CN111165663B - Rumen-bypass arginine and preparation method and application thereof - Google Patents
Rumen-bypass arginine and preparation method and application thereof Download PDFInfo
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- CN111165663B CN111165663B CN202010028077.5A CN202010028077A CN111165663B CN 111165663 B CN111165663 B CN 111165663B CN 202010028077 A CN202010028077 A CN 202010028077A CN 111165663 B CN111165663 B CN 111165663B
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/142—Amino acids; Derivatives thereof
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/105—Aliphatic or alicyclic compounds
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/158—Fatty acids; Fats; Products containing oils or fats
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/26—Compounds containing phosphorus
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/10—Shaping or working-up of animal feeding-stuffs by agglomeration; by granulation, e.g. making powders
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K40/00—Shaping or working-up of animal feeding-stuffs
- A23K40/30—Shaping or working-up of animal feeding-stuffs by encapsulating; by coating
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Abstract
The invention relates to rumen-bypass arginine and a preparation method and application thereof. The rumen bypass arginine mainly comprises arginine, polyethylene glycol, a binder and an excipient. Rumen bypass arginines of some embodiments include: a pellet core comprising arginine and polyethylene glycol; a first coating covering the pellet core; wherein the coating comprises a binder and an excipient. The embodiment of the invention provides novel rumen-bypass arginine, which has low degradation rate in rumen. The rumen-bypass arginine can improve the milk yield and the production performance of the dairy cows and greatly increase the income of a pasture.
Description
Technical Field
The invention relates to rumen-bypass amino acid, in particular to novel rumen-bypass arginine and a preparation method and application thereof.
Background
In recent years, it has been found that arginine has been considered to be the next limiting amino acid after lysine and methionine for perinatal cows. The addition of arginine into daily cow feed in perinatal period can increase prolactin, growth hormone and insulin obviously, increase milk yield in lactation period, and improve milk yield and production performance of cow. Therefore, the application of arginine to cows is receiving more attention.
Due to the microbial action of the rumen, arginine added directly to the daily ration will be degraded in the rumen and will not reach the small intestine. Thus, not only the effect of adding arginine is not achieved, but also arginine is wasted. The rumen-bypass arginine is not degraded in rumen and directly reaches small intestine to be absorbed and utilized. The arginine subjected to protection treatment is added into daily ration of the dairy cow, so that the utilization rate of protein can be improved, protein feed is saved, the production cost is reduced, and the milk yield of the dairy cow is improved; further improving the economic benefit of the production of the dairy cows, reducing the emission of nitrogen in the excrement and urine and playing an important role in reducing the environmental pollution.
Disclosure of Invention
The embodiment of the invention provides novel rumen-bypass arginine, which has low degradation rate in rumen. The rumen-bypass arginine can improve the milk yield and the production performance of the dairy cows and greatly increase the income of a pasture.
The rumen bypass arginine provided by the embodiment of the invention comprises arginine, polyethylene glycol (PEG), a binder and an excipient as main raw materials.
In some embodiments, the rumen bypass arginine provided by the invention comprises: a pellet core comprising arginine and polyethylene glycol; a first coating covering the pellet core; wherein the coating comprises a binder and an excipient.
In some embodiments, rumen bypass arginine is provided, comprising:
a pellet core comprising arginine and polyethylene glycol;
a first coating covering the pellet core; wherein the first coating consists of a first binder and an excipient; the first adhesive is selected from one or more of glyceryl monostearate, stearic acid, solid paraffin and sodium alginate; the excipient is one or two of calcium hydrophosphate and calcium phosphate.
According to the invention, arginine and polyethylene glycol are prepared into the pill core, and the first coating is coated on the pill core, so that the degradation rate of arginine in rumen is obviously reduced.
In some embodiments of the invention, the polyethylene glycol is selected from polyethylene glycol 6000 (PEG 6000) or polyethylene glycol 4000 (PEG 4000), preferably polyethylene glycol 6000 (PEG 6000).
