CN111094267A - 作为RORγ抑制剂的磺酰基取代的双环化合物 - Google Patents

作为RORγ抑制剂的磺酰基取代的双环化合物 Download PDF

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Publication number
CN111094267A
CN111094267A CN201880061818.0A CN201880061818A CN111094267A CN 111094267 A CN111094267 A CN 111094267A CN 201880061818 A CN201880061818 A CN 201880061818A CN 111094267 A CN111094267 A CN 111094267A
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hydroxy
amino
cyano
nitro
alkoxy
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CN201880061818.0A
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CN111094267B (zh
Inventor
王小龙
阳安乐
姜洪建
周建
陈磊
蒋晓龙
杨玲
徐宏江
耿晓函
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Nanjing Gearpharma Technology Co ltd
Chia Tai Tianqing Pharmaceutical Group Co Ltd
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Nanjing Gearpharma Technology Co ltd
Chia Tai Tianqing Pharmaceutical Group Co Ltd
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/58—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems with hetero atoms directly attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Rheumatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

提供作为RORγ抑制剂的磺酰基取代的双环化合物(A)，其具有良好的RORγ抑制活性，有望用于治疗哺乳动物由RORγ受体介导的疾病。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201880061818.0A 2017-09-30 2018-09-30 作为RORγ抑制剂的磺酰基取代的双环化合物 Active CN111094267B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201710913429 2017-09-30
CN2017109134293 2017-09-30
PCT/CN2018/109110 WO2019063015A1 (zh) 2017-09-30 2018-09-30 作为RORγ抑制剂的磺酰基取代的双环化合物

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CN111094267A true CN111094267A (zh) 2020-05-01
CN111094267B CN111094267B (zh) 2022-06-14

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Country Link
US (1) US11396503B2 (zh)
EP (1) EP3689860A4 (zh)
CN (1) CN111094267B (zh)
WO (1) WO2019063015A1 (zh)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113166061A (zh) * 2018-11-27 2021-07-23 正大天晴药业集团股份有限公司 含有磺酰基结构的RORγ抑制剂
CN113912597A (zh) * 2020-07-07 2022-01-11 赛诺哈勃药业（成都）有限公司 一类RORγ抑制剂、其制备方法及其在医药上的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112250628B (zh) * 2020-10-21 2022-07-08 上海应用技术大学 一种钌催化剂催化氢化制备四氢喹啉类化合物的方法
US20240300986A1 (en) * 2020-12-31 2024-09-12 Scinnohub Pharmaceutical Co., Ltd Plasmin inhibitor, preparation method therefor and application thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0795548A1 (en) * 1995-09-28 1997-09-17 Suntory Limited Quinazoline derivatives and use thereof
CN106458991A (zh) * 2014-05-23 2017-02-22 豪夫迈·罗氏有限公司 苯磺酰胺衍生物和它们作为 rorc 调节剂的用途

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB201116641D0 (en) 2011-09-27 2011-11-09 Glaxo Group Ltd Novel compounds
GB201207406D0 (en) 2012-04-27 2012-06-13 Glaxo Group Ltd Novel compounds
US9428452B2 (en) 2012-04-27 2016-08-30 Glaxo Group Limited Compounds
US9266827B2 (en) 2012-05-08 2016-02-23 Merck Sharp & Dohme Corp. Bicyclic sulfone compounds for inhibition of RORgamma activity and the treatment of disease
US9868748B2 (en) 2013-05-01 2018-01-16 Vitae Pharmaceuticals, Inc. Thiazolopyrrolidine inhibitors of ROR- γ
PE20161372A1 (es) 2014-02-03 2017-01-08 Vitae Pharmaceuticals Inc Inhibidores de dihidropirrolopiridina de ror-gamma
JP6728061B2 (ja) 2014-05-05 2020-07-22 リセラ・コーポレイションＬｙｃｅｒａ Ｃｏｒｐｏｒａｔｉｏｎ ＲＯＲγアゴニストとして用いるテトラヒドロキノリンスルホンアミド及び関連化合物ならびに疾患の治療
UA118989C2 (uk) 2014-10-14 2019-04-10 Вітае Фармасьютікалс, Інк. Дигідропіролопіридинові інгібітори ror-гамма

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0795548A1 (en) * 1995-09-28 1997-09-17 Suntory Limited Quinazoline derivatives and use thereof
CN106458991A (zh) * 2014-05-23 2017-02-22 豪夫迈·罗氏有限公司 苯磺酰胺衍生物和它们作为 rorc 调节剂的用途

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ACS: "RN 2217321-08-7", 《STN REGISTRY》 *
ACS: "RN 948816-15-7", 《STN REGISTRY》 *

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113166061A (zh) * 2018-11-27 2021-07-23 正大天晴药业集团股份有限公司 含有磺酰基结构的RORγ抑制剂
CN113166061B (zh) * 2018-11-27 2023-11-21 正大天晴药业集团股份有限公司 含有磺酰基结构的RORγ抑制剂
CN113912597A (zh) * 2020-07-07 2022-01-11 赛诺哈勃药业（成都）有限公司 一类RORγ抑制剂、其制备方法及其在医药上的应用
CN113912597B (zh) * 2020-07-07 2023-06-13 赛诺哈勃药业（成都）有限公司 一类RORγ抑制剂、其制备方法及其在医药上的应用

Also Published As

Publication number Publication date
US11396503B2 (en) 2022-07-26
EP3689860A1 (en) 2020-08-05
US20200239454A1 (en) 2020-07-30
CN111094267B (zh) 2022-06-14
EP3689860A4 (en) 2021-06-02
WO2019063015A1 (zh) 2019-04-04

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