CN111110820A - 一种治疗病毒性心肌炎的药剂及其制备方法 - Google Patents
一种治疗病毒性心肌炎的药剂及其制备方法 Download PDFInfo
- Publication number
- CN111110820A CN111110820A CN202010115218.7A CN202010115218A CN111110820A CN 111110820 A CN111110820 A CN 111110820A CN 202010115218 A CN202010115218 A CN 202010115218A CN 111110820 A CN111110820 A CN 111110820A
- Authority
- CN
- China
- Prior art keywords
- medicament
- viral myocarditis
- treating
- medicine
- treating viral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
- A61K36/605—Morus (mulberry)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
- A61K36/195—Strobilanthes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/236—Ligusticum (licorice-root)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
- A61K36/238—Saposhnikovia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
- A61K36/258—Panax (ginseng)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/286—Carthamus (distaff thistle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/287—Chrysanthemum, e.g. daisy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/288—Taraxacum (dandelion)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/31—Brassicaceae or Cruciferae (Mustard family), e.g. broccoli, cabbage or kohlrabi
- A61K36/315—Isatis, e.g. Dyer's woad
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/346—Platycodon
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/35—Caprifoliaceae (Honeysuckle family)
- A61K36/355—Lonicera (honeysuckle)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/36—Caryophyllaceae (Pink family), e.g. babysbreath or soapwort
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/484—Glycyrrhiza (licorice)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/537—Salvia (sage)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/538—Schizonepeta
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/57—Magnoliaceae (Magnolia family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/63—Oleaceae (Olive family), e.g. jasmine, lilac or ash tree
