CN101246113A - Monitoring method for hemoglobin test result - Google Patents
Monitoring method for hemoglobin test result Download PDFInfo
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- CN101246113A CN101246113A CNA2007100733252A CN200710073325A CN101246113A CN 101246113 A CN101246113 A CN 101246113A CN A2007100733252 A CNA2007100733252 A CN A2007100733252A CN 200710073325 A CN200710073325 A CN 200710073325A CN 101246113 A CN101246113 A CN 101246113A
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- 238000012360 testing method Methods 0.000 title claims abstract description 80
- 238000000034 method Methods 0.000 title claims abstract description 38
- 238000012544 monitoring process Methods 0.000 title claims abstract description 8
- 102000001554 Hemoglobins Human genes 0.000 title abstract description 9
- 108010054147 Hemoglobins Proteins 0.000 title abstract description 9
- 239000002245 particle Substances 0.000 claims abstract description 20
- 230000000149 penetrating effect Effects 0.000 claims description 8
- 238000010790 dilution Methods 0.000 claims description 7
- 239000012895 dilution Substances 0.000 claims description 7
- 239000003219 hemolytic agent Substances 0.000 claims description 6
- 238000005259 measurement Methods 0.000 claims description 5
- 238000002156 mixing Methods 0.000 claims description 5
- 230000002159 abnormal effect Effects 0.000 claims description 4
- 238000006243 chemical reaction Methods 0.000 claims description 4
- 238000007865 diluting Methods 0.000 claims description 2
- 238000012545 processing Methods 0.000 claims 1
- 210000000265 leukocyte Anatomy 0.000 abstract description 21
- 230000000694 effects Effects 0.000 abstract description 2
- 239000000523 sample Substances 0.000 description 18
- 210000000601 blood cell Anatomy 0.000 description 7
- 238000003745 diagnosis Methods 0.000 description 5
- 239000007788 liquid Substances 0.000 description 5
- 210000004027 cell Anatomy 0.000 description 4
- 210000004369 blood Anatomy 0.000 description 2
- 239000008280 blood Substances 0.000 description 2
- 210000001772 blood platelet Anatomy 0.000 description 2
- 238000001514 detection method Methods 0.000 description 2
- 238000010586 diagram Methods 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 210000003743 erythrocyte Anatomy 0.000 description 2
- 230000000630 rising effect Effects 0.000 description 2
- 208000007502 anemia Diseases 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 239000004020 conductor Substances 0.000 description 1
- 238000002425 crystallisation Methods 0.000 description 1
- 230000008025 crystallization Effects 0.000 description 1
- 238000007405 data analysis Methods 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000000428 dust Substances 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 238000005534 hematocrit Methods 0.000 description 1
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Abstract
The present invention discloses a method for monitoring the hemoglobin test result, the hemoglobin and white blood cell are tested in a count tank, the numerical value of the hemoglobin are obtained by the measuring and calculating to the reference light-permeating strength and the sample light-permeating strength, and when the particle of the white blood cell in the counting tank is counted with a micropore resistor method, the air bubble wherein is executed with discriminating and counting and the numerical value of the air bubble is obtained; afterwards according to the measured numerical value of the air bubble the effect which is likely generated by the air bubble to the accuracy of the test result of the hemoglobin is judged, and the corresponding reminding is presented according to the prescribed regulation. The method realizes the monitoring to the accuracy of the test result of the hemoglobin and guarantees the reliability of the test result of the hemoglobin is guaranteed.
Description
Technical field
The present invention relates to technical field of medical instruments, relate in particular in a kind of blood cell analyzer monitoring haemoglobin test result, and the method that the haemoglobin precision of test result is pointed out.
Background technology
Blood cell analyzer has been widely used in clinical and the field, laboratory as the instrument of the human body blood cell parameter being counted and classify, leucocyte (WBC), red blood cell (RBC), blood platelet (PLT), mean corpuscular volume (MCV) (MCV), hematocrit value (HCT), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC) (MCHC), haemoglobin test parameters such as (HGB) mainly are provided, and test result is used for the diagnosis of clinician to patient's state of an illness.Wherein, HGB is the important parameter that blood cell analyzer provides, and the diagnosis of diseases such as anaemia is played an important role, and the result who therefore requires test accurately and reliably.At present, the test of haemoglobin is directly by the measurement to reference penetrating light intensity and sample penetrating light intensity, calculate haemoglobin numerical value, if certain part owing to instrument in the test process breaks down, cause that bubble increases in the haemoglobin test cell, and instrument itself can't be diagnosed out corresponding failure, when number of bubbles during greater than some, will directly influence the haemoglobin precision of test result, to cause misleading the diagnosis of clinician to patient's state of an illness.
