CN111122578A - Material tray type pathological section scanner and section scanning method - Google Patents
Material tray type pathological section scanner and section scanning method Download PDFInfo
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
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Abstract
The invention relates to a tray type pathological section scanner and a section scanning method, wherein the tray type pathological section scanner comprises: a first detecting unit, a second detecting unit arranged side by side with the first detecting unit, a carrying unit for conveying the slice, a control unit electrically connected with the first detecting unit, the second detecting unit and the carrying unit, and a supporting unit for supporting the first detecting unit, the second detecting unit, the carrying unit and the control unit, wherein the first detecting unit comprises: the device comprises a first camera, a prism, an objective lens module, a light collecting lens and a first light source which are arranged in sequence; the object carrying unit is positioned between the objective lens module and the light collecting lens. Through adopting first detecting element and second detecting element's successively detection, realize pathological section's automatic scanning, the assistant user carries out slide detection, improves work efficiency by a wide margin, alleviates the labour.
Description
Technical Field
The invention relates to the field of optics, in particular to a material tray type pathological section scanner and a section scanning method.
Background
At present, tissue sections are frequently used in clinical medicine pathology departments, and a traditional film reading mode is that a pathologist or an expert observes the tissue shapes of the sections through a microscope, so that diagnosis basis is provided for clinical medicine. If a doctor detects pathological sections one by one under a microscope, manpower is wasted, efficiency is low, the consistency of the judgment result is often determined according to the experience enrichment degree of a user, and the consistency of judgment of some critical values is poor.
Therefore, in recent years, a digital pathological section scanning technology has emerged, and clinical medicine pathology department can convert a tissue section into a digital section through a pathological section scanner and then diagnose a disease condition by analyzing the digital section. However, the conventional pathological section scanner has a slow scanning speed in reading the tissue section information. The problem of low efficiency leads to the fact that doctors cannot obtain the scanning result of pathological sections in time
Disclosure of Invention
The invention aims to provide a material tray type pathological section scanner and a section scanning method, and solves the problem of low pathological section scanning efficiency.
In order to achieve the above object, the present invention provides a tray type pathological section scanner, including: a first detection unit, a second detection unit arranged in parallel with the first detection unit, a loading unit for conveying the slice, a control unit electrically connected with the first detection unit, the second detection unit and the loading unit, and a supporting unit for supporting the first detection unit, the second detection unit, the loading unit and the control unit;
the first detection unit includes: the device comprises a first camera, a prism, an objective lens module, a light collecting lens and a first light source which are arranged in sequence;
the object carrying unit is positioned between the objective lens module and the light collecting lens.
According to one aspect of the invention, the second detection unit scans the whole section of the carrying unit to extract a range to be scanned in the section, and the first detection unit performs line scanning or surface scanning according to the range to be scanned.
According to an aspect of the present invention, the objective lens module includes: the device comprises a first support, a first Z-axis drive arranged on the first support, a connecting piece arranged on the first Z-axis drive, and an objective lens arranged on the connecting piece;
the first Z-axis drive drives the connecting piece and the objective lens to jointly reciprocate along the vertical direction.
According to an aspect of the present invention, the objective lens module further includes: the elastic support assembly, the first limiting assembly, the limiting block and the position identification assembly;
the elastic supporting assembly is respectively connected with the first support and the connecting piece and is used for providing an elastic force opposite to the gravity direction;
the first limiting assembly and the limiting block are used for limiting the position of the connecting piece in the Z-axis direction;
the position identification component is used for identifying the position of the connecting piece relative to the first support in the Z-axis direction.
According to one aspect of the invention, the resilient support assembly comprises: the first connecting piece is connected with the first support, the second connecting piece is connected with the connecting piece, and the elastic piece is arranged between the first connecting piece and the second connecting piece;
the location identification component comprises: a read head connected to the first support and a grating connected to the connector.
According to one aspect of the invention, the elastic force of the elastic support assembly is greater than the weight force of the connecting member.
According to an aspect of the invention, the first detection unit further comprises: a zoom lens module located between the first camera and the prism;
the zoom lens module includes: the multiple times of mirror that sets up side by side along Z axle direction for along Z axle direction drive the second Z axle drive of doubly mirror linear movement, and be used for right the spacing subassembly of second that doubly mirror position restricted.
