CN111110600B - Scalp purification and hair growth promoting composition and emulsion thereof - Google Patents
Scalp purification and hair growth promoting composition and emulsion thereof Download PDFInfo
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/49—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
- A61K8/4906—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom
- A61K8/4913—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with one nitrogen as the only hetero atom having five membered rings, e.g. pyrrolidone carboxylic acid
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/26—Aluminium; Compounds thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/345—Alcohols containing more than one hydroxy group
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/60—Sugars; Derivatives thereof
- A61K8/602—Glycosides, e.g. rutin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/673—Vitamin B group
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/92—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof
- A61K8/922—Oils, fats or waxes; Derivatives thereof, e.g. hydrogenation products thereof of vegetable origin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9755—Gymnosperms [Coniferophyta]
- A61K8/9761—Cupressaceae [Cypress family], e.g. juniper or cypress
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/14—Drugs for dermatological disorders for baldness or alopecia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/008—Preparations for oily hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q7/00—Preparations for affecting hair growth
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/40—Chemical, physico-chemical or functional or structural properties of particular ingredients
- A61K2800/59—Mixtures
- A61K2800/592—Mixtures of compounds complementing their respective functions
- A61K2800/5922—At least two compounds being classified in the same subclass of A61K8/18
Abstract
The invention belongs to the technical field of cosmetics, and particularly relates to a scalp purification and hair growth promoting composition and an emulsion thereof. The invention provides a scalp purification and hair growth promoting composition and an emulsion thereof, wherein the composition comprises a scalp purification composition, an osmosis promoting composition, a hair growth promoting composition and a scalp nutrition composition, the scalp purification composition comprises caprylyl glycine, zinc PCA, bentonite, nicotinamide, a radix sophorae flavescentis extract, melaleuca alternifolia leaf oil and eucalyptus globulus leaf oil, and the osmosis promoting composition comprises propylene glycol, dimethyl isosorbide anhydride, isononyl isononanoate, isopropyl myristate and dodecanoic acid. The scalp purification and hair growth promoting composition has the effects of controlling oil, preventing hair loss and fixing hair, and the emulsion has the advantages of good stability, good percutaneous absorbability and simple preparation process, and is suitable for industrial mass production.
Description
Technical Field
The invention belongs to the field of cosmetics, and particularly relates to a scalp purification and hair growth promoting composition and an emulsion thereof.
Background
Currently, the number of people with alopecia in China is about 2 hundred million, and 1.3 hundred million of people with alopecia is male, and about 1 person in every 4 adult men in China is in alopecia, and the alopecia age syndrome tends to be younger. The classification method for treating alopecia in medicine at home and abroad mainly comprises western medicine treatment and traditional Chinese medicine treatment, or comprises medicine treatment and operation treatment. The western medicine treatment method comprises the steps of externally applying 2% or 5% minoxidil, or orally taking finasteride and the like, injecting corticosteroid and the like, and performing surgical treatment such as hair transplantation, low-energy laser treatment (LLLT therapy), autologous platelet rich plasma (PRP therapy) and the like, and the methods have side effects and are not suitable for all people, and the treatment course is at least more than 6 months. Such as minoxidil, can be used not only for treating hypertension but also for topical application to the scalp to prolong the growth cycle of hair, but for women who suffer from hair loss due to autoimmune diseases, minoxidil may only maintain existing hair without any benefit for regrowth.
In recent 50 years, traditional Chinese medicine takes deficiency tonifying as a treatment basis, and treatment is based on syndrome differentiation such as clearing internal heat, removing turbidity and promoting diuresis, promoting blood circulation and removing blood stasis according to symptom type. The external treatment is assisted by activating blood circulation to dissipate blood stasis, dispelling pathogenic factors with pungent flavor, and clearing heat and eliminating dampness. Meanwhile, attention is paid to the regulation and the nourishing of liver and kidney, spleen and stomach, and the psychological treatment of androgenetic alopecia patients is also considered. The mechanism of treating desertion is relatively not clear, and the effect is not obvious, but the traditional Chinese medicine components used with high frequency, such as angelica, tuber fleeceflower root, arborvitae leaf, prepared rehmannia root, safflower, and the like, are promoted.
