CN111135273A

CN111135273A - Freckle-removing and whitening traditional Chinese medicine composition, preparation and application thereof

Info

Publication number: CN111135273A
Application number: CN202010060893.4A
Authority: CN
Inventors: 姚佳祺; 林天东
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-01-19
Filing date: 2020-01-19
Publication date: 2020-05-12
Anticipated expiration: 2040-01-19
Also published as: CN111135273B

Abstract

The invention provides a freckle-removing and whitening traditional Chinese medicine composition, a preparation and application thereof, wherein active components of the traditional Chinese medicine composition comprise the following raw material medicines in parts by weight: 1-3 parts of pseudo-ginseng, 3-8 parts of salvia miltiorrhiza, 4-8 parts of rhizoma sparganii, 4-8 parts of curcuma zedoary, 5-15 parts of caulis spatholobi, 5-15 parts of red peony root, 3-9 parts of bighead atractylodes rhizome, 1-3 parts of safflower, 10-20 parts of bovine macrostemon, 5-15 parts of achyranthes root, 5-15 parts of hawthorn, 5-15 parts of liquorice, 4-12 parts of cortex mori radicis, 4-12 parts of cortex lycii radicis, 5-15 parts of radix puerariae, 5-15 parts of motherwort and 5-15 parts of radix angelicae. The traditional Chinese medicine composition has the effects of promoting blood circulation to remove blood stasis, regulating qi and blood, soothing liver and regulating qi, has a good freckle removing effect, and has a whitening effect.

Description

Freckle-removing and whitening traditional Chinese medicine composition, preparation and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, and particularly relates to a freckle-removing and whitening traditional Chinese medicine composition, a preparation and application thereof.

Background

The color spot is the pigmentation of human skin caused by various reasons, so that the skin color is deepened. The common stains include chloasma, freckle, coffee stain, etc. Among them, chloasma is a symmetric pigmentary dermatosis which is often seen in the faces of young and middle-aged women. Currently, the causes of chloasma are unknown, and can be related to factors such as ultraviolet irradiation, endocrine disorder, cosmetics, pregnancy, oral contraceptives, chronic diseases, ethnicity, heredity and the like. The main clinical manifestations of chloasma are that the face appears light brown, coffee and light black speckles, and the sizes and shapes are different; skin damage occurs at two frequency parts, is symmetrical and butterfly-shaped, and is called butterfly-shaped; the macula tablet can also invade forehead, nose, lip, cheek, etc., and is of mid-face type; if the skin lesion is found in the region of the three nerve and the mandibular branch, the skin lesion is of the mandibular type; in addition, skin pigmentation at the areola and external genitalia is also seen.

The traditional Chinese medicine has a long-term freckle removing history, but the traditional Chinese medicine is not widely applied due to poor curative effect. At present, laser is a main means for treating various color spots, and laser freckle removal is quick in effect, but the effect is not permanent, and the soil is easily rolled up.

Disclosure of Invention

In view of the above, the invention provides a freckle-removing and whitening traditional Chinese medicine composition which has the effects of activating blood and dissolving stasis, regulating qi and blood and soothing liver and regulating qi, and has the effects of treating both symptoms and root causes and good freckle removing effect.

The technical scheme of the invention is realized as follows:

the invention provides a freckle-removing and whitening traditional Chinese medicine composition, which comprises the following active components in parts by weight: 1-3 parts of pseudo-ginseng, 3-8 parts of salvia miltiorrhiza, 4-8 parts of rhizoma sparganii, 4-8 parts of curcuma zedoary, 5-15 parts of caulis spatholobi, 5-15 parts of red peony root, 3-9 parts of bighead atractylodes rhizome, 1-3 parts of safflower, 10-20 parts of bovine macrostemon, 5-15 parts of achyranthes root, 5-15 parts of hawthorn, 5-15 parts of liquorice, 4-12 parts of cortex mori radicis, 4-12 parts of cortex lycii radicis, 5-15 parts of radix puerariae, 5-15 parts of motherwort and 5-15 parts of radix angelicae.

