CN109393164A - A kind of novel rumen bypass folic acid and the preparation method and application thereof - Google Patents
A kind of novel rumen bypass folic acid and the preparation method and application thereof Download PDFInfo
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- CN109393164A CN109393164A CN201811437695.4A CN201811437695A CN109393164A CN 109393164 A CN109393164 A CN 109393164A CN 201811437695 A CN201811437695 A CN 201811437695A CN 109393164 A CN109393164 A CN 109393164A
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/174—Vitamins
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Abstract
The present invention relates to a kind of novel rumen bypass folic acid and the preparation method and application thereof.The novel rumen bypass folic acid is made of coating and packet core two parts, and the coating is rumen-undegraded fat powder, and the packet core is the particle being prepared by active constituent folic acid and auxiliary material；The auxiliary material is made of the first auxiliary material and the second auxiliary material, and first auxiliary material is calcium stearate or silica, and second auxiliary material is made of starch, dextrin and sodium carboxymethylcellulose.Rumen bypass folic acid of the present invention is coated with rational technology, and coating is uniformly complete, and rumen bypass effect is ideal, and degradation rate is low；Pasture income is significantly increased in the output of milk that milk cow can be improved.
Description
Technical field
The invention belongs to technical field of animal nutrition, and in particular to a kind of novel rumen bypass folic acid and preparation method thereof with answer
With.
Background technique
Folic acid is as a kind of B family vitamin, and related with animal Cell division in vivo and protein metabolism, milk cow is in new tissue life
It is larger to the requirement of folic acid when being synthesized at, fetus and fetal membrane growth, mammogenesis and lactoprotein, therefore folic acid is often by as B
The reason of family vitamin overriding concern.Although microorganism can synthesize folic acid required for animal in ruminant tumor gastric,
The raising of continuous improvement and cultivation intensive degree recently as dairy bread, the demand to folic acid is also higher, especially
It is high yield cow.Existing numerous studies confirm both at home and abroad, milk cow Supplement of folic acid can be improved the production performance of milk cow.Thus having must
Folic acid is added by external source meet needs, however due to the microbial action of cud, folic acid is directly added in daily ration, a part
Can degrade in cud, can reach small intestine be utilized it is seldom.The effect of addition folic acid is not only not achieved in this way, also will cause
The waste of folic acid.Rumen bypass folic acid, makes it not be degraded in cud, directly reaches small intestine and is absorbed and used.In milk cow day
The folic acid handled through overprotection is added in grain, the production performance of milk cow can be improved, and then improve the economic benefit of Cow product.
The research report of rumen bypass folic acid is less at present, and the present invention provides a kind of rumen-protected folic acid and its preparation thus
Method increases economic benefit to improve the output of milk and production performance.
Summary of the invention
The purpose of the present invention is to provide a kind of novel rumen bypass folic acid and the preparation method and application thereof, the rumen bypass folic acid
Pasture income is significantly increased in the output of milk that milk cow can be improved.The present invention can pass completely through tumor using rumen-undegraded fat powder
Stomach goes directly small intestine, does not influence rumen microorganism activity, will not influence coarse-fibred digestion and metabolism；Pure plant source, palm
Oil content is high；It is not calcium soap, there is good palatability；Even particle size, 100% fat；Without trans-fatty acid.
The research of the invention finds that when auxiliary material selection the first auxiliary material (i.e. calcium stearate or silica) and the second auxiliary material is (i.e.
Starch, dextrin and sodium carboxymethylcellulose), can be preferably rumen-protected to folic acid progress, it is substantially reducing in cud
Degradation rate.Wherein when auxiliary material selects calcium stearate, starch, dextrin and sodium carboxymethylcellulose, the rumen bypass of folic acid is protected
It is more preferable to protect effect.It is demonstrated experimentally that calcium stearate is used to stablize as nuclear particle physicochemical properties made of the first auxiliary material, generate
Dust is few, strong adsorption, easy to form, and more conducively subsequent packet is operated.Based on the studies above, the present invention is specifically proposed.
