-one derivatives as trpa1 inhibitors
CN114409664B (zh) * 2021-12-24 2023-07-18 河北威远生物化工有限公司 一种螺杂环四氢吡喃化合物及其制备方法和应用

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103923084A (zh) * 2014-01-29 2014-07-16 苏州晶云药物科技有限公司 几种新晶型及其制备方法
CN104105485A (zh) * 2011-11-11 2014-10-15 尼普斯阿波罗有限公司 Acc抑制剂和其用途
WO2015003879A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicylic derivatives
CN104363758A (zh) * 2012-05-30 2015-02-18 拜耳作物科学公司 包含生物防治剂和杀虫剂的组合物
CN105358155A (zh) * 2013-05-10 2016-02-24 尼普斯阿波罗有限公司 Acc抑制剂和其用途
WO2016067012A1 (en) * 2014-10-27 2016-05-06 Imperial Innovations Limited Compounds as sirt2 inhibitors
CN106137971A (zh) * 2015-11-17 2016-11-23 南京瑞捷医药科技有限公司 一种他克莫司分散体及其缓释组合物及制备方法
WO2017091600A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
WO2017091617A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
CN110382503A (zh) * 2017-03-03 2019-10-25 吉利德科学公司 制备acc抑制剂及其固体形式的方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2018501276A (ja) 2015-01-09 2018-01-18 ギリアド アポロ， エルエルシー 非アルコール性脂肪肝疾患の処置のためのａｃｃ阻害剤併用療法
CN205115664U (zh) * 2015-10-15 2016-03-30 阳光能源（青海）有限公司 一种用于单晶炉的二次填料装置
CN119977993A (zh) 2016-03-02 2025-05-13 吉利德阿波罗公司 噻吩并嘧啶二酮acc抑制剂的固体形式及其制备方法
WO2018228369A1 (zh) * 2017-06-15 2018-12-20 浙江海正药业股份有限公司 杂芳基并嘧啶酮类衍生物、其制备方法及其在医药上用途
WO2019020041A1 (zh) * 2017-07-26 2019-01-31 南京圣和药业股份有限公司 作为acc抑制剂的化合物及其应用

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104105485A (zh) * 2011-11-11 2014-10-15 尼普斯阿波罗有限公司 Acc抑制剂和其用途
CN104363758A (zh) * 2012-05-30 2015-02-18 拜耳作物科学公司 包含生物防治剂和杀虫剂的组合物
CN105358155A (zh) * 2013-05-10 2016-02-24 尼普斯阿波罗有限公司 Acc抑制剂和其用途
WO2015003879A1 (en) * 2013-07-08 2015-01-15 Syngenta Participations Ag Microbiocidal heterobicylic derivatives
CN103923084A (zh) * 2014-01-29 2014-07-16 苏州晶云药物科技有限公司 几种新晶型及其制备方法
WO2016067012A1 (en) * 2014-10-27 2016-05-06 Imperial Innovations Limited Compounds as sirt2 inhibitors
CN106137971A (zh) * 2015-11-17 2016-11-23 南京瑞捷医药科技有限公司 一种他克莫司分散体及其缓释组合物及制备方法
WO2017091600A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Pyrazole acc inhibitors and uses thereof
WO2017091617A1 (en) * 2015-11-25 2017-06-01 Gilead Apollo, Llc Triazole acc inhibitors and uses thereof
CN110382503A (zh) * 2017-03-03 2019-10-25 吉利德科学公司 制备acc抑制剂及其固体形式的方法

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022166761A1 (zh) * 2021-02-07 2022-08-11 正大天晴药业集团股份有限公司 噻吩并嘧啶衍生物
CN116745299A (zh) * 2021-02-07 2023-09-12 正大天晴药业集团股份有限公司 噻吩并嘧啶衍生物
CN114815020A (zh) * 2022-04-21 2022-07-29 岭南师范学院 一种高品质因数折射率传感器的设计方法及折射率传感器
CN114815020B (zh) * 2022-04-21 2023-09-22 岭南师范学院 一种高品质因数折射率传感器的设计方法及折射率传感器
CN116747321A (zh) * 2023-06-14 2023-09-15 厦门君德医药科技有限公司 一种接枝改性的介孔二氧化硅及其制备方法和应用

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EP3655409A1 (en) 2020-05-27
EP3655409B1 (en) 2023-12-27
WO2019015583A1 (en) 2019-01-24
JP2020527175A (ja) 2020-09-03
JP7067725B2 (ja) 2022-05-16
US10995099B2 (en) 2021-05-04
WO2020015343A1 (en) 2020-01-23
US20200140454A1 (en) 2020-05-07
EP3655409A4 (en) 2020-12-16

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