CN111220617A - Novel pathological section scanner - Google Patents
Novel pathological section scanner Download PDFInfo
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- CN111220617A CN111220617A CN202010226841.XA CN202010226841A CN111220617A CN 111220617 A CN111220617 A CN 111220617A CN 202010226841 A CN202010226841 A CN 202010226841A CN 111220617 A CN111220617 A CN 111220617A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/84—Systems specially adapted for particular applications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/01—Arrangements or apparatus for facilitating the optical investigation
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/02—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor using a plurality of sample containers moved by a conveyor system past one or more treatment or analysis stations
- G01N35/04—Details of the conveyor system
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
- G01N35/10—Devices for transferring samples or any liquids to, in, or from, the analysis apparatus, e.g. suction devices, injection devices
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Abstract
The invention relates to the field of medical instruments, in particular to a novel pathological section scanner. Comprises a conveying device, a loading device, a positioning device, an image device and a movable platform; the conveying device, the loading device and the imaging device are independent and are all arranged on the scanner platform; the alignment device and the movable platform are both arranged on the image base. By adopting the automatic loading device for the glass slide, one-time super-capacity loading can be realized, frequent feeding and discharging of operators and whole-process monitoring are not needed, the time is saved, and the scanning efficiency is improved; the automatic glass slide clamping device can also achieve simultaneous taking and placing, improves clamping efficiency, reduces waiting time between sheets, can perform setting control on clamping force in an effective stroke, can monitor whether glass slides are clamped or not and prevent the glass slides from being broken, can also accurately judge the quantity of the glass slides loaded in each sheet box, can also achieve shooting of multiple visual fields, and can accurately and completely acquire information of the glass slides.
Description
Technical Field
The invention relates to the field of medical instruments, in particular to a novel pathological section scanner.
Background
Pathological examination is a pathomorphological method for examining pathological changes in organs, tissues or cells of the body. In order to study the disease process of organs, tissues or cells, some kind of pathological morphological examination method can be used to examine the pathological changes of them, study the cause, pathogenesis and the process of pathological changes, and finally make pathological diagnosis. The pathological morphological examination method is that the pathological change of the general specimen is observed, then the pathological tissue with certain size is cut out, the pathological section is made by the pathological histological method, and the pathological change is further examined by a microscope.
The digital section system can rapidly scan the whole glass slide in a full-information and all-round way, so that the traditional materialized glass slide becomes a new generation of digital pathological section, and the digital section system is an epoch-making revolution for realizing pathological diagnosis technology. The system can separate a pathologist from a microscope, solve pathological diagnosis through a network at any time and any place, realize global online synchronous remote consultation or offline remote consultation, and has great significance for time and space alternation and transmission advantages of diagnosis value equal to that of microscope observation due to the fact that full-section information is provided. And multilayer three-dimensional reconstruction of pathological sections and management digitization of the pathological sections are also realized. The system can be widely used for pathological clinical diagnosis, pathological teaching, histological cell imaging, fluorescence analysis and immunohistochemical digital imaging. The glass slice is scanned into a digital slice, so that the storage and the circulation are convenient; just like scanning the common developed photo into a digital photo, the photo can be read and examined on a computer without singly observing the photo by using a microscope.
The existing digital pathological section scanner is internally provided with a section scanning part and a section replacing part, but the existing digital pathological section scanner basically adopts a mode of controlling the scanner to work by a computer, so that the following defects are caused: 1. when the worker finishes loading the slices at the scanner end, the worker needs to go to the computer to operate and know the working state of the scanner, and if the worker operates for multiple times, the worker needs to go back and forth between the scanner and the computer for multiple times, so that the time of the worker is wasted, and the working efficiency is also reduced. 2. The working state of the scanner cannot be known in real time, and if the working state of the scanner needs to be known, the scanner needs to be checked in front of a computer. 3. Because the loading and the scanning are carried out on the two machines, the workers cannot directly operate at the scanner after loading. Meanwhile, the section is made of glass and has the characteristics of fragility, smoothness and thinness, so that the section is difficult to take and place safely, and the flatness of the section is easy to influence when the section is arranged in a section replacement part.
Disclosure of Invention
In order to solve the above problems, the present invention provides a novel pathological section scanner, which comprises a conveying device, a loading device, a positioning device, an imaging device and a movable platform; the conveying device, the loading device and the imaging device are independent and are all arranged on the scanner platform; the alignment device and the movable platform are both arranged on the image base.
As a preferable technical solution, the conveying device comprises an X-axis lifting mechanism, a Y-axis lifting mechanism and a Z-axis lifting mechanism; the X-axis lifting mechanism is movably connected with a Z-axis support in the Z-axis direction, one side of the Z-axis support is connected with a Z-axis lifting mechanism, the Z-axis lifting mechanism is movably connected with a scanning sensor, and the upper end face of the scanning sensor is connected with a group of Y-axis lifting mechanisms; the bottom of the Z-axis support is connected with an X-axis moving wire casing, and the X-axis moving wire casing can move on the X-axis lifting mechanism so as to drive the Z-axis support to move; the top of the Z-axis support is connected with a Z-axis moving line slot, and the Z-axis moving line slot can move on the Z-axis lifting mechanism so as to drive the scanning sensor to move; a group of electric film taking mechanisms are connected between the Y-axis lifting mechanisms; the number of the Y-axis lifting mechanisms is two, and the two Y-axis lifting mechanisms are connected in parallel; the two electric film taking mechanisms are connected in parallel; the two Y-axis lifting mechanisms respectively control the two electric sheet taking mechanisms to move in the Y-axis direction.
