CN111107809B - 包括微胶囊的牙齿卫生湿巾 - Google Patents
包括微胶囊的牙齿卫生湿巾 Download PDFInfo
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Abstract
本发明涉及一种牙齿清洁湿巾,其包括浸渍有牙齿卫生成分的非编织的纺织载体,该牙齿清洁湿巾包含:机械断裂式微胶囊,其内容物通过壁的断裂来释放;以及,受控扩散式微胶囊,其内容物通过穿过壁的渗透来释放,所述微胶囊的壁不可溶于水。
Description
技术领域
本发明涉及湿巾类型的一次性牙齿卫生产品。
背景技术
已知在每次用餐后清洁牙齿不仅对于良好的口腔卫生是有利的,而且还提供大多数人所欣赏的干净、清新和口腔舒适度。
常用的牙齿清洁装置(例如:牙刷和牙膏、漱口水、牙齿喷雾等)不适于在出门在外的白天期间使用,除了因为它们占空间的特征,它们还要求前往有水处使用,而这并不总是可能的。
在现有技术中描述了用于使人们能够在一天中任何时刻在任何地点清洁牙齿的众多牙齿卫生物品。尤其是湿巾类型的一次性设备,其包括浸渍有清洁成分的纺织载体。这样的设备可呈不同的形式。它们经常呈指套或可折叠片的形式以适于使用者手指。例如在专利US 3 902 509、US 4 335 731、EP 1 267 663或FR 3 022 134中描述了这样的设备。
已提出封装清洁成分的某些组分,尤其是香气,以保护它们不至改变物理和化学特性(美国专利6 898 819;美国专利6 721 987;美国专利3 902 509)。所使用的封装材料可溶于水,并在与口腔湿度接触时释放胶囊的内容物。由于这些胶囊是单一类型的,它们的内容物同时被释放。
发明内容
本发明的目的在于提供一种牙齿湿巾,既能够获得立即的干净和清新效果,又具有比现有技术的牙齿湿巾使用后延续更长时间的延迟效果。
由此,本发明的主题在于一种牙齿清洁湿巾,其包括浸渍有合适的牙齿卫生成分的非编织的纺织载体,该牙齿卫生成分的至少一部分组分封装在沉积在所述载体的表面处的微胶囊中,所述湿巾的特征在于,其联合了两种不同类型的微胶囊:即时释放的微胶囊,和缓释微胶囊。
第一类型微胶囊(在下文中也称作“机械断裂式”)能够在使用湿巾时由使用者施加在牙齿上的压力作用下使微胶囊的壁断裂而释放其内容物。第二类型微胶囊(在下文中也称作“受控扩散式”)能够通过其内容物穿过微胶囊壁的受控渗透而释放其内容物。
这两种类型的微胶囊的组合的主要优点在于,既能够通过即时释放包含在机械断裂式微胶囊的活性成分而获得在使用时的即时有效性,又能够在时间上延长该有效性,后者是通过活性成分穿过受控扩散式微胶囊的壁渗透而实现的,受控扩散式微胶囊是通过湿巾的摩擦而沉积在牙齿和牙龈上的。
无论是机械断裂式或受控扩散式的微胶囊,其壁必须显著地不溶于水,以避免其在湿巾的存储过程中被微胶囊所包含的牙齿卫生成分溶解。此外,对受控扩散式微胶囊来说,封装膜与唾液接触时的快速水溶性必然会导致其即时释放其内容物,这与所追求的缓释效果背道而驰。
机械断裂式微胶囊具有强度必须足够高的壁,以免屈服于在制造、运输和存储产品时产生的机械应力。相反地,它又必须能够在使用湿巾时在最终使用者施加的压强下断裂并释放它们的内容物。由此,这些微胶囊中的至少80%必须能够抵抗20g/cm2的压强,并且这些微胶囊中的大约90%必须在500g/cm2的压强下断裂。
受控扩散式微胶囊则不应在使用湿巾时所施加的压强下断裂。因此它们必须能够抵抗大约2000g/cm2的压强。
机械断裂式微胶囊和受控扩散式微胶囊的比例可以从95/5变化至5/95的相对百分比例。
微胶囊的壁基于显著不溶于水的材料或通过沉淀剂或交联剂作用而不可水溶的材料构成。它优选地由甲醛残余比率低的三聚氰胺树脂、交联的羧甲基纤维素(CMC)、来源于海洋胶原、牛皮或猪皮的交联明胶、聚氨酯、聚酰胺、聚丙烯酸酯、(二甲硅油)有机硅或改性有机硅构成。它也可由纤维素衍生物、多糖、壳聚糖、多元醇、聚乙烯醇、聚乙烯吡咯烷酮、PLGA-PLA(聚D,L乳酸乙醇酸-聚D,L乳酸)或聚己内酯构成,通过交联或沉淀使其不溶于水。
