CN111067994A - 一种治疗胃癌前病变及胃癌的药物组合物及其制备方法 - Google Patents
一种治疗胃癌前病变及胃癌的药物组合物及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗胃癌前病变及胃癌的药物组合物及其制备方法,属于医药技术领域,该药物组合物包括以下重量份的原料药:太子参50份‑80份、炙黄芪30份‑50份、生山药30‑60份、密点麻蜥30份‑60份、麦冬10份‑30份、乌梅10份‑30份、升麻6份‑12份、半枝莲30份‑60份、炒白芍10份‑30份、枳实30份‑60份、三七粉6份‑9份、蛇莓20份‑60份、硇砂2份‑6份、蜂房10份‑40份、鹿角胶10份‑30份、大黄3份‑6份。本发明还公开一种治疗胃癌前病变及胃癌的药物组合物的制备方法,诸药配伍更加合理,能够迅速消除胃部疼痛,抑制肿瘤增长。
Description
技术领域
本发明属于医药技术领域,涉及一种治疗胃癌前病变及胃癌的药物组合物及其制备方法。
背景技术
胃癌是四大常见癌症之一,也是全球癌症死亡的第二大原因。每年超过95万例患者被诊断为胃癌,我国是胃癌高发区,每年新发病例约40万例,占世界总发病例数的42%。
医学界普遍认为,胃癌的发展是一个从胃黏膜良性病变向恶性病变渐变的一个过程,即慢性萎缩性胃炎-胃黏膜癌前病变(肠上皮化生、不典型增生)-胃癌。可见胃癌前病变,是从正常胃黏膜向胃癌转化过程中的一个重要阶段,对胃癌前病变的有效干预对控制胃癌发病率具有重要意义。
目前,针对胃癌前病变的西医治疗包括根除幽门螺旋杆菌、补充抗氧化剂和微量元素、胃黏膜保护剂、抗生素等。但是对于伴有幽门螺旋杆菌感染的患者,即使杀灭幽门螺旋杆菌的感染之后,仍然无法有效阻止向胃癌的发展,而抗氧化剂和维生素等药物对胃癌前病变的治疗效果仍然得不到较好的数据支持,已经确定有效的胃黏膜保护剂,其仅能减缓胃癌前病变的发展进程,但是无法阻止或逆转整个病理过程。因此胃癌前病变的治疗至今仍为西医领域中的治疗难点。
中医药对该病的治疗则有一定优势,取得了良好的疗效,大量临床治疗及实验研究都表明中医药对具有明显的预防甚至逆转作用。但中药传统方剂存在服药量大,需要患者自行煎煮,药材质量不稳定导致疗效不确切的缺点。
胃癌前病变临床表现为上腹饱胀、隐痛不适、纳差、暖气、反胃等,属中医“胃院痛”、“痞满”、“嘈杂”、“腹胀”、“暖气”等范畴,中医认为其发生与饮食不当、情绪失调、湿热“虫”毒感染等密切相关,这些因素可引起脾胃运化功能失调,中气耗损,阴血生化乏源,加之浊毒内留,血脉运行不畅,脉络瘀阻,日久致胃失荣养,胃腑受损,腺体萎缩,黏膜变薄,逐渐形成癌变。胃镜下可见胃黏膜变薄、苍白、血管网显露,黏膜呈现粗糙颗粒状物。
因此,益气养阴、解毒通络是主要治疗法则。本发明针对脾胃升降的生理病理特点,运用药物升降浮沉理论,以辛味药与苦味药为主,寒热并调,用于治疗脏腑功能失调、气机升降失常所致脘痞腹痛、恶心呕吐、肠鸣泄泻或口咽溃烂等病证。
目前现有技术中急需一种起效快的治疗胃癌前病变及胃癌的药物组合物及其制备方法。
发明内容
本发明的目的在于提供一种起效快的治疗胃癌前病变及胃癌的药物组合物,以中草药为原料制备的中成药,本发明还涉及该药物的制备方法。本发明的药物组合物可以补益脾胃气阴,活血通络解毒,可以有效改善胃癌前病变患者临床症状,修复糜烂粘膜,阻断癌变的作用。
其具体技术方案为:
一种治疗胃癌前病变及胃癌的药物组合物,其包括以下重量份的原料药:太子参50份-80份、炙黄芪30份-50份、生山药30-60份、密点麻蜥30份-60份、麦冬10份-30份、乌梅10份-30份、升麻6份-12份、半枝莲30份-60份、炒白芍10份-30份、枳实30份-60份、三七粉6份-9份、蛇莓20份-60份、硇砂2份-6份、蜂房10份-40份、鹿角胶10份-30份、大黄3份-6份。
