CN111150683B - A cream containing taxifolin for moistening, activating and solidifying skin, and its preparation method - Google Patents
A cream containing taxifolin for moistening, activating and solidifying skin, and its preparation method Download PDFInfo
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- CN111150683B CN111150683B CN202010062962.5A CN202010062962A CN111150683B CN 111150683 B CN111150683 B CN 111150683B CN 202010062962 A CN202010062962 A CN 202010062962A CN 111150683 B CN111150683 B CN 111150683B
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- 239000006071 cream Substances 0.000 title claims abstract description 46
- CXQWRCVTCMQVQX-LSDHHAIUSA-N (+)-taxifolin Chemical compound C1([C@@H]2[C@H](C(C3=C(O)C=C(O)C=C3O2)=O)O)=CC=C(O)C(O)=C1 CXQWRCVTCMQVQX-LSDHHAIUSA-N 0.000 title claims abstract description 35
- KQNGHARGJDXHKF-UHFFFAOYSA-N dihydrotamarixetin Natural products C1=C(O)C(OC)=CC=C1C1C(O)C(=O)C2=C(O)C=C(O)C=C2O1 KQNGHARGJDXHKF-UHFFFAOYSA-N 0.000 title claims abstract description 15
- 230000003213 activating effect Effects 0.000 title claims abstract description 10
- 238000002360 preparation method Methods 0.000 title claims abstract description 8
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 117
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 59
- 235000011187 glycerol Nutrition 0.000 claims abstract description 46
- 241000220317 Rosa Species 0.000 claims abstract description 26
- 241000196324 Embryophyta Species 0.000 claims abstract description 22
- 239000012153 distilled water Substances 0.000 claims abstract description 20
- 235000008124 Picea excelsa Nutrition 0.000 claims abstract description 17
- 239000002023 wood Substances 0.000 claims abstract description 15
- TXFPEBPIARQUIG-UHFFFAOYSA-N 4'-hydroxyacetophenone Chemical compound CC(=O)C1=CC=C(O)C=C1 TXFPEBPIARQUIG-UHFFFAOYSA-N 0.000 claims abstract description 14
- 240000007817 Olea europaea Species 0.000 claims abstract description 14
- 229940049964 oleate Drugs 0.000 claims abstract description 14
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 claims abstract description 14
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims abstract description 14
- -1 polydimethylsiloxane Polymers 0.000 claims abstract description 8
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 claims abstract description 7
- IIZPXYDJLKNOIY-JXPKJXOSSA-N 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine Chemical class CCCCCCCCCCCCCCCC(=O)OC[C@H](COP([O-])(=O)OCC[N+](C)(C)C)OC(=O)CCC\C=C/C\C=C/C\C=C/C\C=C/CCCCC IIZPXYDJLKNOIY-JXPKJXOSSA-N 0.000 claims abstract description 7
- 241000221095 Simmondsia Species 0.000 claims abstract description 7
- 235000004433 Simmondsia californica Nutrition 0.000 claims abstract description 7
- 229920002385 Sodium hyaluronate Polymers 0.000 claims abstract description 7
- 239000004205 dimethyl polysiloxane Substances 0.000 claims abstract description 7
- ACCCMOQWYVYDOT-UHFFFAOYSA-N hexane-1,1-diol Chemical compound CCCCCC(O)O ACCCMOQWYVYDOT-UHFFFAOYSA-N 0.000 claims abstract description 7
- JXTPJDDICSTXJX-UHFFFAOYSA-N n-Triacontane Natural products CCCCCCCCCCCCCCCCCCCCCCCCCCCCCC JXTPJDDICSTXJX-UHFFFAOYSA-N 0.000 claims abstract description 7
- 229920000435 poly(dimethylsiloxane) Polymers 0.000 claims abstract description 7
- 229940010747 sodium hyaluronate Drugs 0.000 claims abstract description 7
- YWIVKILSMZOHHF-QJZPQSOGSA-N sodium;(2s,3s,4s,5r,6r)-6-[(2s,3r,4r,5s,6r)-3-acetamido-2-[(2s,3s,4r,5r,6r)-6-[(2r,3r,4r,5s,6r)-3-acetamido-2,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-2-carboxy-4,5-dihydroxyoxan-3-yl]oxy-5-hydroxy-6-(hydroxymethyl)oxan-4-yl]oxy-3,4,5-trihydroxyoxane-2- Chemical compound [Na+].CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 YWIVKILSMZOHHF-QJZPQSOGSA-N 0.000 claims abstract description 7
- 229940032094 squalane Drugs 0.000 claims abstract description 7
- 235000015112 vegetable and seed oil Nutrition 0.000 claims abstract description 7
- 230000001112 coagulating effect Effects 0.000 claims abstract description 6
- 238000010438 heat treatment Methods 0.000 claims description 30
- 238000004821 distillation Methods 0.000 claims description 25
- 239000000203 mixture Substances 0.000 claims description 24