能够使通常可溶于水的聚合物变为不可溶的交联剂例如是二氯化酸或对苯二甲酰氯(对于明胶)或硼砂(对于聚乙烯醇),它们会桥接界面处的聚合物并由此在水滴周边形成不溶性膜。不溶性沉淀剂可以例如是钙或镁盐(对于羧甲基纤维素)。
受控扩散式微胶囊优选地基于交联明胶、聚酰胺或有机硅获得。它们的壁必须允许其内容物在可控的时长内扩散,这取决于其结构中的微孔的数量和平均直径;该时长从数分钟到数天不等。扩散也可由壁的厚度来控制;微胶囊的壁的多孔性和厚度被设置在正常存储条件下能够充分密封,而在唾液和/或口腔温度的作用下使得内容物在从数分钟到至数小时的时长内逐渐地释放。
微胶囊可通过本身为本领域技术人员已知的工艺来制备。在大多数情况中,根据对于实施工艺所选择的条件,可获得机械断裂式微胶囊或受控扩散式微胶囊。作为非限制性例子,以下将提及利用复杂凝聚的封装、利用原位聚合的封装,和利用界面聚合的封装。
a)利用复杂凝聚的封装
通过在pH的影响下形成明胶和阴离子聚合物(CMC、多磷酸盐、海藻酸盐、阿拉伯胶等)的络合物来获得微胶囊。
为了获得成簇或单个胶囊,被称为保护性胶体的阴离子聚合物的存在是必要的。
该工艺包括5个步骤:
·乳化
·凝聚(法语coacervation)
·紧实
·交联
·温度上升和调整pH
由此获得柔性和透明的胶囊,其直径可在1μm到500μm之间变化。
根据它们的交联程度和它们的尺寸,这些胶囊可以是密封的并通过施加确定压强而断裂(机械断裂式胶囊),或是可渗透的并能够以根据需求调节的盐析速度受控地盐析。
尺寸更大的胶囊倾向于在壁上产生更大的孔隙率,并由此为活性成分的受控渗透创造了更有利的条件。
b)利用树脂原位聚合的封装
该工艺允许通过脆弱性可调节的外壳破裂来释放活性成分(机械断裂式微胶囊)。
通过外壳的聚合来实现的微胶囊是在水相下从聚合物溶液获得的,该聚合物溶液在pH、温度变化的作用下或通过添加交联剂而变得不可溶并在油性化合物液滴周围沉淀或难溶于水。
该操作经两个由pH和温度调控的步骤来实现:
·乳化和聚合:使得乳化稳定的是正在形成的聚合物
·交联
该操作也要求存在被称为保护性胶体的阴离子聚合物。
三聚氰胺树脂和甲醛尿素是所使用的主要成分。
通过外壳的机械破裂来实现活性成分的释放;微胶囊的壁的脆弱性可根据交联时间来调节。
这些硬的微胶囊是不透明的,具有非常好的密封性和非常好的化学抵抗性,并具有1μm至200μm的平均直径。
c)通过有机硅树脂原位聚合来封装
原理与前述的接近,使用有机硅单体或功能化有机硅。
获得柔性且透明的胶囊,其具有1μm至500μm的直径。
根据交联程度和它们的尺寸,这些胶囊可通过外壳断裂来释放它们的内容物,或能够受控释放。
d)通界面聚合来封装
原理在于通过两种单体或预聚物之间的反应来形成聚合物,两种物品中的一种处于水相,另一种处于油相。
该工艺经两个由pH和温度调控的步骤来进行:
·乳化和聚合:使得乳化稳定的是正在形成的聚合物;
·交联
所使用的主要聚合物是聚氨酯(二异氰酸酯+二胺)和聚酰胺(二酰氯+二胺)。
该工艺能够获得机械断裂式微胶囊,但是如果需要,通过减小壁的厚度,尤其是通过降低交联温度,则还可以获得受控扩散式微胶囊。
根据本发明的牙齿湿巾可具有不同的形式,例如为平片的形式。然而,它们优选地具有指套的形式。
在这些牙齿湿巾中所使用的非编织载体优选地由纤维素、化学改性纤维素或纤维素衍生吸收性材料构成。
尤其是当湿巾的形式为指套时,非编织载体被焊接或胶合在位于指套内部面上的不可渗透膜层。该不可渗透膜形成屏障,以保护使用者手指免于接触唾液,并避免浸渍非编织载体的成分扩散到指套内部。该不可渗透的膜形成屏障,使得可以保护使用者的手指免受唾液的侵害,并且避免浸渍无纺布载体的组合物在手套手指内部扩散。作为非限制性举例,该屏障层可以由PVC、聚乙烯、聚丙烯、聚酰胺、复合共挤膜等构成。
