CN111067943A

CN111067943A - Nasal cavity paste for treating rhinitis and nasosinusitis as well as preparation method and application thereof

Info

Publication number: CN111067943A
Application number: CN202010021956.5A
Authority: CN
Inventors: 杨立光; 杨继红; 杨继英
Original assignee: Individual
Current assignee: Individual
Priority date: 2020-01-09
Filing date: 2020-01-09
Publication date: 2020-04-28

Abstract

The invention discloses a nasal paste for treating rhinitis and nasosinusitis and a preparation method and application thereof, belonging to the technical field of medicines. The nasal paste for treating rhinitis and nasosinusitis comprises the following components in parts by weight: 6-10 parts of cocklebur fruit, 2-10 parts of biond magnolia flower, 1-5 parts of ephedra herb, 1-3 parts of asarum, 5-10 parts of salvia miltiorrhiza, 10-20 parts of dandelion, 10-20 parts of fructus cnidii, 10-20 parts of fructus forsythiae, 10-20 parts of honeysuckle flower, 3-8 parts of rheum officinale and 5-10 parts of angelica dahurica. The nasal paste provided by the embodiment of the invention takes Chinese herbal medicines as main raw materials, has no toxic or side effect, has the effects of clearing heat, dispelling inflammation, reducing swelling, detoxifying, expelling pus, preventing corrosion, dredging orifices, promoting blood circulation and removing blood stasis, can be used for treating acute, chronic and allergic rhinitis and nasosinusitis, has good treatment effect and short treatment course, and can avoid adverse reactions generated by the traditional treatment of the rhinitis and the nasosinusitis.

Description

Nasal cavity paste for treating rhinitis and nasosinusitis as well as preparation method and application thereof

Technical Field

The invention relates to the technical field of medicines, in particular to a nasal cavity paste for treating rhinitis and nasosinusitis and a preparation method and application thereof.

Background

Acute and chronic rhinitis and nasosinusitis are common diseases and frequently encountered diseases. Among them, ephedrine and rhinoceros are common in nasal drugs, but these drugs are not suitable for chronic rhinitis sicca, atrophic rhinitis and the like, and have a problem of insignificant therapeutic effect on symptoms such as rhinitis and sinusitis. Moreover, the two medicines are vasoconstrictors, some patients with hypertension and coronary heart disease are very sensitive to the medicines, the blood pressure is possibly increased or angina pectoris attacks after the medicines are dripped into the nose, and the vasoconstrictors have secondary vasodilation effect, namely, the nose is ventilated after the medicines are dripped into the nose, but after a few hours, the nasal obstruction is heavier and can be repeatedly used for a long time, malignant circulation is easily formed, finally, the nasal cavity is disordered in relaxation function, the olfactory nerve is not tip denatured, the nasal obstruction is heavier and heavier, the olfactory sensation is worse and worse, and the drug-induced rhinitis is caused.

Therefore, the existing medicines for treating rhinitis and nasosinusitis have the problems of easily generating adverse reactions and the like.

Disclosure of Invention

The embodiment of the invention aims to provide a nasal paste for treating rhinitis and nasosinusitis, which aims to solve the problem that the existing medicines for treating rhinitis and nasosinusitis proposed in the background art are easy to generate adverse reactions.

In order to achieve the above purpose, the embodiments of the present invention provide the following technical solutions:

a nasal cavity paste for treating rhinitis and nasosinusitis comprises the following components in parts by weight: 6-10 parts of cocklebur fruit, 2-10 parts of biond magnolia flower, 1-5 parts of ephedra herb, 1-3 parts of asarum, 5-10 parts of salvia miltiorrhiza, 10-20 parts of dandelion, 10-20 parts of fructus cnidii, 10-20 parts of fructus forsythiae, 10-20 parts of honeysuckle flower, 3-8 parts of rheum officinale and 5-10 parts of angelica dahurica.

As a preferable scheme of the embodiment of the invention, the nasal paste comprises the following components in parts by weight: 7-9 parts of cocklebur fruit, 4-6 parts of biond magnolia flower, 2-4 parts of ephedra herb, 1.5-2.5 parts of asarum, 7-9 parts of salvia miltiorrhiza, 13-17 parts of dandelion, 13-17 parts of fructus cnidii, 13-17 parts of fructus forsythiae, 13-17 parts of honeysuckle, 5-7 parts of rheum officinale and 6-8 parts of radix angelicae.