Summary of the invention
Technical matters to be solved by this invention is: the method that provides a kind of blood cell analyzer that haemoglobin test result accuracy is monitored, so that improve the haemoglobin reliability of testing result.
The present invention solves the problems of the technologies described above the technical scheme that is adopted to be:
A kind of monitoring method to the haemoglobin test result comprises the steps:
A, haemoglobin and leucocyte are tested in same counting chamber, obtain haemoglobin numerical value by measurements and calculations to reference penetrating light intensity and sample penetrating light intensity, and when the particle of leucocyte passage carries out test count in to described counting chamber with the micropore electric-resistivity method, bubble is wherein screened and counted, obtain bubble numerical value;
B, according to the bubble numerical value that records, judge the influence that bubble may produce haemoglobin test result accuracy, and provide corresponding prompting.
Described method comprises following concrete steps:
A1, in described counting chamber, add dilution, record haemoglobin background voltage;
A2, the test sample book after will diluting add in the described counting chamber, and add the hemolytic agent mixing in counting chamber;
A3, the particle of leucocyte passage in the described counting chamber is carried out test count, and bubble is wherein screened and counted, obtain bubble numerical value, after recording the haemoglobin sample voltage, by calculating haemoglobin numerical value.
Described method, wherein: described steps A 3 obtains bubble numerical value according to following treatment step:
A31, the simulating signal that the particle of leucocyte passage is produced during by micropore are amplified;
A32, the simulating signal that will be higher than predetermined threshold collect in the internal memory by the A/D conversion;
A33, CPU analyze and handle the pulse signal that collects in the described internal memory, screen leucocyte and bubble, obtain the gentle bubble numerical value of leucocyte numerical value respectively.
Described method, wherein: described step B provides corresponding prompting according to following rule: when number of bubbles during less than first numerical value, setting bubble does not influence the haemoglobin test result, and instrument provides the haemoglobin test result, no abnormal prompting; When number of bubbles during greater than first numerical value and less than second value, providing the haemoglobin test result when instrument provides test result may inaccurate prompting; When number of bubbles during greater than second value, instrument does not provide the haemoglobin test result.
Described method, wherein: adopt following formula to calculate haemoglobin numerical value among the described step D:
Beneficial effect of the present invention is: adopt the inventive method, by identification and statistics to bubble, discovery in time and prompting bubble may be to the influences of haemoglobin test result, got rid of in the test process bubble to the interference of haemoglobin test result, realized monitoring, guaranteed the haemoglobin reliability of testing result haemoglobin test result accuracy.
Description of drawings
Fig. 1 is for adopting micropore electric-resistivity method test haemocyte principle schematic;
Fig. 2 is for realizing the blood analyser circuit structure block diagram of the inventive method;
Fig. 3 a, Fig. 3 b are respectively the pulse signal figure that comprises bubble
Fig. 4 a, Fig. 4 b are respectively the front elevation and the side view of the counting chamber of test WBC and HGB;
Fig. 5 is the inventive method process flow diagram.
Embodiment
With embodiment the present invention is described in further detail with reference to the accompanying drawings below:
The present invention proposes a kind of new method, under the situation that this method can break down at instrument, number of bubbles increases, by the detection of number of bubbles in the sample, to bubble disturbed test result, may cause the inaccuracy of HGB test result to point out, avoid misleading doctor's diagnosis.Basic skills of the present invention is: HGB and WBC are set test in same counting chamber, obtain HGB numerical value by measurements and calculations to reference penetrating light intensity and sample penetrating light intensity, when the particle of WBC passage carries out test count in to counting chamber with the micropore electric-resistivity method, feature identification bubble according to bubble, and bubble wherein counted, obtain bubble numerical value; Afterwards, according to the bubble numerical value that records, judge the influence that bubble may produce HGB test result accuracy, and provide corresponding prompting according to pre-defined rule.