The existing anti-hair loss and hair growth promoting composition mainly comprises traditional plant extracts or is compounded with polypeptide components and prepared into an aqueous solution for use, and the premise of the efficacy exertion is that the composition needs to be absorbed to a hair follicle target point through skin. Patent document CN110013455A discloses a composition with effects of relieving itching, controlling oil, strengthening hair and preventing alopecia, which overcomes the disadvantage of slow effect of treating alopecia by using traditional plant extracts, and adds polypeptide components, but the anti-alopecia route is not comprehensive, and the matched composition has no deep research in the aspect of percutaneous absorption system, and is a problem as to whether the active components can reach the target site deeply to play a role. Patent document CN108324610B discloses a hair growth composition and PIC nanoemulsion prepared from the hair growth composition, which has the advantages of good transdermal penetration and excellent hair growth effect, but does not solve the problem of pore blockage caused by vigorous oil secretion, and has no outstanding oil control effect. Patent document CN108430452A discloses an aerosol composition containing ginseng extract for preventing hair loss or promoting hair growth, which enables a liquid preparation to be atomized and permeated to exert efficacy, but the action route of the active ingredient is not comprehensive, and the problem of pore blockage is not caused, the prepared composition has no intensive research on a percutaneous absorption system, and the problem of whether the active ingredient can reach the target site to exert the effect is caused.
Therefore, in the efficacy range of hair-nourishing cosmetics, the problem of pore blockage caused by excessive oil secretion and the problem of effective delivery of effective ingredients to corresponding targets are urgently solved while alopecia is alleviated.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a scalp cleansing and hair growth promoting composition and an emulsion thereof. The composition has the effects of controlling oil, preventing hair loss and fixing hair, and the emulsion has the advantages of good stability, good percutaneous absorbability and simple preparation process, and is suitable for industrial mass production.
In order to achieve the purpose, the invention adopts the following technical scheme:
a scalp cleansing hair growth promoting composition comprising a scalp cleansing composition, a hair growth promoting composition, a scalp nutritional composition, and an penetration promoting composition; the scalp cleansing composition comprises caprylyl glycine, zinc PCA, bentonite, nicotinamide, radix Sophorae Flavescentis extract, melaleuca alternifolia leaf oil and Eucalyptus globulus leaf oil; the penetration enhancing composition comprises propylene glycol, dimethyl isosorbide anhydride, isononyl isononanoate, isopropyl myristate and dodecanoic acid; the hair growth promoting composition comprises adenosine, acetyl tetrapeptide-3, tripeptide-1 copper, cacumen biotae extract, ginseng root extract and burdock of May; the scalp nutritional composition includes inositol, biotin, and arginine.
Preferably, the composition comprises the following components in parts by weight: 1-6 parts of scalp purification composition, 10-30 parts of penetration promoting composition, 1-2 parts of adenosine, 30.01-1 parts of acetyl tetrapeptide, 0.01-1 part of tripeptide-1 copper, 1-3 parts of cacumen biotae extract, 1-3 parts of ginseng root extract, 1-3 parts of Maackia scabra Bunge extract, 1-5 parts of inositol, 1-5 parts of biotin and 0.1-0.5 part of arginine.
Preferably, the composition comprises the following components in parts by weight: 5.8 parts of scalp purification composition, 26.1 parts of permeation-promoting composition, 2 parts of adenosine, 30.05 parts of acetyl tetrapeptide, 0.05 part of tripeptide-1 copper, 2 parts of cacumen biotae extract, 2 parts of ginseng root extract, 2 parts of May burdock extract, 2 parts of inositol, 1 part of biotin and 0.1 part of arginine.
Preferably, the scalp purification composition comprises caprylyl glycine, zinc PCA, nicotinamide, a radix sophorae flavescentis extract, melaleuca alternifolia leaf oil and eucalyptus globulus leaf oil in a mass ratio of (1-2): (0.5-1): (1-2): (1-3): (0.05-0.1): (0.05-0.1).