As another preferable scheme of the embodiment of the invention, the nasal paste comprises the following components in parts by weight: 8 parts of cocklebur fruit, 5 parts of biond magnolia flower, 3 parts of ephedra herb, 2 parts of asarum, 8 parts of salvia miltiorrhiza, 15 parts of dandelion, 15 parts of common cnidium fruit, 15 parts of weeping forsythia, 15 parts of honeysuckle flower, 6 parts of rhubarb and 7 parts of angelica dahurica.

Another object of the present invention is to provide a method for preparing the nasal paste, which comprises the following steps:

weighing the cocklebur fruit, the magnolia flower, the ephedra herb, the asarum, the salvia miltiorrhiza, the dandelion, the fructus cnidii, the forsythia, the honeysuckle, the rhubarb and the angelica dahurica for later use according to the weight parts;

pulverizing herba Ephedrae, herba asari, Saviae Miltiorrhizae radix, herba Taraxaci, fructus Cnidii, fructus forsythiae, flos Lonicerae, radix et rhizoma Rhei, and radix Angelicae Dahuricae to no less than 300 mesh, and mixing to obtain mixed powder;

extracting the fructus Xanthii and flos Magnoliae with sesame oil to obtain an extract oil;

adding Borneolum Syntheticum and the above mixed powder into the above extract oil, and mixing and rotating into colloidal liquid to obtain the nasal cavity unguent.

As another preferable aspect of the embodiment of the present invention, the step of extracting the cocklebur fruit and magnolia flower with sesame oil to obtain the extracted oil specifically includes:

heating the sesame oil to 150-180 ℃, adding the cocklebur fruit and the magnolia flower, frying until the cocklebur fruit turns black, and filtering to obtain the extracted oil.

As another preferable scheme of the embodiment of the invention, in the step, the mass ratio of the borneol, the sesame oil and the fructus xanthil is 1 (8-12) to (4-6).

Another object of the present invention is to provide a nasal paste prepared by the above preparation method.

Another object of the embodiment of the invention is to provide an application of the nasal cavity ointment in preparing a medicine for treating rhinitis.

Another object of the embodiment of the present invention is to provide an application of the nasal paste in preparing a medicament for treating sinusitis.

Wherein, the pharmacology of each component is as follows:

cocklebur fruit, nature and taste: sweet, bitter and warm in nature with slight toxicity. Meridian tropism: enter the lung meridian. The functions are as follows: induce sweating, dispel wind and remove dampness. The main treatment is as follows: headache due to wind-cold, nasosinusitis, arthralgia and spasm.

Magnolia flower, nature and taste: pungent and warm in nature. Meridian tropism: enter lung and stomach meridians. The functions are as follows: dispelling pathogenic wind, and dredging nasal orifice. The main treatment is as follows: cold, headache, nasal obstruction, nasosinusitis.

Ephedra herb, nature and taste: pungent, bitter and warm. Meridian tropism: enter lung and bladder meridians. The functions are as follows: sweating, relieving asthma, and inducing diuresis. Raw one has strong sweating power, and honey processed one is mostly used for treating asthma and relieving cough. The main treatment is as follows: wind-cold type common cold, asthma, cough and edema. It is applicable to common cold with no sweating due to wind-cold exterior syndrome.

Asarum, wild ginger, nature and taste: pungent and warm in nature. Meridian tropism: enter lung and kidney meridians. The functions are as follows: dispel wind and cold, induce resuscitation and alleviate pain, descend qi and dispel phlegm. The main treatment is as follows: common cold due to wind-cold, nasal obstruction, headache, arthralgia due to wind-cold-dampness, dyspnea with excessive phlegm, cough and asthma due to adverse rising of qi, and toothache.

Red sage root, nature and taste: bitter and slightly cold in taste. Meridian tropism: it enters heart and liver meridians. The efficacy is as follows: promoting blood circulation, dispelling blood stasis, dredging meridians, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood, and eliminating carbuncle. The main treatment is as follows: can be used for treating thoracic obstruction, heart pain, abdominal pain, hypochondriac pain, abdominal mass, pain due to pyretic arthralgia, vexation, insomnia, menoxenia, dysmenorrhea, amenorrhea, and pyocutaneous disease with swelling and pain.

