CN111095477B - 用同位素选择性ms/ms评估mrm峰纯度 - Google Patents

用同位素选择性ms/ms评估mrm峰纯度 Download PDF

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Publication number
CN111095477B
CN111095477B CN201880059814.9A CN201880059814A CN111095477B CN 111095477 B CN111095477 B CN 111095477B CN 201880059814 A CN201880059814 A CN 201880059814A CN 111095477 B CN111095477 B CN 111095477B
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China
Prior art keywords
ion
precursor
child
mrm
intensity
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CN201880059814.9A
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Chinese (zh)
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CN111095477A (zh
Inventor
Y·勒布朗
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DH Technologies Development Pte Ltd
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DH Technologies Development Pte Ltd
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    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/0027—Methods for using particle spectrometers
    • H—ELECTRICITY
    • H01—ELECTRIC ELEMENTS
    • H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
    • H01J49/00—Particle spectrometers or separator tubes
    • H01J49/26—Mass spectrometers or separator tubes
    • H01J49/34—Dynamic spectrometers
    • H01J49/42—Stability-of-path spectrometers, e.g. monopole, quadrupole, multipole, farvitrons
    • H01J49/4205—Device types
    • H01J49/421—Mass filters, i.e. deviating unwanted ions without trapping
    • H01J49/4215—Quadrupole mass filters

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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
CN201880059814.9A 2017-09-29 2018-09-25 用同位素选择性ms/ms评估mrm峰纯度 Active CN111095477B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201762565140P 2017-09-29 2017-09-29
US62/565,140 2017-09-29
PCT/IB2018/057395 WO2019064173A1 (en) 2017-09-29 2018-09-25 EVALUATION OF PIC MRM PURITY WITH SELECTIVE MS / MS OF ISOTOPES

Publications (2)

Publication Number Publication Date
CN111095477A CN111095477A (zh) 2020-05-01
CN111095477B true CN111095477B (zh) 2023-12-22

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CN201880059814.9A Active CN111095477B (zh) 2017-09-29 2018-09-25 用同位素选择性ms/ms评估mrm峰纯度

Country Status (5)

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US (1) US11024494B2 (enExample)
EP (1) EP3688788B1 (enExample)
JP (2) JP2020535599A (enExample)
CN (1) CN111095477B (enExample)
WO (1) WO2019064173A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3916754A1 (en) * 2020-05-28 2021-12-01 Thermo Fisher Scientific (Bremen) GmbH Methods and apparatus for determining interference in ms scan data, filtering ions and performing mass spectrometry analysis on a sample
US20230393107A1 (en) * 2020-10-30 2023-12-07 Dh Technologies Development Pte. Ltd. Compound Identification by Mass Spectrometry
US20240355605A1 (en) * 2021-09-03 2024-10-24 Dh Technologies Development Pte. Ltd. Prediction of precursor charge state in dm-swath analysis
US20240420939A1 (en) * 2021-11-01 2024-12-19 Dh Technologies Development Pte. Ltd. Ultra high throughput screening combined with definitive testing in a single sample preparation step

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009105491A2 (en) * 2008-02-22 2009-08-27 Mds Analytical Technologies Method of improving signal-to-noise for quantitation by mass spectrometry
CA2836112A1 (en) * 2011-06-03 2012-12-06 Dh Technologies Development Pte. Ltd. Use of variable xic widths of tof-msms data for the determination of background interference in srm assays
CA2862834A1 (en) * 2012-01-10 2013-07-18 David B. Krizman Srm/mrm assay for the insulin receptor protein
GB2525709A (en) * 2014-02-04 2015-11-04 Micromass Ltd Optimized multiple reaction monitoring or single ion recording method
WO2016125059A1 (en) * 2015-02-05 2016-08-11 Dh Technologies Development Pte. Ltd. Interference detection and peak of interest deconvolution

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4720254B2 (ja) * 2005-03-31 2011-07-13 日本電気株式会社 分析方法、分析システム、及び分析プログラム
JP4821400B2 (ja) * 2006-03-28 2011-11-24 株式会社島津製作所 構造解析システム
US8335655B2 (en) * 2008-05-30 2012-12-18 Dh Technologies Development Pte. Ltd. Intelligent saturation control for compound specific optimization of MRM
WO2012035412A2 (en) * 2010-09-15 2012-03-22 Dh Technologies Development Pte. Ltd. Data independent acquisition of production spectra and reference spectra library matching
WO2015189605A1 (en) 2014-06-11 2015-12-17 Micromass Uk Limited Ion profiling with a scanning quadrupole mass filter
EP3086353A1 (en) * 2015-04-24 2016-10-26 Thermo Fisher Scientific (Bremen) GmbH A method of producing a mass spectrum

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2009105491A2 (en) * 2008-02-22 2009-08-27 Mds Analytical Technologies Method of improving signal-to-noise for quantitation by mass spectrometry
CA2836112A1 (en) * 2011-06-03 2012-12-06 Dh Technologies Development Pte. Ltd. Use of variable xic widths of tof-msms data for the determination of background interference in srm assays
CN103563044A (zh) * 2011-06-03 2014-02-05 Dh科技发展私人贸易有限公司 使用tof-msms数据的可变xic宽度确定srm分析中的背景干扰
CA2862834A1 (en) * 2012-01-10 2013-07-18 David B. Krizman Srm/mrm assay for the insulin receptor protein
GB2525709A (en) * 2014-02-04 2015-11-04 Micromass Ltd Optimized multiple reaction monitoring or single ion recording method
WO2016125059A1 (en) * 2015-02-05 2016-08-11 Dh Technologies Development Pte. Ltd. Interference detection and peak of interest deconvolution
CN107209151A (zh) * 2015-02-05 2017-09-26 Dh科技发展私人贸易有限公司 干扰检测及所关注峰值解卷积

Also Published As

Publication number Publication date
JP2020535599A (ja) 2020-12-03
EP3688788B1 (en) 2024-02-21
US20200279725A1 (en) 2020-09-03
US11024494B2 (en) 2021-06-01
JP2024083502A (ja) 2024-06-21
EP3688788A1 (en) 2020-08-05
WO2019064173A1 (en) 2019-04-04
EP3688788A4 (en) 2021-08-18
CN111095477A (zh) 2020-05-01

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