其中,密点麻蜥有抗癌、修复、免疫调节等作用,能增强机体免疫力,能够促进受损组织的修复和再生,对胃粘膜糜烂有靶向作用。三七粉有止血、活血化瘀、消肿定痛、滋补强壮、抗疲劳、耐缺氧、抗衰老、降血脂、降血压、提高机体免疫功能等作用;硇砂:消积软坚,破瘀散结;蜂房:抗炎、镇痛,抑制癌症形成;蛇莓、半枝莲清热解毒、凉血消肿可助密点麻蜥解毒通络,平衡阴阳;太子参,味甘、微苦;性平,具有益气健脾,生津润肺之功效;石斛、炙黄芪相配,补气养阴,和中养胃,增强免疫力;枳壳理气宽中,通行脾胃之气;升麻提举一身之正气,达邪外出,清热解肌。
进一步,其包括以下重量份的原料药:太子参65份、炙黄芪40份、生山药45份、密点麻蜥45份、麦冬20份、乌梅20份、升麻10份、半枝莲45份、炒白芍20份、枳实45份、三七粉7份、蛇莓40份、硇砂4份、蜂房25份、鹿角胶200份、大黄5份。
一种本发明治疗胃癌前病变及胃癌的药物组合物的制备方法,包括以下步骤:
步骤1、按本发明的药方准备各药材,将诸药材研磨粉碎至80-120目,混匀研磨后所得的粉末微粒,蒸晒,消毒后加入丙二醇,分散碾匀成药物分散液,待用。
步骤2、将卡波姆与适量抗氧化剂EDTA-2Na(乙二胺四乙酸二钠)、防腐剂尼泊金乙酯溶于水中,溶胀24~48小时,制得凝胶基质;
步骤3、将步骤1制得的超细药物粉散液与步骤2制得的凝胶基质混合,加入蒸馏水足量,搅拌均匀,即得凝胶剂。
与现有技术相比,本发明的有益效果为:
本发明的治疗胃癌前病变及胃癌的药物组合物本发明处方配伍在治疗胃癌前病变的理论上,诸药配伍更加合理,具有益气健脾养阴、解毒通络、养胃和胃之效,达到改善血液循环,营养胃壁黏膜的目的,从而标本兼治。能够迅速消除胃部疼痛,抑制肿瘤增长。
并且,本发明采用生物活性凝胶新型模式,可有效弥补中药汤剂口感苦、药量大及丸剂质硬、起效缓等缺点,且凝胶剂型具有良好的生物相容性,对药物释放具有缓释、控释作用,应用于消化道疾病诊疗中有较好疗效。
具体实施方式
下面结合具体实施方式对本发明的技术方案作进一步详细地说明。
实施例1
一种治疗胃癌前病变及胃癌的药物组合物,包括以下重量份的原料药:太子参50份份、炙黄芪30份份、生山药30份、密点麻蜥30份份、麦冬10份、乌梅10份、升麻6份、半枝莲30份、炒白芍10份、枳实30份、三七粉6份、蛇莓20份、硇砂2份、蜂房10份、鹿角胶10份、大黄3份-6份。
一种本发明所述的治疗胃癌前病变及胃癌的药物组合物的制备方法,包括以下步骤:
步骤1、按本发明的药方准备各药材,将诸药材研磨粉碎至80目,混匀研磨后所得的粉末微粒,蒸晒,消毒后加入丙二醇,分散碾匀成药物分散液,待用;
步骤2、将卡波姆与适量抗氧化剂EDTA-2Na(乙二胺四乙酸二钠)、防腐剂尼泊金乙酯溶于水中,溶胀24小时,制得凝胶基质;
步骤3、将步骤1制得的超细药物粉散液与步骤2制得的凝胶基质混合,加入蒸馏水足量,搅拌均匀,即得凝胶剂。
实施例2
一种治疗胃癌前病变及胃癌的药物组合物,其包括以下重量份的原料药:太子参65份、炙黄芪40份、生山药45份、密点麻蜥45份、麦冬20份、乌梅20份、升麻10份、半枝莲45份、炒白芍20份、枳实45份、三七粉7份、蛇莓40份、硇砂4份、蜂房25份、鹿角胶200份、大黄5份。
一种本发明所述的治疗胃癌前病变及胃癌的药物组合物的制备方法,包括以下步骤:
步骤1、按本发明的药方准备各药材,将诸药材研磨粉碎至100目,混匀研磨后所得的粉末微粒,蒸晒,消毒后加入丙二醇,分散碾匀成药物分散液,待用;