Dandelion, nature and taste: bitter and sweet, cold. Meridian tropism: enter liver and stomach meridians. The functional indications are as follows: clear heat and remove toxicity, induce diuresis and dissipate nodulation. It can be used for treating acute mastitis, lymphadenitis, lymphoid tuberculosis, furunculosis, acute conjunctivitis, common cold with fever, acute tonsillitis, acute bronchitis, gastritis, hepatitis, cholecystitis, and urinary tract infection.

Cnidium fruit, nature and taste: pungent, bitter and warm. Meridian tropism: enter the kidney meridian. The functions are as follows: tonify kidney yang, dispel wind-cold, dry dampness and kill parasites. The main treatment is as follows: impotence, itching scrotum, vaginal itching due to vaginal discharge, cold uterus and infertility. It is used externally to treat scabies, eczema, dermatitis, eczema, etc.

Fructus forsythiae, nature and taste: bitter and slightly cold. Meridian tropism: enter the heart and small intestine meridians. The functions are as follows: clearing away heart-fire, relieving fever, relieving swelling, resolving hard mass, and inducing diuresis. The main treatment is as follows: the onset of acute fever is due to affection of exogenous wind-heat. Dysphoria with smothery sensation, coma, carbuncle, swelling, sore and scrofula.

Honeysuckle, nature and taste: sweet; is cold. Meridian tropism: a lung; the heart, stomach channel. The efficacy is as follows: clear heat and remove toxicity, stir-baked to charcoal to cool blood and stop bleeding. The main treatment is as follows: affection of exogenous wind-heat, fever due to epidemic febrile disease; dysentery with bloody stool due to heat-toxicity; carbuncle and furuncle; pharyngitis and various infectious diseases.

Rhubarb, nature and taste: bitter and cold. Meridian tropism: it enters spleen, stomach, large intestine, liver and pericardium meridians. The functions are as follows: purgation, promoting bowel movement, removing blood stasis, removing stagnation, clearing pathogenic fire and relieving swelling. The main treatment is as follows: excess heat accumulation in the intestines and stomach, excess heat syndrome in blood system, jaundice, edema, and blood stasis accumulation. Carbuncle, swelling, sore and toxin, and scald due to hot water and fire.

Radix angelicae, nature and taste: pungent and warm in nature. Meridian tropism: enter lung and stomach meridians. The functions are as follows: relieving exterior syndrome and dispelling pathogenic wind. Relieving swelling and pain. The main treatment is as follows: cold, headache, nasal obstruction, nasosinusitis pain, supraorbital pain, carbuncle, swelling and sores.

Compared with the prior art, the embodiment of the invention has the beneficial effects that:

the nasal cavity paste provided by the embodiment of the invention takes Chinese herbal medicines as main raw materials, has no toxic or side effect, can be used for treating acute, chronic and allergic rhinitis and nasosinusitis, has good treatment effect and short treatment course, and can avoid adverse reactions generated by the traditional treatment of the rhinitis and the nasosinusitis. Compared with the traditional treatment methods such as medicine drinking, injection, transfusion or operation, the nasal paste provided by the embodiment of the invention can achieve the treatment effect only by external application, and is more convenient to use.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Example 1

The embodiment provides a nasal paste for treating rhinitis and nasosinusitis, wherein the preparation method of the nasal paste comprises the following steps:

(1) weighing 60g of cocklebur fruit, 20g of biond magnolia flower, 10g of ephedra herb, 10g of asarum, 50g of salvia miltiorrhiza, 100g of dandelion, 100g of fructus cnidii, 100g of fructus forsythiae, 100g of honeysuckle flower, 30g of rheum officinale and 50g of angelica dahurica for later use.

(2) Respectively washing the ephedra, the asarum, the salvia miltiorrhiza, the dandelion, the fructus cnidii, the fructus forsythiae, the honeysuckle, the rheum officinale and the radix angelicae, drying in the shade, crushing, mixing together, and sieving to obtain mixed powder of 300 meshes for later use.

(3) Pouring 80g of sesame oil into an oil pan, heating to 150 ℃, adding cocklebur fruit and magnolia flower, frying until the cocklebur fruit turns black, and filtering to obtain the extracted oil.