Specifically, the present invention provides a kind of novel rumen bypass folic acid, it is made of coating and packet core two parts, the coating
For rumen-undegraded fat powder, the active constituent of the packet core is folic acid；The packet core is to be prepared by active constituent folic acid with auxiliary material
The particle arrived；The auxiliary material is made of the first auxiliary material and the second auxiliary material, and first auxiliary material is calcium stearate or silica, institute
The second auxiliary material is stated to be made of starch, dextrin and sodium carboxymethylcellulose.
On the basis of experimental study, the present invention has further determined the ratio of active constituent folic acid and auxiliary material, with
And in auxiliary material each ingredient usage ratio.When the mass ratio of active constituent folic acid and the auxiliary material is (50:50)-(60:40),
Preferably (55:45)-(56:44) when；And/or the first auxiliary material and starch, dextrin, sodium carboxymethylcellulose quality in the auxiliary material
Than for (5.2-5.5): (22-22.5): (16.5-16.8): when (0.18-0.4), for folic acid rumen-protected effect more
It is good.
Specifically, the mass ratio of active constituent folic acid and the auxiliary material can be 50:50,55:45,56:44,55.56:
44.44 or 60:40.
Preferably, the mass ratio of active constituent folic acid and the auxiliary material is 55.56 in the novel rumen bypass folic acid:
44.44；And/or the first auxiliary material and starch, dextrin, sodium carboxymethylcellulose mass ratio are 5.33:22.2 in the auxiliary material:
16.67:0.22。
Further result of study is found, coating folic acid rumen digestibility declines with the raising of the ratio of fatty powder；It is excellent
The mass ratio of selection of land, the packet core and coating is (35:65)-(50:50), preferably (40:60)-(45:55).
Specifically, the mass ratio of the packet core and the coating can be 35:65,38:62,40:60,42:58,45:55 or
50:50。
In a specific embodiment of the invention, the mass ratio of the packet core and the coating can be 45:55.
In a specific embodiment of the invention, the mass ratio of the packet core and the coating can be 40:60.
Further, the rumen-undegraded fat powder is preferably palm oil fatty powder.Using rumen-undegraded fat powder of the present invention
Advantage is can to pass completely through cud and goes directly small intestine, does not influence rumen microorganism activity, will not influence coarse-fibred digestion and
Metabolism；Pure plant source, palm oil content are high；It is not calcium soap, there is good palatability；Even particle size, carrier-free,
100% fat；Without trans-fatty acid.
Specifically, in above-mentioned novel rumen bypass folic acid, the content of folic acid is 24%-26%, and the content of the first auxiliary material is
2.3%-2.5%, the content of starch are 9%-11%, and the content of dextrin is 7%-8%, and the content of sodium carboxymethylcellulose is
0.09%-0.11%；Surplus is rumen-undegraded fat powder.
Preferably, the content of folic acid is that the content of the 25%, first auxiliary material is 2.4% in above-mentioned novel rumen bypass folic acid, form sediment
The content of powder is 10%, and the content of dextrin is 7.5%, and the content of sodium carboxymethylcellulose is 0.1%, and surplus is rumen-undegraded fat
Powder.
Further, rumen bypass folic acid of the present invention is graininess, and the partial size of the particle is 0.90-1.10mm,
Advantage is that partial size is small, good fluidity, is conducive to reduce residence time of the product in cud quickly through cud, reduce loss.
Further, the partial size of the packet core is that 0.40-0.60mm or partial size are less than more than or equal to 0.40mm
0.60mm。
Rumen bypass folic acid of the present invention can be prepared by conventional method in that art.
Preferably to improve rumen-protected effect, the present invention also provides the preparation methods of above-mentioned rumen bypass folic acid, including
Following steps:
1) coated core particle is prepared
Folic acid is uniformly mixed in proportion with the auxiliary material, is modulated with water, dry, it is 0.40- that partial size, which is then made,
The coated core particle of 0.60mm；
Specifically, drying can carry out in fluidized granulation seed-coating machine, and the heating temperature in the drying is 80 DEG C, air inducing frequency
Rate 35Hz, revolving speed 45Hz, drying time are 30 minutes；Obtained particle is sieved after the drying；
2) coating of coated core particle
The rumen-undegraded fat powder is melted, the coated core particle that step 1) obtains is coated with, is obtained rumen-protected
Folic acid.