Preferably, the active components of the freckle-removing and whitening traditional Chinese medicine composition comprise the following raw material medicines in parts by weight: 1.5-2.5 parts of pseudo-ginseng, 4-6 parts of salvia miltiorrhiza, 5-7 parts of rhizoma sparganii, 5-7 parts of curcuma zedoary, 8-12 parts of caulis spatholobi, 8-12 parts of red paeony root, 4-8 parts of bighead atractylodes rhizome, 1.5-2.5 parts of safflower, 12-18 parts of beautiful millettia root, 8-12 parts of achyranthes root, 8-12 parts of hawthorn, 8-12 parts of liquorice, 6-10 parts of white mulberry root-bark, 6-10 parts of cortex lycii radicis, 8-12 parts of kudzuvine root, 8-12 parts of motherwort and 8-12 parts of angelica dahurica.

Preferably, the active components of the freckle-removing and whitening traditional Chinese medicine composition comprise the following raw material medicines in parts by weight: 2 parts of pseudo-ginseng, 5 parts of salvia miltiorrhiza, 6 parts of rhizoma sparganii, 6 parts of curcuma zedoary, 10 parts of caulis spatholobi, 10 parts of red paeony root, 6 parts of bighead atractylodes rhizome, 2 parts of safflower, 15 parts of beautiful millettia root, 10 parts of achyranthes root, 10 parts of hawthorn, 10 parts of liquorice, 8 parts of cortex mori radicis, 8 parts of cortex lycii radicis, 10 parts of radix puerariae, 10 parts of motherwort and 10 parts of radix angelicae.

The invention provides a freckle-removing and whitening traditional Chinese medicine composition preparation which comprises any one of freckle-removing and whitening traditional Chinese medicine compositions, wherein the traditional Chinese medicine composition preparation is one of decoction, granules, pills, capsules and oral liquid.

The application of the freckle-removing and whitening traditional Chinese medicine composition in preparing freckle-removing and whitening medicines is provided.

Compared with the prior art, the invention has the beneficial effects that: the traditional Chinese medicine composition of the invention, radix notoginseng, radix salviae miltiorrhizae, caulis spatholobi, red peony root, safflower, radix paeoniae rubra, flos carthami, radix paeoniae rubra, radix; the angelica dahurica has the effects of dredging orifices and expelling pus, and the bighead atractylodes rhizome has the effects of tonifying spleen and qi, and the angelica dahurica and the bighead atractylodes rhizome are used as ministerial drugs; rhizoma sparganii breaks blood and moves qi, rhizoma zedoariae moves qi and breaks blood, cortex lycii radicis clears lung and lowers fire, radix puerariae raises yang, cortex mori radicis induces diuresis to alleviate edema, radix millettiae speciosae tonifies deficiency and activates collaterals, and hawthorn moves qi and removes stasis, and all the medicines are adjuvant medicines; achyranthes root, radix achyranthis bidentatae, the stasis-removing and meridian-stimulating functions, motherwort, the blood circulation-promoting, liquorice, spleen-tonifying and qi-benefiting, and the harmonizing drugs are combined as guiding drugs; has the effects of promoting blood circulation, removing blood stasis, regulating qi and blood, soothing liver, regulating qi, removing freckles and whitening skin.

Detailed Description

In order to better understand the technical content of the invention, specific examples are provided below to further illustrate the invention.

The experimental methods used in the examples of the present invention are all conventional methods unless otherwise specified.

The materials, reagents and the like used in the examples of the present invention can be obtained commercially without specific description.

The basic conditions of the main raw material drugs are described in the Chinese pharmacopoeia, the Chinese dictionary and the Chinese herbal medicine.