According to an aspect of the invention, the first detection unit further comprises: a distance-increasing mirror;
the distance increasing lens is positioned between the prism and the objective lens module.
According to one aspect of the invention, the incident light path and the exit light path of the prism are perpendicular to each other.
According to one aspect of the invention, the first camera is a line scan camera or an area scan camera;
the first light source is a fiber light source.
According to an aspect of the invention, the second detection unit includes: the second camera, the coaxial light source and the surface light source are arranged in sequence;
the carrying unit is positioned between the coaxial light source and the surface light source.
According to one aspect of the invention, the second camera is a panoramic camera.
According to one aspect of the invention, the carrier unit comprises: the XY axis driving device, the scanning platform arranged on the XY axis driving device, and the material tray detachably connected with the scanning platform;
the scanning platform is provided with a tray groove for mounting the tray;
the side walls of two opposite sides of the tray groove are provided with tray guide grooves along the Y-axis direction;
a material tray stop block is arranged at one end of the material tray groove along the X-axis direction;
and one end of the tray groove, which is provided with the tray stop block, is provided with a microswitch for detecting whether the tray is in place or not along the Y-axis direction.
According to one aspect of the invention, a tray clamping groove is arranged on one side of the tray stop block adjacent to the tray;
along the X-axis direction, the other end of charging tray recess is provided with the charging tray locating part, the charging tray locating part supporting is in on two lateral walls of charging tray recess along the Y axle direction, with the charging tray recess constitutes the passageway that supplies the charging tray passes.
According to one aspect of the invention, a clamping groove for positioning the charging tray is arranged on the side wall of the charging tray groove along the Y-axis direction;
and a ball plunger capable of being clamped with the clamping groove is arranged on the side wall of the material tray.
According to one aspect of the invention, the bottom surface of the tray groove and the bottom surface of the tray are respectively provided with a magnetic attraction piece.
According to one aspect of the invention, a slicing mounting groove for mounting slices is arranged on the tray;
a slice pressing block for clamping a slice is arranged at one end of the slice mounting groove;
the slicing and pressing block is connected with the material tray in a sliding manner and is elastically connected with the material tray;
one end of the slice pressing block can abut against the side edge of the slice.
According to one aspect of the invention, the end face of one end of the slice pressing block, which is abutted against the slice, is an inclined face.
To achieve the above object, the present invention provides a slice scanning method, including:
s1, taking down a material tray in the carrying unit and loading the material tray into a slice;
s2, reloading the material tray into the carrying unit, and switching on a power supply to start up;
s3, the material loading unit drives the material tray to move to the position of the second detection unit, panoramic scanning is carried out, and the range to be scanned in the slice is obtained;
s4, the material loading unit drives the material tray to move to the position of the first detection unit, and the first detection unit scans the slice according to the range to be scanned;
and S5, acquiring the scanning result of the first detection unit, and splicing to form a complete slice image.
According to one scheme of the invention, the automatic scanning of pathological sections is realized by adopting the sequential detection of the first detection unit and the second detection unit, so that a user is assisted in carrying out slide detection, the working efficiency is greatly improved, and the labor force is reduced.
According to one scheme of the invention, the second detection unit can greatly reduce the scanning time by adopting the preselected scanning range of the panoramic camera, so as to prevent the scanning in the blank area and save the scanning time.
According to one scheme of the invention, the design of the material module can be focused quickly to realize scanning, and in addition, under the conditions of unexpected power failure and the like, the objective lens can rebound automatically to protect the objective lens device and the corresponding slice, and after being electrified again, the objective lens device and the corresponding slice can automatically return to zero to scan again.
According to one scheme of the invention, the section is positioned and information is read in a machine vision mode, the section is divided into areas according to the requirements of a user, the scanning position is extracted in advance for judgment, the scanning time of a blank area can be effectively removed in the subsequent scanning, and the scanning efficiency of the pathological slide is greatly improved.
According to one scheme of the invention, the objective lens module can move back and forth in the Z-axis direction to adjust the position, a phase focusing mode is realized, layered scanning is carried out, a clearer focusing light path image can be obtained, and the accuracy consistency is higher.