Specifically, the coating can be carried out with fluidisation granulator coater, and the method for coating includes: by the coated core particle
35 DEG C are heated to, the rumen-undegraded fat powder of fusing is sprayed into coated core particle surface: compressed air temperature 100 under the following conditions
DEG C, wriggling revolution speed 8rpm, air inducing frequency 28Hz, revolving speed 49Hz, air inducing temperature 50 C, 40 DEG C of leaving air temp.
The invention also includes application of the above-mentioned rumen bypass folic acid in terms of preparing ruminant feed or feed addictive.
The raw materials used in the present invention is commercially available to buy, or prepares by conventional method in that art.
On the basis of common knowledge of the art, above-mentioned each optimum condition can be combined with each other each preferably to get the present invention
Example.
Furthermore, it is to be understood that herein, also included in the meaning of terms such as "include", "comprise", " containing " " by ...
Composition ", " by ... constitute ", " by ... it is made " etc..
Rumen bypass folic acid of the present invention is coated with rational technology, and coating is uniformly complete, and rumen bypass effect is ideal, and degradation rate is low；It should
Rumen bypass folic acid has ideal physical aspect, and particle is small, and uniformly, good fluidity is easy to directly use in production.Through pasture
Use prove, rumen bypass folic acid of the present invention is added in dairy cow diet, the output of milk of milk cow can be improved, obtain considerable economy
Benefit.
Specific embodiment
The following examples are used to illustrate the present invention, but are not intended to limit the scope of the present invention..It is not specified in embodiment specific
Technology or conditions person, described technology or conditions according to the literature in the art, or carried out according to product description.It is used
Production firm person is not specified in reagent or instrument, is the conventional products that can be commercially available by regular distributor.
Rumen-undegraded fat powder used below is palm oil fatty powder.
Embodiment 1
A kind of rumen bypass folic acid is made of coating and packet core two parts, and the coating is rumen-undegraded fat powder, the packet core
Active constituent be folic acid；The packet core is the particle being prepared by active constituent folic acid and auxiliary material, and the auxiliary material is tristearin
Sour calcium (the first auxiliary material) and starch, dextrin, sodium carboxymethylcellulose；Active constituent folic acid and the mass ratio of the auxiliary material are
55.56:44.44, calcium stearate in the auxiliary material, starch, dextrin, sodium carboxymethylcellulose mass ratio be 5.33:22.22:
The mass ratio of 16.67:0.22, the packet core and the coating is 45:55.
The present embodiment also provides the preparation method of above-mentioned rumen bypass folic acid, comprising the following steps:
1) folic acid and auxiliary material calcium stearate, starch, dextrin, sodium carboxymethylcellulose are mixed to get mixture in proportion,
In the mixture, the mass content of folic acid is 55.56%, and the mass content of calcium stearate is 5.33%, the mass content of starch
It is 22.22%, the mass content of dextrin is 16.67%, and the mass content of sodium carboxymethylcellulose is 0.22%；It then will with water
The mixture is modulated into the state that can be pelletized, and is prepared into particle with granulator, then with spherical shot-blasting machine ball blast, obtains folic acid
Grain；
Folic acid particle is put into fluidized granulation seed-coating machine and is dried.Equipment heating temperature is 80 DEG C, air inducing frequency
35Hz, revolving speed 45Hz are 30 minutes dry.Then it is sieved respectively with 30 mesh and 40 meshes, collection cut size 0.40-0.60mm
Folic acid coated core particle；
2) by rumen-undegraded fat powder greater than 60 DEG C at a temperature of melt, by step 1) prepare folic acid coated core particle flowing
Change in granulator coater and be coated with using bottom pressure spray process, wherein folic acid coated core particle and rumen-undegraded fat powder mass ratio are 45:
55, obtain rumen bypass folic acid.