In some embodiments of the invention, the weight ratio of arginine to polyethylene glycol in the pellet core is (0.5-1.5) to (0.2-0.8), preferably 1.
In some embodiments of the invention, the pellet core is comprised of arginine and polyethylene glycol.
The research of the invention finds that the polyethylene glycol can be mixed with the arginine, and the mixture has good solubility, thereby being beneficial to the subsequent process operation.
In some embodiments of the present invention, the first coating layer completely covers the pellet core, thereby being capable of better reducing the degradation rate of rumen bypass arginine.
In some embodiments of the invention, the thickness of the first coating layer is 200-300 μm, for example 220-250 μm, which ensures complete coverage of the pellet core.
Research finds that if the dosage of the first coating is excessive, although the rumen bypass effect of arginine is improved, namely the degradation rate is reduced, the content of the pellet core is reduced; if the amount of the first coating is too small, the pellet core (mainly arginine) may not be effectively protected.
In some embodiments of the invention, the weight ratio of the pellet core to the first coating is (40-50) to (50-60), preferably 40. This may better reduce the degradation rate of rumen bypass arginine.
In some embodiments of the invention, the weight ratio of the first binder to the excipient is (37-43): (18-22), preferably 40.
In some embodiments of the invention, the first binder is a mixture of glyceryl monostearate (or stearic acid), paraffin wax and sodium alginate. For example, the weight ratio of glyceryl monostearate (or stearic acid), paraffin wax and sodium alginate is (14-16): (9-11), preferably 15.
In some embodiments of the invention, the excipients are calcium hydrogen phosphate and calcium phosphate. For example, the weight ratio of calcium hydrogen phosphate to calcium phosphate is (9-11) to (9-11), preferably 10.
In some embodiments of the invention, the first coating consists of glycerol monostearate (or stearic acid), paraffin wax, sodium alginate, calcium hydrogen phosphate, calcium phosphate in a weight ratio of (14-16) to (9-11), preferably in a weight ratio of 15. This may better reduce the degradation rate of rumen bypass arginine.
In some embodiments of the invention, the weight percentage of the pellet core in the rumen bypass arginine is 40-50%.
In some embodiments of the invention, the weight percentage of the pellet core in the rumen bypass arginine is 40-45%.
In some embodiments of the invention, the ruminal bypass arginine is in granular form.
In some embodiments of the present invention, the pellet core and the first coating layer covering the pellet core are sometimes referred to as pellets.
Experiments show that the rumen bypass arginine has low degradation rate in rumen and can basically meet the production requirement.
The invention also provides a preparation method of the rumen bypass arginine, which comprises the following steps:
1) Mixing arginine and polyethylene glycol to obtain solid dispersion as pill core;
2) Coating a first coating layer on the pellet core.
In the above preparation method, the pellet core and the above first coating layer are the same as above.
In some embodiments of the invention, the method of preparing the pellet core specifically comprises: pulverizing arginine (for example, sieving with 100-200 mesh sieve, preferably 120 mesh sieve), mixing with polyethylene glycol, heating to melt (about 60-70 deg.C), and cooling to obtain solid dispersion as pill core.
In some embodiments of the present invention, the method of applying a first coating layer on said pellet core specifically comprises: rounding the pellet core, adhesive and excipient by melting high-speed stirring method to coat the first coating on the pellet core, and making into pellet. More specific methods include: preheating a melting high-speed stirring granulator, granulating the pellet core, the first adhesive and the excipient in a ratio in the melting stirring granulator, starting a stirring paddle, setting the initial rotating speed to be 100-200r/min (for example, 150 r/min), setting the initial temperature of a water bath to be 50-60 ℃ (for example, 55 ℃), adjusting the stirring rotating speed to be 450-550r/min (for example, 500 r/min) after the first adhesive starts to melt, and increasing the stirring rotating speed by 1 ℃ every 5-8 minutes until the temperature is kept constant at 62 ℃. Stopping heating when small particles appear in the pot, and continuously stirring until the mixture is completely molded.