According to one scheme of the invention, the balance weight of the objective lens module is reasonably distributed and designed, so that the stability of the upper buoyancy of the objective lens can be ensured.
According to one scheme of the invention, the objective lens module adopts a mode of grating motion and immovable reading head, thereby effectively reducing the influence of dynamic errors generated by pulling a line and ensuring the stable and low fluctuation of speed operation in the up-and-down moving process of the objective lens.
According to one scheme of the invention, the scanning platform and the material tray are matched and positioned by adopting various structures, so that the material loading positions of the material trays are the same every time, and the positioning is accurate and stable.
According to one scheme of the invention, the scanning platform is provided with the micro switch, so that whether the material tray is in place or not can be directly and visually monitored.
According to one scheme of the invention, the first detection unit is provided with the zoom lens module, and the module operates in an automatic zoom lens switching mode, so that different multiplying powers in an optical path can be adjusted according to requirements, and the detection device is low in cost and high in efficiency.
According to one scheme of the invention, the second detection unit has a wide shooting range, can be compatible with two-inch slides, can meet the use requirements of different medical workers, and improves the application range of the invention.
According to one scheme of the invention, the first detection unit adopts a prism bending mode to perform 90-degree angle folding on the optical path system, so that the overall height of the optical path system is effectively shortened, and the installation space of the optical path system is saved.
Drawings
Fig. 1 schematically shows a front view of a tray-type pathological section scanner according to an embodiment of the present invention;
fig. 2 schematically shows a structural layout of a tray-type pathological section scanner according to an embodiment of the present invention;
FIG. 3 schematically shows an optical path diagram of a first detection unit according to an embodiment of the present invention;
fig. 4 schematically shows a structural view of an objective lens module according to an embodiment of the present invention.
FIG. 5 schematically shows a block diagram of a second detection unit according to an embodiment of the invention;
fig. 6 schematically shows a construction of a carrier unit according to an embodiment of the invention;
FIGS. 7 and 8 schematically illustrate a block diagram of a carrier and tray according to an embodiment of the invention;
FIG. 9 schematically shows a bottom block diagram of a tray according to an embodiment of the invention;
FIG. 10 schematically shows a cross-sectional view of a tray according to an embodiment of the invention;
fig. 11 schematically shows a housing diagram of a tray-type pathological section scanner according to an embodiment of the present invention.
Detailed Description
In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings used in the embodiments will be briefly described below. It is obvious that the drawings in the following description are only some embodiments of the invention, and that for a person skilled in the art, other drawings can be derived from them without inventive effort.
In describing embodiments of the present invention, the terms "longitudinal," "lateral," "upper," "lower," "front," "rear," "left," "right," "vertical," "horizontal," "top," "bottom," "inner," "outer," and the like are used in an orientation or positional relationship that is based on the orientation or positional relationship shown in the associated drawings, which is for convenience and simplicity of description only, and does not indicate or imply that the referenced device or element must have a particular orientation, be constructed and operated in a particular orientation, and thus, the above-described terms should not be construed as limiting the present invention.
The present invention is described in detail below with reference to the drawings and the specific embodiments, which are not repeated herein, but the embodiments of the present invention are not limited to the following embodiments.
As shown in fig. 1, according to an embodiment of the present invention, a tray type pathological section scanner includes: the device comprises a first detection unit 11, a second detection unit 12 arranged side by side with the first detection unit 11, a carrying unit 13 used for conveying slices, a control unit 14 electrically connected with the first detection unit 11, the second detection unit 12 and the carrying unit 13, and a supporting unit 15 used for supporting the first detection unit 11, the second detection unit 12, the carrying unit 13 and the control unit 14. In the present embodiment, the first detection unit 11 is located before the second detection unit 12 in the feeding direction of the loading unit 13.
According to one embodiment of the present invention, the second detection unit 12 scans the whole section of the loading unit 13 to extract the range to be scanned in the section, and the first detection unit 11 performs line scanning or surface scanning according to the range to be scanned. In this embodiment, the second detection unit 12 directly images all the slices on the object carrying unit 13 at one time, and then locates and reads the slices (or test slides) by using machine vision, and divides the slices (or test slides) into regions according to the user's requirements, and determines the range to be scanned in advance, so that the scanning time of blank regions can be effectively removed in the subsequent scanning of the first detection unit 11.