As a preferred technical solution, the loading device comprises a slicing box device, and the slicing box device is used for containing slices; the conveying device can move out the slice to be scanned in the slice box device for scanning and move the scanned slice into the slice box device again.
As a preferred technical scheme, the alignment device comprises an alignment base, a fixing component, an alignment bracket, an alignment camera and an alignment light source; the alignment base and the fixing assembly are arranged below the alignment support and are connected with the alignment support; the alignment support is provided with a camera mounting frame, an alignment camera is arranged at the top of the camera mounting frame, and an alignment light source is arranged in the middle of the camera mounting frame; one side of the aligning support is provided with an aligning cylinder, and the other side of the aligning support is provided with a second fixed stop block; a first fixed stop block is arranged on the alignment cylinder; an alignment platform is further arranged between the first fixed stop block and the second fixed stop block; the alignment platform is located in the middle of the alignment support and is arranged in parallel with the first fixed stop block and the second fixed stop block.
As a preferred technical solution, the alignment light source is located below a lens of the alignment camera and is used for polishing a photographed glass slide when the alignment camera takes a picture; when the glass slide is placed on the alignment platform, the alignment cylinder starts to move and pushes the glass slide to the lower part of a camera of an alignment camera for shooting; the alignment camera is internally provided with an image processing module, and the image processing module is used for identifying image information on the glass slide.
As a preferred technical solution, the imaging device includes an image base, a support pillar, an image bracket, an image light source, a vision module, and a Z-axis motor; the image base, support columns vertically arranged on the left side and the right side of the image base and image supports vertically arranged on the tops of the support columns form a machine platform whole, a groove is formed in the image base, and an image light source is arranged in the groove; the vision module is in clearance fit with the bayonet of the image bracket; the Z-axis motor is fixedly connected with the vision module through a metal fixing piece; a motor wire slot is arranged on the Z-axis motor and is fixedly connected with the image bracket; the image light source and the micro lens of the vision module are coaxially arranged and used for polishing the bottom of a shot object during shooting.
As a preferred technical solution, the image device further includes a dual-lens switching motor, and the dual-lens switching motor is fixedly connected to the metal fixing member.
As a preferred technical scheme, the movable platform comprises a platform base, an X movable platform, a Y movable platform, a rotary cylinder, a claw and a platform bracket; the X-axis and Y-axis parallel moving platform is arranged on the X-axis and Y-axis parallel moving platform, and the X-axis and Y-axis parallel moving platform are arranged on the X-axis and Y-axis parallel moving platform; a platform support is arranged on the Y-shaped moving platform; a rotary cylinder is arranged on the platform bracket; the center of the claw is connected with a rotating shaft arranged on the Y-shaped moving platform and is arranged on the platform bracket; an X-shaped moving wire slot is arranged on the X-shaped moving platform; a Y-shaped moving wire slot is formed in the Y-shaped moving platform; the glass slide polishing device is characterized in that an object stage is arranged on the platform support, and a platform light source is arranged below the object stage and used for polishing glass slides placed on the object stage.
As a preferred technical scheme, a claw connecting piece is arranged below the claw and used for bearing the claw; the claw connecting piece is fixedly arranged on the Y-shaped moving platform, and the center of the claw connecting piece penetrates through the rotating shaft; the tail end of the hook claw connecting piece is provided with an arc-shaped hole.
As a preferable technical scheme, one end of the hook claw is provided with a clamping foot, and the bottom of the other end of the hook claw is provided with a bulge; the protrusions are arranged corresponding to the arc-shaped holes, and when the hook claw rotates forwards or backwards relative to the hook claw connecting piece, the protrusions of the hook claw slide in the corresponding arc-shaped holes, so that the clamping feet of the hook claw are tightly supported or loosened.
Compared with the prior art, the invention has the following beneficial effects:
the invention provides a novel pathological section scanner, which can realize one-time super-large-capacity loading without frequent feeding and discharging of operators and whole-process monitoring by adopting the automatic glass slide loading device, thereby saving time and improving scanning efficiency; the device can also realize simultaneous taking and placing, improve the clamping efficiency, reduce the waiting time between sheets, simultaneously perform the setting control of the clamping force in the effective stroke, monitor whether the slide glass is clamped or not and prevent the slide glass from being broken, and also can accurately judge the number of the slide glass loaded on each sheet box and confirm whether the states of lamination, oblique insertion sheets and the like occur or not; secondly, the slide glass can be accurately positioned, manual correction by operators is not needed, time is saved, and scanning efficiency is improved; meanwhile, the shooting with more visual fields can be realized, and the information of the glass slide can be accurately and completely acquired.
Drawings
In order to more clearly illustrate the technical solution of the present invention, the drawings used in the embodiments will be briefly described below, the drawings described below are only some embodiments of the present invention, and it is obvious to those skilled in the art that other drawings can be obtained based on the drawings without creative efforts.