In some embodiments of the invention, the rumen-bypass arginine is obtained in a granular form.
Further research shows that the second coating is coated on the first coating, so that the degradation rate of arginine in rumen can be further reduced, and the production requirement can be better met. Thus, in some embodiments of the invention, the ruminal bypass arginine further comprises a second coating covering the first coating; wherein, the material of the second coating can be one or more selected from glyceryl monostearate, stearic acid, solid paraffin and sodium alginate, and is preferably solid paraffin and/or glyceryl monostearate.
In some embodiments of the invention, the second coating completely covers the first coating, thereby enabling a better reduction in the degradation rate of rumen bypass arginine.
Further studies have found that the degradation rate of arginine in the rumen is further reduced by applying a second coating, but the amount of arginine in the pellet core is reduced throughout the rumen bypass, thereby reducing the effective amount of arginine. The inventors have surprisingly found that by adjusting the amount of binder in the first coating, i.e. wherein part of the binder is used as a second coating, the degradation rate of arginine in the rumen can be further reduced without increasing the amount of binder as a whole. Therefore, the effective content of arginine is not reduced, the rumen bypass effect is ensured, and the degradation rate of arginine in rumen is obviously reduced.
Specifically, in some embodiments of the present invention, there is also provided another rumen bypass arginine, comprising:
a pellet core comprising arginine and polyethylene glycol;
a first coating covering the pellet core; wherein the first coating consists of a first binder and an excipient; the first adhesive is glyceryl monostearate or stearic acid, solid paraffin and sodium alginate; the excipient is calcium hydrogen phosphate and calcium phosphate;
a second coating overlying the first coating; wherein the second coating consists of a second binder; the second adhesive is selected from one or more of glyceryl monostearate, stearic acid, solid paraffin and sodium alginate, and is preferably solid paraffin and/or glyceryl monostearate.
In some embodiments of the invention, the polyethylene glycol is the same as above; the pellet core is the same as above.
In some embodiments of the invention, the ratio of the weight of the pellet core to the sum of the weights of the first coating and the second coating is (40-50) to (50-60), preferably 40.
In some embodiments of the invention, the weight ratio of the sum of the weight of the first binder and the second binder to the weight of the excipient is (37-43): (18-22), preferably 40.
In some embodiments of the invention, the weight ratio of the first coating to the second coating is (40-50): 5-25), preferably 45.
In some embodiments of the invention, the weight ratio of the first binder to the excipient is (19-31): (18-22), preferably 25.
In some embodiments of the present invention, the first binder is composed of glyceryl monostearate (or stearic acid), solid paraffin, and sodium alginate in a weight ratio of (5-10): (9-11), for example, is composed of glyceryl monostearate (or stearic acid), solid paraffin, and sodium alginate in a weight ratio of 5.
In some embodiments of the invention, the excipient consists of calcium hydrogen phosphate and calcium phosphate in a weight ratio of (9-11) to (9-11), with a preferred weight ratio of 10.
In some embodiments of the invention, the ruminal bypass arginine comprises, in weight percent: the content of the pill core is 35-45%, preferably 40%; the content of the first coating is 40-50%, preferably 45%; the content of the second coating layer is 5 to 25%, preferably 15%.
In some embodiments of the invention, the ruminal bypass arginine comprises, in weight percent:
the content of the pill core is 35-45%, preferably 40-45%;
the content of the first coating is 40-50%, preferably 45%; wherein the weight ratio of the first binder to the excipient in the first coating is (19-31): (18-22), preferably 25; the first adhesive consists of glyceryl monostearate (or stearic acid), solid paraffin and sodium alginate in a weight ratio of (5-10) to (9-11), wherein the preferred weight ratio is 5; the excipient consists of calcium hydrogen phosphate and calcium phosphate according to the weight ratio of (9-11) to (9-11), and the preferable weight ratio is 10;
the content of the second coating layer is 5-25%, preferably 15%.