(4) And adding 10g of borneol and the mixed powder into the extracted oil while the extracted oil is hot, mixing and rotating into a colloidal liquid, and then sterilizing to obtain the nasal cavity ointment.

Example 2

(1) weighing 100g of cocklebur fruit, 100g of biond magnolia flower, 50g of ephedra herb, 30g of asarum, 100g of salvia miltiorrhiza, 200g of dandelion, 200g of fructus cnidii, 200g of fructus forsythiae, 200g of honeysuckle flower, 80g of rheum officinale and 100g of angelica dahurica for later use.

(3) Pouring 300g of sesame oil into an oil pan, heating to 180 ℃, adding cocklebur fruit and biond magnolia flower, frying until the cocklebur fruit turns black, and filtering to obtain the extracted oil.

(4) Adding 25g of borneol and the mixed powder into the extracted oil while the extracted oil is hot, mixing and rotating into a colloidal liquid, and then sterilizing to obtain the nasal paste.

Example 3

(1) weighing 70g of cocklebur fruit, 40g of biond magnolia flower, 20g of ephedra herb, 15g of asarum, 70g of salvia miltiorrhiza, 130g of dandelion, 130g of fructus cnidii, 130g of fructus forsythiae, 130g of honeysuckle flower, 50g of rhubarb and 60g of angelica dahurica for later use.

(3) Pouring 140g of sesame oil into an oil pan, heating to 150 ℃, adding cocklebur fruit and biond magnolia flower, frying until the cocklebur fruit turns black, and filtering to obtain the extracted oil.

(4) Adding 14g of borneol and the mixed powder into the extracted oil while the extracted oil is hot, mixing and spinning the mixture into colloidal liquid, and then sterilizing to obtain the nasal paste.

Example 4

(1) weighing 90g of cocklebur fruit, 60g of biond magnolia flower, 40g of ephedra herb, 25g of asarum, 90g of salvia miltiorrhiza, 170g of dandelion, 170g of fructus cnidii, 170g of fructus forsythiae, 170g of honeysuckle flower, 70g of rheum officinale and 80g of angelica dahurica for later use.

(3) 150g of sesame oil is poured into an oil pan, the temperature is raised to 160 ℃, cocklebur fruit and biond magnolia flower are added for frying until the cocklebur fruit becomes black, and then the oil is filtered to obtain the extracted oil.

(4) Adding 15g of borneol and the mixed powder into the extracted oil while the extracted oil is hot, mixing and rotating into a colloidal liquid, and then sterilizing to obtain the nasal paste.

Example 5

(1) weighing 80g of cocklebur fruit (extract), 50g of biond magnolia flower (extract), 30g of ephedra herb, 20g of asarum, 80g of salvia miltiorrhiza, 150g of dandelion, 150g of fructus cnidii, 150g of fructus forsythiae, 150g of honeysuckle flower, 60g of rhubarb and 70g of angelica dahurica for later use.

(3) 160g of sesame oil is poured into an oil pan, the temperature is raised to 170 ℃, cocklebur fruit and biond magnolia flower are added for frying until the cocklebur fruit turns black, and then the oil is filtered to obtain the extracted oil.

(4) Adding 16g of borneol and the mixed powder into the extracted oil while the extracted oil is hot, mixing and rotating into a colloidal liquid, and then sterilizing to obtain the nasal paste.

The nasal paste provided by the embodiment is smeared in the nasal cavity of a patient suffering from rhinitis or nasosinusitis for 1-3 times every day, and the effect can be achieved after 10 days as a treatment course.

According to clinical observation of the invention for treating rhinitis, nasosinusitis and complications, more than 160 patients are diagnosed by accumulative treatment, wherein 90 patients are male, and 70 patients are female. Age 4-10 years 35 cases. 46 cases aged 8-20 years. 79 cases above 20 years old. The disease condition is divided into 30 cases of acute patients and 130 cases of chronic patients, and through the observation of outpatient service, 100 cases of rhinitis ointment for nasal cavity of the invention are used for 1-2 hours, 100 cases of rhinitis ointment for nasal cavity are cured for 10 days to 1 month, 60 cases of rhinitis ointment are cured for 5 days to 10 days, and 130 cases of rhinitis ointment have obvious effect.