- 238000002156 mixing Methods 0.000 claims description 22
- 238000001914 filtration Methods 0.000 claims description 16
- 244000193463 Picea excelsa Species 0.000 claims description 15
- 239000000706 filtrate Substances 0.000 claims description 14
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 12
- 235000010254 Jasminum officinale Nutrition 0.000 claims description 11
- 230000002829 reductive effect Effects 0.000 claims description 11
- 238000007599 discharging Methods 0.000 claims description 10
- 239000000047 product Substances 0.000 claims description 10
- 241000628997 Flos Species 0.000 claims description 8
- 230000003020 moisturizing effect Effects 0.000 claims description 7
- 238000010992 reflux Methods 0.000 claims description 6
- 238000003756 stirring Methods 0.000 claims description 6
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 238000010025 steaming Methods 0.000 claims description 5
- 241000109329 Rosa xanthina Species 0.000 claims description 4
- 235000004789 Rosa xanthina Nutrition 0.000 claims description 4
- 238000001816 cooling Methods 0.000 claims description 3
- 238000004042 decolorization Methods 0.000 claims description 3
- 240000005385 Jasminum sambac Species 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 230000000694 effects Effects 0.000 abstract description 9
- 229940095133 larix sibirica wood extract Drugs 0.000 abstract description 3
- 230000007774 longterm Effects 0.000 abstract description 3
- 241000896100 Larix sibirica Species 0.000 abstract 2
- 231100000241 scar Toxicity 0.000 description 15
- 239000003205 fragrance Substances 0.000 description 13
- 210000000245 forearm Anatomy 0.000 description 12
- 238000012360 testing method Methods 0.000 description 11
- 241000207840 Jasminum Species 0.000 description 10
- 230000000052 comparative effect Effects 0.000 description 9
- 208000032544 Cicatrix Diseases 0.000 description 7
- 230000037387 scars Effects 0.000 description 7
- 238000011081 inoculation Methods 0.000 description 6
- XCGZWJIXHMSSQC-UHFFFAOYSA-N dihydroquercetin Natural products OC1=CC2OC(=C(O)C(=O)C2C(O)=C1)c1ccc(O)c(O)c1 XCGZWJIXHMSSQC-UHFFFAOYSA-N 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 239000002537 cosmetic Substances 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 3
- 206010020751 Hypersensitivity Diseases 0.000 description 3
- 230000001276 controlling effect Effects 0.000 description 3
- 230000003203 everyday effect Effects 0.000 description 3
- 229930003939 flavanonol Natural products 0.000 description 3
- 230000007794 irritation Effects 0.000 description 3
- 239000000463 material Substances 0.000 description 3
- 238000001556 precipitation Methods 0.000 description 3
- YEDFEBOUHSBQBT-UHFFFAOYSA-N 2,3-dihydroflavon-3-ol Chemical compound O1C2=CC=CC=C2C(=O)C(O)C1C1=CC=CC=C1 YEDFEBOUHSBQBT-UHFFFAOYSA-N 0.000 description 2
- XUMBMVFBXHLACL-UHFFFAOYSA-N Melanin Chemical compound O=C1C(=O)C(C2=CNC3=C(C(C(=O)C4=C32)=O)C)=C2C4=CNC2=C1C XUMBMVFBXHLACL-UHFFFAOYSA-N 0.000 description 2
- 206010039580 Scar Diseases 0.000 description 2
- 208000026935 allergic disease Diseases 0.000 description 2
- 230000007815 allergy Effects 0.000 description 2
- 239000003963 antioxidant agent Substances 0.000 description 2
- 230000003078 antioxidant effect Effects 0.000 description 2
- 238000011156 evaluation Methods 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 238000005259 measurement Methods 0.000 description 2
- 230000000813 microbial effect Effects 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- 230000000717 retained effect Effects 0.000 description 2
- 230000035807 sensation Effects 0.000 description 2
- 230000001953 sensory effect Effects 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 230000009967 tasteless effect Effects 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 241000228245 Aspergillus niger Species 0.000 description 1
- 206010013786 Dry skin Diseases 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000003251 Pruritus Diseases 0.000 description 1
- 240000004808 Saccharomyces cerevisiae Species 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 244000269722 Thea sinensis Species 0.000 description 1