Preferably, the permeation-promoting composition comprises propylene glycol, dimethyl isosorbide anhydride, isononyl isononanoate, isopropyl myristate and dodecanoic acid in a mass ratio of (2-5): (5-10): (4-8): (4-8): (1-4).
The invention provides application of the scalp cleansing and hair growth promoting composition in preparation of emulsion
The invention also provides an emulsion containing the scalp cleansing hair-growth promoting composition, which comprises the scalp cleansing hair-growth promoting composition.
Preferably, the antibacterial composition, the emulsion stabilizing composition, the glycerin, the sodium phytate and the cetyl alcohol are also included.
Preferably, the antibacterial composition is prepared from 1, 2-pentanediol and ethylhexyl glycerol in a mass ratio of 2-5: 0.5-3, wherein the emulsion stabilizing composition is prepared by mixing sorbitan stearate and polysorbate-60 according to a mass ratio of 0.5-5: 0.5-5 by weight.
The invention also provides an emulsion containing the scalp cleansing hair growth promoting composition, and a preparation method of the emulsion comprises the following steps:
(1) weighing the raw materials according to a formula, and grouping for later use;
(2) sequentially delivering water, glycerol, propylene glycol, dimethyl isosorbide anhydride, sodium phytate, inositol, nicotinamide and bentonite, adding into a water phase pot of a homogenizing and emulsifying pot, stirring and dissolving at a rotation speed of 20r/min, and heating to 80-85 ℃ to obtain phase A; putting isononyl isononanoate, isopropyl myristate, cetyl alcohol, dodecanoic acid, sorbitan stearate, polysorbate-60 and caprylyl glycine into an oil phase pot of a homogenizing and emulsifying pot, stirring and dissolving at the rotating speed of 20r/min, and heating to 80-85 ℃ to obtain a phase B;
(3) dissolving PCA zinc, radix Sophorae Flavescentis extract, adenosine, acetyl tetrapeptide-3, tripeptide-1 copper, folium Platycladi extract, Ginseng radix extract, May burdock extract, biotin, and arginine in water to obtain phase C; mixing melaleuca alternifolia leaf oil, eucalyptus globulus leaf oil, 1, 2-pentanediol and ethylhexyl glycerin to obtain a phase D;
(4) mixing the phase A and the phase B obtained in the step (2), homogenizing at 3500r/min for 5-10min at 70-80 ℃, then keeping the temperature at 80-85 ℃ for 15-20min, stirring at a rotating speed of 10r/min, cooling to 50 ℃, then adding the phase C obtained in the step (3), and homogenizing at 3500r/min for 0.5-1min to obtain a mixed solution E;
(5) and (4) continuing stirring the mixed solution E in the step (4) and cooling to below 45 ℃, adding the phase D and cooling to 30 ℃ to obtain the emulsion containing the scalp purification and hair growth promotion composition.
The secretion of sebum is mainly controlled by male hormone, testosterone and dehydroepiandrosterone, and the oily scalp is characterized by pore expansion, hyperkeratosis, skin microorganism increase, sebaceous gland hypersecretion, folliculitis, sebaceous gland enlargement and the like in the physiological aspect; the percutaneous absorption is promoted by adopting the components such as propylene glycol, isosorbide dimethyl ether, isononyl isononanoate, isopropyl myristate and dodecanoic acid, and the octanoyl glycine can inhibit the bacterial proliferation generated by hair follicles, reduce inflammatory factors caused by the bacterial proliferation and avoid the excessive secretion of sebaceous glands caused by the inflammatory stimulation; the nicotinamide can promote blood microcirculation of hair follicles, regulate oil secretion and realize water-oil balance; the radix Sophorae Flavescentis extract has effects of balancing lipid secretion, dredging and astringing follicular orifice.
