CN111122841A - Method for improving sample result accuracy and sample analyzer - Google Patents
Method for improving sample result accuracy and sample analyzer Download PDFInfo
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- CN111122841A CN111122841A CN201811285515.5A CN201811285515A CN111122841A CN 111122841 A CN111122841 A CN 111122841A CN 201811285515 A CN201811285515 A CN 201811285515A CN 111122841 A CN111122841 A CN 111122841A
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- 238000000034 method Methods 0.000 title claims abstract description 46
- 238000001514 detection method Methods 0.000 claims abstract description 111
- 239000002245 particle Substances 0.000 claims abstract description 51
- 238000012806 monitoring device Methods 0.000 claims description 14
- 238000012544 monitoring process Methods 0.000 claims description 7
- 238000004140 cleaning Methods 0.000 claims description 3
- 239000000523 sample Substances 0.000 description 120
- 238000010586 diagram Methods 0.000 description 6
- 239000010437 gem Substances 0.000 description 6
- 229910001751 gemstone Inorganic materials 0.000 description 6
- 210000000601 blood cell Anatomy 0.000 description 5
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 238000004820 blood count Methods 0.000 description 3
- 210000000265 leukocyte Anatomy 0.000 description 3
- 238000012360 testing method Methods 0.000 description 3
- 210000004027 cell Anatomy 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 1
- 210000001124 body fluid Anatomy 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 210000005259 peripheral blood Anatomy 0.000 description 1
- 239000011886 peripheral blood Substances 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5094—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for blood cell populations
Abstract
The application discloses a method for improving the accuracy of sample results and a sample analyzer, wherein the method for improving the accuracy of the sample results comprises the following steps: in the process of detecting a sample by a sample analyzer, when the time that the particle number of particles to be detected in the sample is continuously lower than a particle number threshold reaches a time threshold, judging whether a detection channel of the sample analyzer is blocked; and if the detection channel is blocked, discarding the obtained detection result, and if the detection channel is not blocked, judging the sample as a low-value sample.
Description
Technical Field
The application relates to the technical field of medical treatment, in particular to a method for improving sample result accuracy and a sample analyzer.
Background
Blood cell analyzers have been widely used in the medical field and become routine clinical testing devices. The blood cell count in a blood cell analyzer generally adopts an electrical impedance method and works by utilizing an electric pulse signal generated by blood cells through a gem micropore. Some proteins and cell debris in the blood may adhere around the gem micro-holes during the operation, and if the gem micro-holes are not washed thoroughly in time, the cell debris and proteins adhering around the gem micro-holes can affect the accuracy of blood cell counting. Along with the adhesion is more and more, can produce the common "stifled hole" phenomenon of hematology analyzer to make the unable normal work of instrument, consequently, accurately judge stifled hole and in time wash the precious stone micropore, help improving the accuracy of blood cell count.
In the prior art, the low-value sample test by using the electric impedance method can involve low-value whole blood or pre-diluted samples, and at the moment, the detection result is generally subjected to denoising processing by hardware, an algorithm and the like and then calculated, so that a certain sample result accurate value can be ensured. However, the method still has the following defects that the actually measured low-value sample particle number statistic is possibly less, the accuracy of the low-value sample result is influenced, and the low-value sample result is easily subjected to micro-plugging and misjudgment, so that the accuracy of the sample result is greatly reduced.
The prior art is therefore still deficient.
Disclosure of Invention
In view of the above, the present application provides a method for improving the accuracy of a sample result and a sample analyzer, which can improve the accuracy of a sample detection result.
In order to solve the technical problem, the application adopts a technical scheme that: a method of improving the accuracy of sample results is provided, the method comprising:
in the process of detecting a sample by a sample analyzer, when the time that the particle number of particles to be detected in the sample is continuously lower than a particle number threshold value reaches a time threshold value, judging whether a detection channel of the sample analyzer is blocked;
and if the detection channel is blocked, discarding the obtained detection result, and if the detection channel is not blocked, judging the sample as a low-value sample.
Wherein the detection channel comprises: a micro-well for passing the sample to detect the sample.
Wherein the step of determining whether a detection channel of the sample analyzer is clogged includes:
measuring the voltage of the microwell;
and if the voltage of the micropore exceeds the voltage threshold value, judging that the detection channel is blocked, and if the voltage of the micropore does not exceed the voltage threshold value, judging that the detection channel is not blocked.
Wherein the method further comprises:
performing a background count upon start-up of the sample analyzer;
collecting the voltage of the microwells during the background counting;
setting the average value of the acquired voltages of the micropores as the voltage threshold.
Wherein after the sample is determined to be a low value sample, the method further comprises:
the time to detect the sample is extended.