- A61K36/634—Forsythia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/704—Polygonum, e.g. knotweed
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
- A61K36/718—Coptis (goldthread)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/756—Phellodendron, e.g. corktree
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/79—Schisandraceae (Schisandra family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
- A61K36/855—Clerodendrum, e.g. glorybower
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8968—Ophiopogon (Lilyturf)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
- A61K36/8969—Polygonatum (Solomon's seal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
Abstract
本发明公开了一种治疗病毒性心肌炎的药剂,所述药剂是由以下重量份的组分制成的:桑叶10g,菊花10g,金银花15~30g,连翘15g,鱼腥草15~30g,荆芥10g,防风10g,牛蒡子10g,薄荷10g,生姜6g,甘草6g,桔梗10g,大青叶15g,板蓝根15g,蒲公英15~30g,黄芩10g,黄连6~10g,黄柏10g;所述药剂的剂型为胶囊剂、片剂、颗粒剂、饮剂和滴丸剂中任意一种;本发明还公开了该药剂的制备方法。本发明的药剂各组分协同作用,针对病毒性心肌炎毒、瘀、虚的病因病机给予阶段辛凉解表及清热解毒、全程活血化瘀和补益气阴等治疗,效果很好;药剂中各组分药量基本符合国家药典要求,药量合适药效佳;临床疗效评价试验结果显示本发明的方法和药剂可有效治疗病毒性心肌炎;本发明的方法切实可行,药剂无明显的毒副作用,安全性高。
Description
技术领域
本发明涉及中医、中药技术领域,尤其涉及一种治疗病毒性心肌炎的药剂及其制备方法。
背景技术
病毒性心肌炎是指嗜心肌病毒感染所致的局限性或弥散性心肌炎性改变。约占心肌炎的50%。本病轻者可无症状,重者可并发严重的心律失常、心力衰竭、心源性休克、猝死,亦可演变成扩张性心肌病,严重危害生命健康。其见于各年龄段,以儿童及青少年多见。本病属中医“心悸”、“胸痹”、“虚劳”、“水肿”等范畴。
目前认为病毒性心肌炎早期和急性期以病毒直接侵犯心肌为主,同时存在免疫反应,晚期和慢性期,免疫反应是发病的主要机制。
由于病情轻重不同,患者临床表现差异较大,取决于病变的广泛程度与部位,轻者可无症状,重者可并发严重心律失常、心功能不全、心源性休克、甚至猝死。
目前,迫切需要一种有效治疗病毒性心肌炎的方法和药物。
发明内容
为了解决上述问题,本发明提供一种治疗病毒性心肌炎的采用传统中医辨证施治包括药剂及其制备方法。
本发明的一种治疗病毒性心肌炎的药剂及其制备方法是这样实现的:
一种治疗病毒性心肌炎的药剂,其特征在于,所述药剂是由以下重量份的组分制成的:桑叶10g,菊花10g,金银花15~30g,连翘15g,鱼腥草15~30g,荆芥10g,防风10g,牛蒡子10g,薄荷10g,生姜6g,甘草6g,桔梗10g,大青叶15g,板蓝根15g,蒲公英15~30g,黄芩10g,黄连6~10g,黄柏10g。
优选的,所述药剂用于治疗病毒性心肌炎的热毒症。
一种治疗病毒性心肌炎的药剂,其特征在于,所述药剂是由以下重量份的组分制成的:丹参20~30g,川芎10g,红花10g,赤芍10g,生黄芪10~30g,人参3g,麦冬10g,五味子10g,阴虚甚加玉竹10g,黄精10g。
优选的,所述人参3g可用党参10~30g或太子参15~30g替换。
优选的,所述药剂用于治疗病毒性心肌炎的血瘀和气阴虚症。
优选的,所述药剂的剂型为胶囊剂、片剂、颗粒剂、饮剂和滴丸剂中任意一种。
中药的配伍讲究相须、相使、相畏、相杀、相恶、相反,由于不同的中药之间存在不同的配伍关系,因此在使用两味以上中药时,必须有所选择,充分发挥药物之间相须相使的配伍关系。本发明通过将多味中药组分进行配伍,药物之间共同发挥了治疗病毒性心肌炎的作用,具有明显的增效作用,充分发挥了相须相使的配伍关系。
药物组方中各味药的药理分析如下:
桑叶、菊花、薄荷、牛蒡子为发散风热药;