Compared with the prior art, the invention has the following advantages: the hair growth promoting composition can be effectively delivered to the corresponding target of the hair follicle in a percutaneous permeation mode through the permeation promoting composition to play a role, meanwhile, the scalp purifying composition can effectively control oil, so that the scalp is purified, pores are prevented from being blocked due to the fact that oil is secreted vigorously, hair falling is further accelerated, and the product achieves the effects of oil control, permeation promotion, hair loss prevention and hair fixation through the synergistic matching of the components with good compatibility.
Drawings
FIG. 1 shows cumulative permeation results.
Detailed Description
The present invention will be described in further detail with reference to the following examples. It should not be understood that the scope of the above-described subject matter of the present invention is limited to the following examples.
Example 1 anti-run emulsion
The preparation method comprises the following steps:
(1) weighing the raw materials according to a formula, and grouping for later use;
(2) sequentially delivering water, glycerol, propylene glycol, dimethyl isosorbide anhydride, sodium phytate, inositol, nicotinamide and bentonite, adding into a water phase pot of a homogenizing and emulsifying pot, stirring and dissolving at a rotation speed of 20r/min, and heating to 80-85 ℃ to obtain phase A; putting isononyl isononanoate, isopropyl myristate, cetyl alcohol, dodecanoic acid, sorbitan stearate, polysorbate-60 and caprylyl glycine into an oil phase pot of a homogenizing and emulsifying pot, stirring and dissolving at the speed of 20r/min, and heating to 80-85 deg.C to obtain phase B;
(3) dissolving PCA zinc, radix Sophorae Flavescentis extract, adenosine, acetyl tetrapeptide-3, tripeptide-1 copper, folium Platycladi extract, Ginseng radix extract, May burdock extract, biotin, and arginine in water to obtain phase C; mixing Melaleuca alternifolia leaf oil, Eucalyptus globulus leaf oil, 1, 2-pentanediol, and ethylhexyl glycerol to obtain phase D;
(4) mixing the phase A and the phase B obtained in the step (2), homogenizing at 3500r/min for 5-10min at 70-80 ℃, then keeping the temperature at 80-85 ℃ for 15-20min, stirring at the rotating speed of 10r/min, cooling to 50 ℃, then adding the phase C obtained in the step (3), and homogenizing at 3500r/min for 0.5-1min to obtain a mixed solution E;
(5) and (4) continuously stirring the mixed solution E in the step (4), cooling to below 45 ℃, adding the phase D, and cooling to 30 ℃ to obtain the anti-hair loss emulsion.
Example 2 anti-run emulsion
The preparation method is the same as example 1.
Comparative example 1 anti-run emulsion
Comparative example 1 differs from example 1 in that: no penetration enhancing composition was present and the missing part was replaced by white oil, prepared as in example 1.
Comparative example 2 anti-run emulsion
Comparative example 2 differs from example 1 in that: the scalp-free cleansing composition, lacking the replacement of the portion by bentonite clay, was prepared in the same manner as in example 1.
Comparative example 3 anti-run emulsion
Comparative example 3 differs from example 1 in that: scalp cleansing compositions without scalp cleansing compositions and penetration enhancing compositions, lacking the scalp cleansing compositions partially replaced with bentonite and lacking the penetration enhancing compositions partially replaced with white oil were prepared according to the same method as in example 1.
Test example 1 stability
The anti-dropping emulsion prepared in the examples 1 to 2 and the comparative examples 1 to 3 is bottled and placed in test tubes with the diameter of 20nm multiplied by 20nm respectively, the liquid level is about 80mm, the test tubes are sealed by a sealing film, the test tubes are respectively placed in a thermostat with a preset value of 45 ℃ and a refrigerator with the temperature of-20 ℃, the stability is respectively checked for 1 week, 3 months and 6 months, and then the test tubes are taken out and restored to the room temperature and then are visually compared with the test samples of the other test tube.
Table 1 stability test results
The results in table 1 show that the emulsions prepared in examples 1 to 2 showed no significant change in pH, consistency and odor and showed excellent stability after stability test for 1 week, 3 months and 6 months, while the pH changes of comparative examples 2 and 3 were significant, indicating that the scalp cleansing composition affected the stability of the anti-alopecia emulsion and that the scalp cleansing composition containing the antimicrobial component may inhibit the growth of microorganisms.