- 102000003425 Tyrosinase Human genes 0.000 description 1
- 108060008724 Tyrosinase Proteins 0.000 description 1
- 208000030961 allergic reaction Diseases 0.000 description 1
- 230000003385 bacteriostatic effect Effects 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 238000009835 boiling Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000000994 depressogenic effect Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 230000037336 dry skin Effects 0.000 description 1
- 230000029142 excretion Effects 0.000 description 1
- 230000001815 facial effect Effects 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 230000014759 maintenance of location Effects 0.000 description 1
- 229930014626 natural product Natural products 0.000 description 1
- 230000009965 odorless effect Effects 0.000 description 1
- 230000008058 pain sensation Effects 0.000 description 1
- 239000003755 preservative agent Substances 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 230000008439 repair process Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 210000004243 sweat Anatomy 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9767—Pinaceae [Pine family], e.g. pine or cedar
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/31—Hydrocarbons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4973—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
- A61K8/498—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/553—Phospholipids, e.g. lecithin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/89—Polysiloxanes
- A61K8/891—Polysiloxanes saturated, e.g. dimethicone, phenyl trimethicone, C24-C28 methicone or stearyl dimethicone
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/005—Preparations for sensitive skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
- A61K2800/805—Corresponding aspects not provided for by any of codes A61K2800/81 - A61K2800/95
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- Dermatology (AREA)
- Emergency Medicine (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Cosmetics (AREA)
Abstract
The invention belongs to the field of skin care products, and particularly relates to a cream containing taxifolin for moistening, activating and coagulating and a preparation method thereof, wherein the cream comprises, by weight percent, 4-4.2 parts of glycerin, 0.27-0.29 part of Siberian larch (LARIX SIBIRICA) WOOD EXTRACT (LARIX SIBIRICA WOOD EXTRACT); 1.8-2 parts of glycerin extract of plant flowers, 0.28-0.32 part of p-hydroxyacetophenone and 0.28-0.32 part of hexanediol; 5.4-5.6 parts of jojoba seed oil, 4.9-5.1 parts of squalane, 3.4-3.6 parts of cetearyl olive oleate, 1.4-1.6 parts of sorbitan olive oleate, 1.0 part of polydimethylsiloxane and 2.1-2.3 parts of hydrogenated lecithin; 4.9 to 5.1 parts of glycerin extract of plant flowers and 0.28 to 0.32 part of sodium hyaluronate; the balance is made up by rose distilled water. The face cream containing the taxifolin has the effects of continuously locking water and keeping moisture for the skin, can brighten the skin color and improve the complexion, and can improve the skin quality after long-term use.
Description
Technical Field
The invention belongs to the field of skin care products, and particularly relates to a taxifolin-containing cream for moisturizing, activating and coagulating and a preparation method thereof.
Background
With the improvement of civilization of society and the continuous improvement of living standard and quality of people, people pay more attention to the quality and safety of cosmetic raw materials, and expect to use green natural raw materials which have skin-care and beauty-care effects and are harmless to human health. The material used for cosmetics is characterized by good stability and no allergic reaction to human skin. The main development trend of cosmetics in all countries in the world is to advocate nature and strive to use natural plant raw materials in the cosmetics. However, the face cream in the prior art can not keep moisture for a long time, and causes damage to skin after long-term use.
Disclosure of Invention
The invention provides a preparation method of a face cream containing taxifolin for moistening, activating and coagulating.