荆芥、防风、生姜为发散风寒药;
金银花、连翘、大青叶、板蓝根、鱼腥草、蒲公英为清热解毒药;
黄芩、黄连、黄柏为清热燥湿药,桔梗宣肺化痰止咳利咽(无抗病毒作用,其水提取物可增强巨噬细胞吞噬功能,增强中性白细胞的杀菌力,提高溶菌酶活性);
甘草调和诸药解毒、益气补中、抗病毒,以上药物绝大部分药除桔梗外经现代药理研究显示可广谱抗病毒,同时具有广谱抗菌作用,此外栀子10g、穿心莲10g、苦参(可治疗心律失常)10g、丹皮10g也有抗菌功效,可选用;
丹参、红花为活血调经药;
川芎为活血止痛药;
赤芍为清热凉血活血药;
以上药物有活血化瘀、改善冠脉循环及微循环、改善心肌供血等保护心肌作用;
黄芪有增强心肌细胞抗病毒的作用,抑制感染细胞的病毒核酸复制,减轻病毒对心肌的直接损伤,改善内皮细胞生长,激活干扰素系统,有正性肌力作用;
黄芪、人参、党参、太子参、甘草为补气药,以黄芪、人参具有增强吞噬功能、增强细胞免疫、增强体液免疫、合成蛋白质、抗氧化损伤、强心、扩张冠状血管、增强造血功能最明显;
麦冬为补阴药,也有增强吞噬功能、增强体液免疫、抗氧化损伤、强心、扩张冠状动脉、增强造血功能作用,还有抗休克和抗心律失常作用;
玉竹、黄精也是补阴药;
五味子具有敛肺滋肾、温和兴奋呼吸、改善呼吸衰竭、加强和调节心肌细胞和心脏小动脉能量代谢、改善心肌营养和功能、增强免疫和吞噬机能及抗氧化、宁心安神、生津止渴、抗过敏及抗炎作用。
一种治疗病毒性心肌炎的药剂的饮剂的制备方法,其特征在于,包括以下步骤:
步骤1,浸泡:应每付药于陶制器皿中清水没过草药面2公分浸泡约1小时;
步骤2,煮沸:用武火加热步骤1所述浸泡后的药物至药液沸腾,即调文火使药液继续沸腾,约沸腾共30分钟停火;
步骤3,过滤:对步骤2所述沸腾后的药液进行过滤,过滤出药液约200ml置食品级器皿中备用;
步骤4,煎煮:注入清水没过步骤3所得草药面1.5公分煎药,然后重复步骤2和步骤3的操作,煎得药液约200ml与之前者混合后再分2等份,得到用于早晚各1份服用的药液。
优选的,所述煎煮操作中需对人参进行单独水煎煮,武火加热药液沸腾后改文火,保持药液沸腾约1小时停火,晾至液体温度为39~42℃时服用。
优选的,煎煮治疗病毒性心肌炎的热毒症的药剂时仅用武火,时间宜短,煮沸后煎5分钟即可。
本发明提供一种治疗病毒性心肌炎的方法和药剂,该药剂针对病毒性心肌炎毒、瘀、虚的病因病机给予阶段辛凉解表清热解毒、全程活血化瘀和补益气阴等治疗,效果很好;药剂中各组分药量基本符合国家药典要求,药量合适药效佳;各组分按照君臣佐使的关系进行配伍使用,协同作用,共同起到扶正祛邪、宁心安神的功效,达到标本兼治的作用;通过临床疗效评价试验,结果显示本发明提供的药剂可有效治疗病毒性心肌炎;且在整个治疗过程中未发现患者出现不良反应,表明本发明的药剂无明显的毒副作用,安全性高。
具体实施方式
以下通过具体实施方式的描述对本发明作进一步说明,但这并非是对本发明的限制,本领域技术人员根据本发明的基本思想,可以做出各种修改或改进,但是只要不脱离本发明的基本思想,均在本发明的范围之内。
实施例1
本实施例提供一种治疗病毒性心肌炎的药剂,所述药剂是由以下重量份的组分制成的:桑叶10g,菊花10g,金银花15~30g,连翘15g,鱼腥草15~30g,荆芥10g,防风10g,牛蒡子10g,薄荷10g,生姜6g,甘草6g,桔梗10g,大青叶15g,板蓝根15g,蒲公英15~30g,黄芩10g,黄连6~10g,黄柏10g。
本实施例主要针对病毒性心肌炎发病早期,提供的一种用于治疗病毒性心肌炎早期热毒侵心证的具有宣肺解表、清热解毒、广谱抗病毒、广谱抗菌、调节免疫效果的药剂。所述药剂中桑叶、菊花、薄荷、牛蒡子为发散风热药;荆芥、防风、生姜为发散风寒药;金银花、连翘、大青叶、板蓝根、鱼腥草、蒲公英为清热解毒药;黄芩、黄连、黄柏为清热燥湿药,桔梗宣肺化痰止咳利咽(无抗病毒作用,其水提取物可增强巨噬细胞吞噬功能,增强中性白细胞的杀菌力,提高溶菌酶活性);甘草调和诸药解毒、益气补中、抗病毒,以上绝大部分药物除桔梗外经现代药理研究显示可广谱抗病毒,同时具有广谱抗菌作用,此外栀子、穿心莲、苦参(可治疗心律失常)、丹皮也有抗菌功效,可选用。
实施例2
本实施例提供一种治疗病毒性心肌炎的药剂,所述药剂是由以下重量份的组分制成的:丹参20~30g,川芎10g,红花10g,赤芍10g,生黄芪10~30g,人参3g,麦冬10g,五味子10g,阴虚甚加玉竹10g,黄精10g。
实施例3
本实施例提供一种治疗病毒性心肌炎的药剂,所述药剂是由以下重量份的组分制成的:丹参20~30g,川芎10g,红花10g,赤芍10g,生黄芪10~30g,党参10~30g,麦冬10g,五味子10g,阴虚甚加玉竹10g,黄精10g。
实施例4