Test example 2 evaluation of scalp oil-controlling efficacy
Test sample anti-run emulsions prepared in example 1 and comparative examples 1 to 3
Testing the population: screening 10 female volunteers with itching head oil and baldness worries and 20 male volunteers with itching head oil 25-45 years old
The test principle is as follows: the sebum test is based on quartz crystal sensor technology, with the sensor collecting the sebum mass from the scalp. The greater the mass of sebum, the greater the sebum content. The smaller the value, the lower the sebum content, and the better the oil control effect of the product.
The test method comprises the following steps: it is administered 1 g/time in the morning and evening each day. During the test period, the testee avoids excessive ultraviolet exposure and excessive physical activity, head oil control products and the like except for a test sample are not used during the test period, the test sample is continuously used for 28 days, sebum at the top of the head of the testee is respectively collected on 0 th, 7 th, 14 th and 28 th days after the use, the sebum at the top of the head is respectively tested, the real-time dynamic monitoring is carried out in the test environment with the humidity of 40-60% and the temperature of 20-22 ℃, and the results are shown in table 2.
TABLE 2 scalp oil content with time table
The results in Table 2 show that the oil content in the test part was gradually reduced but the degree of reduction was different after the continuous use of the anti-shedding emulsion. The oil content of the group in example 1 is respectively reduced by 23.7% and 50.4% in the return visit test of the 14 th and 28 th days, and the oil control effect is obvious, which shows that the oil control effect of the anti-hair loss emulsion added with the penetration promoting composition and the scalp purifying composition is obviously better than that of the anti-hair loss emulsion only containing the single hair promoting composition.
Test example 3 evaluation of percutaneous absorption permeation Effect
And (3) testing a sample: anti-shedding emulsions of examples 1 to 2 and comparative examples 1 to 3
The test method comprises the following steps:
taking Kunming mouse with mass (20 + -2) g, removing abdominal hair, cutting off abdominal skin, removing adherent adipose tissue, storing in refrigerator at 4 deg.C with normal saline as storage solution, and sucking off skin surface water when it is used. The treated rat skin stratum corneum is upwards fixed on a Franz diffusion cell, 7.5mL of 30% ethanol-normal saline solution is added into a receiving cell to ensure that the inner layer of the rat skin is completely contacted with receiving liquid, a transdermal instrument is opened, the constant temperature is set at 37 ℃, and the constant rotating speed is kept at 200 r/min. And (5) balancing for 1h, and discharging bubbles in the receiving tank and then administering the medicine. Uniformly coating 0.1g of sample anti-hair-loss emulsion on the area of a diffusion cell supplied to rat skin, enabling each group to be parallel for 3 times, sucking 1mL of receiving liquid when 1.0, 2.0, 4.0, 6.0, 8.0, 10.0 and 12.0 hours are respectively carried out, supplementing the receiving liquid with the same volume after each sampling, carrying out chromatographic sample injection analysis, determining the content of the hair-promoting composition, and calculating the cumulative permeation amount (Q) according to the following formulan，μg/cm2)。
Qn＝(CnV+ΣCiVi)/A
Cn: concentration of aspirated fluid mg/L at the nth time point
Ci: concentration of aspirated fluid mg/L at time point n-i
V: the total volume of the receiving liquid
Vi: volume of liquid drawn at a time
A: volume of receiving tank
As can be seen from figure 1, the cumulative permeation amount of the examples 1-2 is greater than that of the comparative examples 1-2, wherein the cumulative permeation amount of the example 1 is the best, and the result shows that the penetration promoting composition and the scalp purifying composition in the anti-alopecia emulsion can synergistically promote the transdermal absorption of the anti-alopecia emulsion, so that the anti-alopecia effect can be exerted.