Wherein, after discarding the obtained detection result, the method further comprises:
and cleaning the detection channel and detecting the sample again.
In order to solve the above technical problem, another technical solution adopted by the present application is: providing a sample analyzer, the sample analyzer comprising:
a detection channel for detecting a sample;
the monitoring device is used for monitoring the blockage condition of the detection channel;
and the processor is respectively connected with the detection channel and the monitoring device and is used for counting the number of particles of the particles to be detected in the sample, judging whether the detection channel is blocked according to the monitoring condition of the monitoring device when the time that the number of the particles to be detected in the sample is continuously lower than the number threshold of the particles reaches a time threshold, further discarding the obtained detection result when the detection channel is blocked, and judging the sample as a low-value sample when the detection channel is not blocked.
Wherein the detection channel comprises: a micro-well for passing the sample to detect the sample.
Wherein, the monitoring device is specifically configured to: measuring the voltage of the microwell;
the processor is specifically configured to: and if the voltage of the micropore exceeds a voltage threshold value, judging that the detection channel is blocked, and if the voltage of the micropore does not exceed the voltage threshold value, judging that the detection channel is not blocked.
Wherein the monitoring device is further configured to: collecting the voltage of the microwells during background counting when the sample analyzer is started;
the processor is further configured to: setting the average value of the acquired voltages of the micropores as the voltage threshold.
The beneficial effects are that: the method for improving the accuracy of the sample result comprises the following steps: in the process of detecting a sample by a sample analyzer, when the time that the particle number of particles to be detected in the sample is continuously lower than a particle number threshold reaches a time threshold, judging whether a detection channel of the sample analyzer is blocked; and if the detection channel is blocked, discarding the obtained detection result, and if the detection channel is not blocked, judging the sample as a low-value sample.
Drawings
In order to more clearly illustrate the technical solutions in the embodiments of the present application, the drawings needed to be used in the description of the embodiments are briefly introduced below, and it is obvious that the drawings in the following description are only some embodiments of the present application, and it is obvious for those skilled in the art to obtain other drawings based on these drawings without creative efforts. Wherein:
FIG. 1 is a schematic flow chart diagram illustrating one embodiment of a method for improving the accuracy of sample results according to the present application;
FIG. 2 is a schematic illustration of a flow of particles in the prior art;
FIG. 3 is a schematic diagram of the structure of a detection channel of the present application;
FIG. 4 is a partial flowchart of step S100 according to another embodiment of the method for improving the accuracy of the sample result;
FIG. 5 is a schematic flow chart of a portion of the method for improving the accuracy of sample results in the embodiment of FIG. 4;
FIG. 6 is a schematic diagram of the structure of an embodiment of the sample analyzer of the present application.
Detailed Description
The technical solutions in the embodiments of the present application will be clearly and completely described below with reference to the drawings in the embodiments of the present application, and it is obvious that the described embodiments are only a part of the embodiments of the present application, and not all the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present application.
Referring to fig. 1, fig. 1 is a schematic flow chart of an embodiment of the method for improving the accuracy of a sample result according to the present application, the method including:
s100: in the process of detecting a sample by a sample analyzer, when the time that the particle number of particles to be detected in the sample is continuously lower than a particle number threshold value reaches a time threshold value, whether a detection channel of the sample analyzer is blocked or not is judged.
In the process of detecting a sample by a sample analyzer, counting and classifying particles to be detected can be realized, and a particle flow diagram as shown in fig. 2 is formed in real time, wherein the abscissa in fig. 2 represents time, and the ordinate represents the number of particles detected in unit time. Wherein the sample may be a whole blood sample, a peripheral blood sample or even a body fluid.
The detection channel is blocked in two situations, namely complete blockage and micro-blockage, wherein the sample cannot pass through the detection channel when the detection channel is completely blocked, and the sample can still pass through the detection channel when the detection channel is micro-blocked.
When the time that the number of particles to be detected in the sample is continuously lower than the number threshold reaches the time threshold, it indicates that a continuous and stable situation that the number of particles is lower is present, and two reasons are caused, one is that the detection channel is micro-blocked, and the other is that the sample itself is a low-value sample, where the low-value sample means that the concentration of the particles to be detected in the sample is lower than that in a normal sample for the particles to be detected, that is, the number of particles is smaller, for example, when detecting blood cells, white blood cells are the particles to be detected, the concentration of white blood cells in the normal sample is 4000-10000 ul, and if the concentration of white blood cells in the sample is lower than 4000/ul, the sample is the low-value sample.
The time threshold may be set by a designer according to experience or experiments, for example, set to 10S, and the like, without limitation.