Pseudo-ginseng: sweet, slightly bitter and warm in nature and taste. Meridian tropism enters liver and stomach meridians. The functions are mainly used for dissipating blood stasis and stopping bleeding, and relieving swelling and pain. Can be used for treating hemoptysis, hematemesis, epistaxis, hematochezia, metrorrhagia, traumatic hemorrhage, thoracico-abdominal pain, and traumatic swelling and pain.

Red sage root: bitter in property and slightly cold in nature. Meridian tropism enters heart and liver meridians. The functions are mainly used for removing blood stasis, relieving pain, promoting blood circulation, stimulating the menstrual flow, clearing away the heart fire and relieving restlessness. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, abdominal mass, thoracico-abdominal pain, arthralgia due to heat, pyocutaneous disease, swelling and pain, vexation, and insomnia; hepatosplenomegaly, angina pectoris.

Three-edge: pungent, bitter and mild in nature. Meridian tropism enters liver and spleen meridians. The functions are mainly used for breaking blood and promoting qi circulation, and removing food retention and relieving pain. Can be used for treating abdominal mass, blood stasis, amenorrhea, food stagnation, and pain.

Red peony root: bitter in property and slightly cold in nature. Meridian tropism enters liver meridian. The functions are mainly used for clearing heat and cooling blood, and removing blood stasis and relieving pain. Can be used for treating macula due to toxic heat, hematemesis, epistaxis, conjunctival congestion, swelling and pain, liver depression, hypochondriac pain, amenorrhea, dysmenorrhea, abdominal pain, traumatic injury, carbuncle, swelling, and pyocutaneous disease.

Caulis spatholobi: bitter and sweet in property and warm in nature. Meridian tropism enters liver and kidney meridians. The functions are mainly for enriching blood, promoting blood circulation and dredging collaterals. Can be used for treating menoxenia, blood deficiency, sallow complexion, numbness, paralysis, and rheumatalgia.

White atractylodes rhizome: bitter and sweet in property and warm in nature. The meridian entered spleen and stomach. The functions are mainly used for strengthening spleen and replenishing qi, eliminating dampness and promoting diuresis, suppressing sweating and preventing miscarriage. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion. Tu Bai Zhu strengthens spleen, harmonizes stomach and prevents abortion. Can be used for treating spleen deficiency, anorexia, diarrhea, loose stool, and threatened abortion.

Safflower: pungent and warm in nature and flavor. Meridian tropism enters heart and liver meridians. The functions are mainly used for promoting blood circulation, dredging channels, dissipating blood stasis and relieving pain. Can be used for treating amenorrhea, dysmenorrhea, lochiorrhea, abdominal mass, traumatic injury, and swelling and pain of skin and external diseases.

Beautiful millettia root: sweet in nature and taste and mild in nature. The functions are mainly used for tonifying deficiency, moistening lung, strengthening tendons and activating collaterals. Can be used for treating lumbar muscle strain, rheumatic arthritis, pulmonary tuberculosis, chronic bronchitis, chronic hepatitis, spermatorrhea, and leucorrhea.

Achyranthes root: bitter, sour and neutral in nature. Meridian tropism enters liver and kidney meridians. The functions are mainly used for nourishing liver and kidney, strengthening tendons and bones, removing blood stasis, stimulating the menstrual flow and leading blood to descend. Can be used for treating soreness of waist and knees, weakness of tendons and bones, amenorrhea, abdominal mass, and vertigo due to liver-yang.

Hawthorn fruit: sour, sweet and slightly warm in nature and taste. Meridian tropism includes spleen, stomach and liver meridians. The functions are mainly to promote digestion, invigorate the stomach, promote qi circulation and remove blood stasis. Can be used for treating meat food stagnation, gastric cavity distention, dysentery abdominal pain, blood stasis amenorrhea, puerperal blood stasis, heart and abdomen stabbing pain, and hernia pain; hyperlipidemia. The charred fructus crataegi has effects of resolving food stagnation. Can be used for treating food stagnation and diarrhea and dysentery.