Test example 4 evaluation of efficacy against alopecia
Test samples: emulsions prepared in examples 1-2 and comparative examples 1-3
Adult volunteers aged between 20-45 years who suffered from hair loss were divided into a test group (examples 1-2) and a control group (comparative examples 1-3), each group having 30 subjects, 15 male and 15 female. The principle of random, double-blind and self-contrast is adopted, the product is used 2 times in the morning and at night every day, 1-2 g of the product is used every time, and the using part is a hair thinning area. At weeks 0, 8 and 16 of 16 weeks, the subject was evaluated for hair density and hair growth rate according to the subjective evaluation of the subject, the hair loss screen collection count at the time of shampooing, and by using a hair photograph as a non-invasive hair evaluation method, and the results are shown in tables 3 to 5.
TABLE 3 comparison of efficacy against alopecia in examples 1-2
TABLE 4 comparative examples 1-3 efficacy against hair loss
TABLE 5 questionnaire feedback results
The anti-hair loss efficacy evaluation is shown in tables 3-5, and the results show that after 8 weeks and 16 weeks, the average density and average growth rate of hair are significantly increased, the average number of fallen hair roots is significantly improved, 82% of subjects in example 1 consider that the hair loss is significantly reduced, 85% of subjects consider that the secretion of scalp oil is significantly improved, and the average density, average growth rate and average number of fallen hair roots of comparative examples 1-3 are less effective in improving hair, so that the penetration promoting composition and the scalp cleansing composition of the present invention can synergistically promote hair growth and prevent hair loss.
The foregoing embodiments are merely illustrative of the principles and utilities of the present invention and are not intended to limit the invention. Any person skilled in the art can modify or change the above-mentioned embodiments without departing from the spirit and scope of the present invention. Accordingly, it is intended that all equivalent modifications or changes which can be made by those skilled in the art without departing from the spirit and technical spirit of the present invention be covered by the claims of the present invention.
Claims (7)
1. A scalp cleansing hair growth promoting composition comprising a scalp cleansing composition, an penetration promoting composition, a hair growth promoting composition, and a scalp nutritional composition;
the scalp cleansing composition comprises caprylyl glycine, zinc PCA, bentonite, nicotinamide, radix Sophorae Flavescentis extract, melaleuca alternifolia leaf oil and Eucalyptus globulus leaf oil;
the penetration enhancing composition comprises propylene glycol, dimethyl isosorbide anhydride, isononyl isononanoate, isopropyl myristate and dodecanoic acid;
the hair growth promoting composition comprises adenosine, acetyl tetrapeptide-3, tripeptide-1 copper, cacumen biotae extract, ginseng root extract and burdock of May;
the scalp nutritional composition includes inositol, biotin, and arginine;
comprises the following components in parts by weight: 1-6 parts of scalp purification composition, 10-30 parts of penetration promoting composition, 1-2 parts of adenosine, 30.01-1 parts of acetyl tetrapeptide, 0.01-1 part of tripeptide-1 copper, 1-3 parts of cacumen biotae extract, 1-3 parts of ginseng root extract, 1-3 parts of Maackia scabra Bunge extract, 1-5 parts of inositol, 1-5 parts of biotin and 0.1-0.5 part of arginine;
the scalp purification composition comprises caprylyl glycine, PCA zinc, nicotinamide, a radix sophorae flavescentis extract, melaleuca alternifolia leaf oil and eucalyptus globulus leaf oil in a mass ratio of (1-2): (0.2-1): (1-2): (1-3): (0.05-0.1): (0.05-0.1); the permeation-promoting composition comprises propylene glycol, isosorbide dimethyl ether, isononyl isononanoate, isopropyl myristate and dodecanoic acid in a mass ratio of (2-5): (5-10): (4-8): (4-8): (1-4).
2. The scalp cleansing hair growth promoting composition according to claim 1, comprising the following components in parts by weight: 5.8 parts of scalp purification composition, 26.1 parts of permeation-promoting composition, 2 parts of adenosine, 30.05 parts of acetyl tetrapeptide, 0.05 part of tripeptide-1 copper, 2 parts of cacumen biotae extract, 2 parts of ginseng root extract, 2 parts of May burdock extract, 2 parts of inositol, 1 part of biotin and 0.1 part of arginine.