Through the arrangement, the mode that the double detection units are arranged in parallel is adopted, so that the two detection units can realize a cooperative detection effect, and the scanning speed of pathological sections is greatly improved. Particularly, one detection unit is used for extracting and positioning the scanning range of the slice, and the other detection unit can directly perform line scanning or surface scanning according to the extracted scanning range, so that the scanning process of other non-effective areas is effectively eliminated, and the scanning efficiency of the invention is greatly improved. In addition, by positioning the scanning range in advance, the invalid region does not need to be scanned in the subsequent scanning process, so that the data volume obtained by scanning can be effectively reduced, and the scanning efficiency is further improved.
Referring to fig. 1, 2 and 3, according to an embodiment of the present invention, the first detecting unit 11 includes: a first camera 111, a prism 112, an objective lens module 113, a condenser 114, and a first light source 115, which are sequentially disposed. In the present embodiment, the loading unit 13 is located between the objective lens module 113 and the condenser 114. In the present embodiment, the first detection unit 11 is further provided with a protective cover 11 a. In this embodiment, the first camera 111 and the prism 112 are both surrounded in a cavity by the protective cover 11a, so that the influence of the falling of impurities such as dust on the optical path is effectively avoided, the imaging definition is ensured, and the detection precision is effectively improved. In addition, the protective cover 11a can also block the entering of external light, further ensuring the imaging effect of the first detection unit 11 and effectively improving the detection precision.
As shown in fig. 4, according to an embodiment of the present invention, the objective lens module 113 includes: a first support 1131, a first Z-axis drive 1132 mounted on the first support 1131, a coupling 1133 mounted on the first Z-axis drive 1132, and an objective lens 1134 mounted on the coupling 1133. In this embodiment, the first Z-axis drive 1132 drives the link 1133 and the objective 1134 to reciprocate together in the vertical direction. In this embodiment, the connecting member 1133 may be provided with a transition piece 1133a connected to the objective lens 1134, the transition piece 1133a is an L-shaped structure, and the objective lens 1134 is mounted on the transition piece 1133a so that the objective lens may directly face the slice on the object carrying unit 13.
As shown in fig. 4, according to an embodiment of the present invention, the objective lens module 113 further includes: a resilient support assembly 1135, a first stop assembly 1136, a stop block 1137, and a location identification assembly 1138; in this embodiment, resilient support assemblies 1135 are coupled to first support 1131 and to connector 1133, respectively, and are configured to provide a resilient force in a direction opposite to the direction of gravity. In this embodiment, the first limiting component 1136 is connected to the first support 1131 and the connecting component 1133, the limiting component 1137 is connected to the first support 1131, and the first limiting component 1136 and the limiting component 1137 are used for limiting the position of the connecting component 1133 in the Z-axis direction. In this embodiment, position indicator assembly 1138 is coupled to first support 1131 and connector 1133, respectively, for indicating the position of connector 1133 relative to first support 1131 in the Z-axis direction.
As shown in FIG. 4, according to one embodiment of the present invention, the resilient support assembly 1135 comprises: a first connector 1135a connected to the first support 1131, a second connector 1135b connected to the connector 1133, and an elastic member 1135c disposed between the first connector 1135a and the second connector 1135 b. In this embodiment, the first connector 1135a and the second connector 1135b are slidably connected, and an elastic member 1135c is provided at the connection position thereof. In this embodiment, the elastic force of the elastic support assembly 1135 is greater than the gravity of the connecting member 1133, so that when the first Z-axis driver 1132 fails, the objective lens 1134 is timely reset, the objective lens 1134 is prevented from dropping and colliding with the carrying unit 13, secondary damage caused by the first Z-axis driver 1132 is eliminated, and the safety in use and the service life of the present invention are ensured.