Fig. 1 is a schematic configuration diagram of a pathological section scanner according to example 1;
FIG. 2 is a schematic structural view of a transfer apparatus according to embodiment 1;
FIG. 3 is a schematic front view of a transfer apparatus according to embodiment 1;
FIG. 4 is a right-side view schematically showing the transfer device according to embodiment 1;
FIG. 5 is a schematic configuration diagram of a transfer device and a loading device according to embodiment 1;
FIG. 6 is a schematic structural diagram of an alignment apparatus according to embodiment 1;
FIG. 7 is a left side view of the aligning apparatus of embodiment 1;
FIG. 8 is a right-side view schematically showing the aligning device of embodiment 1;
fig. 9 is a schematic structural diagram of the imaging device according to embodiment 1;
FIG. 10 is a front view of the imaging apparatus according to embodiment 1;
FIG. 11 is a right-view diagram of the imaging device of embodiment 1;
FIG. 12 is a schematic structural view of a movable stage according to embodiment 1;
fig. 13 is a partially enlarged schematic view of a claw structure of the movable platform of embodiment 1;
fig. 14 is a left side schematic view of the movable platform of embodiment 1;
the numbering in the figure is as follows:
1. a conveying device; 2. a loading device; 3. an alignment device; 4. an imaging device; 5. a movable platform; 6. a scanner platform; 11. a scanning sensor; 12. a Z-axis lifting mechanism; 13. a Y-axis lifting mechanism; 14. an X-axis lifting mechanism; 15. an electric film taking mechanism; 16. a Z-axis support; 17. a motor; 18-1, an X-axis moving wire groove; 18-2, a Z-axis moving wire slot; 19. a cutting box; 110. slicing; 31. aligning the base; 32. a fixing assembly; 33. aligning the support; 34. aligning a camera; 35. aligning the light source; 36. a camera mounting bracket; 37. aligning a cylinder; 38. a second fixed stop; 39. a first fixed stop; 310. aligning the platform; 41. an image base; 42. a support pillar; 43. an image support; 44. an image light source; 45. a vision module; 46. a groove; 47. a Z-axis motor; 48. a metal fixing member; 49. a motor wire slot; 410. a dual lens switching motor; 51. a platform base; 52. an X moving platform; 53. a Y moving platform; 54. a rotating cylinder; 55. a hook claw; 56. a platform support; 57. a guide rail; 58. x moving a wire slot; 59. a Y-shaped movable wire slot; 510. an object stage; 511. a third fixed stop; 512. a platform light source; 513. a hook connector; 514. an arc-shaped hole; 515. clamping a pin; 516. a protrusion; 517. and a metal supporting seat.
Detailed Description
The technical features of the technical solutions provided by the present invention are further clearly and completely described below with reference to the specific embodiments.
The invention provides a novel pathological section scanner, which comprises a conveying device 1, a loading device 2, an aligning device 3, an imaging device 4 and a movable platform 5, wherein the conveying device is arranged on the conveying device; the conveying device 1, the loading device 2 and the imaging device 4 are independent respectively and are arranged on the scanner platform 6; the alignment device 3 and the movable platform 5 are both arranged on the image base 41.
In a preferred embodiment, the conveying device 1 comprises an X-axis lifting mechanism 14, a Y-axis lifting mechanism 13 and a Z-axis lifting mechanism 12; the X-axis lifting mechanism 14 is movably connected with a Z-axis support 16 in the Z-axis direction, one side of the Z-axis support 16 is connected with a Z-axis lifting mechanism 12, the Z-axis lifting mechanism 12 is movably connected with a scanning sensor 11, and the upper end face of the scanning sensor 11 is connected with a group of Y-axis lifting mechanisms 13.
In a preferred embodiment, a set of electric sheet taking mechanisms 15 is connected between the set of Y-axis lifting mechanisms 13.
In a preferred embodiment, the bottom of the Z-axis bracket 16 is connected with an X-axis moving wire slot 18-1, and the X-axis moving wire slot 18-1 can move on the X-axis lifting mechanism 14 to drive the Z-axis bracket 16 to move; the top of the Z-axis support 16 is connected with a Z-axis moving line slot 18-2, and the Z-axis moving line slot 18-2 can move on the Z-axis lifting mechanism 12 so as to drive the scanning sensor 11 to move.
In a preferred embodiment, there are two Y-axis lifting mechanisms 13 in the set, and the two Y-axis lifting mechanisms 13 are connected side by side; the two groups of electric film taking mechanisms 15 are connected in parallel; the two Y-axis lifting mechanisms 13 respectively control the two electric sheet taking mechanisms 15 to move in the Y-axis direction.
In a preferred embodiment, a motor 17 is connected to one end of each of the X-axis lifting mechanism 14 and the Z-axis lifting mechanism 12.
In a preferred embodiment, the two motors 17 can respectively control the movement of the X-axis moving wire slot 18-1 and the Z-axis moving wire slot 18-2, so that the control device can move in the X-axis direction and the Z-axis direction at will.
The conveying device can allow rotation, telescopic movement, translation and the like through the structure, the conveying device can be accurately positioned at a certain point in space to perform operation, the two motors 17 are adopted to respectively control the device to move towards an X axis and a Z axis, the two electric sheet taking mechanisms 15 are respectively controlled through the two Y-axis lifting mechanisms 13 to simultaneously take out and put in the slices 110, the number of the slices 110 in the slice box 19 is monitored and judged through the scanning sensor 1, whether the states of lamination, inclined insertion sheets and the like occur is confirmed, meanwhile, information is returned and displayed through signal lamps, green representation is completed, blue representation is ready, and red representation is abnormal.
In a preferred embodiment, the loading device 2 comprises a slicing cassette device for containing slices 110; the slide transfer device can move the slice 110 to be scanned out of the slide cassette apparatus for scanning and move the scanned slice 110 back into the slide cassette apparatus.
The two parallel electric slice taking mechanisms 15 are controlled by the conveying device to carry out taking and placing operations on the slices 110 in the slice box device, one electric slice taking mechanism 15 takes out the slices 110, the other electric slice taking mechanism 15 replaces the scanned slices 110 in the original slice box 19, and the slice box device bears 1000 slices at most, so that the slice box device is more convenient and more convenient to take and place operations and more in bearing quantity compared with the traditional single slice taking and placing operations, and the time is saved and the efficiency is improved.