It is coated with technological parameter are as follows: folic acid coated core particle is heated to 35 DEG C, 100 DEG C of compressed air temperature, wriggling revolution speed
8rpm, air inducing frequency 28Hz, revolving speed 49Hz, air inducing temperature 50 C are 40 DEG C of leaving air temp, whole by the rumen-undegraded fat powder of fusing
Folic acid coated core particle surface is sprayed to, rumen-protected folic acid is obtained.The rumen-protected folic acid of gained be graininess, particle it is straight
Diameter is 0.90-1.10mm.
Embodiment 2
A kind of rumen bypass folic acid, the difference with embodiment 1 are only that: calcium stearate is replaced with to the silica of equivalent.
Preparation method is referring to embodiment 1.
Embodiment 3
A kind of rumen bypass folic acid, the difference with embodiment 1 are only that: the mass ratio of the packet core and the coating is 40:
60.Preparation method is referring to embodiment 1.
Embodiment 4
A kind of rumen bypass folic acid, the difference with embodiment 1 are only that: calcium stearate is replaced with to the silica of equivalent,
And the packet core and the mass ratio of the coating are 40:60.Preparation method is referring to embodiment 1.
Comparative example 1
A kind of rumen bypass folic acid, the difference with embodiment 1 are only that: preparing auxiliary material used in packet core is only calcium stearate, i.e.,
Packet core is the particle being prepared by active constituent folic acid and calcium stearate, and the content of Bao Hezhong folic acid is 55.56%, and surplus is
Calcium stearate.Preparation method is referring to embodiment 1.
Comparative example 2
A kind of rumen bypass folic acid, the difference with embodiment 1 are only that: preparing auxiliary material used in packet core is only silica, i.e.,
Packet core is the particle being prepared by active constituent folic acid and silica, and the content of Bao Hezhong folic acid is 55.56%, and surplus is
Silica.Preparation method is referring to embodiment 1.
Comparative example 3
A kind of rumen bypass folic acid, the difference with embodiment 1 are only that: packet core is to be prepared by active constituent folic acid with auxiliary material
The particle arrived, the content of Bao Hezhong folic acid are 55.56%, and surplus is auxiliary material, prepares auxiliary material used in packet core by calcium stearate and shallow lake
Powder composition, the two mass ratio are 5.33:22.22.Preparation method is referring to embodiment 1.
Comparative example 4
A kind of rumen bypass folic acid, the difference with embodiment 1 are only that: packet core is to be prepared by active constituent folic acid with auxiliary material
The particle arrived, the content of Bao Hezhong folic acid are 55.56%, and surplus is auxiliary material, prepares auxiliary material used in packet core by starch and dextrin group
At the two mass ratio is 22.22:16.67.Preparation method is referring to embodiment 1.
Comparative example 5
A kind of rumen bypass folic acid, the difference with embodiment 1 are only that: preparing auxiliary material used in packet core is only carboxymethyl cellulose
Sodium, i.e. packet core are the particles being prepared by active constituent folic acid and sodium carboxymethylcellulose, and the content of Bao Hezhong folic acid is
55.56%, surplus is sodium carboxymethylcellulose.Preparation method is referring to embodiment 1.
The assessment of performance of 1 rumen bypass folic acid of experimental example
Using 10 He Sitan lactating cows equipped with permanence lymphoma stomach fistulization pipe as experimental animal, using Rumen Nylon Bag point
Not Ce Ding 1-4 of the embodiment of the present invention and comparative example 1-5 preparation rumen bypass folic acid and be not coated the rumen bypass folic acid of processing and exist
0, the rumen digestibility of 2,6,12,24 hours 5 training center.Wherein 0 hour sample does not put cow rumen into as blank test
Middle degradation, sample puts cud into and degrades in remaining period.Sample sack taking-up is cleaned up after Rumen, is surveyed
Determine the content of sample in each Nylon Bag and calculates its degradation rate.
The calculation method of degradation rate is as follows:
Degradation rate: (weight of the degradation amount ÷ correction pack folic acid of certain incubation time point folic acid) × 100%；
The degradation amount at folic acid time point: the weight of certain incubation time point folic acid of the weight-of correction pack folic acid；
Correct the weight of bag folic acid: practical pack folic acid weight × (1- folic acid packs escapement ratio)；Folic acid packs escapement ratio
(%): [weight of folic acid in (weight of folic acid residue in weight-blank test of folic acid in blank test) ÷ blank test
Amount] × 100%
Measurement result is shown in Table 1.Data in table 1 are the average value of 5 repetition tests.