The present invention is applied to the blood cell analyzer of electric-resistivity method counting principle, micropore electric-resistivity method test blood parameters principle as shown in Figure 1, after test sample book is by a certain amount of conductive liquid dilution, deliver to detecting unit, detecting unit has a micropore, there is pair of positive and negative the micropore both sides, connect constant-current supply.Because particle (comprises cell, dust etc., be referred to as particle) and bubble have the characteristic of poor conductor, when the particle in the diluted sample and bubble under suction function when detecting micropore, resistance between positive and negative electrode will change, thereby forms a change in voltage that is in proportion with particle and bubble volume at the electrode two ends.The simulating signal that particle and bubble produce during by micropore is amplified through amplifying circuit shown in Figure 2, the simulating signal that will be higher than setting threshold collects in the internal memory by analog to digital conversion under given sample frequency, CPU analyzes the pulse signal (data) that collects in the internal memory, particle and bubble have determined the pulse of its each self-forming to have different shapes by characteristic separately, when particle passes through micropore continuously, the number of pulse is directly proportional with cell number by micropore, the amplitude of pulse is directly proportional with the big small size of particle and cell, and the size of the bubble that bubble produces during by micropore is directly proportional with the width of bubble pulse.Pulse signal such as Fig. 3 a that particle and bubble form, shown in Fig. 3 b, wherein the wideest pulse of height and width degree of amplitude is bubble pulse.Feature according to bubble pulse, passage WBC particle is counted with volume distributed median statistics in, the bubble by micropore is counted, and according to number of bubbles, provide reliable, the possible unreliable and insecure prompting of HGB, improved HGB parameter testing result's reliability.Need to prove that setting threshold is for acquired signal length is compressed, general WBC passage threshold value is made as 150mV in the practical application, and the A/D conversion is general adopts 8～16, and frequency acquisition is 300～4000k/s.
The present invention is mainly used in a as Fig. 4, counting chamber shown in the 4b, and HGB and WBC (leucocyte) test in same counting chamber, and the HGB part of detecting is in the bottom of counting chamber.The idiographic flow of the inventive method is as shown in Figure 5:
1, carry out the test of HGB background voltage (reference voltage), when adding dilution in the counting chamber, test HGB receiving-end voltage is the HGB reference voltage;
2, sample is diluted according to a certain percentage, rare this adding of sample WBC counting chamber;
3, in the WBC counting chamber, add hemolytic agent, and carry out mixing;
When 4, the sample in the WBC counting chamber behind the mixing being counted with the micropore electric-resistivity method, bubble is wherein screened and counted, obtain bubble numerical value;
5, in the WBC channel counts, or after the WBC channel counts finished, test HGB receiving-end voltage was the HGB sample voltage, and calculates the HGB value according to following formula
6,, judge the influence that bubble may produce haemoglobin test result accuracy, and provide corresponding prompting according to pre-defined rule according to the bubble numerical value that records.
As can be seen, after adding the hemolytic agent mixing, one WBC test sample period of midfeather, under normal circumstances, after the WBC test was finished, bubble residual in the counting chamber can be ignored to the influence of the measured value of HGB sample voltage, and the HGB test result is reliable.And occur when unusual when instrument, for example hemolytic agent liquid outlet or dilution liquid outlet are because crystallization occurs little when stifled, bubble in the counting chamber is with showed increased, these bubbles reduce in WBC counting process gradually, but still can exert an influence during test HGB sample voltage, because the existence of bubble, the HGB sample voltage will be lower than actual value, bubble can produce deviation effects more than 20% to the HGB count value, these faults can't be found by blood cell analyzer tradition fault detection method, if do not monitor and provide corresponding prompting this moment to number of bubbles, the HGB test result that instrument provides will be insecure, very easily mislead doctor's diagnosis.Adopt the inventive method,, the bubble number of WBC passage is counted, and whether the HGB test result is accurately provided corresponding prompting, therefore guaranteed the haemoglobin reliability of testing result according to number of bubbles owing to utilize WBC passage particle counting.
Data analysis by experiment, the feature of bubble signal such as Fig. 3 a, shown in Fig. 3 b, according to the bubble feature identification of bubble there are a lot of methods, the present invention adopts following method to discern bubble in actual applications, that is: when the pulse signal in the internal memory satisfied following three conditions simultaneously, CPU judged that it is a bubble:
1, the height of pulse signal is the maximal value of A/D identification;
2, the width of pulse signal is greater than the maximal value of particle pulse width;
3, because the negative edge of bubble pulse signal is steep more a lot of than rising edge, therefore the 3rd criterion to bubble pulse is, it is that the pulse negative edge is gathered 3 times that count between peak value to 1/15 height that the pulse signal rising edge is highly counted to the collection the peak value from 1/15 of peak value.