In a preferred embodiment, the slicing cassette device is designed in a multi-layer structure, wherein four rows by 10 columns of slicing cassette slots are arranged in the slicing cassette device, a maximum of 40 slicing cassettes 19 can be placed in the slicing cassette device, and a maximum of 25 slicing cassettes 110 can be placed in each slicing cassette 19.
In a preferred embodiment, the cassette 19 is detectable when placed in the cassette device and is indicated by a light, green for completion, blue for readiness, and red for an anomaly.
In a preferred embodiment, the alignment device 3 includes an alignment base 31, a fixing component 32, an alignment bracket 33, an alignment camera 34, an alignment light source 35; the alignment base 31 and the fixing component 32 are both arranged below the alignment bracket 33 and are both connected with the alignment bracket 33; the alignment support 33 is provided with a camera mounting frame 36, the top of the camera mounting frame 36 is provided with an alignment camera 34, and the middle of the camera mounting frame 36 is provided with an alignment light source 35.
In a preferred embodiment, the alignment bracket 33 is provided with an alignment cylinder 37 at one side and a second fixed stopper 38 at the other side.
The alignment cylinder 37 is externally connected with an air pipe (not shown), and the air pipe compresses air to generate air pressure so as to control the movement of the alignment cylinder 37.
In a preferred embodiment, the register cylinder 37 is provided with a first fixed stop 39.
In a preferred embodiment, the alignment cylinder 37 is connected to the first fixed stop 39 by two fixed links; when the alignment cylinder 37 moves under the pushing of the air pressure, the first fixed stopper 39 connected to the alignment cylinder 37 moves accordingly.
In a preferred embodiment, an alignment platform 310 is further disposed between the first fixed stop 39 and the second fixed stop 38; the alignment platform 310 is located in the middle of the bracket and is parallel to the first fixed stop 39 and the second fixed stop 38.
In a preferred embodiment, the alignment platform 310 is used to place a slide; and the slide is placed in a fixed position on the aligning platform 310 by the movement of the aligning air cylinder 7.
The first fixed stopper 39 has a pushing force on the slide glass placed on the aligning platform 310 along with the movement of the aligning cylinder 37, so that the slide glass is pushed backwards by the first fixed stopper 39 until the position pushed to the second fixed stopper 38 is not pushed, the position of the slide glass on the aligning platform 310 is fixed, namely, the position is below the camera of the aligning camera 34, and the slide glass can be subjected to the next shooting action.
In a preferred embodiment, the alignment light source 35 is located below the lens of the alignment camera 34 and is used for polishing the photographed slide glass when the alignment camera 34 photographs.
In a preferred embodiment, when the slide is placed on the alignment platform 310, the alignment air cylinder 37 starts moving and pushes the slide under the camera of the alignment camera 34 for shooting.
In a preferred embodiment, the alignment camera 34 has an image processing module built therein for recognizing image information on the slide.
In a preferred embodiment, the alignment camera 34 is fixedly mounted on the image support 43.
In a preferred embodiment, the alignment cylinder 37 is fixed to the bracket 33 by welding.
In a preferred embodiment, the second fixed stop 39 is integrally formed with the alignment bracket 33.
In a preferred embodiment, the alignment base 31, the fixing component 32, and the alignment bracket 33 are made of metal.
In a preferred embodiment, the imaging device 4 comprises an image base 41, a support column 42, an image support 43, an image light source 44, a vision module 45, a Z-axis motor 47; the image base 41, the supporting columns 42 vertically installed at the left and right sides of the image base 41, and the image support 43 vertically installed at the top of the supporting columns 42 form a machine platform whole, the image base 41 is provided with a groove 46, and the groove 46 is internally provided with an image light source 44; the vision module 45 is in clearance fit with the bayonet of the image bracket 43; the Z-axis motor 47 is fixedly connected with the vision module 45 through a metal fixing piece 48.
In a preferred embodiment, a motor slot 49 is formed on the Z-axis motor 47, and the motor slot 49 is fixedly connected to the bracket 43.
The motor wire casing 49 is used for wiring, and when the Z-axis motor 47 is started under the electric energy, the Z-axis motor 47 drives the vision module 45 to move up and down on the Z axis, so that the microscope head can photograph pathological sections with different depths of field.
In a preferred embodiment, the image device further includes a dual lens switching motor 410, and the dual lens switching motor 410 is fixedly connected to the metal fixing member 48.
The dual-lens switching motor 410 can control the lenses with different multiples to be switched in the horizontal direction for taking pictures, so that the large data volume of the slices can be quickly accumulated.
In a preferred embodiment, the image light source 44 is disposed coaxially with a micro lens of the vision module 45, and is used for polishing the bottom of the object to be photographed during photographing.
In a preferred embodiment, the Z-axis motor 47 is fixedly connected to the metal fixing member 48 by a fixing screw; the vision module 45 is fixedly connected with the metal fixing piece 48 through a fixing screw.
In a preferred embodiment, the dual lens switching motor 410 is fixedly connected to the metal fixing member 48 by a fixing screw.
In a preferred embodiment, the image light source 44 is secured to the recess 46 by any one of threaded fasteners, rivets, welding, or adhesive.
In a preferred embodiment, the image base 41, the supporting column 42 and the image bracket 43 are connected by bolts or integrally formed.
In a preferred embodiment, the image base 41, the supporting posts 42, and the image support 43 are all made of marble.