步骤2、将卡波姆与适量抗氧化剂EDTA-2Na(乙二胺四乙酸二钠)、防腐剂尼泊金乙酯溶于水中,溶胀36小时,制得凝胶基质;
步骤3、将步骤1制得的超细药物粉散液与步骤2制得的凝胶基质混合,加入蒸馏水足量,搅拌均匀,即得凝胶剂。
实施例3
一种治疗胃癌前病变及胃癌的药物组合物,其特征在于,包括以下重量份的原料药:太子参80份、炙黄芪50份、生山药60份、密点麻蜥60份、麦冬30份、乌梅30份、升麻12份、半枝莲60份、炒白芍30份、枳实60份、三七粉9份、蛇莓60份、硇砂6份、蜂房40份、鹿角胶30份、大黄6份。
一种本发明所述的治疗胃癌前病变及胃癌的药物组合物的制备方法,包括以下步骤:
步骤1、按本发明的药方准备各药材,将诸药材研磨粉碎至120目,混匀研磨后所得的粉末微粒,蒸晒,消毒后加入丙二醇,分散碾匀成药物分散液,待用;
步骤2、将卡波姆与适量抗氧化剂EDTA-2Na(乙二胺四乙酸二钠)、防腐剂尼泊金乙酯溶于水中,溶胀48小时,制得凝胶基质;
步骤3、将步骤1制得的超细药物粉散液与步骤2制得的凝胶基质混合,加入蒸馏水足量,搅拌均匀,即得凝胶剂。
以上所述,仅为本发明较佳的具体实施方式,本发明的保护范围不限于此,任何熟悉本技术领域的技术人员在本发明披露的技术范围内,可显而易见地得到的技术方案的简单变化或等效替换均落入本发明的保护范围内。
Claims (3)
1.一种治疗胃癌前病变及胃癌的药物组合物,其特征在于,包括以下重量份的原料药:太子参50份-80份、炙黄芪30份-50份、生山药30-60份、密点麻蜥30份-60份、麦冬10份-30份、乌梅10份-30份、升麻6份-12份、半枝莲30份-60份、炒白芍10份-30份、枳实30份-60份、三七粉6份-9份、蛇莓20份-60份、硇砂2份-6份、蜂房10份-40份、鹿角胶10份-30份、大黄3份-6份。
2.根据权利要求1所述的治疗胃癌前病变及胃癌的药物组合物,其特征在于,其包括以下重量份的原料药:太子参65份、炙黄芪40份、生山药45份、密点麻蜥45份、麦冬20份、乌梅20份、升麻10份、半枝莲45份、炒白芍20份、枳实45份、三七粉7份、蛇莓40份、硇砂4份、蜂房25份、鹿角胶200份、大黄5份。
3.一种权利要求1所述的治疗胃癌前病变及胃癌的药物组合物的制备方法,包括以下步骤:
步骤1、按权利要求1的药方准备各药材,将诸药材研磨粉碎至80-120目,混匀研磨后所得的粉末微粒,蒸晒,消毒后加入丙二醇,分散碾匀成药物分散液,待用;
步骤2、将卡波姆与适量抗氧化剂EDTA-2Na(乙二胺四乙酸二钠)、防腐剂尼泊金乙酯溶于水中,溶胀24~48小时,制得凝胶基质;
步骤3、将步骤1制得的超细药物粉散液与步骤2制得的凝胶基质混合,加入蒸馏水足量,搅拌均匀,即得凝胶剂。
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CN1489990A (zh) * | 2003-09-12 | 2004-04-21 | 南京中医药大学 | 中药超细凝胶剂的制备方法 |
CN107837338A (zh) * | 2017-11-09 | 2018-03-27 | 宁夏医科大学 | 一种治疗萎缩性胃炎及其癌前病变的中药 |
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CN107837338A (zh) * | 2017-11-09 | 2018-03-27 | 宁夏医科大学 | 一种治疗萎缩性胃炎及其癌前病变的中药 |
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