In this embodiment, the elastic force of the elastic support assembly 1135 is slightly greater than the total mass of the coupling 1133 and the components mounted thereon, which can cause the first Z-axis drive 1132 to lose its function and generate an upward restoring force to reposition the objective lens 1134. In this embodiment, the connecting member 1133 may be provided with a mounting location for mounting a weight, and when the elastic force of the elastic support assembly 1135 is much greater than the total mass of the connecting member 1133 and each assembly mounted on the connecting member, the weight may be mounted on the connecting member to adjust the elastic return speed of the elastic support assembly 1135.
In this embodiment, the first limiting assembly 1136 includes: a first photosensor 1136a connected to the first support 1131, and a flap 1136b connected to the connector 1133. In this embodiment, the first limiting component 1136 can effectively prevent the objective 1134 from colliding with the carrying unit 13 due to the excessively low falling height, thereby ensuring the safety of the present invention.
In this embodiment, the limiting block 1137 is made of a soft material. In this embodiment, the stop 1137 can be made of polyurethane. The limiting block 1137 can effectively prevent the objective 1134 from being collided with other units due to overhigh rising height, and the use safety of the invention is ensured.
In this embodiment, the location identifier component 1138 includes: a read head 1138a connected to the first support 1131 and a grating 1138b connected to the connection 1133.
Referring to fig. 2 and 3, according to an embodiment of the present invention, the first detecting unit 11 further includes: a zoom lens module 116 located between the first camera 111 and the prism 112. In the present embodiment, the zoom lens module 116 includes: a plurality of doubling mirrors 1161 arranged side by side along the Z-axis direction, a second Z-axis drive 1162 for driving the doubling mirrors 1161 to move linearly along the Z-axis direction, and a second limiting component for limiting the position of the doubling mirrors 1161. In the present embodiment, the second stopper means is also realized by a photoelectric sensor.
According to one embodiment of the present invention, the first camera 111 is a line scan camera or an area scan camera; the first light source 115 is a fiber optic light source.
As shown in fig. 3, according to an embodiment of the present invention, a distance increasing lens 117 may be optionally disposed between the prism 112 and the objective lens module 113 to reduce the total distance between the first camera 111 and the light collecting lens 114.
As shown in fig. 3, according to one embodiment of the present invention, the incident light path and the emergent light path of the prism 112 are perpendicular to each other. In the present embodiment, the incident optical path of the prism 112 refers to an optical path between the first light source 115 and the prism 112, through which the light is transmitted from the first light source 115 to the prism 112, and the emergent optical path of the prism 112 refers to an optical path between the prism 112 and the first camera 111, through which the light is transmitted from the prism 112 to the first camera 111.
As shown in fig. 5, according to an embodiment of the present invention, the second sensing unit 12 includes: a second camera 121, a coaxial light source 122, and a surface light source 123, which are sequentially disposed. In the present embodiment, the loading unit 13 is located between the coaxial light source 122 and the surface light source 123. In the present embodiment, the second camera 121 is a panoramic camera.
Referring to fig. 6, 7 and 8, according to an embodiment of the present invention, the loading unit 13 includes: an XY-axis driving device 131, a scanning platform 132 installed on the XY-axis driving device 131, and a tray 133 detachably connected to the scanning platform 132. In the present embodiment, the scanning platform 132 is provided with a tray recess 1321 for mounting the tray 133. The side walls of the opposite sides of the tray groove 1321 are provided with tray guide grooves 1321a along the Y-axis direction. In the present embodiment, the tray guide 1321a may be formed by directly machining the side wall of the tray recess 1321, or a long plate-like body may be attached to the side wall of the tray recess 1321 so that the tray guide 1321a is formed between the plate-like body and the side wall of the tray recess 1321. In the present embodiment, a tray stopper 1321b is provided at one end of the tray recess 1321 in the X-axis direction; one end of the tray groove 1321, at which the tray stopper 1321b is provided, is provided with a micro switch 1321c for detecting whether the tray 133 is in place along the Y-axis direction.
According to the invention, the tray guide grooves 1321a are arranged on the side walls of the two opposite sides of the tray groove 1321, so that the mounting tray 133 can be guided, and the mounted tray 133 can be positioned, so that the mounting tray 133 is smoothly mounted, the tilting of the tray 133 in the detection process is avoided, and the detection precision is ensured. In addition, the accurate positioning of the loading position of the tray 133 is realized by the tray stopper 1321b, and the slice on the tray 133 is ensured to be accurately detected. The microswitch 1321c is arranged in parallel with the tray stop 1321b, so that the microswitch 1321c is triggered when the tray 133 abuts against the tray stop 1321b for limiting, the signal output of the in-place installation is realized, and the scanner can automatically perform the subsequent detection process.