In some embodiments of the invention, the method of applying the second coating is substantially the same as the method of applying the first coating.
The invention also comprises rumen-bypass arginine prepared by the method.
Experiments have shown that in some embodiments of the present invention, the degradation rate of rumen bypass arginine containing the second coating is only 16.44% in the rumen for 24 h.
The invention also comprises the application of the rumen-bypass arginine in preparing animal feed. Among these, the animals include ruminants such as cattle, sheep, deer, alpaca, antelope, and the like. The feed is preferably a cattle (cow) feed.
The coating process adopted by the embodiment of the invention is reasonable, the coating is uniform and complete, and the rumen bypass effect is ideal; the prepared rumen-bypass arginine has ideal physical form, small and uniform particles and good fluidity, and is easy to be directly used in production. The use of pastures proves that the rumen-bypass arginine is added into daily ration of dairy cows, so that the milk yield of the dairy cows can be improved, the daily ration of protein is saved, and considerable economic benefit is obtained.
Detailed Description
The following examples are intended to illustrate the invention but are not intended to limit the scope of the invention. The examples do not show the specific techniques or conditions, according to the technical or conditions described in the literature in the field, or according to the product specifications. The reagents or instruments used are conventional products available from regular distributors, not indicated by the manufacturer.
Example 1
Rumen bypass arginine, which consists of: a pellet core consisting of arginine and PEG 6000; the weight ratio of arginine to PEG6000 is 1; a first coating covering the pellet core; wherein the first coating consists of glyceryl monostearate, solid paraffin, sodium alginate, calcium hydrophosphate and calcium phosphate according to a weight ratio of 15; the weight ratio of the pellet core to the first coating is 40.
In the rumen bypass arginine described in this example, the weight percentages are: the content of the pill core is 40 percent, and the content of the first coating layer is 60 percent.
The present embodiment also provides a method for preparing ruminal bypass arginine, including:
putting arginine into a pulverizer, sieving with a 120-mesh sieve, mixing the obtained product with PEG6000 according to a ratio of 1.
And respectively sieving the glyceryl monostearate, the solid paraffin and the sodium alginate by a 50-mesh sieve, and taking 50-mesh fine powder for later use.
Pulverizing the above solid dispersion to obtain pellet core, mixing with adhesive such as glyceryl monostearate, solid paraffin, sodium alginate, excipient such as calcium hydrogen phosphate and calcium phosphate, and stirring at high speed to obtain round pellet. Specifically, preheating a melting high-speed stirring granulator, granulating the core pellets and the fine powder of glyceryl monostearate, the solid paraffin, the calcium hydrophosphate and the calcium phosphate in the melting stirring granulator according to a ratio of 10. Stopping heating when small particles appear in the pot, and continuously stirring until the mixture is completely molded.
The rumen bypass arginine prepared in this example was in granular form.
Example 2
A rumen bypass arginine which differs from example 1 only in that: the glyceryl monostearate was replaced with an equal amount of stearic acid. The preparation method is as in example 1.
Example 3
A rumen bypass arginine which differs from example 1 only in that: PEG6000 was replaced with an equal amount of PEG4000.
Example 4
Rumen bypass arginine, which consists of: the pill core consists of arginine and PEG6000, wherein the weight ratio of the arginine to the PEG6000 is 1; a first coating covering the pellet core; the first coating consists of glyceryl monostearate, solid paraffin, sodium alginate, calcium hydrophosphate and calcium phosphate according to the weight ratio of 5; a second coating overlying the first coating; wherein the second coating is a paraffin wax; the weight ratio of the pill core to the first coating to the second coating is 40.
In the rumen bypass arginine described in this example, the weight percentages are: the content of the pill core is 40%, the content of the first coating layer is 45%, and the content of the second coating layer is 15%.