本实施例提供一种治疗病毒性心肌炎的药剂,所述药剂是由以下重量份的组分制成的:丹参20~30g,川芎10g,红花10g,赤芍10g,生黄芪10~30g,太子参15~30g,麦冬10g,五味子10g,阴虚甚加玉竹10g,黄精10g。
实施例2-4主要是针对解决病毒性心肌炎发病早期正虚不甚明显、中晚期正虚明显的症状,提供一种治疗病毒性心肌炎发病早期、中晚期气阴虚损证的具有益气养阴、改善心功能、降低耗氧量及抗心肌缺血、保护心肌细胞、改善微循环、抗心律失常、增强免疫力等功效的药剂。其中丹参、红花为活血调经药;川芎为活血止痛药;赤芍为清热凉血活血药,均有活血化瘀、改善冠脉循环及微循环、改善心肌供血等保护心肌作用;黄芪有增强心肌细胞抗病毒的作用,抑制感染细胞的病毒核酸复制,减轻病毒对心肌的直接损伤,改善内皮细胞生长,激活干扰素系统,有正性肌力作用,其安全性较高,但超量可促进凝血;黄芪(早期用10g)、人参(早期热毒盛时可选西洋参,中晚期可选白参或生晒参,出现阳虚症时可选红参)、党参、太子参、甘草为补气药,以黄芪、人参具有增强吞噬功能、增强细胞免疫、增强体液免疫、合成蛋白质、抗氧化损伤、强心、扩张冠状血管、增强造血功能最明显;麦冬为补阴药,也有增强吞噬功能、增强体液免疫、抗氧化损伤、强心、扩张冠状动脉、增强造血功能作用,还有抗休克和心律失常作用;玉竹、黄精也是补阴药;五味子具有敛肺滋肾、温和兴奋呼吸、改善呼吸衰竭、加强和调节心肌细胞和心脏小动脉能量代谢、改善心肌营养和功能、增强免疫和吞噬机能及抗氧化、宁心安神、生津止渴、抗过敏及抗炎作用。
实施例1-4中所涉及的用量是针对成人的,18岁以下少儿的用药比例可根据成人剂量折算,但剂量偏小,较为安全,如表1所示:
表1小儿年龄及其所对应的药剂用量
小儿年龄 | 相当于成人用量比例 | 小儿年龄 | 相当于成人用量比例 |
初生~1月 | 1/18~1/14 | 2岁~4岁 | 1/4~1/3 |
1月~6月 | 1/14~1/7 | 4岁~6岁 | 1/3~2/5 |
6月~1岁 | 1/7~1/5 | 6岁~9岁 | 2/5~1/2 |
1岁~2岁 | 1/5~1/4 | 9岁~14岁 | 1/2~2/3 |
实施例5
本实施例提供一种用于制备实施例1-4所述治疗病毒性心肌炎药剂制成饮剂的煎剂方法,包括以下步骤:
步骤1,浸泡:应每付药于陶制器皿中清水没过草药面2公分浸泡约1小时;
步骤2,煮沸:用武火加热步骤1所述浸泡后的药物至药液沸腾,即调文火使药液继续沸腾,约沸腾共30分钟停火;
步骤3,过滤:对步骤2所述沸腾后的药液进行过滤,过滤出药液约200ml置食品级器皿中备用;
步骤4,煎煮:注入清水没过步骤3所得草药面1.5公分煎药,然后重复步骤2和步骤3的操作,煎得药液约200ml与之前者混合后再分2等份,得到用于服用的药液。
优选的,所述煎煮操作中需对人参(包括白参、西洋参、红参)进行单独水煎煮,武火加热药液沸腾后改文火,保持药液沸腾约1小时停火,晾至温和,即液体温度为39~42℃时服用。
优选的,所述制备方法、步骤适合治疗病毒性心肌炎的血瘀和气阴虚症所用活血化瘀药和补益气阴药;治疗病毒性心肌炎的热毒症所用解表及清热药有别于前者,即煎煮实施例所述药剂的饮剂时仅用武火,时间宜短,煮沸后煎5分钟即可。
实验例
1)诊断标准:
根据1995年全国心肌炎心肌病专题座谈会提出的“成人急性病毒性心肌炎诊断参考标准”(草案)确诊。以1999年中华心血管病拟定的成人急性病毒性心肌炎诊断参考标准为准。
2)疗效评定标准:
治愈:无发热恶寒、咽痛、乏力、全身痛、胸闷、心慌等症,无后遗症及病情反复,查体心律、心率正常,血沉、血常规、血清心肌酶CK-MB、肌钙蛋白I或T等正常,心电图正常,胸部X线正常等;
有效:临床症状、体征减轻,血清心肌酶学检查基本恢复正常,心电图检查T波和ST段较治疗前明显好转或基本恢复正常;
无效:临床症状、体征、血清酶学检查及心电图检查等均无改善。
3)病例
对比病例1:女大学生,20岁左右,胸闷、心慌、乏力1周余,活动后加重,休息时减轻,查体:神清,精神欠佳,自由体位;两肺呼吸音清,无干湿啰音,心音弱,心率正常,心律齐,无病理性杂音,余无异常。辅助检查有些项目异常,支持拟诊急性病毒性心肌炎。
该患者系经上级医院抗病毒抗菌扩冠等西药治疗1周后转我院继续住院治疗,给予:黄芪注射液静滴2周(后改黄芪注射液口服约1年),同时口服生脉饮(党参方)、复方丹参滴丸、曲美他嗪、维生素C、复合维生素B等,免除体力活动,加强营养,共治疗约1年心肌炎痊愈。
病例1:女,35岁,高校女教师,乙流确诊病例密切接触者,急性上呼吸道感染,症状明显,乙流待查,口服本发明实施例1所述药剂所制成的成药颗粒剂1周左右后治愈。
病例2:女,50余岁,脑溢血开颅术后,卧床,行动受限,反复呼吸道病毒合并细菌感染,曾使用多种抗生素,直至因耐药无效,发热不退,给予本发明实施例1所述的解表清热药剂煎剂,服用三日热退,继续服用该药煎剂数日感染控制。