3. The scalp cleansing hair growth promoting composition according to claim 1, wherein the scalp cleansing composition comprises caprylylglycine, zinc PCA, niacinamide, sophora flavescens extract, melaleuca alternifolia leaf oil and eucalyptus globulus leaf oil in a mass ratio of 1: 0.2: 2: 1: 0.05: 0.05; the penetration-promoting composition comprises propylene glycol, dimethyl isosorbide anhydride, isononyl isononanoate, isopropyl myristate and dodecanoic acid in a mass ratio of 3: 5: 5: 5: 1.
4. use of a scalp cleansing hair growth promoting composition according to any one of claims 1 to 3 in the preparation of an emulsion.
5. An emulsion containing a scalp cleansing hair growth promoting composition characterized by comprising the scalp cleansing hair growth promoting composition according to any one of claims 1 to 3.
6. The emulsion containing the scalp cleansing hair growth promoting composition according to claim 5, further comprising 6 parts of a bacteriostatic composition, 1 part of an emulsion stabilizing composition, 5 parts of glycerin, 0.1 part of sodium phytate and 2 parts of cetyl alcohol;
the antibacterial composition is prepared from 1, 2-pentanediol and ethylhexyl glycerol in a mass ratio of 5: 1, and the emulsion stabilizing composition is prepared by mixing sorbitan stearate and polysorbate-60 according to a mass ratio of 1: 1 are mixed.
7. The emulsion comprising the scalp cleansing hair growth promoting composition according to claim 5, wherein the emulsion is prepared by a method comprising the steps of:
(1) weighing the raw materials according to a formula, and grouping for later use;
(2) sequentially delivering water, glycerol, propylene glycol, dimethyl isosorbide anhydride, sodium phytate, inositol, nicotinamide and bentonite, adding into a water phase pot of a homogenizing and emulsifying pot, stirring and dissolving at a rotation speed of 20r/min, and heating to 80-85 ℃ to obtain phase A; putting isononyl isononanoate, isopropyl myristate, cetyl alcohol, dodecanoic acid, sorbitan stearate, polysorbate-60 and caprylyl glycine into an oil phase pot of a homogenizing and emulsifying pot, stirring and dissolving at the rotating speed of 20r/min, and heating to 80-85 ℃ to obtain a phase B;
(3) dissolving PCA zinc, radix Sophorae Flavescentis extract, adenosine, acetyl tetrapeptide-3, tripeptide-1 copper, folium Platycladi extract, Ginseng radix extract, May burdock extract, biotin, and arginine in water to obtain phase C; mixing Melaleuca alternifolia leaf oil, Eucalyptus globulus leaf oil, 1, 2-pentanediol, and ethylhexyl glycerol to obtain phase D;
(4) mixing the phase A and the phase B obtained in the step (2), homogenizing at 3500r/min for 5-10min at 70-80 ℃, then keeping the temperature at 80-85 ℃ for 15-20min, stirring at a rotating speed of 10r/min, cooling to 50 ℃, then adding the phase C obtained in the step (3), and homogenizing at 3500r/min for 0.5-1min to obtain a mixed solution E;
(5) and (4) continuing stirring the mixed solution E in the step (4) and cooling to below 45 ℃, adding the phase D and cooling to 30 ℃ to obtain the emulsion containing the scalp purification and hair growth promotion composition.
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| CN112168759A (en) * | 2020-10-29 | 2021-01-05 | 东方爱堡(北京)母婴健康科技有限公司 | Infant skin lotion and preparation method thereof |
| CN112315835A (en) * | 2020-11-26 | 2021-02-05 | 广州环亚化妆品科技有限公司 | Oil-control and anti-dandruff composition and application thereof |
| CN112494532B (en) * | 2020-12-17 | 2022-05-31 | 弘美制药（中国）有限公司 | Composition for preventing hair loss and nourishing scalp as well as preparation method and application thereof |
| CN113662873B (en) * | 2021-08-11 | 2023-08-22 | 广州杰铿生物科技有限公司 | Osmotic composition, skin care product and preparation method thereof |
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