The present invention also provides a method for preparing rumen-bypass arginine, comprising: preparing a pellet core in substantially the same manner as in example 1 (the raw material ratio is different from that in example 1), and coating a first coating layer on the pellet core to obtain pellets; then granulating the pellets and solid paraffin in a melting and stirring granulator according to the proportion, setting the initial rotating speed to be 150r/min, setting the initial temperature of a water bath to be 55 ℃, adjusting the stirring rotating speed to be 500r/min after the solid paraffin is melted, and increasing the stirring rotating speed to 1 ℃ every 5 minutes till the temperature is kept constant at 62 ℃; stopping heating when small particles appear in the pan, continuing stirring until the pellets are completely formed, and coating a second coating layer on the pellets.
The rumen bypass arginine produced in this example was in granular form.
Example 5
Rumen bypass arginine, which consists of: the pill core consists of arginine and PEG6000, wherein the weight ratio of the arginine to the PEG6000 is 1; a first coating covering the pellet core; wherein the first coating consists of glyceryl monostearate, solid paraffin, sodium alginate, calcium hydrophosphate and calcium phosphate according to a weight ratio of 10; a second coating overlying the first coating; wherein the second coating is glyceryl monostearate; the weight ratio of the pill core to the first coating to the second coating is 40.
In the rumen bypass arginine described in this example, the weight percentages are: the content of the pill core is 40%, the content of the first coating layer is 45%, and the content of the second coating layer is 15%.
The rumen bypass arginine production method of this example was substantially as described in example 4.
Comparative example 1
A rumen bypass arginine which differs from example 1 only in: the first coating does not contain sodium alginate, namely the adhesive is only glyceryl monostearate and solid paraffin; and the first coating consists of glyceryl monostearate, solid paraffin, calcium hydrophosphate and calcium phosphate according to a weight ratio of 20.
Comparative example 2
A rumen bypass arginine which differs from example 1 only in: the first coating does not contain glyceryl monostearate, namely the adhesive is only solid paraffin and sodium alginate; and the first coating consists of solid paraffin, sodium alginate, calcium hydrophosphate and calcium phosphate according to the weight ratio of 22.5.
Comparative example 3
A rumen bypass arginine which differs from example 1 only in that: the first coating does not contain paraffin wax, namely the adhesive is only glyceryl monostearate and sodium alginate; and the first coating consists of glyceryl monostearate, sodium alginate, calcium hydrophosphate and calcium phosphate according to a weight ratio of 22.5.
Comparative example 4
A rumen bypass arginine which differs from example 1 only in that: the first coating is also coated with a second coating; the second coating is solid paraffin; the weight ratio of the second coating to the first coating was 10.
In the rumen bypass arginine, 110 parts by weight are as follows: the content of the pill core is 40 parts, the content of the first coating layer is 60 parts, and the content of the second coating layer is 10 parts.
The rumen bypass arginine production method of this example was substantially as described in example 4.
Comparative example 5
A rumen bypass arginine which differs from example 1 only in that: the first coating is also coated with a second coating; the second coating is glyceryl monostearate; the weight ratio of the second coating to the first coating was 10.
In the rumen bypass arginine, 110 parts by weight of: the content of the pill core is 40 parts, the content of the first coating is 60 parts, and the content of the second coating is 10 parts.
The rumen bypass arginine production method of this example was substantially as described in example 4.
Experimental example 1 evaluation of rumen-bypass arginine Performance
Rumen degradation rates of rumen-protected arginine prepared in examples 1 to 5 and comparative examples 1 to 4 and rumen-protected arginine which was not coated were measured at 4 culture points of 2, 6, 12 and 24 hours using 5 holstein lactating cows having permanent rumen fistulas as test animals by the rumen nylon bag method, respectively. The results of the measurements on 1 plastic tube (2 nylon bags) per cow per time point are shown in table 1 below. The data in table 1 below are the average of 10 replicates.