In a preferred embodiment, the movable platform 5 includes a platform base 51, an X moving platform 52, a Y moving platform 53, a rotary cylinder 54, a claw 55, a platform bracket 56; the platform base 51, the X moving platform 52 and the Y moving platform 53 are arranged in parallel from bottom to top, two guide rails 57 are arranged between the platform base 51 and the X moving platform 52, and two guide rails 57 are arranged between the X moving platform 52 and the Y moving platform 53; a platform bracket 56 is arranged on the Y moving platform 53; the platform bracket 56 is provided with a rotary cylinder 54; the center of the hook 55 is connected to a rotary shaft provided on the Y moving stage 53 and is mounted on the stage support 56.
Two guide rails 57 between the platform base 51 and the X moving platform 52 and two guide rails 57 between the X moving platform 52 and the Y moving platform 53 are arranged vertically at 90 degrees, the guide rails are of a guide groove and ball structures, and ball limit pins are arranged at two ends of the guide groove.
When the X moving platform 52 and the Y moving platform 53 move in the direction X, Y, respectively, under the action of an external force, the balls arranged on the X moving platform 52 and the Y moving platform 53 slide in the corresponding guide grooves, and the ball limit pins can ensure that the X moving platform 52 and the Y moving platform 53 do not slide out when moving.
In a preferred embodiment, the X moving platform 52 is provided with an X moving wire slot 58; and a Y-shaped moving wire groove 59 is formed in the Y-shaped moving platform 53.
The X moving wire slot 58 and the Y moving wire slot 59 are controlled by a linear track motor and can respectively move in the X, Y direction, so that the X moving platform 52 and the Y moving platform 53 are respectively controlled to respectively move in the X, Y direction, and stay at any position on a plane is realized.
In a preferred embodiment, the platform bracket 56 is provided with an object stage 510, and a third fixed stop 511 is arranged behind the object stage 510.
In a preferred embodiment, a platform light source 512 is disposed below the stage 510 for illuminating a slide placed on the stage 510.
In a preferred embodiment, the stage light source 512 is fixed to the Y moving stage 53 by screws.
In a preferred embodiment, a hook connector 513 is provided below the hook 55 for carrying the hook 55.
In a preferred embodiment, the claw coupling member 513 is fixedly disposed on the Y moving stage 53 with its center passing through the rotation shaft.
In a preferred embodiment, the distal end of the finger link 513 is provided with an arcuate aperture 514.
In a preferred embodiment, one end of the hook 55 is provided with a clamping foot 515, and the bottom of the other end is provided with a protrusion 516.
In a preferred embodiment, the protrusions 516 are disposed corresponding to the arc-shaped holes 514, and when the hook 55 rotates forward or backward relative to the hook connector 513, the protrusions 516 of the hook 55 slide in the corresponding arc-shaped holes 514, so that the clamping legs 515 of the hook 55 are pressed or released.
After the slide glass is placed on the object stage 510, the rotary air cylinder 54 is started to further drive the hook claw 55 to slide on the hook claw connecting piece 513, so that the clamping feet 515 of the hook claw 55 are gradually in a butting state from an original loosening state, and the position where the slide glass is pushed in is fixed through the third fixed stop block 511, at this time, the slide glass with the identified effective cell area can be continuously photographed, the X moving platform 52 and the Y moving platform 53 can move on the plane as required, the camera can photograph for a single time or multiple times when moving once, a most clear picture after fusion is stored in each view field, and finally all view field pictures are spliced into a complete large picture. The area that the camera takes is referred to as a single field of view, so the active area of the cell or tissue is made up of multiple fields of view.
In a preferred embodiment, a metal supporting seat 517 is further disposed on the X moving platform 52.
In a preferred embodiment, the platform base 51, the X moving platform 52, the Y moving platform 53 and the platform support 56 are made of metal.
The present invention is described in detail below with reference to examples, which are provided for the purpose of further illustration only and are not to be construed as limiting the scope of the present invention, and the insubstantial modifications and adaptations thereof by those skilled in the art based on the teachings of the present invention will still fall within the scope of the present invention.
Example 1
A novel pathological section scanner, as shown in fig. 1-14, comprising a conveying device 1, a loading device 2, an aligning device 3, an imaging device 4 and a movable platform 5; the conveying device 1, the loading device 2 and the imaging device 4 are independent respectively and are arranged on the scanner platform 6; the alignment device 3 and the movable platform 5 are both arranged on the image base 41.