Licorice root: sweet in nature and taste and mild in nature. Meridian tropism includes heart, lung, spleen and stomach meridians. The functions are mainly used for tonifying spleen and qi, clearing away heat and toxic materials, eliminating phlegm and stopping cough, relieving spasm and pain and harmonizing the medicines. Can be used for treating weakness of spleen and stomach, asthenia, palpitation, short breath, cough, excessive phlegm, abdominal and limb spasm, pain, carbuncle, swelling, sore, and drug toxicity and strong nature.

White mulberry root-bark: sweet in nature and taste and cold in nature. Meridian tropism enters lung meridian. The functions are mainly used for purging the lung and relieving asthma, and inducing diuresis to alleviate edema. Can be used for treating cough and asthma due to lung heat, edema, fullness, oliguria, and edema of face, eye and skin.

Cortex lycii radicis: sweet in nature and taste and cold in nature. Meridian tropism enters lung, liver and kidney meridians. The main functions are cooling blood, removing heat, clearing lung and lowering fire. Can be used for treating hectic fever due to yin deficiency, hectic fever, night sweat, cough due to lung heat, hemoptysis, epistaxis, internal heat, and diabetes.

Kudzu root: sweet, pungent and cool in nature and taste. The meridian entered spleen and stomach. The functions are mainly used for relieving muscles and allaying fever, promoting the production of body fluid, promoting eruption, invigorating yang and stopping diarrhea. Can be used for treating fever, headache, stiffness and pain of neck and back, thirst, diabetes, measles without adequate eruption, dysentery, and diarrhea; hypertension neck and neck pain.

Motherwort: bitter and pungent in property and slightly cold in nature. Meridian tropism enters liver and pericardium. The functions are mainly used for promoting blood circulation, regulating menstruation, inducing diuresis and reducing edema. Can be used for treating menoxenia, dysmenorrhea, amenorrhea, lochiorrhea, edema, and oliguria; edema due to acute nephritis.

Radix angelicae: pungent and warm in nature and flavor. The meridian tropism is entered in stomach, large intestine and lung meridians. The functions are mainly used for dispelling wind and eliminating dampness, dredging orifices and relieving pain, and reducing swelling and expelling pus. Can be used for treating common cold, headache, supraorbital bone pain, nasal obstruction, nasosinusitis, toothache, leucorrhea, and pyocutaneous disease with swelling and pain.

Zedoary turmeric: pungent, bitter and warm in nature. Meridian tropism enters liver and spleen meridians. The functions are mainly to promote the circulation of qi and break blood, and to eliminate stagnation and stop pain. Used for burning and burning masses, blood stasis and amenorrhea, food stagnation and distending pain; early stage cervical cancer.

Example 1

The active components of the traditional Chinese medicine composition for removing freckles and whitening comprise the following raw material medicines by weight: 1g of pseudo-ginseng, 3g of salvia miltiorrhiza, 8g of rhizoma sparganii, 4g of curcuma zedoary, 5g of caulis spatholobi, 15g of red paeony root, 3g of bighead atractylodes rhizome, 1g of safflower, 10g of beautiful millettia root, 5g of achyranthes root, 15g of hawthorn, 5g of liquorice, 4g of white mulberry root-bark, 12g of cortex lycii radicis, 5g of kudzu root, 5g of motherwort herb and 5g of angelica dahurica.

Example 2

The active components of the traditional Chinese medicine composition for removing freckles and whitening comprise the following raw material medicines by weight: 3g of pseudo-ginseng, 8g of salvia miltiorrhiza, 4g of rhizoma sparganii, 8g of curcuma zedoary, 15g of caulis spatholobi, 5g of radix paeoniae rubra, 9g of bighead atractylodes rhizome, 3g of safflower, 20g of beautiful millettia root, 15g of achyranthes bidentata, 5g of hawthorn, 15g of liquorice, 12g of cortex mori radicis, 4g of cortex lycii radicis, 15g of radix puerariae, 15g of motherwort and 15g of radix angelicae.