The degradation rate (%) of folic acid in the rumen bypass folic acid of 1 Nylon Bag of table measurement
Note: significant difference (p < 0.05) is indicated with column data shoulder mark lowercase (a, b, c, d, e, f, g, h, i), contains phase
With letter or not mark expression not significant (p > 0.05).
Measurement result shows that the 12 hours degradation rates of folic acid for not being coated processing are 93.62%, and degradation rate is within 24 hours
97.03%.1 rumen bypass folic acid of embodiment cultivated in cud 12 hours, 24 hours degradation rates be respectively 7.61% and
11.69%, it is significantly better than embodiment 2,4 and comparative example 1-5；3 rumen bypass folic acid of embodiment stopped in cud 12 hours, it is 24 small
When degradation rate be respectively 6.75% and 11.42%, be significantly better than embodiment 2,4 and comparative example 1-5.The result shows that stearic acid
The degradation rate of folic acid can be significantly reduced in the auxiliary material of calcium or silica and sodium carboxymethylcellulose, starch, dextrin composition, preferably
Ground meet demand, it is especially best with auxiliary material effect that calcium stearate and sodium carboxymethylcellulose, starch, dextrin form.
This test finds that 3 degradation rate of embodiment will be lower than embodiment 1, illustrates to be coated with folic acid rumen digestibility with fatty powder
The raising of ratio and decline；However, the content of the effective component folic acid in product can gradually drop with the increase of fatty powder dosage
It is low.In terms of test result, since 1 degradation rate of embodiment and 3 difference of embodiment is not significant, based on raising effective component folate content
The preferable example 1 group formula of purpose.
Influence of the 2 rumen bypass folic acid of experimental example to cow in milk production performance
1 materials and methods
Selection, grouping and the management of 1.1 test milk cows
Choosing average lactating time is 100d, the age, parity, body condition, holstein cow 48 similar in the output of milk, at random
It is divided into 4 groups, every group 12, I, II, III group every addition 30mg, 40mg, 50mg embodiment 1 daily in basal diet respectively
The rumen bypass folic acid of preparation；IV group is control group, feeds basal diet.It tests milk cow list slot to raise, early, middle and late 3 feedings, 3
Secondary milking, rumen bypass folic acid are mixed in fine fodder, experimental period 30d.
1.2 test material
Test material is rumen bypass folic acid prepared by embodiment 1.
1.3 detection project
1.3.1 the measurement of the output of milk and milk composition
The output of milk is recorded daily and passes through automatic milk collection equipment according to early, middle and late 4:3:3 ratio and collects cow's milk 50ml, is used
In the detection and analysis of milk component, detected using Milkoscan analysis of milk composition instrument.
1.4 data processing
Data analysis is carried out using SPSS22.0 software ANOVN (one-way analysis of variance), test data is with average
± standard deviationIt indicates.
2 results and analysis
Influence of the 2.1 rumen bypass folic acid to lactating cow production performance
Influence of the 2 rumen bypass folic acid of table to lactating cow production performance
Note: colleague's data shoulder mark difference lowercase letter indication difference is significant (p < 0.05), does not mark containing same letter or table
Show not significant (p > 0.05).
As shown in Table 2, difference is not significant between butterfat percnetage, lactose each group；Average daily milk production: test I group, II group, III
Group improves 7.4%, 7.8%, 8.4% than control group IV respectively, test I group, II group, III group and control group IV significant difference
(p < 0.05)；Protein ratio: test I group, II group, III group improve 8.7%, 9.3%, 10.6% than control group, test I
Group, II group, III group and control group IV significant difference (p < 0.05).
3 conclusions
By adding the rumen bypass folic acid of various dose in dairy cow diet, the output of milk and lactoprotein of milk cow can be improved
Pasture economic benefit is significantly increased in rate.In this trial, difference is not significant between test group I, II, III.In view of economy
Cost, every cow head adds 30mg rumen bypass folic acid daily in basal diet to meet the requirements.