病例3:男大学生,20岁左右,确诊甲型流感患者,患者有高热、流涕、全身痛等症,给予1/2治疗量奥司他韦和所述解表清热药剂成药,配合对抗革兰氏阳性球菌抗生素等抗病毒、抗菌治疗以及对症治疗,治疗期间患者出现胸闷、心慌、乏力等症状,考虑合并病毒性心肌炎,查体、辅查也支持轻型自限型病毒性心肌炎诊断,立即给予本发明实施例2药剂(活血化瘀药剂)所制成的药丸舌下含服,仅3~5分钟(大概)胸闷、心慌等症缓解,后常规口服本发明实施例2药剂中成药,治疗7日后痊愈出院。
病例4:女大学生,20岁左右,因胸闷、心慌不适3日就诊,1周前曾上呼吸道感染并治疗,基本缓解。查体:心音偏弱,心律心率正常,余基本正常。辅查:心电图示左后分支传导阻滞,疑病毒性心肌炎,立即给予本发明实施例2药剂所制成的药丸舌下含服,几分钟后胸闷心慌缓解,嘱继续常规服用,又嘱立即到上级医院进一步检查,经心肌酶、胸部X线、心脏超声、动态心电图等检查均正常,排除病毒性心肌炎。
以上实验例中,本发明药剂针对病毒性心肌炎毒、瘀、虚的病因病机给予阶段清热解毒、全程活血化瘀和补益气阴等治疗,效果很好,优于其他疗法。
本发明药剂中的药量基本针对成年人,既属于经验用量,又基本符合国家药典要求,药量合适药效佳且对人体是安全的,大于此量造成药材资源浪费,且易出现副作用,如清热解毒药刺激胃肠道粘膜,出现腹部不适、恶心欲呕、轻度腹泻等,小于此量达不到预期效果;活血化瘀药大于此量增加出血风险,小于此量也达不到预期效果;补益气阴药中补气药人参大于此量可诱发中枢神经系统兴奋,红参可升高血压,黄芪可促进凝血,补阴药中麦冬口服大于此量可见腹胀、嗳气、大便增多等反应,黄精大于此量也会腹胀,小于此量达不到预期效果;上述药物均有效,已被临床证实,同时也被现代药理研究证实。
Claims (9)
1.一种治疗病毒性心肌炎的药剂,其特征在于,所述药剂是由以下重量份的组分制成的:桑叶10g,菊花10g,金银花15~30g,连翘15g,鱼腥草15~30g,荆芥10g,防风10g,牛蒡子10g,薄荷10g,生姜6g,甘草6g,桔梗10g,大青叶15g,板蓝根15g,蒲公英15~30g,黄芩10g,黄连6~10g,黄柏10g。
2.如权利要求1所述的一种治疗病毒性心肌炎的药剂,其特征在于,所述药剂用于治疗病毒性心肌炎的热毒症。
3.一种治疗病毒性心肌炎的药剂,其特征在于,所述药剂是由以下重量份的组分制成的:丹参20~30g,川芎10g,红花10g,赤芍10g,生黄芪10~30g,人参3g,麦冬10g,五味子10g,阴虚甚加玉竹10g,黄精10g。
4.如权利要求3所述的一种治疗病毒性心肌炎的药剂,其特征在于,所述人参3g可用党参10~30g或太子参15~30g替换。
5.如权利要求3或4所述的一种治疗病毒性心肌炎的药剂,其特征在于,所述药剂用于治疗病毒性心肌炎的血瘀和气阴虚症。
6.如权利要求1或3所述的一种治疗病毒性心肌炎的药剂,其特征在于,所述药剂的剂型为胶囊剂、片剂、颗粒剂、饮剂和滴丸剂中任意一种。
7.如权利要求1或3所述的一种治疗病毒性心肌炎的药剂的饮剂的制备方法,其特征在于,包括以下步骤:
步骤1,浸泡:应每付药于陶制器皿中清水没过草药面2公分浸泡约1小时;
步骤2,煮沸:用武火加热步骤1所述浸泡后的药物至药液沸腾,即调文火使药液继续沸腾,约沸腾共30分钟停火;
步骤3,过滤:对步骤2所述沸腾后的药液进行过滤,过滤出药液约200ml置食品级器皿中备用;
步骤4,煎煮:注入清水没过步骤3所得草药面1.5公分煎药,然后重复步骤2和步骤3的操作,煎得药液约200ml与之前者混合后再分2等份,得到用于早晚各1份服用的药液。
8.如权利要求7所述的一种治疗病毒性心肌炎药剂的制备方法,其特征在于,所述煎煮操作中需对人参进行单独水煎煮,武火加热药液沸腾后改文火,保持药液沸腾约1小时停火,晾至液体温度为39~42℃时服用。
9.如权利要求7所述的一种治疗病毒性心肌炎药剂的制备方法,其特征在于,煎煮治疗病毒性心肌炎的热毒症的药剂时仅用武火,时间宜短,煮沸后煎5分钟即可。
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010115218.7A CN111110820A (zh) | 2020-02-25 | 2020-02-25 | 一种治疗病毒性心肌炎的药剂及其制备方法 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CN202010115218.7A CN111110820A (zh) | 2020-02-25 | 2020-02-25 | 一种治疗病毒性心肌炎的药剂及其制备方法 |
Publications (1)