The conveying device 1 comprises an X-axis lifting mechanism 14, a Y-axis lifting mechanism 13 and a Z-axis lifting mechanism 12; the X-axis lifting mechanism 14 is movably connected with a Z-axis support 16 in the Z-axis direction, one side of the Z-axis support 16 is connected with a Z-axis lifting mechanism 12, the Z-axis lifting mechanism 12 is movably connected with a scanning sensor 11, and the upper end surface of the scanning sensor 11 is connected with a group of Y-axis lifting mechanisms 13;
a group of electric film taking mechanisms 15 are connected between the group of Y-axis lifting mechanisms 13;
the bottom of the Z-axis support 16 is connected with an X-axis moving line slot 18-1, and the X-axis moving line slot 18-1 can move on the X-axis lifting mechanism 14 so as to drive the Z-axis support 16 to move; the top of the Z-axis support 16 is connected with a Z-axis moving line slot 18-2, and the Z-axis moving line slot 18-2 can move on the Z-axis lifting mechanism 12 so as to drive the scanning sensor 11 to move;
the number of the Y-axis lifting mechanisms 13 is two, and the two Y-axis lifting mechanisms 13 are connected in parallel; the two groups of electric film taking mechanisms 15 are connected in parallel; the two Y-axis lifting mechanisms 13 respectively control the two electric sheet taking mechanisms 15 to move in the Y-axis direction;
one end of each of the X-axis lifting mechanism 14 and the Z-axis lifting mechanism 12 is connected with a motor 17;
the two motors 17 can respectively control the X-axis moving wire slot 18-1 and the Z-axis moving wire slot 18-2 to move, so that the control device can move randomly in the X-axis direction and the Z-axis direction;
the conveying device can allow rotation, telescopic movement, translation and the like through the structure, the conveying device can be accurately positioned at a certain point in space to perform operation, the two motors 17 are adopted to respectively control the device to move towards an X axis and a Z axis, the two electric sheet taking mechanisms 15 are respectively controlled through the two Y-axis lifting mechanisms 13 to simultaneously take out and put in the slices 110, the number of the slices 110 in the slice box 19 is monitored and judged through the scanning sensor 1, whether the states of lamination, inclined insertion sheets and the like occur is confirmed, meanwhile, information is returned and displayed through signal lamps, green representation is completed, blue representation is ready, and red representation is abnormal.
The loading device 2 comprises a slicing box device which is used for containing slices 110; the slide glass conveying device can move out the section 110 to be scanned in the section box device for scanning, and move the scanned section 110 into the section box device again;
the conveying device is used for controlling the two parallel electric slice taking mechanisms 15 to carry out taking and placing operations on the slices 110 in the slice box device, when one electric slice taking mechanism 15 takes out the slices 110, the other electric slice taking mechanism 15 is used for replacing the scanned slices 110 in the original slice box 19, and the slice box device bears 1000 slices at most, so that the operation is more convenient and faster than the traditional single taking and placing operation, the bearing quantity is more, the time is saved, and the efficiency is improved;
the slicing box device is designed in a multilayer structure, wherein four rows of slicing box clamping grooves with 10 columns are arranged in the slicing box device, at most 40 slicing boxes 19 can be placed in the slicing box device, and at most 25 slices 110 can be placed in each slicing box 19;
the slicing box 19 is placed in the slicing box device and can be detected, and is displayed by a signal lamp, wherein green represents completion, blue represents readiness, and red represents abnormity.
The alignment device 3 comprises an alignment base 31, a fixing component 32, an alignment bracket 33, an alignment camera 34 and an alignment light source 35; the alignment base 31 and the fixing component 32 are both arranged below the alignment bracket 33 and are both connected with the alignment bracket 33; the alignment support 33 is provided with a camera mounting rack 36, the top of the camera mounting rack 36 is provided with an alignment camera 34, and the middle of the camera mounting rack 36 is provided with an alignment light source 35;
an alignment cylinder 37 is arranged on one side of the alignment support 33, and a second fixed stop block 38 is arranged on the other side;
the alignment cylinder 37 is externally connected with an air pipe (not shown in the figure), and the air pipe compresses air to generate air pressure so as to control the movement of the alignment cylinder 37;
a first fixed stop block 39 is arranged on the alignment cylinder 37;
the alignment cylinder 37 is connected with the first fixed stop block 39 through two fixed connecting rods; when the alignment cylinder 37 moves under the pushing of the air pressure, the first fixed stop 39 connected to the alignment cylinder 37 moves therewith;
an alignment platform 310 is further arranged between the first fixed stop 39 and the second fixed stop 38; the alignment platform 310 is positioned in the middle of the bracket and is parallel to the first fixed stop 39 and the second fixed stop 38;
the alignment platform 310 is used for placing a slide; and the slide glass is placed at the fixed position on the aligning platform 310 through the movement of the aligning air cylinder 7;
the first fixed stopper 39 has a pushing force on the slide glass placed on the alignment platform 310 along with the movement of the alignment cylinder 37, so that the slide glass is pushed backwards by the first fixed stopper 39 until the position pushed to the second fixed stopper 38 is not pushed, the position of the slide glass on the alignment platform 310 is fixed, namely the position is below the camera of the alignment camera 34, and the slide glass can be subjected to the next shooting action;
the alignment light source 35 is located below the lens of the alignment camera 34 and is used for polishing the shot glass slide when the alignment camera 34 takes a picture;
when the slide glass is placed on the alignment platform 310, the alignment air cylinder 37 starts to move and pushes the slide glass to be below the camera of the alignment camera 34 for shooting;
the alignment camera 34 is internally provided with an image processing module which is used for identifying image information on the glass slide;
the alignment camera 34 is fixedly mounted on the image support 43;
the alignment cylinder 37 is fixed on the bracket 33 by welding;
the second fixed stopper 39 and the alignment bracket 33 are integrally formed;
the alignment base 31, the fixing component 32 and the alignment bracket 33 are made of metal materials.