The purpose of the invention is realized by the following technical scheme:
a preparation method of a face cream containing taxifolin for moistening, activating and coagulating comprises the following components in percentage by weight,
A. 4-4.2 wt% of glycerin, and 0.27-0.29wt% of Siberian larch wood extract;
B. 1.8-2 wt% of glycerin extract of plant flowers, 0.28-0.32wt% of p-hydroxyacetophenone and 0.28-0.32wt% of hexanediol;
C. 5.4-5.6 wt% of jojoba seed oil, 4.9-5.1 wt% of squalane, 3.4-3.6 wt% of cetearyl olive oleate, 1.4-1.6 wt% of sorbitan olive oleate, 1.0 wt% of polydimethylsiloxane and 2.1-2.3 wt% of hydrogenated lecithin;
D. 4.9-5.1 wt% of plant flower glycerin extract and 0.28-0.32wt% of sodium hyaluronate;
E. the balance of the distilled water of the plant flowers is made up, so that the total content of all the components A + B + C + D + E of the face cream is 100.0 wt%;
the production process comprises the following steps:
1) mixing fresh plant flowers with water 4-5 times of the fresh plant flowers, adding the mixture into a distillation pot, heating the distillation pot to boil the water, distilling the water vapor, discharging the water vapor through a condenser, controlling the reflux amount of the water vapor, and steaming the water added into the distillation pot within 15-20 minutes to obtain the plant flower distilled water, wherein the volume of the added water is 80% -90%;
heating the remainder in the distillation pot at 80-90 deg.C for 5-10 min, adding glycerol 0.8-1.2 times of the weight of fresh plant flower into the distillation pot, heating at 90-110 deg.C for 20-30 min, filtering to collect glycerol filtrate, adding activated carbon 1/5-1/6 volume of the glycerol filtrate for decolorizing, and filtering to collect glycerol extract of plant flower;
2) uniformly mixing the components of the phase A; heating to 50-55 deg.C, and standing for 5-8 min;
3) at normal temperature, uniformly mixing all the components of the phase B;
4) mixing the phase D and the phase E, and heating to 72-75 ℃;
5) mixing the phase C and heating to 68-70 ℃;
6) adding the mixture of the phase D and the phase E into the phase C under stirring (40-60rpm), homogenizing in a homogenizer (3000-3500rpm) for 10-15 minutes, and then cooling;
7) when the temperature is reduced to 42-45 ℃, respectively adding the phase A and the phase B, and homogenizing in a homogenizer again (1800-2000rpm) for 2-5 minutes;
8) when the temperature is reduced to 25-35 ℃, filtering and discharging to obtain the finished product.
The plant flower is flos Rosae Rugosae or flos Jasmini sambac.
EXTRACT of Larix sibirica (Larixsibiica) wood (Larixsibiicawood EXTRACT); the composition contains dihydroquercetin (dihydroquercetin), also called taxifolin (taxifolin), and has a chemical name: 5,7,3, 4-tetrahydroxy flavanonol is a natural flavanonol compound and a natural strong antioxidant; the dihydroquercetin can inhibit tyrosinase, thereby inhibiting melanin precipitation in skin; the dihydroquercetin can be used as flavanonol substance, and can effectively absorb ultraviolet rays in the atmosphere; dihydroquercetin has strong antioxidant capacity, is derived from natural products, and has no toxic or side effect;
the invention has the following advantages:
1. essence is not adopted, pure natural plant flowers are used as raw materials, and water-soluble fragrance components in the flowers are extracted, so that the fragrance is elegant, fresh and natural, is not strong and non-irritant, and is more acceptable to people;
2. the components of the invention contain Siberian larch wood extract and glycerin extract in flowers, and the combination of the components can further repair the damage on the skin and simultaneously has the functions of moisturizing, diminishing inflammation, resisting allergy and the like on the skin.
3. Can soften and smooth dry skin, and has moisture regulating effect.
4. At room temperature, the stability is good, and no water is separated out. Has no sticky feeling and does not influence sweat excretion. Pleasant fragrance, white color, and no irritation or allergy to human skin.
Detailed Description
Example 1
The rose fragrance type cream containing taxifolin for moistening, activating and coagulating,
1. the components and the compositions of the formula are calculated according to the weight percentage,
A. glycerin 4 wt%, Siberian larch (larixsbirica) wood extract (LARIX sibirica wood extract)0.28 wt%;
B. 2wt% of rose glycerin extract, 0.3wt% of p-hydroxyacetophenone and 0.3wt% of hexanediol;
C. 5.5 wt% of jojoba seed oil, 5.0 wt% of squalane, 3.5 wt% of cetearyl olive oleate, 1.5 wt% of sorbitan olive oleate, 1.0 wt% of polydimethylsiloxane, and 2.2 wt% of hydrogenated lecithin;
D. 5 wt% of rose glycerin extract and 0.3wt% of sodium hyaluronate;
E. adding rose distilled water to make up the balance, so that the total content of all components A + B + C + D + E of the face cream is 100.0 wt%;
2. the production process comprises the following steps:
1) mixing fresh roses and water which is 5 times of the weight of the fresh roses, adding the mixture into a distillation pot, heating the distillation pot to boil the water, distilling the distilled water, discharging the water vapor through a condenser, controlling the reflux amount of the water vapor, and steaming the water added into the distillation pot within 15 minutes to obtain the rose distilled water, wherein the volume of the added water is 85 percent; the rose tea is colorless and transparent, and has rose fragrance of rose distilled water;
heating the residue in the distillation pot at 80 deg.C for 10 min (to reduce the strong fragrance of flos Rosae Rugosae in the product after subsequent treatment), adding glycerol with the same weight as fresh flos Rosae Rugosae into the distillation pot, heating at 100 deg.C for 20 min, filtering to collect glycerol filtrate, adding activated carbon 1/6 volume of the glycerol filtrate, decolorizing, filtering to collect glycerol extractive solution of flos Rosae Rugosae; the rose glycerin extract is tasteless, colorless and transparent;
2) uniformly mixing the components of the phase A; heating to 50 deg.C, standing for 5 min, heating to remove bitter and astringent odor of Siberian larch wood extract with glycerol, and making the mixture bright, uniform and semitransparent;
3) at normal temperature, uniformly mixing all the components of the phase B;
4) mix phase D and phase E and heat to 75 ℃.