S110: if the detection channel is blocked, the obtained detection result is discarded, and if the detection channel is not blocked, the sample is judged to be a low-value sample.
If the detection channel is judged to be blocked, specifically micro-blocked, the detection sample is stopped, and the obtained detection result is discarded, namely the previous detection is completely abandoned, so that the influence on the final detection result caused by the blockage of the detection channel is avoided, and if the detection channel is not blocked, the sample is judged to be a low-value sample, namely the sample is judged to be the low-value sample under the condition of eliminating the micro-blocked detection channel.
In the prior art, when the number of particles is low continuously and stably, the sample is generally directly determined to be a low-value sample and further analyzed, and the situation that the detection channel is slightly blocked is ignored, so that the final detection result is not accurate enough.
Referring to fig. 3, fig. 3 is a schematic structural diagram of a detection channel in this embodiment, the detection channel 10 includes: and a micro-hole 101 for passing the sample to detect the sample.
The detection channel 10 detects the number of particles to be detected in a sample by using an impedance method, when the particles to be detected in the sample pass through the micropore 101, the equivalent resistance of the micropore 101 becomes large instantly, the increased resistance causes an equal proportion increased voltage under the action of a power supply, when the particles to be detected leave the micropore 101, the equivalent resistance of the micropore 101 returns to be normal again until the next particle to be detected in the sample passes through the micropore 101, and thus when the continuous particles to be detected pass through the micropore 101, a series of voltage pulses can be generated, and the counting of the particles to be detected in the sample is realized.
Wherein, the micropore is a gem micropore.
Referring to fig. 4, fig. 4 is a partial schematic flowchart of step S100 in another embodiment of the method for improving the accuracy of the sample result, in which the step S100 of determining whether the detection channel of the sample analyzer is blocked includes:
s101: the voltage of the microwell was measured.
S102: and if the voltage of the micropore does not exceed the voltage threshold, determining that the detection channel is not blocked.
By measuring the voltage of the micropores 101, it can be determined whether the detection channel 10 is clogged, particularly, when the clogging is occurred, and generally, the more serious the clogging of the detection channel 10 is, the larger the voltage of the micropores 101 is.
In the prior art, the detection channel 10 is completely blocked and is easily perceived through the change of the number of particles, but the detection channel 10 is slightly blocked, which is usually detected by a volume metering method after the detection is completed, and at the moment, the detection result is obtained after the detection is completed, so that the detection result is not accurate enough, therefore, the voltage of the micropore 101 in the detection channel 10 can be detected to find that the detection channel 10 is slightly blocked in the detection process in time in the embodiment, and the accuracy of the detection result of the sample is improved.
Referring to fig. 5, in this embodiment, the method for improving the accuracy of the sample result further includes:
s120: background counting is performed at start-up of the sample analyzer.
S130: the voltage of the microwells was collected during background counting.
S140: the average value of the voltage of the collected microwells was set as a voltage threshold.
The background counting is that no sample is added when the sample analyzer is started, the sample analyzer directly runs the predetermined detection program, and simultaneously collects the voltage of the micropores 101 in the background counting process, and sets the average value of the voltage of the micropores 101 as the voltage threshold, although in other embodiments, the maximum value or the minimum value of the voltage of the micropores 101 may also be set as the voltage threshold.
Of course, in other embodiments, the voltage threshold may be set by a designer based on experience, so as to improve the accuracy of the determination result.
In any of the above embodiments, after the step S110 determines that the sample is a low value sample, the method further includes: s150: the time for detecting the sample is prolonged.
More samples flow through the detection channel 10 for detection, so that the statistical number of particles to be detected is increased, and the accuracy of the detection result of the low-value sample is further improved.
In any of the above embodiments, after discarding the obtained detection result in step S110, the method further includes: s160: and cleaning the detection channel and detecting the sample again.
After stopping detecting the sample and abandoning the detection result, use washing liquid etc. to wash the measuring channel 10, guarantee to detect the sample again after measuring channel 10 is unobstructed, guarantee the accuracy of sample testing result.
Referring to fig. 6, fig. 6 is a schematic structural diagram of an embodiment of the sample analyzer of the present application, the sample analyzer including: a detection channel 10, a monitoring device 20 and a processor 30.
The detection channel 10 is used for detecting a sample.
The monitoring device 20 is used to monitor the blockage of the detection channel 10.
The processor 30 is connected to the detection channel 10 and the monitoring device 20, and is configured to count the number of particles of the particles to be detected in the sample, determine whether the detection channel 10 is blocked according to the monitoring condition of the monitoring device 20 when the time that the number of particles of the particles to be detected in the sample is continuously lower than the number of particles reaches the time threshold, further discard the obtained detection result when the detection channel 10 is blocked, and determine that the sample is a low-value sample when the detection channel 10 is not blocked.