The imaging device 4 comprises an image base 41, a support column 42, an image bracket 43, an image light source 44, a vision module 45 and a Z-axis motor 47; the image base 41, the supporting columns 42 vertically installed at the left and right sides of the image base 41, and the image support 33 vertically installed at the top of the supporting columns 42 form a machine platform whole, the image base 41 is provided with a groove 46, and an image light source 44 is arranged in the groove 46; the vision module 45 is in clearance fit with the bayonet of the image bracket 43;
a motor wire slot 49 is formed in the Z-axis motor 47, and the motor wire slot 49 is fixedly connected with the bracket 43;
the motor wire slot 49 is used for wiring, when the Z-axis motor 47 is started under electric energy, the Z-axis motor 47 drives the vision module 45 to move up and down on the Z axis, and photographing of different depths of field of pathological sections by the microscope head can be realized;
the image device further comprises a dual-lens switching motor 410, and the dual-lens switching motor 410 is fixedly connected with the metal fixing member 48;
the double-lens switching motor 410 can control the lenses with different multiples to be switched in the horizontal direction for taking a picture, so that the large data volume of the slices can be quickly accumulated;
the image light source 44 and the micro lens of the vision module 45 are coaxially arranged and used for polishing the bottom of the shot object during shooting;
the Z-axis motor 47 is fixedly connected with a metal fixing piece 48 through a fixing screw; the vision module 45 is fixedly connected with a metal fixing piece 48 through a fixing screw;
the dual-lens switching motor 410 is fixedly connected with the metal fixing piece 48 through a fixing screw;
the image light source 44 is fixed on the groove 46 through a threaded fastener;
the image base 41, the supporting column 42 and the image support 43 are integrally formed;
the image base 41, the supporting columns 42 and the image support 43 are all made of marble.
The movable platform 5 comprises a platform base 51, an X moving platform 52, a Y moving platform 53, a rotary cylinder 54, a claw 55 and a platform bracket 56; the platform base 51, the X moving platform 52 and the Y moving platform 53 are arranged in parallel from bottom to top, two guide rails 57 are arranged between the platform base 51 and the X moving platform 52, and two guide rails 57 are arranged between the X moving platform 52 and the Y moving platform 53; a platform bracket 56 is arranged on the Y moving platform 53; the platform bracket 56 is provided with a rotary cylinder 54; the center of the hook 55 is connected with a rotating shaft arranged on the Y moving platform 53 and is arranged on the platform bracket 56;
the two guide rails 57 between the platform base 51 and the X moving platform 52 and the two guide rails 57 between the X moving platform 52 and the Y moving platform 53 are vertically arranged at 90 degrees, the guide rails are of a guide groove and ball structure, and ball limit pins are arranged at two ends of the guide groove;
when the X moving platform 52 and the Y moving platform 53 move in the direction X, Y, respectively, under the action of an external force, the balls arranged on the X moving platform 52 and the Y moving platform 53 slide in the corresponding guide grooves, and the ball limit pins can ensure that the X moving platform 52 and the Y moving platform 53 do not slide out when moving;
an X moving wire slot 58 is arranged on the X moving platform 52; a Y-shaped moving wire slot 59 is formed in the Y-shaped moving platform 53;
the X-moving wire slot 58 and the Y-moving wire slot 59 are controlled by a linear track motor and can respectively move in the X, Y direction, so that the X-moving platform 52 and the Y-moving platform 53 are respectively controlled to respectively move in the X, Y direction, and stay at any position on a plane is realized;
an object stage 510 is arranged on the platform bracket 56, and a third fixed stop 511 is arranged behind the object stage 510;
a platform light source 512 is arranged below the object stage 510 and used for polishing the glass slide placed on the object stage 510; the platform light source 512 is fixed on the Y moving platform 53 through screws;
a claw connecting piece 513 is arranged below the claw 55 and is used for bearing the claw 55; the claw connecting piece 513 is fixedly arranged on the Y moving platform 53, and the center of the claw connecting piece penetrates through the rotating shaft; the tail end of the claw connecting piece 513 is provided with an arc-shaped hole 514; one end of the hook claw 55 is provided with a clamping foot 515, and the bottom of the other end is provided with a bulge 516; the protrusions 516 are arranged corresponding to the arc-shaped holes 514, and when the claw 55 rotates forwards or reversely relative to the claw connecting piece 513, the protrusions 516 of the claw 55 slide in the corresponding arc-shaped holes 514, so that the clamping feet 515 of the claw 55 are pressed tightly or loosened;
after the slide glass is placed on the object stage 510, the rotary air cylinder 54 is started to further drive the hook claw 55 to slide on the hook claw connecting piece 513, so that the clamping feet 515 of the hook claw 55 are gradually in a butting state from an original loosening state, and the position where the slide glass is pushed in is fixed through the third fixed stop block 511, at this time, the slide glass with the identified effective cell area can be continuously photographed, the X moving platform 52 and the Y moving platform 53 can move on the plane as required, the camera can photograph for a single time or multiple times when moving once, a most clear picture after fusion is stored in each view field, and finally all view field pictures are spliced into a complete large picture. The area that the camera takes is called a single field of view, so the active area of the cell or tissue is made up of multiple fields of view;
a metal supporting seat 517 is further arranged on the X moving platform 52;
the platform base 51, the X moving platform 52, the Y moving platform 53 and the platform support 56 are all made of metal materials.
Claims (10)
1. A novel pathological section scanner is characterized by comprising a conveying device, a loading device, an aligning device, an imaging device and a movable platform; the conveying device, the loading device and the imaging device are independent and are all arranged on the scanner platform; the alignment device and the movable platform are both arranged on the image base.