5) Mix phase C and heat to 70 ℃.
6) The mixture of phases D and E was added to phase C with stirring (60rpm), homogenized in a homogenizer (3000rpm) for 10 minutes, and then cooled.
7) When the temperature had dropped to 45 deg.C, phase A and phase B were added separately and homogenized again in the homogenizer (2000rpm) for 2 minutes.
8) When the temperature is reduced to 35 ℃, filtering and discharging to obtain the finished product.
After the finished product is stored for 6 months at room temperature, no water is separated out and no quality is changed.
The cream of example 1 retained most of the rose components beneficial to human skin, had the strong pungent aroma removed by water distillation and heating to remove the open air, and retained a mild part of the floral fragrance.
Comparative example 1
Mixing 1Kg of fresh rose with 5Kg of water and 1Kg of glycerin, adding into a distillation pot, heating, boiling, refluxing for 30 min, filtering, collecting filtrate, and adding 1/6 volume of activated carbon into the filtrate for decolorization; the decolorized filtrate has strong rose fragrance and irritation, and is light red transparent liquid.
Putting 10mL of the rose distilled water prepared in the example 1 into an open bottle, placing the bottle indoors, and smelling light rose fragrance at a position 1-2 meters away from the open bottle after 2 minutes without stimulation, wherein the rose distilled water cannot smell flower fragrance after exceeding 3 meters;
then 10mL of the filtrate prepared in the comparative example is put in an open bottle and placed in the same indoor environment, and after 2 minutes, strong rose fragrance with irritation can be smelled at a position 6-8 meters away from the open bottle.
Comparative example 2
1. The formula comprises, by weight, 11 wt% of glycerol, 0.28 wt% of Siberian larch wood extract, 0.3wt% of p-hydroxyacetophenone, 0.3wt% of hexanediol, 5.5 wt% of jojoba seed oil, 5.0 wt% of squalane, 3.5 wt% of cetearyl olive oleate, 1.5 wt% of sorbitan olive oleate, 1.0 wt% of polydimethylsiloxane, 2.2 wt% of hydrogenated lecithin and 0.3wt% of sodium hyaluronate;
adding distilled water to make up the balance, so that the total content of all the components of the face cream is 100.0 wt%; stirring to mix all the materials evenly to obtain the product. Slightly bitter, yellowish, translucent, viscous liquid.
Comparative example 3
The difference from example 1 is that the extract of Siberian larch (larixabercica) wood (larixabercica) is not contained, and the deficiency amount of the extract of Siberian larch (larixabercica) wood (larixabensica woodextrect) is complemented by rose distilled water; the remaining materials and contents were the same as in example 1.
And (3) performance measurement:
1) example 1 cream moisturizing test: female 10 persons of a healthy age between 25 and 35 years were selected and tested on the cream of example 1.
The test method comprises the following steps: the test environment temperature is room temperature, the relative humidity is 60-70%, and the right forearm of the detected person is cleaned and wiped dry before the measurement; 2 adjacent parallel rectangular areas of 6CM multiplied by 3CM are drawn on the right forearm at intervals of 1CM and are used as a test area and a comparison area for coating the face cream, after the test area is coated and lightly massaged according to the dosage of 0.05g/CM2, a CM825 skin moisture tester (CK company, Germany) is used for measuring the skin moisture content of the test area and the comparison area after 10 hours, three parts are taken in each area, the average value is taken as a test value, the test value of the comparison area is recorded as A0, the test value of the test area is recorded as A1, and the calculation is carried out: the skin moisture increase amount was [ (a1-a0)/a0] × 100%, and the moisture retention of the product was evaluated.