非编织载体的厚度为20至1500μm,该厚度优选地至少为沉积在其表面处的微胶囊的平均直径的两倍。当该非编织件的制造和存储过程涉及卷绕操作时,微胶囊的与非编织件的弹性相关的强度必须能够吸收高达20g/cm2的卷绕压强而不会使微胶囊过早断裂。
封装对于本发明有用的活性成分的微胶囊的平均直径为1至500μm,优选地为1至50μm,更优选地为2至20μm。
沉积在非编织件上的微胶囊的量约为5至50g/m2乘以非编织载体的面积。
浸渍非编织件的牙齿卫生成分可包含选自通常用于口腔卫生成分中的组成成分的各种组成成分;作为非限制例子,可涉及例如表面活性剂,抛光剂,增白剂,抗牙斑剂,防龋齿剂,抗菌剂,香味剂等。一般来说,组成成分中的一部分包括在微胶囊中,另一部分则直接浸渍非编织载体。包括在微胶囊中的组成成分一般是香味剂和/或抗菌剂,例如植物精油,以及如有必要,抗牙斑剂和/或防龋齿剂.
这些微胶囊通过喷涂、上浆(法语foulardage)(浸泡)、涂布(法语couchage)或涂覆(法语enduction)而被固定在非编织件的表面。
为了改善它们的稳定性和它们粘附到非编织件的粘附性能,这些微胶囊与添加剂结合,例如:相对于微胶囊质量占高至30质量%的防腐剂,乳化剂,粘合剂。
·乳化剂:例如聚山梨酯80(乙氧基化脱水山梨糖醇酯),氢化卵磷脂,单硬脂酸甘油酯等;
·粘合剂(0.5至1.5质量%):所有具有增稠和稳定特性使其能够增加微胶囊在非编织件上的粘附力的试剂,例如:羧甲基纤维素,纤维素胶,黄原胶等。
·防腐剂:例如异噻唑啉酮衍生物,苯甲酸钠,山梨酸钾,EDTA,脱氢乙酸等。
具体实施方式
借助以下的附加说明,会更好地理解本发明,附加说明参照非限制性例子示出根据本发明的牙齿湿巾的制备。
例1:消毒牙齿清洁剂1
受控扩散式有机硅微胶囊通过原位聚合来制备。
机械断裂式明胶微胶囊通过存在海藻酸盐的条件下的复杂凝聚来制备。
呈指套形式的湿巾由厚度为50μm的纤维素层构成并加衬有厚度为20μm的不可渗透膜,通过上浆浸渍有如上表中显示的成分,该成分通过简单的冷混合来制备;在混合结束时,通过轻微搅拌将两种均呈浓稠水性悬浮物形式且干胶囊浓度大约为35%的微胶囊添加到其中。
例2:牙齿清洁剂2
受控扩散式有机硅微胶囊通过原位聚合来制备。
机械断裂式明胶微胶囊通过存在羧甲基纤维素的条件下的复杂凝聚来制备。
呈指套形式的湿巾由厚度为50μm的纤维素层构成并加衬有厚度为20μm的不可渗透膜,通过喷涂纤维素部分而浸渍有如上表中显示的成分,微胶囊以外的成分通过简单的在45℃温度下的混合来制备;在冷却到最高30℃之后,通过轻微搅动将微胶囊添加到其中。受控扩散式有机硅微胶囊以干胶囊浓度35%的浓稠水性悬浮物的形式被加入,而机械断裂式鱼明胶微胶囊呈干胶囊的形式并在混合工艺末尾被引入。
例3:消毒牙齿清洁剂3
受控扩散式有机硅微胶囊通过原位聚合来制备。
小厚度的机械断裂式明胶微胶囊通过存在海藻酸盐的条件下的复杂凝聚来制备。
呈指套形式的湿巾由厚度为50μm的纤维素层构成并加衬有厚度为20μm的不可渗透膜,通过喷涂纤维素部分而浸渍有如上表中所示的成分,微胶囊以外的成分通过在45℃温度下的简单混合来制备;在冷却到最高30℃之后,通过轻微搅动将微胶囊添加到其中。受控扩散式有机硅微胶囊以干胶囊浓度35%的浓稠水性悬浮物的形式被加入,而机械断裂式鱼明胶微胶囊呈干胶囊的形式并在混合工艺末尾被引入。
例4:牙齿清洁剂4
受控扩散式交联明胶微胶囊通过复杂凝聚来制备。
机械断裂式聚酰胺微胶囊通过原位聚合来制备。
呈指套形式的湿巾由厚度为40μm的纤维素层构成,并通过喷涂纤维素部分浸渍有如上表所示的成分,微胶囊以外的成分通过45℃温度下的简单混合来制备;在冷却到最高30℃之后,通过轻微搅动将微胶囊添加到其中。两种类型的微胶囊以干胶囊浓度为35%的浓稠水性悬浮物(浆料)形式被加入。