Wherein, the detection channel 10 is the same as or similar to the detection channel 10 in fig. 2, specifically, the detection channel 10 includes: and a micro-hole 101 for passing the sample to detect the sample. The detailed detection channel 10 can be referred to the above embodiments, and is not described herein.
In an application scenario, the monitoring apparatus 20 is specifically configured to: measuring the voltage at microwell 101, processor 30 is specifically configured to: if the voltage of the microwell 101 exceeds the voltage threshold, it is determined that the detection channel 10 is clogged, and if the voltage of the microwell 101 does not exceed the voltage threshold, it is determined that the detection channel 10 is not clogged.
In an application scenario, the monitoring apparatus 20 is further configured to: collecting the voltage of the micropores 101 in the process of background counting when the sample analyzer is started;
the processor 30 is further configured to: the average value of the acquired voltages of the micropores 101 is set as a voltage threshold.
The sample analyzer in the present application may be a flow cytometer, a blood cell analyzer, or other biological detection devices, and is not limited herein. When the sample analyzer works, the method for improving the accuracy of the sample result in any one of the above embodiments is adopted, and specific methods for improving the accuracy of the sample result can be referred to the above embodiments, and are not described herein again.
In summary, different from the situation of the prior art, the method for improving the accuracy of the sample result in the present application determines the sample as a low-value sample under the condition of excluding the detection channel from being blocked when the particle number of the particles to be detected is continuously lower than the particle number threshold, thereby improving the accuracy of the sample detection result.
The above description is only for the purpose of illustrating embodiments of the present application and is not intended to limit the scope of the present application, and all modifications of equivalent structures and equivalent processes, which are made by the contents of the specification and the drawings of the present application or are directly or indirectly applied to other related technical fields, are also included in the scope of the present application.
Claims (10)
1. A method for improving the accuracy of sample results, the method comprising:
in the process of detecting a sample by a sample analyzer, when the time that the particle number of particles to be detected in the sample is continuously lower than a particle number threshold value reaches a time threshold value, judging whether a detection channel of the sample analyzer is blocked;
and if the detection channel is blocked, discarding the obtained detection result, and if the detection channel is not blocked, judging the sample as a low-value sample.
2. The method of claim 1,
the detection channel includes: a micro-well for passing the sample to detect the sample.
3. The method of claim 2, wherein the step of determining whether a detection channel of the sample analyzer is clogged comprises:
measuring the voltage of the microwell;
and if the voltage of the micropore exceeds a voltage threshold value, judging that the detection channel is blocked, and if the voltage of the micropore does not exceed the voltage threshold value, judging that the detection channel is not blocked.
4. The method of claim 3, further comprising:
performing a background count upon start-up of the sample analyzer;
collecting the voltage of the microwells during the background counting;
setting the average value of the acquired voltages of the micropores as the voltage threshold.
5. The method of claim 1, further comprising, after determining the sample as a low value sample:
the time to detect the sample is extended.
6. The method of claim 1, further comprising, after discarding the obtained detection results:
and cleaning the detection channel and detecting the sample again.
7. A sample analyzer, comprising:
a detection channel for detecting a sample;
the monitoring device is used for monitoring the blockage condition of the detection channel;
and the processor is respectively connected with the detection channel and the monitoring device and is used for counting the number of particles of the particles to be detected in the sample, judging whether the detection channel is blocked according to the monitoring condition of the monitoring device when the time that the number of the particles to be detected in the sample is continuously lower than the number threshold of the particles reaches a time threshold, further discarding the obtained detection result when the detection channel is blocked, and judging the sample as a low-value sample when the detection channel is not blocked.
8. The sample analyzer of claim 7,
the detection channel includes: a micro-well for passing the sample to detect the sample.
9. The sample analyzer of claim 8,
the monitoring device is specifically configured to: measuring the voltage of the microwell;
the processor is specifically configured to: and if the voltage of the micropore exceeds the voltage threshold value, judging that the detection channel is blocked, and if the voltage of the micropore does not exceed the voltage threshold value, judging that the detection channel is not blocked.
10. The sample analyzer of claim 9,
the monitoring device is further configured to: collecting the voltage of the microwells during background counting when the sample analyzer is started;
the processor is further configured to: setting the average value of the acquired voltages of the micropores as the voltage threshold.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN112730202A (en) * | 2020-12-29 | 2021-04-30 | 深圳市科曼医疗设备有限公司 | Impedance method detection system of blood cell analyzer and method for identifying impedance channel blocked hole |
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