The skin moisture increment of 10 persons is 68%, 72%, 74.7%, 74.8%, 75.1%, 75.3%, 76%, 76.2%, 77% and 77.4% respectively;
the average increase in skin moisture was 74.65% in 10 persons.
Meanwhile, the right forearm of 10 persons is washed and wiped dry after getting up every day according to the dosage of 0.05g/cm2, and is coated with the face cream once, and after continuously carrying out the washing and wiping operation for 20 days, the right forearm is compared with the left forearm which is not coated with the face cream, so that the right forearm of each person is found to be ruddy, white, smooth, less in dark spots and smaller in area relative to the color of the left forearm.
Meanwhile, 10 persons carry out sensory evaluation on the application effect, testers carry out sensory evaluation according to own feelings, and the score is divided into 10 points, wherein 1 point is the worst, and 10 points are the best. The mildness is averagely 9.71, the water-moist feeling is averagely 9.48, the comfort is averagely 9.63, and the smooth feeling is averagely 9.80; after the composition is used, no heat sensation, no pruritus sensation and no stabbing pain sensation are caused.
The facial cream disclosed by the embodiment 1 of the invention has the effects of continuously locking water and moisturizing the skin, can brighten the skin color and improve the complexion, and can improve the skin quality after long-term use.
2) Comparative example 3 cream moisturizing test: female 10 healthy people between 25-35 years of age were selected and tested on comparative 3 cream. The test procedure was as above, and the average of the skin moisture increment of 10 persons was 62.11%.
Meanwhile, the right forearm of 10 persons gets up every day continuously according to the dosage of 0.05g/cm2, is washed and wiped dry and is smeared with the face cream once, and after continuously going on for 30 days, the right forearm is compared with the left forearm which is not smeared with the face cream, so that the skin color of the right forearm of each person is more ruddy relative to that of the left forearm, the white and clean smoothness degree is slightly increased, and the dark spot is slightly reduced; the effect of removing roughness and dark spots is slightly lower than the application effect of the cream in example 1, and the effect of locking water and moisturizing is not much different from the application effect of the cream in example 1.
3) Stability:
example 1 the cream was observed after 3 months at 40 ℃, 25 ℃ and-25 ℃ respectively: the three groups of face creams are not layered and separated out, the smell is unchanged, and the liquid is semitransparent viscous liquid.
Comparative example 2 the cream was observed after 3 months at 40 ℃, 25 ℃ and-25 ℃ respectively: the cream surface of the cream of the 40 ℃ group has a light yellow slightly dry thin layer without precipitation, and the cream surface of the cream of the 25 ℃ and-25 ℃ group has light yellow, is not layered, has no precipitation, is odorless and is light yellow semitransparent viscous liquid.
4) The microbial preservative efficacy of the cream of example 1 was tested with the following results:
aspergillus niger: example 1 the number of viable bacteria was measured at 5.8 x 103cfu/mL on day 2 after the cream inoculation, and the number of viable bacteria was measured at less than 8cfu/mL on days 7, 15 and 30 after the inoculation; yeast: example 1 the number of viable bacteria was measured at 7.6 x 103cfu/mL on day 2 after the cream inoculation, and less than 9cfu/mL on days 7, 15 and 30 after the inoculation;
coli: example 1 viable count was determined to be less than 10cfu/mL on days 7, 15, and 30 after cream inoculation;
staphylococcus aureus: example 1 viable count was determined to be less than 10cfu/mL on days 2, 7, 15, and 30 after cream inoculation;
the detection result shows that the cream in the embodiment 1 has the microbial preservative effect and the bacteriostatic effect is good because the rose distilled water and the rose glycerin extract are added.
5) Repairing acne scars: 20 healthy men with acne scars on their faces and between 28 and 35 years of age were selected and divided into two groups and tested on the creams of example 1 and comparative example 3, respectively. Clinical contrast tests of depressed scars are all observed for 8 months in clinic, each sample is used twice a day, the sample is lightly smeared on the surface of the scar in the morning and at the evening every day, and 0.05g of each sample is evenly smeared on the surface of the scar per square centimeter every time.
Example 1 group: the average depth (cm) of the scar before use is 0.27, the average depth (cm) of the scar after use is 0.12, and the average increase height (cm) of the scar is 0.15;
the total area (cm) of the scars before use is 1.34, the total area (cm) of the scars after use is 0.42, and the area (cm) of the scars is reduced by 0.92;
comparative example 3 group: the average depth (cm) of the scar before use is 0.26, the average depth (cm) of the scar after use is 0.21, and the average increase height (cm) of the scar is 0.05;
the total area (cm) of the scars before use is 1.41, the total area (cm) of the scars after use is 1.20, and the area (cm) of the scars is reduced by 0.21.