The degradation rate is calculated as follows:
degradation rate: (degradation of rumen-bypass arginine at a certain culture time ÷ corrected weight of packaged rumen-bypass arginine) × 100%;
amount of degradation of rumen bypass arginine at a certain time point: correcting the weight of the rumen-bypass arginine in the bag-at a certain culture time point;
correcting the weight of the packaged rumen-bypass arginine: actually bagging rumen bypass arginine with weight x (1-rumen bypass arginine bagging escape rate);
rumen-bypass arginine bagging escape rate (%): [ (weight of rumen bypass arginine in blank test-weight of rumen bypass arginine residue in blank test) ÷ weight of rumen bypass arginine in blank test ] × 100%
The results are shown in Table 1.
TABLE 1 degradation ratio (%) -of rumen-protected arginine by Nylon bag method
Note: the data in the same column are marked with lower case letters (a, b, c, d, e, f, g, h, i, j) to indicate significant difference (p < 0.05), and the same letter or no mark indicates no significant difference (p > 0.05)
The measurement result shows that the untreated arginine is basically degraded, and the degradation rates of the rumen bypass arginine in the rumen of the example 1 are 26.16 percent and 32.78 percent respectively after being cultured for 12 hours and 24 hours, which are obviously better than those of the examples 2-3 and the comparative examples 1-3; the rumen bypass rate of example 4 and example 5 is better than that of example 1, and the rumen bypass rate of example 4 in 12 hours is close to 88%.
In addition, comparative examples 4 and 5, which prepare the second coating by increasing the amount of the binder (paraffin wax, glyceryl monostearate), although the rumen degradation rate of rumen bypass arginine can also be reduced, the difference is not significant compared to examples 4 and 5, and the content of the pellet core is also reduced, so that the effective content of arginine is also reduced accordingly. This is not an optimal solution for practical production. Therefore, the preferred embodiments in practical application are examples 4 and 5.
Although the invention has been described in detail hereinabove with respect to a general description and specific embodiments thereof, it will be apparent to those skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. A rumen bypass arginine comprising:
a core composed of arginine and polyethylene glycol;
a first coating covering the pellet core; wherein the first coating consists of a first binder and an excipient; the first adhesive is glyceryl monostearate or stearic acid, solid paraffin and sodium alginate; the excipient is calcium hydrogen phosphate and calcium phosphate;
a second coating overlying the first coating; wherein the second coating consists of a second binder; the second adhesive is selected from one or more of glyceryl monostearate, stearic acid, solid paraffin and sodium alginate;
the polyethylene glycol is selected from polyethylene glycol 6000 or polyethylene glycol 4000; the weight ratio of arginine to polyethylene glycol in the pill core is (0.5-1.5) to (0.2-0.8); the ratio of the weight of the pill core to the sum of the weight of the first coating and the weight of the second coating is (40-50) to (50-60);
the weight ratio of the sum of the weight of the first binder and the second binder to the weight of the excipient is (37-43) to (18-22);
the weight ratio of the first coating to the second coating is (40-50) to (5-25);
the weight ratio of the first adhesive to the excipient is (19-31) to (18-22);
the first adhesive consists of glyceryl monostearate or stearic acid, solid paraffin and sodium alginate in a weight ratio of (5-10) to (9-11);
the excipient consists of calcium hydrogen phosphate and calcium phosphate in the weight ratio of 9-11 to 9-11.
2. The rumen bypass arginine according to claim 1, wherein the second binder is paraffin wax and/or glycerol monostearate; and/or the presence of a gas in the atmosphere,
the polyethylene glycol is polyethylene glycol 6000; and/or the presence of a gas in the atmosphere,
the weight ratio of arginine to polyethylene glycol in the pill core is 1; and/or the presence of a gas in the atmosphere,
the ratio of the weight of the pellet core to the sum of the weight of the first coating and the second coating is (40), (45) or (50).