Claims (6)
1.一种牙齿清洁湿巾,其包括浸渍有牙齿卫生成分的非编织的纺织载体,该牙齿卫生成分的至少一部分组分封装在沉积在所述非编织的纺织载体的表面处的微胶囊中,所述湿巾的特征在于,
所述牙齿卫生成分选自由以下成分组成的组:香味剂、抗菌剂、植物精油、抗牙斑剂、防龋齿剂和/或增白剂,而且
所述牙齿清洁湿巾包括两种不同类型的微胶囊:
-机械断裂式微胶囊,所述机械断裂式微胶囊中的至少80%能够抵抗20g/cm2的压强,但所述机械断裂式微胶囊的内容物在压力或摩擦的作用下通过壁的断裂来释放;而且所述机械式微胶囊的壁显著地不溶于水,或通过交联剂或沉淀剂作用而不溶于水;所述机械式微胶囊的壁选自由以下成分组成的组:交联明胶、交联的羧甲基纤维素、聚酰胺、聚丙烯酸酯、甲醛残余比率低的三聚氰胺、由硼砂交联的聚乙烯醇、壳聚糖;和,
-受控扩散式微胶囊,其内容物通过穿过壁的渗透来释放,而且所述受控扩散式微胶囊的壁显著地不溶于水,或通过交联剂或沉淀剂作用而不溶于水;所述受控扩散式微胶囊的壁选自由以下成分组成的组:交联明胶、聚酰胺、硅;所述受控扩散式微胶囊的内容物的扩散取决于所述壁的多孔性和厚度。
2.如权利要求1所述的牙齿清洁湿巾,其特征在于,所述湿巾呈指套形式。
3.如权利要求1中所述的牙齿清洁湿巾,其特征在于,所述非编织的纺织载体选自纤维素、化学改性纤维素,和纤维素衍生吸收材料。
4.如权利要求1至3中任一项所述的牙齿清洁湿巾,其特征在于,所述非编织的纺织载体的厚度范围为20至1500μm,并且至少等于沉积在其表面处的微胶囊的平均直径的两倍。
5.如权利要求1至3中任一项所述的牙齿清洁湿巾,其特征在于,沉积在其表面处的微胶囊的平均直径为1至50μm。
6.如权利要求1至3任一项所述的牙齿清洁湿巾,其特征在于,沉积在所述非编织的纺织载体上的微胶囊的量为5至50g/m2乘以所述非编织的纺织载体的面积。
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CA2457086A1 (en) * | 2001-08-17 | 2003-02-27 | Smithkline Beecham P.L.C. | Oral care substance delivery strip |
US20030120180A1 (en) * | 2001-12-21 | 2003-06-26 | Kimberly-Clark Worldwide, Inc. | Method and apparatus for collecting and testing biological samples |
AU2006338510A1 (en) * | 2006-02-17 | 2007-08-23 | The Procter & Gamble Company | Oral care regimens and devices |
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TWI404544B (zh) * | 2008-08-11 | 2013-08-11 | Colgate Palmolive Co | 含珠粒之口腔保健組成物 |
BR112012002152A2 (pt) * | 2009-07-30 | 2016-06-07 | Procter & Gamble | artigo de tratamento bucal |
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-
2017
- 2017-07-24 EP EP17182835.3A patent/EP3434223A1/fr not_active Withdrawn
-
2018
- 2018-07-20 LT LTEPPCT/EP2018/069844T patent/LT3658071T/lt unknown