Although above the present invention is described in detail with a general description of the specific embodiments,
On the basis of the present invention, it can be made some modifications or improvements, this will be apparent to those skilled in the art.Cause
This, these modifications or improvements, fall within the scope of the claimed invention without departing from theon the basis of the spirit of the present invention.
Claims (10)
1. a kind of novel rumen bypass folic acid, which is characterized in that be made of coating and packet core two parts, the coating is rumen bypass rouge
Fat powder, the packet core are the particles being prepared by active constituent folic acid and auxiliary material；The auxiliary material is auxiliary by the first auxiliary material and second
Material composition, first auxiliary material are calcium stearate or silica, and second auxiliary material is by starch, dextrin and carboxymethyl cellulose
Sodium composition.
2. rumen bypass folic acid according to claim 1, which is characterized in that the mass ratio of active constituent folic acid and the auxiliary material
Example is (50:50)-(60:40)；And/or the first auxiliary material with starch, dextrin, sodium carboxymethylcellulose mass ratio is in the auxiliary material
(5.2-5.5):(22-22.5):(16.5-16.8):(0.18-0.4)；
Preferably, the mass ratio of active constituent folic acid and the auxiliary material is (55:45)-(56:44).
3. rumen bypass folic acid according to claim 1, which is characterized in that the mass ratio of active constituent folic acid and the auxiliary material
Example is 55.56:44.44；And/or the first auxiliary material with starch, dextrin, sodium carboxymethylcellulose mass ratio is in the auxiliary material
5.33:22.2:16.67:0.22。
4. rumen bypass folic acid according to claim 1-3, which is characterized in that the mass ratio of the packet core and coating
For (35:65)-(50:50), preferably (40:60)-(45:55).
5. rumen bypass folic acid according to claim 1-4, which is characterized in that the rumen-undegraded fat powder is preferably
Palm oil fatty powder.
6. rumen bypass folic acid according to claim 1-5, which is characterized in that the rumen bypass folic acid is particle
Shape, partial size 0.90-1.10mm；And/or the partial size of the packet core is 0.40-0.60mm or partial size is more than or equal to 0.40mm
Less than 0.60mm.
7. rumen bypass folic acid according to claim 1-6, which is characterized in that in the rumen bypass folic acid, folic acid
Content be 24%-26%, the content of the first auxiliary material is 2.3%-2.5%, and the content of starch is 9%-11%, the content of dextrin
For 7%-8%, the content of sodium carboxymethylcellulose is 0.09%-0.11%；Surplus is rumen-undegraded fat powder.
8. rumen bypass folic acid according to claim 7, which is characterized in that in the rumen bypass folic acid, the content of folic acid is
25%, the content of the first auxiliary material is 2.4%, and the content of starch is 10%, and the content of dextrin is 7.5%, sodium carboxymethylcellulose
Content be 0.1%, surplus be rumen-undegraded fat powder.
9. the preparation method of any one of the claim 1-8 rumen bypass folic acid, which comprises the steps of:
1) coated core particle is prepared
Folic acid is uniformly mixed in proportion with the auxiliary material, is modulated with water, dry, it is 0.40- that partial size, which is then made,
The coated core particle of 0.60mm；
2) coating of coated core particle
The rumen-undegraded fat powder is melted, the coated core particle that step 1) obtains is coated with, rumen-protected folic acid is obtained.
10. any one of the claim 1-8 rumen bypass folic acid or the rumen bypass folic acid of claim 9 the method preparation are being made
Application in terms of standby ruminant feed or feed addictive.
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| WO2021013271A1 (en) * | 2019-07-25 | 2021-01-28 | 中国农业大学 | Use of rumen bypass melatonin in improving ruminal microflora structure of ruminants and improving milk quality |
| CN110447778B (en) * | 2019-07-25 | 2022-02-15 | 中国农业大学 | Application of rumen-bypass melatonin in improving rumen microbial flora structure and improving milk quality of ruminants |
| CN111165663A (en) * | 2020-01-10 | 2020-05-19 | 安徽东方天合生物技术有限责任公司 | Rumen-bypass arginine and preparation method and application thereof |
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