The use effect of a few selected patients is as follows

1. The patient is in certain age, male is 5 years old, the disease is developed for 5 days, the patient is aggravated in the near day, the nasal obstruction and the nasal discharge are caused, the patient opens the mouth to breathe, the nasal paste is smeared by the nasal cavity for 1 hour, and then the nasal discharge is caused to be reduced. After 5 days, the hospital was checked and the disease was basically cured.

2. The patient segment is certain. For male. And 8 years old. Half a year after the onset, the multi-part treatment is not cured, and the doctor visits the hospital. To examine the swollen nasal turbinate on both sides. Swollen glands and large, and snoring. The ointment is added with oral Bitongsan powder (self-made) for 1 week and then rechecked. The ventilation is improved, and the patient can be cured in half a month.

3. The patient should be born at his or her own right. Male age 44 years, rhinitis, sinusitis, nasal aspiration, and during hospital treatment, lung infection. Two years ago, the patient was not cured in a certain hospital in Beijing (two years). And 8, 8 and 26 days in 2019. The rhinitis ointment is applied to nasal cavity (seven agents of rhinitis-relieving nasal orifice-opening sugar) for 1 week, and then the symptoms are reduced. Improvement was observed after 3 weeks and recovery was substantial after 4 weeks.

In conclusion, the nasal cavity paste provided by the embodiment of the invention takes Chinese herbal medicines as main raw materials, has no toxic or side effect, can be used for treating acute, chronic and allergic rhinitis and nasosinusitis, has good treatment effect and short treatment course, and can avoid adverse reactions generated by the traditional treatment of the rhinitis and the nasosinusitis.

In light of the foregoing description of the preferred embodiment of the present invention, many modifications and variations will be apparent to those skilled in the art without departing from the spirit and scope of the invention. The technical scope of the present invention is not limited to the content of the specification, and must be determined according to the scope of the claims.

Claims

1. The nasal paste for treating rhinitis and nasosinusitis is characterized by comprising the following components in parts by weight: 6-10 parts of cocklebur fruit, 2-10 parts of biond magnolia flower, 1-5 parts of ephedra herb, 1-3 parts of asarum, 5-10 parts of salvia miltiorrhiza, 10-20 parts of dandelion, 10-20 parts of fructus cnidii, 10-20 parts of fructus forsythiae, 10-20 parts of honeysuckle flower, 3-8 parts of rheum officinale and 5-10 parts of angelica dahurica.

2. The nasal paste for treating rhinitis and sinusitis according to claim 1, wherein the nasal paste comprises the following components in parts by weight: 7-9 parts of cocklebur fruit, 4-6 parts of biond magnolia flower, 2-4 parts of ephedra herb, 1.5-2.5 parts of asarum, 7-9 parts of salvia miltiorrhiza, 13-17 parts of dandelion, 13-17 parts of fructus cnidii, 13-17 parts of fructus forsythiae, 13-17 parts of honeysuckle, 5-7 parts of rheum officinale and 6-8 parts of radix angelicae.

3. The nasal paste for treating rhinitis and sinusitis according to claim 2, wherein the nasal paste comprises the following components in parts by weight: 8 parts of cocklebur fruit, 5 parts of biond magnolia flower, 3 parts of ephedra herb, 2 parts of asarum, 8 parts of salvia miltiorrhiza, 15 parts of dandelion, 15 parts of common cnidium fruit, 15 parts of weeping forsythia, 15 parts of honeysuckle flower, 6 parts of rhubarb and 7 parts of angelica dahurica.

4. A method of preparing a nasal paste according to any one of claims 1 to 3, comprising the steps of:

extracting the fructus Xanthii and flos Magnoliae with sesame oil to obtain mixed liquid extract;

5. The method for preparing a nasal cavity paste according to claim 4, wherein the step of extracting the cocklebur fruit and magnolia flower with sesame oil to obtain the extracted oil comprises:

6. The method for preparing a nasal cavity paste according to claim 4, wherein in the step, the mass ratio of the borneol, the sesame oil and the fructus xanthil is 1 (8-12) to (4-6).

7. A nasal paste prepared by the method of any one of claims 4 to 6.

8. Use of a nasal paste as claimed in any one of claims 1 to 3 and claim 7 in the manufacture of a medicament for the treatment of rhinitis.

9. Use of a nasal paste according to any one of claims 1 to 3 and claim 7 in the manufacture of a medicament for the treatment of sinusitis.