2. The pathological section scanner of claim 1, wherein said transfer device comprises an X-axis elevating mechanism, a Y-axis elevating mechanism, a Z-axis elevating mechanism; the X-axis lifting mechanism is movably connected with a Z-axis support in the Z-axis direction, one side of the Z-axis support is connected with a Z-axis lifting mechanism, the Z-axis lifting mechanism is movably connected with a scanning sensor, and the upper end face of the scanning sensor is connected with a group of Y-axis lifting mechanisms; the bottom of the Z-axis support is connected with an X-axis moving wire casing, and the X-axis moving wire casing can move on the X-axis lifting mechanism so as to drive the Z-axis support to move; the top of the Z-axis support is connected with a Z-axis moving line slot, and the Z-axis moving line slot can move on the Z-axis lifting mechanism so as to drive the scanning sensor to move; a group of electric film taking mechanisms are connected between the Y-axis lifting mechanisms; the number of the Y-axis lifting mechanisms is two, and the two Y-axis lifting mechanisms are connected in parallel; the two electric film taking mechanisms are connected in parallel; the two Y-axis lifting mechanisms respectively control the two electric sheet taking mechanisms to move in the Y-axis direction.
3. The pathological section scanner of claim 1, wherein said loading device comprises a slice box device for holding slices; the conveying device can move out the slice to be scanned in the slice box device for scanning and move the scanned slice into the slice box device again.
4. The pathological section scanner according to any one of claims 1-3, wherein said alignment device comprises an alignment base, a fixing component, an alignment bracket, an alignment camera, an alignment light source; the alignment base and the fixing assembly are arranged below the alignment support and are connected with the alignment support; the alignment support is provided with a camera mounting frame, an alignment camera is arranged at the top of the camera mounting frame, and an alignment light source is arranged in the middle of the camera mounting frame; one side of the aligning support is provided with an aligning cylinder, and the other side of the aligning support is provided with a second fixed stop block; a first fixed stop block is arranged on the alignment cylinder; an alignment platform is further arranged between the first fixed stop block and the second fixed stop block; the alignment platform is located in the middle of the alignment support and is arranged in parallel with the first fixed stop block and the second fixed stop block.
5. The pathological section scanner of claim 4, wherein the alignment light source is located under the lens of the alignment camera and is used for polishing the photographed slide glass when the alignment camera photographs; when the glass slide is placed on the alignment platform, the alignment cylinder starts to move and pushes the glass slide to the lower part of a camera of an alignment camera for shooting; the alignment camera is internally provided with an image processing module, and the image processing module is used for identifying image information on the glass slide.
6. The pathological section scanner of claim 5, wherein the imaging device comprises an image base, a support post, an image support, an image light source, a vision module, a Z-axis motor; the image base, support columns vertically arranged on the left side and the right side of the image base and image supports vertically arranged on the tops of the support columns form a machine platform whole, a groove is formed in the image base, and an image light source is arranged in the groove; the vision module is in clearance fit with the bayonet of the image bracket; the Z-axis motor is fixedly connected with the vision module through a metal fixing piece; a motor wire slot is arranged on the Z-axis motor and is fixedly connected with the image bracket; the image light source and the micro lens of the vision module are coaxially arranged and used for polishing the bottom of a shot object during shooting.
7. The pathological section scanner of claim 6, wherein the imaging device further comprises a dual lens switching motor, and the dual lens switching motor is fixedly connected to the metal fixing member.
8. The pathological section scanner of claim 7, wherein said movable platform comprises a platform base, an X-motion platform, a Y-motion platform, a rotary cylinder, a claw, a platform support; the X-axis and Y-axis parallel moving platform is arranged on the X-axis and Y-axis parallel moving platform, and the X-axis and Y-axis parallel moving platform are arranged on the X-axis and Y-axis parallel moving platform; a platform support is arranged on the Y-shaped moving platform; a rotary cylinder is arranged on the platform bracket; the center of the claw is connected with a rotating shaft arranged on the Y-shaped moving platform and is arranged on the platform bracket; an X-shaped moving wire slot is arranged on the X-shaped moving platform; a Y-shaped moving wire slot is formed in the Y-shaped moving platform; the glass slide polishing device is characterized in that an object stage is arranged on the platform support, and a platform light source is arranged below the object stage and used for polishing glass slides placed on the object stage.
9. The pathological section scanner of claim 8, wherein a finger connector is provided under said finger for carrying the finger; the claw connecting piece is fixedly arranged on the Y-shaped moving platform, and the center of the claw connecting piece penetrates through the rotating shaft; the tail end of the hook claw connecting piece is provided with an arc-shaped hole.
10. The pathological section scanner of claim 9, wherein one end of said hook has a locking pin and the bottom of the other end has a protrusion; the protrusions are arranged corresponding to the arc-shaped holes, and when the hook claw rotates forwards or backwards relative to the hook claw connecting piece, the protrusions of the hook claw slide in the corresponding arc-shaped holes, so that the clamping feet of the hook claw are tightly supported or loosened.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010226841.XA CN111220617A (en) | 2020-03-27 | 2020-03-27 | Novel pathological section scanner |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202010226841.XA CN111220617A (en) | 2020-03-27 | 2020-03-27 | Novel pathological section scanner |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN111220617A true CN111220617A (en) | 2020-06-02 |
Family
ID=70832718
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202010226841.XA Withdrawn CN111220617A (en) | 2020-03-27 | 2020-03-27 | Novel pathological section scanner |
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| Country | Link |
|---|---|
| CN (1) | CN111220617A (en) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022002144A1 (en) * | 2020-06-30 | 2022-01-06 | 深圳迈瑞生物医疗电子股份有限公司 | Glass slide conveying device, glass slide conveying method, and sample image analyzer |
-
2020
- 2020-03-27 CN CN202010226841.XA patent/CN111220617A/en not_active Withdrawn
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2022002144A1 (en) * | 2020-06-30 | 2022-01-06 | 深圳迈瑞生物医疗电子股份有限公司 | Glass slide conveying device, glass slide conveying method, and sample image analyzer |
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