Publication Number | Publication Date |
---|---|
CN111110820A true CN111110820A (zh) | 2020-05-08 |
Family
ID=70493084
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CN202010115218.7A Pending CN111110820A (zh) | 2020-02-25 | 2020-02-25 | 一种治疗病毒性心肌炎的药剂及其制备方法 |
Country Status (1)
Country | Link |
---|---|
CN (1) | CN111110820A (zh) |
-
2020
- 2020-02-25 CN CN202010115218.7A patent/CN111110820A/zh active Pending
Non-Patent Citations (2)
Title |
---|
孙小冬等: "加味生脉饮治疗小儿病毒性心肌炎的临床观察", 《天津医药》 * |
张淑英等: "小儿病毒性心肌炎的中医辨证治疗", 《浙江中西医结合杂志》 * |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
CN103110844B (zh) | 一种治疗急性扁桃体炎中药 | |
CN103169862A (zh) | 一种治疗病毒性心肌炎的中药组方 | |
CN101579186A (zh) | 一种外用治疗风热型鼻炎的药物鼻炎枕 | |
CN111671864A (zh) | 一种减轻化疗引起的骨髓抑制的中药制剂及其制备方法 | |
CN103330868A (zh) | 一种慢性肾衰竭用肠道给液 | |
CN102861189A (zh) | 一种治疗病毒性脑炎的中药组合物 | |
CN113350429B (zh) | 一种防治非洲猪瘟疾病的中药组合物及其制备方法与应用 | |
CN111228367B (zh) | 一种治疗小儿过敏性紫癜的中药外用洗剂及其制备方法 | |
CN111110820A (zh) | 一种治疗病毒性心肌炎的药剂及其制备方法 | |
CN102293961A (zh) | 一种治疗放射性肺炎的中药 | |
CN105079438B (zh) | 一种治疗病毒性心肌炎的药物制剂 | |
CN111514237B (zh) | 一种治疗病毒性心肌炎的中药组合物及其制备方法 | |
CN111529632A (zh) | 一种用于治疗小儿鼻出血的中药配方及其制备方法 | |
CN105031095B (zh) | 治疗手足口病的中药组合物 | |
CN112206279B (zh) | 一种治疗室性心律失常的中药组合物及其制备方法和应用 | |
CN115869376B (zh) | 一种治疗成人斯蒂尔病的中药复方组合物 | |
CN103494983A (zh) | 一种治疗流行性感冒的中药 | |
CN103341095A (zh) | 一种慢性肾衰竭用灌肠液 | |
CN115869375B (zh) | 一种清热疏风的中药组合物及其制备方法和应用 | |
CN100457177C (zh) | 一种清肺、补肾的中药保健制剂 | |
CN106389756A (zh) | 一种治疗妇女不孕的中医药物配方 | |
CN105250746A (zh) | 一种清热解毒口服液及其制备方法 | |
CN105396000A (zh) | 治疗肺结核的中药组合物及制备方法 | |
CN104758346A (zh) | 一种治疗偏头痛的药物及其制备方法、制剂 | |
CN105250417A (zh) | 一种治疗腹泻型肠易激综合征的药物组合物及其应用 |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PB01 | Publication | ||
PB01 | Publication | ||
SE01 | Entry into force of request for substantive examination | ||
SE01 | Entry into force of request for substantive examination | ||
RJ01 | Rejection of invention patent application after publication |
Application publication date: 20200508 |
|
RJ01 | Rejection of invention patent application after publication |