Referring to fig. 7 and 8, according to an embodiment of the present invention, a tray catching groove (not shown) is provided on a side of the tray stopper 1321b adjacent to the tray 133. In this embodiment, the tray locking groove may be formed directly on the tray stopper 1321b, or may be formed by attaching a long plate-like body so that the plate-like body and the side wall of the tray stopper 1321b form the tray locking groove. In the present embodiment, the other end of the tray recess 1321 is provided with a tray stopper 1321e in the X-axis direction, and the tray stopper 1321e is supported by both side walls of the tray recess 1321 in the Y-axis direction and constitutes a passage through which the feed tray 133 passes together with the tray recess 1321.
According to the invention, the tray clamping groove and the tray limiting piece 1321e are further arranged, so that the limitation on the periphery of the tray 133 can be realized by combining the tray guide groove 1321a, the mounting flatness of the tray is further ensured, and the detection precision of the invention is further improved.
As shown in fig. 7, according to an embodiment of the present invention, a catching groove 1321f for positioning the tray 133 is provided on a side wall of the tray recess 1321 in the Y-axis direction. In this embodiment, a plurality of card slots 1321f may be provided in parallel along the side wall of the tray recess 1321. In this embodiment, the side wall of the tray 133 is provided with a ball plunger engageable with the engaging slot 1321 f.
According to the invention, the clamping grooves 1321f are formed in the side wall of the tray groove 1321, and the ball plungers are correspondingly arranged on the side wall of the tray 133, so that the ball plungers can be mutually clamped with the clamping grooves 1321f after the tray 133 abuts against the tray stop 1321b, the positioning of the tray 133 is further realized, the sliding of the tray 133 in the tray groove 1321 is prevented, the position fixing of the tray 133 in the process of conveying the tray 133 can be effectively ensured, and the detection precision of the invention is further ensured.
According to one embodiment of the invention, the bottom surface of the tray recess 1321 and the bottom surface of the tray 133 are provided with magnetic attraction members, respectively.
Through the arrangement, the magnetic parts are respectively arranged on the bottom surface of the tray groove 1321 and the bottom surface of the tray 133, so that the tray 133 and the tray groove 1321 are mutually attracted and fixed, the flatness of the tray 133 is further ensured, meanwhile, the function of limiting the tray 133 to shake or slide relative to the tray groove 1321 is also achieved, and the detection precision of the invention is further ensured.
As shown in fig. 7, 8, 9 and 10, according to an embodiment of the present invention, the tray 133 is provided with a slice mounting groove 1331 for mounting slices. In the present embodiment, a slice pressing block 1331a for clamping a slice is provided at one end of the slice mounting groove 1331. In this embodiment, the sliced piece pressing block 1331a is slidably connected to the mounting position on the tray 133, and an elastic returning member 1331c is provided between the sliced piece pressing block 1331a and the tray 133 in the sliding direction along the sliced piece pressing block 1331a, and the end of the sliced piece pressing block 1331a abuts against the side edge of the sliced piece under the action of the elastic returning member 1331 c. In the present embodiment, the end surface and the inclined surface of the end of the slice pressing block 1331a that abuts against the slice.
In this embodiment, a tray handle may be provided at one end of the tray 133 to facilitate attachment and detachment of the tray 133.
As shown in fig. 2, according to an embodiment of the present invention, the supporting unit 15 includes: a first supporting plate 151, a second supporting plate 152, a third supporting plate 153, a first upright plate 154, and a second upright plate 155. In the present embodiment, the first support plate 151, the second support plate 152 and the third support plate 153 are disposed in parallel with each other at intervals in the Z-axis direction, the first vertical plate 154 is fixedly coupled to the first support plate 151, the second support plate 152, and the second vertical plate 155 is fixedly coupled to the second support plate 152 and the third support plate 153, respectively. In the present embodiment, the loading unit 13 is fixedly supported on the second support plate 152, the first camera 111, the prism 112, the objective lens module 113, and the zoom lens module 116 in the first detection unit 11 are fixedly supported on the third support plate 153, and the second camera 121 and the coaxial light source 122 in the second detection unit 12 are fixedly supported on the third support plate 153.