Example 3

The active components of the traditional Chinese medicine composition for removing freckles and whitening comprise the following raw material medicines by weight: 1.5g of pseudo-ginseng, 4g of salvia miltiorrhiza, 5g of rhizoma sparganii, 7g of curcuma zedoary, 8g of caulis spatholobi, 12g of radix paeoniae rubra, 4g of bighead atractylodes rhizome, 2.5g of safflower, 12g of beautiful millettia root, 8g of achyranthes root, 12g of hawthorn, 8g of liquorice, 6g of cortex mori radicis, 10g of cortex lycii radicis, 8g of radix puerariae, 12g of motherwort and 8g of radix angelicae.

Example 4

The active components of the traditional Chinese medicine composition for removing freckles and whitening comprise the following raw material medicines by weight: 2.5g of pseudo-ginseng, 6g of salvia miltiorrhiza, 7g of rhizoma sparganii, 5g of curcuma zedoary, 12g of caulis spatholobi, 8g of radix paeoniae rubra, 8g of bighead atractylodes rhizome, 1.5g of safflower, 18g of beautiful millettia root, 12g of achyranthes root, 8g of hawthorn, 12g of liquorice, 10g of cortex mori radicis, 6g of cortex lycii radicis, 12g of radix puerariae, 8g of motherwort and 12g of radix angelicae.

Example 5

The active components of the traditional Chinese medicine composition for removing freckles and whitening comprise the following raw material medicines by weight: 2g of pseudo-ginseng, 5g of salvia miltiorrhiza, 6g of rhizoma sparganii, 6g of curcuma zedoary, 10g of caulis spatholobi, 10g of radix paeoniae rubra, 6g of bighead atractylodes rhizome, 2g of safflower, 15g of beautiful millettia root, 10g of achyranthes bidentata, 10g of hawthorn, 10g of liquorice, 8g of cortex mori radicis, 8g of cortex lycii radicis, 10g of radix puerariae, 10g of motherwort and 10g of radix angelicae.

The Chinese medicinal composition of the invention is applied to clinic, and the treatment effect is as follows:

1. basic data: 300 patients with chloasma are collected together; test group 1 to test group 5, each group had 60 cases.

2. The treatment method and the treatment course are as follows: the test groups 1 to 5 respectively correspond to the traditional Chinese medicine compositions in the examples 1 to 5, and the traditional Chinese medicine compositions are decocted with water for 1 dose per day, and are continuously taken for 30 days as 1 course of treatment, and 1 to 3 courses of treatment are taken.

3. Criteria for judging therapeutic effects

And (3) healing: the plaque completely disappears, and the plaque does not relapse within 1 year of follow-up visit;

the effect is shown: plaque reduction, area reduction > 2/3;

the method has the following advantages: plaque reduction, area reduction > 1/3;

and (4) invalidation: all fail to meet the above standard.

The cure rate is the number of cure/total cases x 100%.

Total effective rate (cure + significant effect + effective)/total number of cases x 100%.

4. Therapeutic results

The clinical conditions show that the traditional Chinese medicine composition has obvious treatment effect on removing chloasma, the cure rate is as high as 88.3%, and the total effective rate is as high as 100.0%.

5. Typical cases

(1) The patient is Yao a certain age at 45 years, plain work is particularly busy, the time is often increased, the patient sleeps late and starts early for many years, the patient is irritated and irritative, the patient has irregular menstruation, and the menstruation is delayed for about ten days per month, so that chloasma appears on two sides of a cheek, the traditional Chinese medicine composition disclosed by the embodiment 5 of the invention is obviously lightened after being orally taken for one week, the skin is whitened and tender and smooth, and the chloasma mark can hardly be seen after the patient continues to take the composition for two months. After 1 year, no relapse occurs after follow-up.