- 2018-07-20 MA MA49674A patent/MA49674B1/fr unknown
- 2018-07-20 PL PL18742802.4T patent/PL3658071T3/pl unknown
- 2018-07-20 RS RS20220909A patent/RS63618B1/sr unknown
- 2018-07-20 US US16/634,101 patent/US11759408B2/en active Active
- 2018-07-20 HU HUE18742802A patent/HUE061941T2/hu unknown
- 2018-07-20 CA CA3084296A patent/CA3084296A1/fr active Pending
- 2018-07-20 EP EP18742802.4A patent/EP3658071B1/fr active Active
- 2018-07-20 WO PCT/EP2018/069844 patent/WO2019020535A1/fr unknown
- 2018-07-20 DK DK18742802.4T patent/DK3658071T3/da active
- 2018-07-20 RU RU2020108131A patent/RU2760615C2/ru active
- 2018-07-20 CN CN201880061716.9A patent/CN111107809B/zh active Active
Patent Citations (2)
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DE10015662A1 (de) * | 2000-03-29 | 2001-10-04 | Henkel Kgaa | Zahnpflegemittel in Portionskapseln |
CN103588920A (zh) * | 2013-10-31 | 2014-02-19 | 天津工业大学 | 单分散多孔聚合物纳米微囊的新型制备方法 |
Also Published As
Publication number | Publication date |
---|---|
PL3658071T3 (pl) | 2022-11-21 |
RU2020108131A3 (zh) | 2021-08-26 |
LT3658071T (lt) | 2023-01-10 |
RS63618B1 (sr) | 2022-10-31 |
WO2019020535A1 (fr) | 2019-01-31 |
EP3658071A1 (fr) | 2020-06-03 |
CA3084296A1 (fr) | 2019-01-24 |
US11759408B2 (en) | 2023-09-19 |
RU2020108131A (ru) | 2021-08-26 |
DK3658071T3 (en) | 2022-10-03 |
RU2760615C2 (ru) | 2021-11-29 |
MA49674B1 (fr) | 2024-03-29 |
EP3658071B1 (fr) | 2022-06-29 |
CN111107809A (zh) | 2020-05-05 |
HUE061941T2 (hu) | 2023-10-28 |
EP3434223A1 (fr) | 2019-01-30 |
US20200206093A1 (en) | 2020-07-02 |
MA49674A (fr) | 2021-03-17 |
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