According to the invention, the supporting unit 15 is simple in structure and firm in connection, and the detection stability and the detection precision of the whole device are ensured.
As shown in fig. 11, the tray-type pathological section scanner according to the present invention further includes a housing 16 according to an embodiment of the present invention. In the embodiment, the shell is designed in a manually detachable mode (similar to a buckling mechanism), so that the whole installation and maintenance of the equipment are facilitated. The scanner of the present invention is enclosed in a cavity by the housing 16, which ensures the safety of the whole operation process. Adopt the soft callus on the sole of rubber, the callus on the sole bottom adopts hard material veneer, has promoted the anti-vibration ability of equipment greatly, can not make equipment callus on the sole contact surface actuation because of soft callus on the sole again, convenient transport.
According to an embodiment of the present invention, a slice scanning method of the present invention includes:
s1, taking down and loading the tray 133 in the carrying unit 13 into slices;
s2, reloading the material tray 133 into the carrying unit 13, and switching on a power supply to start up;
s3, the carrying unit 13 drives the material tray 133 to move to the position of the second detection unit 12, panoramic scanning is carried out, and the range to be scanned in the slice is obtained;
s4, the carrying unit 13 drives the material tray 133 to move to the position of the first detection unit 11, and the first detection unit 11 scans the slice according to the range to be scanned;
and S5, acquiring the scanning result of the first detection unit 11, and splicing to form a complete slice image.
The foregoing is merely exemplary of particular aspects of the present invention and devices and structures not specifically described herein are understood to be those of ordinary skill in the art and are intended to be implemented in such conventional ways.
The above description is only one embodiment of the present invention, and is not intended to limit the present invention, and various modifications and changes may be made by those skilled in the art. Any modification, equivalent replacement, or improvement made within the spirit and principle of the present invention should be included in the protection scope of the present invention.
Claims (10)
1. A tray-type pathological section scanner, comprising: a first detection unit (11), a second detection unit (12) arranged side by side with the first detection unit (11), a carrying unit (13) for conveying a slice, a control unit (14) electrically connected with the first detection unit (11), the second detection unit (12) and the carrying unit (13), and a supporting unit (15) for supporting the first detection unit (11), the second detection unit (12), the carrying unit (13) and the control unit (14);
the first detection unit (11) includes: the device comprises a first camera (111), a prism (112), an objective lens module (113), a light collecting lens (114) and a first light source (115) which are arranged in sequence;
the carrying unit (13) is positioned between the objective module (113) and the condenser (114).
2. The tray type pathological section scanner according to claim 1, wherein the second detection unit (12) scans the whole section of the loading unit (13) to extract the range to be scanned in the section, and the first detection unit (11) performs line scanning or surface scanning according to the range to be scanned.
3. The tray-type pathological section scanner according to claim 2, wherein the objective lens module (113) comprises: a first support (1131), a first Z-axis drive (1132) mounted to the first support (1131), a coupling (1133) mounted to the first Z-axis drive (1132), an objective lens (1134) mounted to the coupling (1133);
the first Z-axis drive (1132) drives the connecting piece (1133) and the objective lens (1134) to reciprocate jointly along the vertical direction;
the objective lens module (113) further comprises: an elastic support assembly (1135), a first limit assembly (1136), a limit block (1137) and a position identification assembly (1138);
the elastic support assembly (1135) is respectively connected with the first support (1131) and the connecting piece (1133) and is used for providing an elastic force opposite to the gravity direction;
the first limiting component (1136) and the limiting block (1137) are used for limiting the position of the connecting piece (1133) in the Z-axis direction;
the position identification component (1138) is used for identifying the position of the connecting piece (1133) relative to the first support (1131) in the Z-axis direction.