Example 2
Jasmine fragrance type cream containing taxifolin for moistening, activating and solidifying,
1. the components and the compositions of the formula are calculated according to the weight percentage,
A. glycerin 4.2 wt%, Siberian Larch (LARIXSIBIRICA) wood extract (LARIX sibirica wood extract)0.28 wt%;
B. 1.8 wt% of jasmine glycerol extract, 0.3wt% of p-hydroxyacetophenone and 0.3wt% of hexanediol;
C. 5.5 wt% of jojoba seed oil, 5.0 wt% of squalane, 3.5 wt% of cetearyl olive oleate, 1.5 wt% of sorbitan olive oleate, 1.0 wt% of polydimethylsiloxane, and 2.2 wt% of hydrogenated lecithin;
D. 5 wt% of jasmine glycerol extract and 0.3wt% of sodium hyaluronate;
E. adding jasmine distilled water to make up the balance, so that the total content of all components A + B + C + D + E of the face cream is 100.0 wt%;
2. the production process comprises the following steps:
1) mixing fresh jasmine flowers with water 4 times of the weight of the fresh jasmine flowers, adding the mixture into a distillation pot, heating the mixture to boil the water, distilling the mixture, discharging water vapor through a condenser, controlling the reflux amount of the water vapor, and steaming the water added into the distillation pot within 18 minutes to obtain 90% of the volume of the added water to obtain jasmine distilled water; has the jasmine fragrance of the jasmine distilled water, and is colorless and transparent;
heating the residue in the distillation pot at 90 deg.C for 5 min, adding glycerol with the same weight as that of fresh flos Jasmini sambac in the distillation pot, heating at 95 deg.C for 20 min, filtering to collect glycerol filtrate, adding 1/5 volumes of activated carbon into the glycerol filtrate for decolorization, filtering to collect glycerol extractive solution of flos Jasmini sambac; the jasmine glycerin extract is tasteless, colorless and transparent;
2) uniformly mixing the components of the phase A; heating to 52 deg.C, standing for 8 min, heating to remove bitter and astringent odor of Siberian larch wood extract with glycerol, and making the mixture bright, uniform and semitransparent;
3) at normal temperature, uniformly mixing all the components of the phase B;
4) mix phase D and phase E and heat to 75 ℃.
5) Mix phase C and heat to 70 ℃.
6) The mixture of phases D and E was added to phase C with stirring (50rpm), homogenized (3500rpm) in a homogenizer for 10 minutes, and then cooled.
7) When the temperature had dropped to 45 deg.C, phase A and phase B were added separately and homogenized again in the homogenizer (1800rpm) for 2 minutes.
8) When the temperature is reduced to 30 ℃, filtering and discharging to obtain the finished product.
Claims (3)
1. A preparation method of a face cream containing taxifolin for moistening, activating and coagulating is characterized in that:
the components and the compositions of the formula are calculated according to the weight percentage,
A. 4-4.2 wt% of glycerin, and 0.27-0.29wt% of Siberian larch wood extract; the Siberian larch wood extract contains taxifolin;
B. 1.8-2 wt% of glycerin extract of plant flowers, 0.28-0.32wt% of p-hydroxyacetophenone and 0.28-0.32wt% of hexanediol;
C. 5.4-5.6 wt% of jojoba seed oil, 4.9-5.1 wt% of squalane, 3.4-3.6 wt% of cetearyl olive oleate, 1.4-1.6 wt% of sorbitan olive oleate, 1.0 wt% of polydimethylsiloxane and 2.1-2.3 wt% of hydrogenated lecithin;
D. 4.9-5.1 wt% of plant flower glycerin extract and 0.28-0.32wt% of sodium hyaluronate;
E. the balance of the distilled water of the plant flowers is made up, so that the total content of all the components A + B + C + D + E of the face cream is 100.0 wt%; the plant flower is rose or jasmine;
the production process comprises the following steps:
1) mixing fresh plant flowers with water 4-5 times of the fresh plant flowers, adding the mixture into a distillation pot, heating the distillation pot to boil the water, distilling the water vapor, discharging the water vapor through a condenser, controlling the reflux amount of the water vapor, and steaming the water added into the distillation pot within 15-20 minutes to obtain the plant flower distilled water, wherein the volume of the added water is 80% -90%;
heating the remainder in the distillation pot at 80-90 deg.C for 5-10 min, adding glycerol 0.8-1.2 times of the weight of fresh plant flower into the distillation pot, heating at 90-110 deg.C for 20-30 min, filtering to collect glycerol filtrate, adding activated carbon 1/5-1/6 volume of the glycerol filtrate for decolorizing, and filtering to collect glycerol extract of plant flower;
2) uniformly mixing the components of the phase A; heating to 50-55 deg.C, and standing for 5-8 min;
3) at normal temperature, uniformly mixing all the components of the phase B;
4) mixing the phase D and the phase E, and heating to 72-75 ℃;
5) mixing the phase C and heating to 68-70 ℃;
6) adding the mixture of the phase D and the phase E into the phase C under the stirring of 40-60rpm, homogenizing in a homogenizer at 3000-3500rpm10-15 minutes, and then cooling;
7) when the temperature is reduced to 42-45 ℃, respectively adding the phase A and the phase B, and homogenizing in a homogenizer for 1800-2000rpm2-5 minutes again;
8) when the temperature is reduced to 25-35 ℃, filtering and discharging to obtain the finished product.