After CPU identification and counting number of bubbles, will provide prompting according to following pre-defined rule: when number of bubbles during less than first numerical value, setting bubble does not influence the HGB test result, and instrument provides the HGB test result, no abnormal prompting; When number of bubbles during greater than first numerical value and less than second value, providing the HGB test result when instrument provides test result may inaccurate prompting; When number of bubbles during greater than second value, instrument does not provide the HGB test result.First second value is mainly relevant with the measurement amount of liquid.For example: under the WBC lane testing sample, after by the dilution of micropore and when adding liquid volume that hemolytic agent mixes and being 500ul,
When number of bubbles during less than 200 of first numerical value, the HGB test result is unaffected, and instrument provides the HGB test result, no abnormal prompting.
When number of bubbles is between first numerical value, 200～second value 300, provide the HGB test result, but provide the inaccurate prompting of HGB possibility, the prompting user discharges the fault that instrument may exist, and whether sends out test report according to concrete test result decision.
When number of bubbles during greater than 300 of second values, HGB does not give test result HGB, and test result shows * * *, and the expression test result is unreliable.
Bubble is to parameter correlations such as the dilution ratio of sample in the influence of HGB test result and the WBC counting chamber and HGB test light paths, and above-mentioned example is only for reference.
Be understandable that, for those of ordinary skills, can be equal to replacement or change according to technical scheme of the present invention and inventive concept thereof, and all these changes or replacement all should belong to the protection domain of the appended claim of the present invention.
Claims (5)
1. monitoring method to the haemoglobin test result, described method comprises the steps:
A, haemoglobin and leucocyte are tested in same counting chamber, obtain haemoglobin numerical value by measurements and calculations to reference penetrating light intensity and sample penetrating light intensity, and when the particle of leucocyte passage carries out test count in to described counting chamber with the micropore electric-resistivity method, bubble is wherein screened and counted, obtain bubble numerical value;
B, according to the bubble numerical value that records, judge the influence that bubble may produce haemoglobin test result accuracy, and provide corresponding prompting.
2. method according to claim 1 is characterized in that: described steps A comprises following processing:
A1, in described counting chamber, when having only dilution, record haemoglobin background voltage;
A2, the test sample book after will diluting add in the described counting chamber, and add the hemolytic agent mixing in counting chamber;
A3, the particle of leucocyte passage in the described counting chamber is carried out test count, and bubble is wherein screened and counted, obtain bubble numerical value, after recording the haemoglobin sample voltage, by calculating haemoglobin numerical value.
3. method according to claim 2 is characterized in that: described steps A 3 obtains bubble numerical value according to following treatment step:
A31, the simulating signal that the particle of leucocyte passage is produced during by micropore are amplified;
A32, the simulating signal that will be higher than predetermined threshold collect in the internal memory by the A/D conversion;
A33, CPU analyze and handle the pulse signal that collects in the described internal memory, screen leucocyte and bubble, obtain the gentle bubble numerical value of leucocyte numerical value respectively.
4. according to the described method of the arbitrary claim of claim 1 to 3, it is characterized in that: described step B provides corresponding prompting according to following rule: when number of bubbles during less than first numerical value, setting bubble does not influence the haemoglobin test result, and instrument provides the haemoglobin test result, no abnormal prompting; When number of bubbles during greater than first numerical value and less than second value, providing the haemoglobin test result when instrument provides test result may inaccurate prompting; When number of bubbles during greater than second value, instrument does not provide the haemoglobin test result.