4. The tray-type pathological section scanner according to claim 3, wherein the elastic support assembly (1135) comprises: a first connector (1135a) connected to the first support (1131), a second connector (1135b) connected to the connector (1133), and an elastic member (1135c) disposed between the first connector (1135a) and the second connector (1135 b);
the location identification component (1138) comprises: a reading head (1138a) connected to the first support (1131) and a grating (1138b) connected to the connection (1133);
the elastic force of the elastic support assembly (1135) is greater than the weight force of the connecting piece (1133).
5. The tray-type pathological section scanner according to any one of claims 1 to 4, wherein the first detection unit (11) further comprises: a zoom lens module (116) located between the first camera (111) and the prism (112);
the zoom lens module (116) includes: the multiple double mirrors (1161) are arranged side by side along the Z-axis direction, the second Z-axis drive (1162) is used for driving the double mirrors (1161) to move linearly along the Z-axis direction, and the second limiting assembly is used for limiting the positions of the double mirrors (1161);
the first detection unit (11) further comprises: a range-increasing mirror (117);
the distance-increasing lens (117) is positioned between the prism (112) and the objective lens module (113);
the incident light path and the emergent light path of the prism (112) are vertical to each other;
the first camera (111) is a line scan camera or an area scan camera;
the first light source (115) is a fiber optic light source.
6. Tray-type pathological section scanner according to any one of claims 1 to 4, characterized in that said second detection unit (12) comprises: the second camera (121), the coaxial light source (122) and the area light source (123) are arranged in sequence;
the loading unit (13) is positioned between the coaxial light source (122) and the surface light source (123).
The second camera (121) is a panoramic camera.
7. Tray-type pathological section scanner according to any one of claims 1 to 4, characterized in that the carrier unit (13) comprises: the device comprises an XY axis driving device (131), a scanning platform (132) arranged on the XY axis driving device (131), and a tray (133) detachably connected with the scanning platform (132);
the scanning platform (132) is provided with a tray groove (1321) for mounting the tray (133);
along the Y-axis direction, the side walls of two opposite sides of the tray groove (1321) are provided with tray guide grooves (1321 a);
a tray stop block (1321b) is arranged at one end of the tray groove (1321) along the X-axis direction;
and a microswitch (1321c) for detecting whether the tray (133) is in place is arranged at one end of the tray groove (1321) where the tray stop block (1321b) is arranged along the Y-axis direction.
8. The tray type pathological section scanner according to claim 7, wherein a tray slot is arranged on one side of the tray stopper (1321b) adjacent to the tray (133);
along the X-axis direction, the other end of charging tray recess (1321) is provided with charging tray locating part (1321e), charging tray locating part (1321e) support on charging tray recess (1321) two lateral walls along the Y axle direction, constitute the passageway that supplies charging tray (133) pass with charging tray recess (1321).
A clamping groove (1321f) for positioning the tray (133) is formed in the side wall of the tray groove (1321) along the Y-axis direction;
and a ball plunger which can be clamped with the clamping groove (1321f) is arranged on the side wall of the charging tray (133).
Magnetic parts are respectively arranged on the bottom surface of the tray groove (1321) and the bottom surface of the tray (133).
9. The tray type pathological section scanner according to claim 8, wherein a section installation slot (1331) for installing the section is arranged on the tray (133);
a slice pressing block (1331a) for clamping a slice is arranged at one end of the slice mounting groove (1331);
the slicing and pressing block (1331a) is connected with the tray (133) in a sliding mode, and the slicing and pressing block (1331a) is elastically connected with the tray (133);
one end of the slice pressing block (1331a) can be abutted against the side edge of the slice.
The end face and the inclined face of one end, which is abutted against the cut piece, of the cut piece pressing block (1331 a).
10. A slice scanning method using the tray-type pathological slice scanner of any one of claims 1 to 9, comprising:
s1, taking down a material tray (133) in the carrying unit (13) and loading the material tray into slices;
s2, reloading the material tray (133) into the carrying unit (13), and switching on a power supply to start up;
s3, the carrying unit (13) drives the material tray (133) to move to the position of the second detection unit (12), panoramic scanning is carried out, and the range to be scanned in the slice is obtained;
s4, the carrying unit (13) drives the material tray (133) to move to the position of the first detection unit (11), and the first detection unit (11) scans the slice according to the range to be scanned;
and S5, acquiring the scanning result of the first detection unit (11), and splicing to form a complete slice image.
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