CN111094254A - 杂芳基类衍生物、其制备方法及其在医药上的应用 - Google Patents

杂芳基类衍生物、其制备方法及其在医药上的应用 Download PDF

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CN111094254A
CN111094254A CN201980004504.1A CN201980004504A CN111094254A CN 111094254 A CN111094254 A CN 111094254A CN 201980004504 A CN201980004504 A CN 201980004504A CN 111094254 A CN111094254 A CN 111094254A
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groups
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cancer
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CN111094254B (zh
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陆标
张俊珍
沈晓冬
贺峰
陶维康
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Shandong Shengdi Pharmaceutical Co ltd
Jiangsu Hengrui Medicine Co Ltd
Shanghai Hengrui Pharmaceutical Co Ltd
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Shanghai Hengrui Pharmaceutical Co Ltd
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Abstract

通式(I)所示的杂芳基类衍生物、其制备方法及含有该衍生物的药物组合物以及其作为治疗剂，特别是作为A2a受体和/或A2b受体拮抗剂的用途和在制备用于治疗通过对A2a受体和/或A2b受体的抑制而改善的病况或病症的药物中的用途，其中通式(I)的各取代基与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (20)

  1. PCT国内申请，权利要求书已公开。
CN201980004504.1A 2018-07-12 2019-07-11 杂芳基类衍生物、其制备方法及其在医药上的应用 Active CN111094254B (zh)

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CN2018107645157 2018-07-12
CN201810764515 2018-07-12
PCT/CN2019/095523 WO2020011220A1 (zh) 2018-07-12 2019-07-11 杂芳基类衍生物、其制备方法及其在医药上的应用

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110655509A (zh) * 2018-06-29 2020-01-07 江苏恒瑞医药股份有限公司 2-胺基嘧啶类衍生物、其制备方法及其在医药上的应用
CN110684020A (zh) * 2018-07-05 2020-01-14 江苏恒瑞医药股份有限公司 2-胺基嘧啶类衍生物、其制备方法及其在医药上的应用

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2615307A (en) 2022-01-28 2023-08-09 Adorx Therapeutics Ltd Antagonist compounds
WO2024193703A1 (zh) * 2023-03-23 2024-09-26 成都赜灵生物医药科技有限公司 三嗪类化合物及其用途

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1575290A (zh) * 2001-10-22 2005-02-02 卫材株式会社 嘧啶化合物以及含有该化合物的药物组合物
CN102822150A (zh) * 2010-02-05 2012-12-12 赫普泰雅治疗有限公司 1,2,4-三嗪-4-胺衍生物
WO2016126570A1 (en) * 2015-02-06 2016-08-11 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as a2a antagonist
WO2018130184A1 (zh) * 2017-01-13 2018-07-19 江苏恒瑞医药股份有限公司 1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用
WO2019018584A1 (en) * 2017-07-18 2019-01-24 GiraFpharma LLC HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2748993C1 (ru) * 2017-09-28 2021-06-02 СиСТОУН ФАРМАСЬЮТИКАЛС (СУЧЖОУ) КО., ЛТД. Производное с конденсированным кольцом в качестве ингибитора рецептора a2a

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1575290A (zh) * 2001-10-22 2005-02-02 卫材株式会社 嘧啶化合物以及含有该化合物的药物组合物
CN102822150A (zh) * 2010-02-05 2012-12-12 赫普泰雅治疗有限公司 1,2,4-三嗪-4-胺衍生物
WO2016126570A1 (en) * 2015-02-06 2016-08-11 Merck Sharp & Dohme Corp. Aminoquinazoline compounds as a2a antagonist
WO2018130184A1 (zh) * 2017-01-13 2018-07-19 江苏恒瑞医药股份有限公司 1,2,4-三嗪-3-胺类衍生物、其制备方法及其在医药上的应用
WO2019018584A1 (en) * 2017-07-18 2019-01-24 GiraFpharma LLC HETEROCYCLIC COMPOUNDS AS ADENOSINE ANTAGONISTS

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110655509A (zh) * 2018-06-29 2020-01-07 江苏恒瑞医药股份有限公司 2-胺基嘧啶类衍生物、其制备方法及其在医药上的应用
CN110655509B (zh) * 2018-06-29 2023-01-24 江苏恒瑞医药股份有限公司 2-胺基嘧啶类衍生物、其制备方法及其在医药上的应用
CN110684020A (zh) * 2018-07-05 2020-01-14 江苏恒瑞医药股份有限公司 2-胺基嘧啶类衍生物、其制备方法及其在医药上的应用
CN110684020B (zh) * 2018-07-05 2023-01-20 江苏恒瑞医药股份有限公司 2-胺基嘧啶类衍生物、其制备方法及其在医药上的应用

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