3. The rumen bypass arginine according to claim 1 or 2, wherein the weight ratio of the sum of the weight of the first binder and the second binder to the excipient is 40; and/or the presence of a gas in the atmosphere,
the weight ratio of the first coating to the second coating is 45; and/or the presence of a gas in the gas,
the weight ratio of the first binder to the excipient is 25; and/or the presence of a gas in the atmosphere,
the first adhesive consists of glyceryl monostearate or stearic acid, solid paraffin and sodium alginate in a weight ratio of 5; and/or the presence of a gas in the gas,
the excipient consists of calcium hydrogen phosphate and calcium phosphate according to a weight ratio of 10.
4. The ruminal bypass arginine of claims 1 or 2, wherein the ruminal bypass arginine comprises, in weight percent: the content of the pill core is 35-45%; the content of the first coating is 40-50%; the content of the second coating is 5-25%.
5. The ruminal bypass arginine of claim 4, wherein the ruminal bypass arginine comprises, in weight percent: the content of the pill core is 40%; the content of the first coating is 45%; the content of the second coating is 15%; alternatively, the first and second electrodes may be,
the rumen bypass arginine comprises the following components in percentage by weight:
the content of the pill core is 40-45%;
the content of the first coating is 45%; wherein the weight ratio of the first binder to the excipient in the first coating is 25; the first adhesive consists of glyceryl monostearate or stearic acid, solid paraffin and sodium alginate in a weight ratio of 5; the excipient consists of calcium hydrogen phosphate and calcium phosphate according to the weight ratio of 10;
the content of the second coating layer is 15%.
6. The method for preparing rumen bypass arginine according to any one of claims 1 to 5, which comprises:
1) Mixing arginine and polyethylene glycol to prepare solid dispersion as a pill core;
2) Coating a first coating layer on the pellet core; further comprising applying a second coating over the first coating.
7. Use of the ruminal bypass arginine of any one of claims 1-5 or the ruminal bypass arginine prepared by the method of claim 6 in the preparation of animal feed.
8. The use of claim 7, wherein the animal comprises a ruminant.
9. Use according to claim 7, wherein the animal is a cow, sheep, deer, alpaca or antelope.
10. Use according to claim 7, wherein the feed is a cattle feed.
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|---|---|---|---|---|
| CA1331713C (en) * | 1988-12-29 | 1994-08-30 | Hitoshi Iijima | Granular composition for ruminant |
| WO1991011915A1 (en) * | 1990-02-08 | 1991-08-22 | Hinman Dan D | Feed pellet for increasing ruminal microbial activity |
| CN104587482A (en) * | 2015-01-14 | 2015-05-06 | 长春大合生物技术开发有限公司 | Coating material used for rumen by-pass amino acid preparation and rumen by-pass amino acid preparation |
| EP3273793B1 (en) * | 2015-03-25 | 2020-08-19 | Benemilk Oy | Amino acid animal feed composition |
| CN107006691A (en) * | 2017-03-15 | 2017-08-04 | 陕西金冠牧业有限公司 | A kind of cow rumen protects B B-complex coating technique |
| CN109393165A (en) * | 2018-11-28 | 2019-03-01 | 安徽东方天合生物技术有限责任公司 | A kind of novel rumen bypass vitamin E and the preparation method and application thereof |
| CN109393164A (en) * | 2018-11-28 | 2019-03-01 | 安徽东方天合生物技术有限责任公司 | A kind of novel rumen bypass folic acid and the preparation method and application thereof |
| CN109393163A (en) * | 2018-11-28 | 2019-03-01 | 安徽东方天合生物技术有限责任公司 | A kind of novel rumen bypass histidine and the preparation method and application thereof |
| CN109619288A (en) * | 2018-12-11 | 2019-04-16 | 北京东方天合生物技术有限责任公司 | A kind of novel rumen glucose and the preparation method and application thereof |
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