2. The method of claim 1, wherein:
the components and the compositions of the formula are calculated according to the weight percentage,
A. 4 wt% of glycerin, and 0.28 wt% of Siberian larch wood extract; the Siberian larch wood extract contains taxifolin;
B. 2wt% of rose glycerin extract, 0.3wt% of p-hydroxyacetophenone and 0.3wt% of hexanediol;
C. 5.5 wt% of jojoba seed oil, 5.0 wt% of squalane, 3.5 wt% of cetearyl olive oleate, 1.5 wt% of sorbitan olive oleate, 1.0 wt% of polydimethylsiloxane, and 2.2 wt% of hydrogenated lecithin;
D. 5 wt% of rose glycerin extract and 0.3wt% of sodium hyaluronate;
E. adding rose distilled water to make up the balance, so that the total content of all components A + B + C + D + E of the face cream is 100.0 wt%;
the production process comprises the following steps:
1) mixing fresh roses and water which is 5 times of the weight of the fresh roses, adding the mixture into a distillation pot, heating the distillation pot to boil the water, distilling the distilled water, discharging the water vapor through a condenser, controlling the reflux amount of the water vapor, and steaming the water added into the distillation pot within 15 minutes to obtain the rose distilled water, wherein the volume of the added water is 85 percent;
heating the residue in the distillation pot at 80 deg.C for 10 min, adding glycerol with the same weight as fresh flos Rosae Rugosae, heating at 100 deg.C for 20 min, filtering to collect glycerol filtrate, adding 1/6 volume of activated carbon into the glycerol filtrate for decolorization, filtering to collect rose glycerol extract;
2) uniformly mixing the components of the phase A; heating to 50 deg.C and standing for 5 min;
3) at normal temperature, uniformly mixing all the components of the phase B;
4) mixing the phase D and the phase E, and heating to 75 ℃;
5) mixing the phase C and heating to 70 ℃;
6) adding the mixture of the phase D and the phase E into the phase C under stirring at 60rpm, homogenizing for 10 minutes at 3000rpm in a homogenizer, and then cooling;
7) when the temperature is reduced to 45 ℃, respectively adding the phase A and the phase B, and homogenizing again in the homogenizer at 2000rpm2 minutes;
8) when the temperature is reduced to 35 ℃, filtering and discharging to obtain the finished product.
3. A cream for moisturizing and activating skin containing taxifolin prepared by the preparation method of any one of claims 1-2.
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| CN108836911A (en) * | 2018-08-10 | 2018-11-20 | 广州碧雅医疗保健科技有限公司 | A kind of compact whitening and moistening skin composition and skin care item containing active ingredient of Chinese herbs |
| CN110075045A (en) * | 2019-05-28 | 2019-08-02 | 南靖珠曼生物科技有限公司 | A kind of tax face cream living and its preparation process |
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| CN108836911A (en) * | 2018-08-10 | 2018-11-20 | 广州碧雅医疗保健科技有限公司 | A kind of compact whitening and moistening skin composition and skin care item containing active ingredient of Chinese herbs |
| CN110075045A (en) * | 2019-05-28 | 2019-08-02 | 南靖珠曼生物科技有限公司 | A kind of tax face cream living and its preparation process |
Non-Patent Citations (1)
| Title |
|---|
| 落叶松中花旗松素对酪氨酸酶的抑制作用;付警辉，柴婧，韩佳彤，刘文丛;《日用化学工业》;20140430;第44卷(第4期);218-221页 * |
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