(2) The patient Wangzhi is 32 years old, the face of the patient grows chloasma in the pregnancy, the chloasma is symmetrical, the chloasma is aggravated due to insufficient sleep and the night and day reversal after the child is cared for after delivery, the traditional Chinese medicine composition in the embodiment 5 of the invention is obviously lightened after being orally taken for one week, and the track of the cyasma can not be seen after the traditional Chinese medicine composition is continuously taken for 3 months. After 1 year, no relapse occurs after follow-up.

6. Observation of adverse reactions

In the treatment and observation cases, patients with adverse reactions are not found, which shows that the traditional Chinese medicine composition is safe and reliable.

In addition, the traditional Chinese medicine composition can also be applied to treating freckles, coffee spots and other color spots. The traditional Chinese medicine composition can also be prepared into granules, pills, capsules and oral liquid by a conventional method, and is convenient for patients with freckle to select and use.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. The freckle-removing and whitening traditional Chinese medicine composition is characterized by comprising the following active components in parts by weight: 1-3 parts of pseudo-ginseng, 3-8 parts of salvia miltiorrhiza, 4-8 parts of rhizoma sparganii, 4-8 parts of curcuma zedoary, 5-15 parts of caulis spatholobi, 5-15 parts of red peony root, 3-9 parts of bighead atractylodes rhizome, 1-3 parts of safflower, 10-20 parts of bovine macrostemon, 5-15 parts of achyranthes root, 5-15 parts of hawthorn, 5-15 parts of liquorice, 4-12 parts of cortex mori radicis, 4-12 parts of cortex lycii radicis, 5-15 parts of radix puerariae, 5-15 parts of motherwort and 5-15 parts of radix angelicae.

2. The traditional Chinese medicine composition for removing freckles and whitening skin, according to claim 1, is characterized in that the active components comprise the following raw material medicines in parts by weight: 1.5-2.5 parts of pseudo-ginseng, 4-6 parts of salvia miltiorrhiza, 5-7 parts of rhizoma sparganii, 5-7 parts of curcuma zedoary, 8-12 parts of caulis spatholobi, 8-12 parts of red paeony root, 4-8 parts of bighead atractylodes rhizome, 1.5-2.5 parts of safflower, 12-18 parts of beautiful millettia root, 8-12 parts of achyranthes root, 8-12 parts of hawthorn, 8-12 parts of liquorice, 6-10 parts of white mulberry root-bark, 6-10 parts of cortex lycii radicis, 8-12 parts of kudzuvine root, 8-12 parts of motherwort and 8-12 parts of angelica dahurica.

3. The traditional Chinese medicine composition for removing freckles and whitening skin, according to claim 1, is characterized in that the active components comprise the following raw material medicines in parts by weight: 2 parts of pseudo-ginseng, 5 parts of salvia miltiorrhiza, 6 parts of rhizoma sparganii, 6 parts of curcuma zedoary, 10 parts of caulis spatholobi, 10 parts of red paeony root, 6 parts of bighead atractylodes rhizome, 2 parts of safflower, 15 parts of beautiful millettia root, 10 parts of achyranthes root, 10 parts of hawthorn, 10 parts of liquorice, 8 parts of cortex mori radicis, 8 parts of cortex lycii radicis, 10 parts of radix puerariae, 10 parts of motherwort and 10 parts of radix angelicae.

4. A freckle-removing and whitening traditional Chinese medicine composition preparation is characterized by comprising the freckle-removing and whitening traditional Chinese medicine composition according to any one of claims 1 to 3, wherein the traditional Chinese medicine composition preparation is one of decoction, granules, pills, capsules and oral liquid.

5. The application of the freckle removing and whitening traditional Chinese medicine composition of any one of claims 1 to 3 in preparing freckle removing medicines.