5. method according to claim 4 is characterized in that: adopt following formula to calculate haemoglobin numerical value among the described step D:
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| CN2007100733252A CN101246113B (en) | 2007-02-14 | 2007-02-14 | Monitoring method for hemoglobin test result |
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| CN2007100733252A CN101246113B (en) | 2007-02-14 | 2007-02-14 | Monitoring method for hemoglobin test result |
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| CN101246113B CN101246113B (en) | 2012-08-15 |
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Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
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| WO2013064032A1 (en) * | 2011-10-31 | 2013-05-10 | 深圳迈瑞生物医疗电子股份有限公司 | Self-diagnosis method and apparatus for measuring results from blood analyzers |
| CN103499700A (en) * | 2013-09-30 | 2014-01-08 | 深圳理邦实验生物电子有限公司 | Signal effectiveness analysis method and device applied to cell analyzer |
| CN102282467B (en) * | 2008-11-13 | 2014-08-13 | 贝克曼考尔特公司 | Method of correction of particle interference to hemoglobin measurement |
| CN105388097A (en) * | 2014-08-21 | 2016-03-09 | 雅玛信过滤器株式会社 | measurement device |
| CN107843542A (en) * | 2017-11-27 | 2018-03-27 | 桂林优利特医疗电子有限公司 | The specimen cup that a kind of cellanalyzer uses |
| CN109313114A (en) * | 2016-05-20 | 2019-02-05 | 粒子监测系统有限公司 | Automated power control liquid particle counter with flow and bubble detection system |
| CN110118715A (en) * | 2018-02-06 | 2019-08-13 | 深圳市帝迈生物技术有限公司 | A kind of hemocyte pulse signal analytical equipment and method |
| CN111122841A (en) * | 2018-10-31 | 2020-05-08 | 深圳市帝迈生物技术有限公司 | Method for improving sample result accuracy and sample analyzer |
| CN113702267A (en) * | 2020-05-22 | 2021-11-26 | 深圳迈瑞生物医疗电子股份有限公司 | Hemoglobin concentration detection method and blood cell analyzer |
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| JPS6435345A (en) * | 1987-07-31 | 1989-02-06 | Canon Kk | Particle analyzing device |
| DE4233379C1 (en) * | 1992-10-05 | 1994-03-31 | Leica Ag Heerbrugg | Method and device for determining the relative visibility |
| CN1130567C (en) * | 1997-10-17 | 2003-12-10 | 库特国际公司 | Cyanide-free reagent and method for hemoglobin determination and leukocyte differentiation |
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| CN102282467B (en) * | 2008-11-13 | 2014-08-13 | 贝克曼考尔特公司 | Method of correction of particle interference to hemoglobin measurement |
| WO2013064032A1 (en) * | 2011-10-31 | 2013-05-10 | 深圳迈瑞生物医疗电子股份有限公司 | Self-diagnosis method and apparatus for measuring results from blood analyzers |
| US10114006B2 (en) | 2011-10-31 | 2018-10-30 | Shenzhen Mindray Bio-Medical Electronics Co., Ltd. | Self-diagnosis method and apparatus for measuring results from blood analyzers |
| CN103499700B (en) * | 2013-09-30 | 2014-12-10 | 深圳理邦实验生物电子有限公司 | Signal effectiveness analysis method and device applied to cell analyzer |
| CN103499700A (en) * | 2013-09-30 | 2014-01-08 | 深圳理邦实验生物电子有限公司 | Signal effectiveness analysis method and device applied to cell analyzer |
| CN105388097A (en) * | 2014-08-21 | 2016-03-09 | 雅玛信过滤器株式会社 | measurement device |
| CN105388097B (en) * | 2014-08-21 | 2019-09-27 | 雅玛信过滤器株式会社 | Measurement device |
| CN109313114A (en) * | 2016-05-20 | 2019-02-05 | 粒子监测系统有限公司 | Automated power control liquid particle counter with flow and bubble detection system |
| US10859487B2 (en) | 2016-05-20 | 2020-12-08 | Particle Measuring Systems, Inc. | Automatic power control liquid particle counter with flow and bubble detection systems |
| CN109313114B (en) * | 2016-05-20 | 2021-08-20 | 粒子监测系统有限公司 | Automatic power control liquid particle counter with flow and bubble detection system |
| CN107843542A (en) * | 2017-11-27 | 2018-03-27 | 桂林优利特医疗电子有限公司 | The specimen cup that a kind of cellanalyzer uses |
| CN110118715A (en) * | 2018-02-06 | 2019-08-13 | 深圳市帝迈生物技术有限公司 | A kind of hemocyte pulse signal analytical equipment and method |
| CN110118715B (en) * | 2018-02-06 | 2024-05-14 | 深圳市帝迈生物技术有限公司 | Blood cell pulse signal analysis device and method |
| CN111122841A (en) * | 2018-10-31 | 2020-05-08 | 深圳市帝迈生物技术有限公司 | Method for improving sample result accuracy and sample analyzer |
| CN113702267A (en) * | 2020-05-22 | 2021-11-26 | 深圳迈瑞生物医疗电子股份有限公司 | Hemoglobin concentration detection method and blood cell analyzer |
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| CN101246113B (en) | 2012-08-15 |
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